Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23140
Gene name Gene Name - the full gene name approved by the HGNC.	Zinc finger ZZ-type and EF-hand domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ZZEF1
Synonyms (NCBI Gene) Gene synonyms aliases	ZZZ4
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2

Show/Hide all(151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051207	hsa-miR-16-5p	CLASH	23622248
MIRT045740	hsa-miR-125a-5p	CLASH	23622248
MIRT042030	hsa-miR-484	CLASH	23622248
MIRT040251	hsa-miR-615-3p	CLASH	23622248
MIRT439172	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439172	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1544932	hsa-miR-122	CLIP-seq
MIRT1544933	hsa-miR-1243	CLIP-seq
MIRT1544934	hsa-miR-1245b-5p	CLIP-seq
MIRT1544935	hsa-miR-149	CLIP-seq
MIRT1544936	hsa-miR-15a	CLIP-seq
MIRT1544937	hsa-miR-15b	CLIP-seq
MIRT1544938	hsa-miR-16	CLIP-seq
MIRT1544939	hsa-miR-1914	CLIP-seq
MIRT1544940	hsa-miR-195	CLIP-seq
MIRT1544941	hsa-miR-1972	CLIP-seq
MIRT1544942	hsa-miR-2110	CLIP-seq
MIRT1544943	hsa-miR-296-5p	CLIP-seq
MIRT1544944	hsa-miR-3064-5p	CLIP-seq
MIRT1544945	hsa-miR-3065-3p	CLIP-seq
MIRT1544946	hsa-miR-3074-5p	CLIP-seq
MIRT1544947	hsa-miR-3127-3p	CLIP-seq
MIRT1544948	hsa-miR-3142	CLIP-seq
MIRT1544949	hsa-miR-3150a-3p	CLIP-seq
MIRT1544950	hsa-miR-3151	CLIP-seq
MIRT1544951	hsa-miR-3184	CLIP-seq
MIRT1544952	hsa-miR-326	CLIP-seq
MIRT1544953	hsa-miR-330-5p	CLIP-seq
MIRT1544954	hsa-miR-3545-5p	CLIP-seq
MIRT1544955	hsa-miR-3654	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT1544957	hsa-miR-3914	CLIP-seq
MIRT1544958	hsa-miR-3977	CLIP-seq
MIRT1544959	hsa-miR-423-5p	CLIP-seq
MIRT1544960	hsa-miR-424	CLIP-seq
MIRT1544961	hsa-miR-4266	CLIP-seq
MIRT1544962	hsa-miR-4283	CLIP-seq
MIRT1544963	hsa-miR-4328	CLIP-seq
MIRT1544964	hsa-miR-4428	CLIP-seq
MIRT1544965	hsa-miR-4432	CLIP-seq
MIRT1544966	hsa-miR-4450	CLIP-seq
MIRT1544967	hsa-miR-4456	CLIP-seq
MIRT1544968	hsa-miR-4530	CLIP-seq
MIRT1544969	hsa-miR-4650-5p	CLIP-seq
MIRT1544970	hsa-miR-4677-3p	CLIP-seq
MIRT1544971	hsa-miR-4695-5p	CLIP-seq
MIRT1544972	hsa-miR-4755-3p	CLIP-seq
MIRT1544973	hsa-miR-4779	CLIP-seq
MIRT1544974	hsa-miR-4794	CLIP-seq
MIRT1544975	hsa-miR-497	CLIP-seq
MIRT1544976	hsa-miR-499-5p	CLIP-seq
MIRT1544977	hsa-miR-499a-5p	CLIP-seq
MIRT1544978	hsa-miR-541	CLIP-seq
MIRT1544979	hsa-miR-654-5p	CLIP-seq
MIRT1544980	hsa-miR-659	CLIP-seq
MIRT1544981	hsa-miR-760	CLIP-seq
MIRT1544982	hsa-miR-873	CLIP-seq
MIRT1544983	hsa-miR-942	CLIP-seq
MIRT2164576	hsa-miR-1268	CLIP-seq
MIRT2164577	hsa-miR-1268b	CLIP-seq
MIRT2164578	hsa-miR-1282	CLIP-seq
MIRT2164579	hsa-miR-1285	CLIP-seq
MIRT2164580	hsa-miR-1293	CLIP-seq
MIRT2164581	hsa-miR-147	CLIP-seq
MIRT2164582	hsa-miR-153	CLIP-seq
MIRT2164583	hsa-miR-1912	CLIP-seq
MIRT2164584	hsa-miR-1913	CLIP-seq
MIRT2164585	hsa-miR-1915	CLIP-seq
MIRT1544942	hsa-miR-2110	CLIP-seq
MIRT2164586	hsa-miR-2115	CLIP-seq
MIRT2164587	hsa-miR-299-3p	CLIP-seq
MIRT2164588	hsa-miR-31	CLIP-seq
MIRT2164589	hsa-miR-3130-3p	CLIP-seq
MIRT1544949	hsa-miR-3150a-3p	CLIP-seq
MIRT2164590	hsa-miR-3158-5p	CLIP-seq
MIRT2164591	hsa-miR-3166	CLIP-seq
MIRT1544951	hsa-miR-3184	CLIP-seq
MIRT2164592	hsa-miR-3187-5p	CLIP-seq
MIRT2164593	hsa-miR-3194-3p	CLIP-seq
MIRT2164594	hsa-miR-324-3p	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT2164595	hsa-miR-3907	CLIP-seq
MIRT2164596	hsa-miR-3910	CLIP-seq
MIRT2164597	hsa-miR-3911	CLIP-seq
MIRT1544959	hsa-miR-423-5p	CLIP-seq
MIRT2164598	hsa-miR-425	CLIP-seq
MIRT2164599	hsa-miR-4252	CLIP-seq
MIRT1544961	hsa-miR-4266	CLIP-seq
MIRT2164600	hsa-miR-4303	CLIP-seq
MIRT2164601	hsa-miR-432	CLIP-seq
MIRT1544965	hsa-miR-4432	CLIP-seq
MIRT1544966	hsa-miR-4450	CLIP-seq
MIRT1544967	hsa-miR-4456	CLIP-seq
MIRT2164602	hsa-miR-448	CLIP-seq
MIRT2164603	hsa-miR-4483	CLIP-seq
MIRT2164604	hsa-miR-4484	CLIP-seq
MIRT2164605	hsa-miR-4491	CLIP-seq
MIRT2164606	hsa-miR-4505	CLIP-seq
MIRT2164607	hsa-miR-4509	CLIP-seq
MIRT2164608	hsa-miR-4648	CLIP-seq
MIRT2164609	hsa-miR-4657	CLIP-seq
MIRT2164610	hsa-miR-4665-3p	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2164612	hsa-miR-4691-3p	CLIP-seq
MIRT1544971	hsa-miR-4695-5p	CLIP-seq
MIRT2164613	hsa-miR-4696	CLIP-seq
MIRT2164614	hsa-miR-4726-3p	CLIP-seq
MIRT2164615	hsa-miR-4749-3p	CLIP-seq
MIRT2164616	hsa-miR-4771	CLIP-seq
MIRT1544973	hsa-miR-4779	CLIP-seq
MIRT1544976	hsa-miR-499-5p	CLIP-seq
MIRT2164617	hsa-miR-508-5p	CLIP-seq
MIRT1544978	hsa-miR-541	CLIP-seq
MIRT2164618	hsa-miR-548an	CLIP-seq
MIRT2164619	hsa-miR-612	CLIP-seq
MIRT2164620	hsa-miR-644	CLIP-seq
MIRT1544979	hsa-miR-654-5p	CLIP-seq
MIRT2164621	hsa-miR-892a	CLIP-seq
MIRT2383650	hsa-miR-2682	CLIP-seq
MIRT2383651	hsa-miR-3120-3p	CLIP-seq
MIRT2164590	hsa-miR-3158-5p	CLIP-seq
MIRT2164591	hsa-miR-3166	CLIP-seq
MIRT2383652	hsa-miR-34a	CLIP-seq
MIRT2383653	hsa-miR-34c-5p	CLIP-seq
MIRT1544958	hsa-miR-3977	CLIP-seq
MIRT2383654	hsa-miR-4267	CLIP-seq
MIRT2383655	hsa-miR-4436b-3p	CLIP-seq
MIRT2383656	hsa-miR-4476	CLIP-seq
MIRT2383657	hsa-miR-449a	CLIP-seq
MIRT2383658	hsa-miR-449b	CLIP-seq
MIRT2383659	hsa-miR-449c	CLIP-seq
MIRT2383660	hsa-miR-4514	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2383661	hsa-miR-4692	CLIP-seq
MIRT2164615	hsa-miR-4749-3p	CLIP-seq
MIRT2383662	hsa-miR-4758-3p	CLIP-seq
MIRT2164616	hsa-miR-4771	CLIP-seq
MIRT2383663	hsa-miR-4773	CLIP-seq
MIRT1544977	hsa-miR-499a-5p	CLIP-seq
MIRT1544956	hsa-miR-3692	CLIP-seq
MIRT1544969	hsa-miR-4650-5p	CLIP-seq
MIRT2164611	hsa-miR-4685-5p	CLIP-seq
MIRT2397794	hsa-miR-4733-3p	CLIP-seq
MIRT2696478	hsa-miR-1287	CLIP-seq
MIRT2696479	hsa-miR-193a-5p	CLIP-seq
MIRT2696480	hsa-miR-3135b	CLIP-seq
MIRT2696481	hsa-miR-3978	CLIP-seq
MIRT2164599	hsa-miR-4252	CLIP-seq
MIRT2696482	hsa-miR-431	CLIP-seq
MIRT2696483	hsa-miR-637	CLIP-seq
MIRT2696484	hsa-miR-875-3p	CLIP-seq

Show/Hide all(2)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0008270	Function	Zinc ion binding	IEA

MIM	HGNC	e!Ensembl
619459	29027	ENSG00000074755

Protein

UniProt ID

O43149

Protein name

Zinc finger ZZ-type and EF-hand domain-containing protein 1

Protein function

Histone H3 reader which may act as a transcriptional coactivator for KLF6 and KLF9 transcription factors.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03256	ANAPC10	226 → 393	Anaphase-promoting complex, subunit 10 (APC10)	Family
PF00569	ZZ	1779 → 1820	Zinc finger, ZZ type	Domain
PF00569	ZZ	1826 → 1870	Zinc finger, ZZ type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low levels in cerebellum. {ECO:0000269|PubMed:15519529}.

Sequence

MGNAPSHSSEDEAAAAGGEGWGPHQDWAAVSGTTPGPGVAAPALPPAAALLEPARLREAA
AALLPTPPCESLVSRHRGALFRWLEERLGRGEESVTLEQFRELLEARGAGCSSEQFEEAF
AQFDAEGDGTVDAENMLEALKNSSGANLQGELSHIIRQLQACSLVPGFTDIFSESKEGLD
IHSSMILRFLHRNRLSSAVMPYPMLEHCNNMCTMRSSVLKESLDQLVQKEKESPGDLTRS
PEMDKLKSVAKCYAYIETSSNSADIDKMTNGETSSYWQSDGSACSHWIRLKMKPDVVLRH
LSIAVAATDQSYMPQQVTVAVGRNASDLQEVRDVHIPSNVTGYVTLLENANVSQLYVQIN
IKRCLSDGCDTRIHGLRAVGFQRVKKSGVSVSDASAIWYWSLLTSLVTASMETNPAFVQT
VLHNTQKALRHMPPLSLSPGSTDFSTFLSPNVLEEVDSFLIRITSCCSTPEVELTLLAFA
LARGSVAKVMSSLCTITDHLDTQYDASSLILSMASVRQNLLLKYGKPLQLTLQACDVKGK
EDKSGPENLLVEPWTRDGFLTETGKTRASTIFSTGTESAFQVTQIRIMVRRGGIGAQCGL
VFAYNSSSDKFCAEEHFKRFEKYDKWKLQELRQFVKSRIGCSSDDLGEDDPIGWFELEEE
WDEADVKLQQCRVAKYLMVKFLCTRQESAERLGVQGLTISGYLRPARAEAEQSVTCAHCR
KDTEESVCGATLLLRTLQFIQQLAHDLVQQKESGLKYKSFLDFAGLDLQIFWNFYSKLKQ
NPREECVSAQTLLLQLLQSCFSVLQGDVLAASEEEKAPIQSPKGVEAAKELYTHLCDVVD
KVDGDSVPMEILKQEVRNTLLNGAAIFFPNRQTRRNHLFTMMNVTEQEHKQSLQLTFRSL
CTYFSDKDPGGLLLLPEKNDLAKMNISEVLAVMDTLVSVAARECELLMLSGAPGEVGSVL
FSLFWSVQGSLLSWCYLQLKSTDSGAKDLAVDLIEKYVGQFLASMRAILESLFSQYSGKT
IVERLCNSVFSMAARQLVIFLLDFCTLDIPHCVLLREFSVLTELLKKLCSGPEGGLRKLD
VETWQQEQPVVLHTWTKESAHNYENNCHEVSVFVSPGATYFEVEFDDRCETEKRYDYLEF
TDARGRKTRYDTKVGTDKWPKKVTFKAGPRLQFLFHSDSSHNEWGYKFTVTACGLPDVAV
SWGLDLQLLVSRLMGRLASQCMALKSVRQLGSNMVVPQAKMALVLSSPLWKPVFRHQVCP
ELELEASWPTHPHRNSKEVKNIPDDPCRHFLLDFAQSEPAQNFCGPYSELFKGFIQACRK
QAPKTDIVAGSTIDQAVNATFAALVYRTPDLYEKLQKYVNSGGKIALSEEFAQVYSLADG
IRIWMLEMKQKSLMSLGNEAEEKHSSEATEVNPESLAKECIEKSLLLLKFLPTGISSKES
CEKLETADETSHLQPLNKRQRTSSVVEEHFQASVSPTEAAPPATGDQSPGLGTQPKLPSS
SGLPAADVSPATAEEPLSPSTPTRRPPFTRGRLRLLSFRSMEEARLVPTVKEKYPVLKDV
MDFIKDQSLSHRSVVKVLSLRKAQAQSILEVLKITQHCAESLGQPHCFHPPFILFLLELL
TCQKDFTNYFGHLEGCGADLHKEIRDTYYQLVLFLVKAVKGFSSLNDRSLLPALSCVQTA
LLHLLDMGWEPNDLAFFVDIQLPDLLMKMSQENISVHDSVISQWSEEDELADAKQNSEWM
DECQDGMFEAWYEKIAQEDPEKQRKMHMFIARYCDLLNVDISCDGCDEIAPWHRYRCLQC
SDMDLCKTCFLGGVKPEGHGDDHEMVNMEFTCDHCQGLIIGRRMNCNVCDDFDLCYGCYA
AKKYSYGHLPTHSITAHPMVTIRISDRQRLIQPYIHNYSWLLFAALALYSAHLASAEDVD
GEKLDPQTRSSATTLRSQCMQLVGDCLMKAHQGKGLKALALLGVLPDGDSSLEDQALPVT
VPTGASEEQLEKKAVQGAELSEAGNGKRAVHEEIRPVDFKQRNKADKGVSLSKDPSCQTQ
ISDSPADASPPTGLPDAEDSEVSSQKPIEEKAVTPSPEQVFAECSQKRILGLLAAMLPPL
KSGPTVPLIDLEHVLPLMFQVVISNAGHLNETYHLTLGLLGQLIIRLLPAEVDAAVIKVL
SAKHNLFAAGDSSIVPDGWKTTHLLFSLGAVCLDSRVGLDWACSMAEILRSLNSAPLWRD
VIATFTDHCIKQLPFQLKHTNIFTLLVLVGFPQVLCVGTRCVYMDNANEPHNVIILKHFT
EKNRAVIVDVKTRKRKTVKDYQLVQKGGGQECGDSRAQLSQYSQHFAFIASHLLQSSMDS
HCPEAVEATWVLSLALKGLYKTLKAHGFEEIRATFLQTDLLKLLVKKCSKGTGFSKTWLL
RDLEILSIMLYSSKKEINALAEHGDLELDERGDREEEVERPVSSPGDPEQKKLDPLEGLD
EPTRICFLMAHDALNAPLHILRAIYELQMKKTDYFFLEVQKRFDGDELTTDERIRSLAQR
WQPSKSLRLEEQSAKAVDTDMIILPCLSRPARCDQATAESNPVTQKLISSTESELQQSYA
KQRRSKSAALLHKELNCKSKRAVRDYLFRVNEATAVLYARHVLASLLAEWPSHVPVSEDI
LELSGPAHMTYILDMFMQLEEKHEWEKILQKVLQGCREDMLGTMALAACQFMEEPGMEVQ
VRESKHPYNNNTNFEDKVHIPGAIYLSIKFDSQCNTEEGCDELAMSSSSDFQQDRHSFSG
SQQKWKDFELPGDTLYYRFTSDMSNTEWGYRFTVTAGHLGRFQTGFEILKQMLSEERVVP
HLPLAKIWEWLVGVACRQTGHQRLKAIHLLLRIVRCCGHSDLCDLALLKPLWQLFTHMEY
GLFEDVTQPGILLPLHRALTELFFVTENRAQELGVLQDYLLALTTDDHLLRCAAQALQNI
AAISLAINYPNKATRLWNVEC

Sequence length

2961

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	28566273, 30054458, 29632382, 30718926

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Diabetes	Diabetes	GWAS
Schizophrenia	Schizophrenia	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Diabetes Mellitus	Associate	33227311
Lung Neoplasms	Associate	33227311
Neoplasms	Associate	33227311

ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1)