ZC3H3 (zinc finger CCCH-type containing 3)

Gene

• Entrez ID: 23144
• Gene name: Zinc finger CCCH-type containing 3
• Gene symbol: ZC3H3
• Synonyms (NCBI Gene): SMICL, ZC3HDC3
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040908	hsa-miR-18a-3p	CLASH	23622248
MIRT039752	hsa-miR-615-3p	CLASH	23622248
MIRT1505864	hsa-miR-1238	CLIP-seq
MIRT1505865	hsa-miR-125a-3p	CLIP-seq
MIRT1505866	hsa-miR-1908	CLIP-seq
MIRT1505867	hsa-miR-2278	CLIP-seq
MIRT1505868	hsa-miR-2467-5p	CLIP-seq
MIRT1505869	hsa-miR-3124-3p	CLIP-seq
MIRT1505870	hsa-miR-3138	CLIP-seq
MIRT1505871	hsa-miR-3165	CLIP-seq
MIRT1505872	hsa-miR-3183	CLIP-seq
MIRT1505873	hsa-miR-3188	CLIP-seq
MIRT1505874	hsa-miR-3202	CLIP-seq
MIRT1505875	hsa-miR-339-5p	CLIP-seq
MIRT1505876	hsa-miR-361-3p	CLIP-seq
MIRT1505877	hsa-miR-3616-3p	CLIP-seq
MIRT1505878	hsa-miR-3657	CLIP-seq
MIRT1505879	hsa-miR-3975	CLIP-seq
MIRT1505880	hsa-miR-4316	CLIP-seq
MIRT1505881	hsa-miR-4514	CLIP-seq
MIRT1505882	hsa-miR-4519	CLIP-seq
MIRT1505883	hsa-miR-4520a-3p	CLIP-seq
MIRT1505884	hsa-miR-4533	CLIP-seq
MIRT1505885	hsa-miR-4640-5p	CLIP-seq
MIRT1505886	hsa-miR-4645-5p	CLIP-seq
MIRT1505887	hsa-miR-4673	CLIP-seq
MIRT1505888	hsa-miR-4692	CLIP-seq
MIRT1505889	hsa-miR-4710	CLIP-seq
MIRT1505890	hsa-miR-4721	CLIP-seq
MIRT1505891	hsa-miR-4723-3p	CLIP-seq
MIRT1505892	hsa-miR-4726-3p	CLIP-seq
MIRT1505893	hsa-miR-4726-5p	CLIP-seq
MIRT1505894	hsa-miR-4755-3p	CLIP-seq
MIRT1505895	hsa-miR-4767	CLIP-seq
MIRT1505896	hsa-miR-485-5p	CLIP-seq
MIRT1505897	hsa-miR-490-5p	CLIP-seq
MIRT1505898	hsa-miR-663	CLIP-seq
MIRT1505899	hsa-miR-663b	CLIP-seq
MIRT1505900	hsa-miR-940	CLIP-seq
MIRT2152292	hsa-miR-137	CLIP-seq
MIRT1505869	hsa-miR-3124-3p	CLIP-seq
MIRT2152293	hsa-miR-4788	CLIP-seq
MIRT2152294	hsa-miR-628-5p	CLIP-seq
MIRT1505864	hsa-miR-1238	CLIP-seq
MIRT2397262	hsa-miR-1255a	CLIP-seq
MIRT2397263	hsa-miR-1255b	CLIP-seq
MIRT1505869	hsa-miR-3124-3p	CLIP-seq
MIRT1505872	hsa-miR-3183	CLIP-seq
MIRT1505891	hsa-miR-4723-3p	CLIP-seq
MIRT2397264	hsa-miR-515-5p	CLIP-seq
MIRT1505869	hsa-miR-3124-3p	CLIP-seq
MIRT1505870	hsa-miR-3138	CLIP-seq
MIRT1505871	hsa-miR-3165	CLIP-seq
MIRT1505883	hsa-miR-4520a-3p	CLIP-seq
MIRT2665573	hsa-miR-3144-5p	CLIP-seq
MIRT2665574	hsa-miR-3191	CLIP-seq
MIRT1505874	hsa-miR-3202	CLIP-seq
MIRT2665575	hsa-miR-342-5p	CLIP-seq
MIRT2665576	hsa-miR-3620	CLIP-seq
MIRT2665577	hsa-miR-4308	CLIP-seq
MIRT1505884	hsa-miR-4533	CLIP-seq
MIRT2665578	hsa-miR-4651	CLIP-seq
MIRT2665579	hsa-miR-4652-5p	CLIP-seq
MIRT2665580	hsa-miR-4664-5p	CLIP-seq
MIRT2665581	hsa-miR-491-5p	CLIP-seq
MIRT2665582	hsa-miR-541	CLIP-seq
MIRT2665583	hsa-miR-608	CLIP-seq
MIRT2665584	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	16115198, 19364924
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IEA
GO:0031124	Process	MRNA 3'-end processing	IEA
GO:0032927	Process	Positive regulation of activin receptor signaling pathway	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051028	Process	MRNA transport	IEA
GO:0070412	Function	R-SMAD binding	IEA
GO:1900363	Process	Regulation of mRNA polyadenylation	IMP	19364924

Other IDs

• MIM: 618640
• HGNC: 28972
• e!Ensembl: ENSG00000014164

Protein

• UniProt ID: Q8IXZ2
• Protein name: Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor)
• Protein function: Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similari
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00642	zf-CCCH	668 → 694	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
  PF00642	zf-CCCH	773 → 798	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

• Sequence:

  MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRR
  GYSSHHGPSWRKKYSLVNRPPGPSDPPADHAVRPLHGARGGQPPVPQQHVLERQVQLSQG
  QNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR
  GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTG
  VALGRKLGSHSVASCAPQLLGDRRVDAGHTDQPVPSGSVGGPARPASGPRQAREASLVVT
  CRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK
  PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRP
  AVGHSGLKPLSGETPLSAYKVKSRTKIIRRRSSTSLPGDKKSGTSPAATAKSHLSLRRRQ
  ALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY
  RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKG
  YRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTGRLDPAGSCSRSLASRAVQRSLAIIR
  QARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHH
  VSKEKMPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPD
  FARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGPSDATARSRVSASHGPRKPSASQRPT
  RQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAA
  ACSNRLCKLPSFISLQSSPSPGAQPRVRAPRAPLTKDSGKPLHIKPRL

• Sequence length: 948

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Myocardial infarction	Myocardial Infarction		21211798	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Adrenocortical Carcinoma	Associate	33725886
Carcinoma Hepatocellular	Associate	33059309
Carcinoma Hepatocellular	Stimulate	38302914
Fibrosis	Associate	38302914
Precancerous Conditions	Associate	36471401
Retinal Vein Occlusion	Associate	33059309