Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23150
Gene name Gene Name - the full gene name approved by the HGNC.	FERM domain containing 4B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FRMD4B
Synonyms (NCBI Gene) Gene synonyms aliases	6030440G05Rik, GRSP1
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p14.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

Show/Hide all(47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019072	hsa-miR-335-5p	Microarray	18185580
MIRT021453	hsa-miR-9-5p	Microarray	17612493
MIRT027864	hsa-miR-98-5p	Microarray	19088304
MIRT1004546	hsa-miR-1184	CLIP-seq
MIRT1004547	hsa-miR-1301	CLIP-seq
MIRT1004548	hsa-miR-2355-5p	CLIP-seq
MIRT1004549	hsa-miR-3164	CLIP-seq
MIRT1004550	hsa-miR-3614-5p	CLIP-seq
MIRT1004551	hsa-miR-3679-3p	CLIP-seq
MIRT1004552	hsa-miR-432	CLIP-seq
MIRT1004553	hsa-miR-4418	CLIP-seq
MIRT1004554	hsa-miR-4446-5p	CLIP-seq
MIRT1004555	hsa-miR-4453	CLIP-seq
MIRT1004556	hsa-miR-4521	CLIP-seq
MIRT1004557	hsa-miR-4538	CLIP-seq
MIRT1004558	hsa-miR-4633-3p	CLIP-seq
MIRT1004559	hsa-miR-4660	CLIP-seq
MIRT1004560	hsa-miR-4686	CLIP-seq
MIRT1004561	hsa-miR-495	CLIP-seq
MIRT1004562	hsa-miR-5047	CLIP-seq
MIRT1004563	hsa-miR-509-3-5p	CLIP-seq
MIRT1004564	hsa-miR-509-5p	CLIP-seq
MIRT1004565	hsa-miR-579	CLIP-seq
MIRT1004566	hsa-miR-606	CLIP-seq
MIRT1004567	hsa-miR-668	CLIP-seq
MIRT1004568	hsa-miR-890	CLIP-seq
MIRT1004550	hsa-miR-3614-5p	CLIP-seq
MIRT2231452	hsa-miR-1297	CLIP-seq
MIRT2231453	hsa-miR-200b	CLIP-seq
MIRT2231454	hsa-miR-200c	CLIP-seq
MIRT2231455	hsa-miR-26a	CLIP-seq
MIRT2231456	hsa-miR-26b	CLIP-seq
MIRT2231457	hsa-miR-323b-3p	CLIP-seq
MIRT2231458	hsa-miR-3647-3p	CLIP-seq
MIRT2231459	hsa-miR-4267	CLIP-seq
MIRT2231460	hsa-miR-4275	CLIP-seq
MIRT2231461	hsa-miR-4276	CLIP-seq
MIRT2231462	hsa-miR-429	CLIP-seq
MIRT2231463	hsa-miR-433	CLIP-seq
MIRT2231464	hsa-miR-4465	CLIP-seq
MIRT2231465	hsa-miR-4668-3p	CLIP-seq
MIRT2231466	hsa-miR-4771	CLIP-seq
MIRT2231467	hsa-miR-4775	CLIP-seq
MIRT2231468	hsa-miR-4799-5p	CLIP-seq
MIRT2231469	hsa-miR-499a-5p	CLIP-seq
MIRT2231470	hsa-miR-590-3p	CLIP-seq
MIRT2231471	hsa-miR-944	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005912	Component	Adherens junction	IBA
GO:0005912	Component	Adherens junction	IEA
GO:0005923	Component	Bicellular tight junction	IBA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	IEA
GO:0090162	Process	Establishment of epithelial cell polarity	IEA

MIM	HGNC	e!Ensembl
617467	24886	ENSG00000114541

Protein

UniProt ID

Q9Y2L6

Protein name

FERM domain-containing protein 4B (GRP1-binding protein GRSP1)

Protein function

Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09379	FERM_N	63 → 125	FERM N-terminal domain	Domain
PF00373	FERM_M	144 → 260	FERM central domain	Domain
PF09380	FERM_C	264 → 365	FERM C-terminal PH-like domain	Domain
PF11819	CUPID	395 → 529	Cytohesin Ubiquitin Protein Inducing Domain	Domain

Sequence

MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRH
CQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRV
LDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKL
AAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQ
AVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLE
NLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDR
KQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSE
EQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRR
VGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTD
AMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQ
RSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGG
RSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRS
SSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMP
NLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYR
SSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLR
GWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNW
RTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQ
RLFWHEDSKPGTLV

Sequence length

1034

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Celiac disease	Celiac disease	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Cardiomyopathies	Associate	20718813
Celiac Disease	Associate	24999842
Heart Failure	Associate	20124441
Pulmonary Disease Chronic Obstructive	Associate	29313708
Salivary Gland Diseases	Associate	25985088

FRMD4B (FERM domain containing 4B)