Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23135
Gene name	Lysine demethylase 6B
Gene symbol	KDM6B
Synonyms (NCBI Gene)	JMJD3NEDCFSANEDSST
Chromosome	17
Chromosome location	17p13.1
Summary	The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization

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SNP ID	Visualize variation	Clinical significance	Consequence
rs769566928	AGAG>-	Uncertain-significance, pathogenic	Frameshift variant, coding sequence variant
rs1597850788	AG>-	Uncertain-significance, pathogenic	Frameshift variant, coding sequence variant

506

Show/Hide all (506)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017568	hsa-miR-335-5p	Microarray	18185580
MIRT021179	hsa-miR-186-5p	Sequencing	20371350
MIRT027296	hsa-miR-101-3p	Sequencing	20371350
MIRT052574	hsa-let-7a-5p	CLASH	23622248
MIRT049017	hsa-miR-92a-3p	CLASH	23622248
MIRT040965	hsa-miR-18a-3p	CLASH	23622248
MIRT289587	hsa-miR-941	Luciferase reporter assayWestern blotImmunofluorescenceqRT-PCR	25049231
MIRT289587	hsa-miR-941	Luciferase reporter assayWestern blotImmunofluorescenceqRT-PCR	25049231
MIRT289587	hsa-miR-941	Luciferase reporter assayWestern blotImmunofluorescenceqRT-PCR	25049231
MIRT289587	hsa-miR-941	Luciferase reporter assayWestern blotImmunofluorescenceqRT-PCR	25049231
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT570659	hsa-miR-4481	PAR-CLIP	20371350
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT570657	hsa-miR-4515	PAR-CLIP	20371350
MIRT570656	hsa-miR-3199	PAR-CLIP	20371350
MIRT570655	hsa-miR-8052	PAR-CLIP	20371350
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	20371350
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT570651	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT570647	hsa-miR-4447	PAR-CLIP	20371350
MIRT570645	hsa-miR-4472	PAR-CLIP	20371350
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT289579	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT289570	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT289577	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT289575	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT289583	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT289581	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT289573	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT289571	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570661	hsa-miR-6746-5p	PAR-CLIP	20371350
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT570659	hsa-miR-4481	PAR-CLIP	20371350
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT570657	hsa-miR-4515	PAR-CLIP	20371350
MIRT570656	hsa-miR-3199	PAR-CLIP	20371350
MIRT570655	hsa-miR-8052	PAR-CLIP	20371350
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	20371350
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT570651	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT570649	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT570648	hsa-miR-7704	PAR-CLIP	20371350
MIRT570647	hsa-miR-4447	PAR-CLIP	20371350
MIRT570645	hsa-miR-4472	PAR-CLIP	20371350
MIRT570646	hsa-miR-6771-5p	PAR-CLIP	20371350
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT493422	hsa-miR-4308	PAR-CLIP	23592263
MIRT493421	hsa-miR-4292	PAR-CLIP	23592263
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	23592263
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	23592263
MIRT493415	hsa-miR-4706	PAR-CLIP	23592263
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT493413	hsa-miR-8085	PAR-CLIP	23592263
MIRT493411	hsa-miR-3178	PAR-CLIP	23592263
MIRT493410	hsa-miR-3175	PAR-CLIP	23592263
MIRT079165	hsa-miR-5787	PAR-CLIP	23592263
MIRT440397	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT440397	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT289587	hsa-miR-941	FlowqRT-PCRWestern blot	27755585
MIRT289575	hsa-miR-106a-5p	PAR-CLIP	26701625
MIRT289575	hsa-miR-106a-5p	PAR-CLIP	26701625
MIRT289577	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT289577	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	26701625
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	26701625
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	26701625
MIRT289570	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT289570	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT289571	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT289571	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT289579	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT289579	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	26701625
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	26701625
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	26701625
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	26701625
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	26701625
MIRT493410	hsa-miR-3175	PAR-CLIP	26701625
MIRT493410	hsa-miR-3175	PAR-CLIP	26701625
MIRT493410	hsa-miR-3175	PAR-CLIP	26701625
MIRT493410	hsa-miR-3175	PAR-CLIP	26701625
MIRT493410	hsa-miR-3175	PAR-CLIP	26701625
MIRT493411	hsa-miR-3178	PAR-CLIP	26701625
MIRT493411	hsa-miR-3178	PAR-CLIP	26701625
MIRT493411	hsa-miR-3178	PAR-CLIP	26701625
MIRT493411	hsa-miR-3178	PAR-CLIP	26701625
MIRT570656	hsa-miR-3199	PAR-CLIP	26701625
MIRT570656	hsa-miR-3199	PAR-CLIP	26701625
MIRT570656	hsa-miR-3199	PAR-CLIP	26701625
MIRT570651	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT570651	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT570651	hsa-miR-328-5p	PAR-CLIP	26701625
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	26701625
MIRT493421	hsa-miR-4292	PAR-CLIP	26701625
MIRT493421	hsa-miR-4292	PAR-CLIP	26701625
MIRT493421	hsa-miR-4292	PAR-CLIP	26701625
MIRT493422	hsa-miR-4308	PAR-CLIP	26701625
MIRT493422	hsa-miR-4308	PAR-CLIP	26701625
MIRT493422	hsa-miR-4308	PAR-CLIP	26701625
MIRT570647	hsa-miR-4447	PAR-CLIP	26701625
MIRT570647	hsa-miR-4447	PAR-CLIP	26701625
MIRT570647	hsa-miR-4447	PAR-CLIP	26701625
MIRT570645	hsa-miR-4472	PAR-CLIP	26701625
MIRT570645	hsa-miR-4472	PAR-CLIP	26701625
MIRT570645	hsa-miR-4472	PAR-CLIP	26701625
MIRT570659	hsa-miR-4481	PAR-CLIP	26701625
MIRT570659	hsa-miR-4481	PAR-CLIP	26701625
MIRT570659	hsa-miR-4481	PAR-CLIP	26701625
MIRT570657	hsa-miR-4515	PAR-CLIP	26701625
MIRT570657	hsa-miR-4515	PAR-CLIP	26701625
MIRT570657	hsa-miR-4515	PAR-CLIP	26701625
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	26701625
MIRT493415	hsa-miR-4706	PAR-CLIP	26701625
MIRT493415	hsa-miR-4706	PAR-CLIP	26701625
MIRT493415	hsa-miR-4706	PAR-CLIP	26701625
MIRT493415	hsa-miR-4706	PAR-CLIP	26701625
MIRT493415	hsa-miR-4706	PAR-CLIP	26701625
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	26701625
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	26701625
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	26701625
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	26701625
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	26701625
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	26701625
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	26701625
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	26701625
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	26701625
MIRT289583	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT289583	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT289581	hsa-miR-526b-3p	PAR-CLIP	26701625
MIRT289581	hsa-miR-526b-3p	PAR-CLIP	26701625
MIRT079165	hsa-miR-5787	PAR-CLIP	26701625
MIRT079165	hsa-miR-5787	PAR-CLIP	26701625
MIRT079165	hsa-miR-5787	PAR-CLIP	26701625
MIRT079165	hsa-miR-5787	PAR-CLIP	26701625
MIRT079165	hsa-miR-5787	PAR-CLIP	26701625
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	26701625
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	26701625
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	26701625
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	26701625
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	26701625
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	26701625
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	26701625
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	26701625
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	26701625
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	26701625
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	26701625
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	26701625
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	26701625
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	26701625
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	26701625
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	26701625
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	26701625
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	26701625
MIRT570655	hsa-miR-8052	PAR-CLIP	26701625
MIRT570655	hsa-miR-8052	PAR-CLIP	26701625
MIRT570655	hsa-miR-8052	PAR-CLIP	26701625
MIRT493413	hsa-miR-8085	PAR-CLIP	26701625
MIRT493413	hsa-miR-8085	PAR-CLIP	26701625
MIRT493413	hsa-miR-8085	PAR-CLIP	26701625
MIRT493413	hsa-miR-8085	PAR-CLIP	26701625
MIRT493413	hsa-miR-8085	PAR-CLIP	26701625
MIRT289573	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT289573	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT289587	hsa-miR-941	PAR-CLIP	26701625
MIRT289587	hsa-miR-941	PAR-CLIP	26701625
MIRT027296	hsa-miR-101-3p	PAR-CLIP	27292025
MIRT493421	hsa-miR-4292	PAR-CLIP	27292025
MIRT079165	hsa-miR-5787	PAR-CLIP	27292025
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	27292025
MIRT732810	hsa-miR-455-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blotting	33505218
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT570659	hsa-miR-4481	PAR-CLIP	20371350
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT570657	hsa-miR-4515	PAR-CLIP	20371350
MIRT570656	hsa-miR-3199	PAR-CLIP	20371350
MIRT570655	hsa-miR-8052	PAR-CLIP	20371350
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	20371350
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT570651	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT570647	hsa-miR-4447	PAR-CLIP	20371350
MIRT570645	hsa-miR-4472	PAR-CLIP	20371350
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT289579	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT289570	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT289577	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT289575	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT289583	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT289581	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT289573	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT289571	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT570662	hsa-miR-1296-3p	PAR-CLIP	20371350
MIRT570661	hsa-miR-6746-5p	PAR-CLIP	20371350
MIRT570660	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT570659	hsa-miR-4481	PAR-CLIP	20371350
MIRT570658	hsa-miR-4745-5p	PAR-CLIP	20371350
MIRT570657	hsa-miR-4515	PAR-CLIP	20371350
MIRT570656	hsa-miR-3199	PAR-CLIP	20371350
MIRT570655	hsa-miR-8052	PAR-CLIP	20371350
MIRT570654	hsa-miR-4652-5p	PAR-CLIP	20371350
MIRT570653	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT570652	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT570651	hsa-miR-328-5p	PAR-CLIP	20371350
MIRT570650	hsa-miR-6885-5p	PAR-CLIP	20371350
MIRT570649	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT570648	hsa-miR-7704	PAR-CLIP	20371350
MIRT570647	hsa-miR-4447	PAR-CLIP	20371350
MIRT570645	hsa-miR-4472	PAR-CLIP	20371350
MIRT570646	hsa-miR-6771-5p	PAR-CLIP	20371350
MIRT570644	hsa-miR-7109-5p	PAR-CLIP	20371350
MIRT493423	hsa-miR-3940-3p	PAR-CLIP	23592263
MIRT493422	hsa-miR-4308	PAR-CLIP	23592263
MIRT493421	hsa-miR-4292	PAR-CLIP	23592263
MIRT493420	hsa-miR-6791-5p	PAR-CLIP	23592263
MIRT493419	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT493418	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT493417	hsa-miR-4746-5p	PAR-CLIP	23592263
MIRT493416	hsa-miR-2277-5p	PAR-CLIP	23592263
MIRT493415	hsa-miR-4706	PAR-CLIP	23592263
MIRT493414	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT493412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT493413	hsa-miR-8085	PAR-CLIP	23592263
MIRT493411	hsa-miR-3178	PAR-CLIP	23592263
MIRT493410	hsa-miR-3175	PAR-CLIP	23592263
MIRT079165	hsa-miR-5787	PAR-CLIP	23592263
MIRT289573	hsa-miR-93-5p	Luciferase reporter assayWestern blottingqRT-PCRCLIP-seq	38218880
MIRT1084947	hsa-miR-101	CLIP-seq
MIRT1084948	hsa-miR-1178	CLIP-seq
MIRT1084949	hsa-miR-1179	CLIP-seq
MIRT1084950	hsa-miR-1229	CLIP-seq
MIRT1084951	hsa-miR-1260	CLIP-seq
MIRT1084952	hsa-miR-1260b	CLIP-seq
MIRT1084953	hsa-miR-1275	CLIP-seq
MIRT1084954	hsa-miR-135a	CLIP-seq
MIRT1084955	hsa-miR-135b	CLIP-seq
MIRT1084956	hsa-miR-139-5p	CLIP-seq
MIRT1084957	hsa-miR-144	CLIP-seq
MIRT1084958	hsa-miR-146a	CLIP-seq
MIRT1084959	hsa-miR-148a	CLIP-seq
MIRT1084960	hsa-miR-148b	CLIP-seq
MIRT1084961	hsa-miR-152	CLIP-seq
MIRT1084962	hsa-miR-1538	CLIP-seq
MIRT1084963	hsa-miR-188-3p	CLIP-seq
MIRT1084964	hsa-miR-2392	CLIP-seq
MIRT1084965	hsa-miR-29a	CLIP-seq
MIRT1084966	hsa-miR-29b	CLIP-seq
MIRT1084967	hsa-miR-29c	CLIP-seq
MIRT1084968	hsa-miR-3121-3p	CLIP-seq
MIRT1084969	hsa-miR-3151	CLIP-seq
MIRT1084970	hsa-miR-3156-3p	CLIP-seq
MIRT1084971	hsa-miR-3173-3p	CLIP-seq
MIRT1084972	hsa-miR-3180	CLIP-seq
MIRT1084973	hsa-miR-3180-3p	CLIP-seq
MIRT1084974	hsa-miR-3181	CLIP-seq
MIRT1084975	hsa-miR-3184	CLIP-seq
MIRT1084976	hsa-miR-3196	CLIP-seq
MIRT1084977	hsa-miR-340	CLIP-seq
MIRT1084978	hsa-miR-342-3p	CLIP-seq
MIRT1084979	hsa-miR-3620	CLIP-seq
MIRT1084980	hsa-miR-3646	CLIP-seq
MIRT1084981	hsa-miR-3649	CLIP-seq
MIRT1084982	hsa-miR-3662	CLIP-seq
MIRT1084983	hsa-miR-3687	CLIP-seq
MIRT1084984	hsa-miR-3689a-3p	CLIP-seq
MIRT1084985	hsa-miR-3689c	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT1084987	hsa-miR-3919	CLIP-seq
MIRT1084988	hsa-miR-3934	CLIP-seq
MIRT1084989	hsa-miR-4254	CLIP-seq
MIRT1084990	hsa-miR-4277	CLIP-seq
MIRT1084991	hsa-miR-4301	CLIP-seq
MIRT1084992	hsa-miR-4323	CLIP-seq
MIRT1084993	hsa-miR-4433	CLIP-seq
MIRT1084994	hsa-miR-4442	CLIP-seq
MIRT1084995	hsa-miR-4446-5p	CLIP-seq
MIRT1084996	hsa-miR-4455	CLIP-seq
MIRT1084997	hsa-miR-4497	CLIP-seq
MIRT1084998	hsa-miR-4645-5p	CLIP-seq
MIRT1084999	hsa-miR-4648	CLIP-seq
MIRT1085000	hsa-miR-4654	CLIP-seq
MIRT1085001	hsa-miR-4665-5p	CLIP-seq
MIRT1085002	hsa-miR-4673	CLIP-seq
MIRT1085003	hsa-miR-4690-3p	CLIP-seq
MIRT1085004	hsa-miR-4723-5p	CLIP-seq
MIRT1085005	hsa-miR-4745-3p	CLIP-seq
MIRT1085006	hsa-miR-4758-5p	CLIP-seq
MIRT1085007	hsa-miR-4769-5p	CLIP-seq
MIRT1085008	hsa-miR-4778-3p	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT1085010	hsa-miR-589	CLIP-seq
MIRT1085011	hsa-miR-603	CLIP-seq
MIRT1085012	hsa-miR-621	CLIP-seq
MIRT1085013	hsa-miR-675	CLIP-seq
MIRT1084947	hsa-miR-101	CLIP-seq
MIRT1084948	hsa-miR-1178	CLIP-seq
MIRT1084949	hsa-miR-1179	CLIP-seq
MIRT2021617	hsa-miR-1238	CLIP-seq
MIRT1084953	hsa-miR-1275	CLIP-seq
MIRT2021618	hsa-miR-1276	CLIP-seq
MIRT1084954	hsa-miR-135a	CLIP-seq
MIRT1084955	hsa-miR-135b	CLIP-seq
MIRT2021619	hsa-miR-138	CLIP-seq
MIRT1084956	hsa-miR-139-5p	CLIP-seq
MIRT1084957	hsa-miR-144	CLIP-seq
MIRT2021620	hsa-miR-150	CLIP-seq
MIRT1084962	hsa-miR-1538	CLIP-seq
MIRT1084964	hsa-miR-2392	CLIP-seq
MIRT1084969	hsa-miR-3151	CLIP-seq
MIRT1084971	hsa-miR-3173-3p	CLIP-seq
MIRT1084974	hsa-miR-3181	CLIP-seq
MIRT1084975	hsa-miR-3184	CLIP-seq
MIRT2021621	hsa-miR-3197	CLIP-seq
MIRT1084979	hsa-miR-3620	CLIP-seq
MIRT1084982	hsa-miR-3662	CLIP-seq
MIRT1084983	hsa-miR-3687	CLIP-seq
MIRT1084984	hsa-miR-3689a-3p	CLIP-seq
MIRT1084985	hsa-miR-3689c	CLIP-seq
MIRT2021622	hsa-miR-3926	CLIP-seq
MIRT1084988	hsa-miR-3934	CLIP-seq
MIRT2021623	hsa-miR-4311	CLIP-seq
MIRT1084992	hsa-miR-4323	CLIP-seq
MIRT1084993	hsa-miR-4433	CLIP-seq
MIRT1084994	hsa-miR-4442	CLIP-seq
MIRT1084995	hsa-miR-4446-5p	CLIP-seq
MIRT1084996	hsa-miR-4455	CLIP-seq
MIRT2021624	hsa-miR-4456	CLIP-seq
MIRT1084997	hsa-miR-4497	CLIP-seq
MIRT1084999	hsa-miR-4648	CLIP-seq
MIRT2021625	hsa-miR-4649-5p	CLIP-seq
MIRT1085000	hsa-miR-4654	CLIP-seq
MIRT1085001	hsa-miR-4665-5p	CLIP-seq
MIRT2021626	hsa-miR-4710	CLIP-seq
MIRT2021627	hsa-miR-4713-5p	CLIP-seq
MIRT1085004	hsa-miR-4723-5p	CLIP-seq
MIRT1085005	hsa-miR-4745-3p	CLIP-seq
MIRT2021628	hsa-miR-4747-5p	CLIP-seq
MIRT2021629	hsa-miR-4753-5p	CLIP-seq
MIRT1085007	hsa-miR-4769-5p	CLIP-seq
MIRT2021630	hsa-miR-532-3p	CLIP-seq
MIRT2021631	hsa-miR-541	CLIP-seq
MIRT2021632	hsa-miR-583	CLIP-seq
MIRT2021633	hsa-miR-599	CLIP-seq
MIRT1085011	hsa-miR-603	CLIP-seq
MIRT1085012	hsa-miR-621	CLIP-seq
MIRT2021634	hsa-miR-654-5p	CLIP-seq
MIRT1084947	hsa-miR-101	CLIP-seq
MIRT2253123	hsa-miR-106a	CLIP-seq
MIRT2253124	hsa-miR-106b	CLIP-seq
MIRT1084948	hsa-miR-1178	CLIP-seq
MIRT1084949	hsa-miR-1179	CLIP-seq
MIRT2253125	hsa-miR-1207-5p	CLIP-seq
MIRT1084951	hsa-miR-1260	CLIP-seq
MIRT1084952	hsa-miR-1260b	CLIP-seq
MIRT2021618	hsa-miR-1276	CLIP-seq
MIRT1084956	hsa-miR-139-5p	CLIP-seq
MIRT1084957	hsa-miR-144	CLIP-seq
MIRT1084958	hsa-miR-146a	CLIP-seq
MIRT1084959	hsa-miR-148a	CLIP-seq
MIRT1084960	hsa-miR-148b	CLIP-seq
MIRT1084961	hsa-miR-152	CLIP-seq
MIRT1084962	hsa-miR-1538	CLIP-seq
MIRT2253126	hsa-miR-17	CLIP-seq
MIRT1084963	hsa-miR-188-3p	CLIP-seq
MIRT2253127	hsa-miR-20a	CLIP-seq
MIRT2253128	hsa-miR-20b	CLIP-seq
MIRT2253129	hsa-miR-296-3p	CLIP-seq
MIRT1084965	hsa-miR-29a	CLIP-seq
MIRT1084966	hsa-miR-29b	CLIP-seq
MIRT1084967	hsa-miR-29c	CLIP-seq
MIRT2253130	hsa-miR-3065-5p	CLIP-seq
MIRT2253131	hsa-miR-30a	CLIP-seq
MIRT2253132	hsa-miR-30b	CLIP-seq
MIRT2253133	hsa-miR-30c	CLIP-seq
MIRT2253134	hsa-miR-30d	CLIP-seq
MIRT2253135	hsa-miR-30e	CLIP-seq
MIRT1084969	hsa-miR-3151	CLIP-seq
MIRT1084970	hsa-miR-3156-3p	CLIP-seq
MIRT1084974	hsa-miR-3181	CLIP-seq
MIRT1084975	hsa-miR-3184	CLIP-seq
MIRT2253136	hsa-miR-3607-3p	CLIP-seq
MIRT1084979	hsa-miR-3620	CLIP-seq
MIRT1084983	hsa-miR-3687	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT1084990	hsa-miR-4277	CLIP-seq
MIRT1084991	hsa-miR-4301	CLIP-seq
MIRT2021623	hsa-miR-4311	CLIP-seq
MIRT1084993	hsa-miR-4433	CLIP-seq
MIRT1084994	hsa-miR-4442	CLIP-seq
MIRT2253137	hsa-miR-4651	CLIP-seq
MIRT2021626	hsa-miR-4710	CLIP-seq
MIRT2253138	hsa-miR-4736	CLIP-seq
MIRT1085005	hsa-miR-4745-3p	CLIP-seq
MIRT2253139	hsa-miR-4763-3p	CLIP-seq
MIRT1085008	hsa-miR-4778-3p	CLIP-seq
MIRT2253140	hsa-miR-493	CLIP-seq
MIRT2253141	hsa-miR-517b	CLIP-seq
MIRT2253142	hsa-miR-519a	CLIP-seq
MIRT2253143	hsa-miR-519d	CLIP-seq
MIRT2253144	hsa-miR-548ad	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT2253145	hsa-miR-561	CLIP-seq
MIRT2021632	hsa-miR-583	CLIP-seq
MIRT1085010	hsa-miR-589	CLIP-seq
MIRT2253146	hsa-miR-608	CLIP-seq
MIRT1085012	hsa-miR-621	CLIP-seq
MIRT1085013	hsa-miR-675	CLIP-seq
MIRT2253147	hsa-miR-93	CLIP-seq
MIRT2253148	hsa-miR-939	CLIP-seq
MIRT1084949	hsa-miR-1179	CLIP-seq
MIRT2021618	hsa-miR-1276	CLIP-seq
MIRT1084958	hsa-miR-146a	CLIP-seq
MIRT1084965	hsa-miR-29a	CLIP-seq
MIRT1084966	hsa-miR-29b	CLIP-seq
MIRT1084967	hsa-miR-29c	CLIP-seq
MIRT2021623	hsa-miR-4311	CLIP-seq
MIRT2021632	hsa-miR-583	CLIP-seq
MIRT1085010	hsa-miR-589	CLIP-seq
MIRT1085012	hsa-miR-621	CLIP-seq
MIRT2253148	hsa-miR-939	CLIP-seq
MIRT2253129	hsa-miR-296-3p	CLIP-seq
MIRT2430256	hsa-miR-3667-5p	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT2430257	hsa-miR-4425	CLIP-seq
MIRT2021628	hsa-miR-4747-5p	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT2430258	hsa-miR-7	CLIP-seq
MIRT1084958	hsa-miR-146a	CLIP-seq
MIRT1084962	hsa-miR-1538	CLIP-seq
MIRT2253129	hsa-miR-296-3p	CLIP-seq
MIRT1084965	hsa-miR-29a	CLIP-seq
MIRT1084966	hsa-miR-29b	CLIP-seq
MIRT1084967	hsa-miR-29c	CLIP-seq
MIRT1084972	hsa-miR-3180	CLIP-seq
MIRT1084973	hsa-miR-3180-3p	CLIP-seq
MIRT1084974	hsa-miR-3181	CLIP-seq
MIRT1084976	hsa-miR-3196	CLIP-seq
MIRT2430256	hsa-miR-3667-5p	CLIP-seq
MIRT1084983	hsa-miR-3687	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT2430257	hsa-miR-4425	CLIP-seq
MIRT1084994	hsa-miR-4442	CLIP-seq
MIRT1085005	hsa-miR-4745-3p	CLIP-seq
MIRT2021628	hsa-miR-4747-5p	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT1085010	hsa-miR-589	CLIP-seq
MIRT2021633	hsa-miR-599	CLIP-seq
MIRT1085011	hsa-miR-603	CLIP-seq
MIRT2430258	hsa-miR-7	CLIP-seq
MIRT2253148	hsa-miR-939	CLIP-seq
MIRT2253129	hsa-miR-296-3p	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT1084959	hsa-miR-148a	CLIP-seq
MIRT1084960	hsa-miR-148b	CLIP-seq
MIRT1084961	hsa-miR-152	CLIP-seq
MIRT2253129	hsa-miR-296-3p	CLIP-seq
MIRT2430256	hsa-miR-3667-5p	CLIP-seq
MIRT1084986	hsa-miR-377	CLIP-seq
MIRT2430257	hsa-miR-4425	CLIP-seq
MIRT2021628	hsa-miR-4747-5p	CLIP-seq
MIRT1085009	hsa-miR-548c-3p	CLIP-seq
MIRT2021633	hsa-miR-599	CLIP-seq
MIRT1085013	hsa-miR-675	CLIP-seq
MIRT2430258	hsa-miR-7	CLIP-seq
MIRT2021633	hsa-miR-599	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0002437	Process	Inflammatory response to antigenic stimulus	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	21841772
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS	23856522
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006338	Process	Chromatin remodeling	ISS
GO:0006954	Process	Inflammatory response	IEA
GO:0007507	Process	Heart development	IBA
GO:0008013	Function	Beta-catenin binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0014823	Process	Response to activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0031490	Function	Chromatin DNA binding	IBA
GO:0032452	Function	Histone demethylase activity	TAS
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0044666	Component	MLL3/4 complex	IBA
GO:0045165	Process	Cell fate commitment	IEA
GO:0045446	Process	Endothelial cell differentiation	IEA
GO:0045446	Process	Endothelial cell differentiation	ISS	23856522
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	23856522
GO:0046872	Function	Metal ion binding	IEA
GO:0048333	Process	Mesodermal cell differentiation	IEA
GO:0048333	Process	Mesodermal cell differentiation	ISS	23856522
GO:0051213	Function	Dioxygenase activity	IEA
GO:0055007	Process	Cardiac muscle cell differentiation	IEA
GO:0055007	Process	Cardiac muscle cell differentiation	ISS	23856522
GO:0060992	Process	Response to fungicide	IEA
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071558	Function	Histone H3K27me2/H3K27me3 demethylase activity	IBA
GO:0071558	Function	Histone H3K27me2/H3K27me3 demethylase activity	IEA
GO:0071558	Function	Histone H3K27me2/H3K27me3 demethylase activity	IMP	28262558
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	IEA
GO:0120162	Process	Positive regulation of cold-induced thermogenesis	ISS	26625958

MIM	HGNC	e!Ensembl
611577	29012	ENSG00000132510

O15054

Protein name

Lysine-specific demethylase 6B (EC 1.14.11.68) (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3) (Lysine demethylase 6B) ([histone H3]-trimethyl-L-lysine(27) demethylase 6B)

Protein function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17713478, PubMed:17825402, PubMed:17851529, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-2

PDB

2XUE , 2XXZ , 4ASK , 5FP3 , 5OY3 , 6F6D

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02373	JmjC	1377 → 1485	JmjC domain, hydroxylase	Domain

Sequence

MHRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAWLPGGRCSASIGQPPLPAPL
PPSHGSSSGHPSKPYYAPGAPTPRPLHGKLESLHGCVQALLREPAQPGLWEQLGQLYESE
HDSEEATRCYHSALRYGGSFAELGPRIGRLQQAQLWNFHTGSCQHRAKVLPPLEQVWNLL
HLEHKRNYGAKRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGL
PPGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPP
ERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATRPPGSDL
RESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIP
GADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPP
PPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDS
HTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLV
PLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGPLSKAPQPVPPGV
GELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEAGVA
PQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPP
LAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPG
PPSGATALPPTSAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPP
PLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEPADSGTERLLPPAQAKE
EAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGN
LDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPSASVPGKKAREEAPG
PPGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAA
DVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPV
LLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLT
GTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDP
KNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYM
KVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPI
LDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERY
EWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKK
IAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLE
QYRTEELAQAYDAFTLAPASTSR

Sequence length

1643

Interactions

View interactions

	Reactome
			Oxidative Stress Induced Senescence HDMs demethylate histones

281

Show/Hide Causal Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability	Likely pathogenic; Pathogenic	rs2544521866	RCV005626626
KDM6B-related disorder	Likely pathogenic	rs1294523865, rs2544524865, rs988670906, rs2544526628	RCV004749834 RCV005250241 RCV003403022 RCV003894683
Malignant tumor of urinary bladder	Likely pathogenic	rs2078522713	RCV005930259
Neurodevelopmental abnormality	Pathogenic	rs957520585	RCV001264704
Neurodevelopmental delay	Likely pathogenic; Pathogenic	rs1597842212	RCV002274351
Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities	Pathogenic; Likely pathogenic	rs59062945, rs2151375529, rs2078638223, rs2151379742, rs2151379880, rs1294523865, rs2151380462, rs2151379290, rs2151376850, rs2151378140, rs2078539742, rs1597842212, rs1311274985, rs761401181, rs2544536378 View all (62 more)	RCV001420566 RCV001775402 RCV003150459 RCV001827593 RCV002071025 RCV002086758 RCV002221946 RCV002245506 RCV005869753 RCV002272591 RCV002272913 RCV003150494 RCV003150496 RCV003150497 RCV003150498 RCV003150499 RCV003150500 RCV003150501 RCV003150502 RCV003150503 RCV003150504 RCV003150505 RCV003150506 RCV003150507 RCV003150508 RCV003150509 RCV003150510 RCV003150511 RCV003150512 RCV003150513 RCV003150514 RCV003150515 RCV003150516 RCV003150517 RCV003150518 RCV003150519 RCV003150520 RCV003150521 RCV003150522 RCV003150523 RCV003150524 RCV003150525 RCV003150526 RCV003150527 RCV003150528 RCV003150529 RCV003150530 RCV003150531 RCV003150532 RCV003150533 RCV003150534 RCV003150535 RCV003150536 RCV003150537 RCV003150538 RCV003150539 RCV003150540 RCV003150541 RCV003150542 RCV003150543 RCV003150554 RCV003150555 RCV002288314 RCV002289096 RCV002291426 RCV003128104 RCV003133855 RCV003148347 RCV003224986 RCV003482902 RCV004566398 RCV004555109 RCV004594859 RCV004594861 RCV000788044 RCV003150416 RCV003150417 RCV003150418
See cases	Pathogenic	rs2151376850	RCV002252514

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Conflicting classifications of pathogenicity	rs148641957	RCV005893878
Colon adenocarcinoma	Conflicting classifications of pathogenicity	rs148641957	RCV005893877
Developmental disorder	Uncertain significance	rs2151379708, rs2544534873	RCV001843808 RCV003764472
KDM6B-related neurodevelopmental disorder	Uncertain significance	rs1378460812	RCV001563620
Malignant tumor of esophagus	Conflicting classifications of pathogenicity	rs148641957	RCV005893879
Oromandibular-limb hypogenesis spectrum	Benign; Likely benign	rs61462443	RCV000240501
Ovarian serous cystadenocarcinoma	Likely benign	rs763262499	RCV005933445

Show/Hide Text Mining Associations (72)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Stimulate	27755585
Attention Deficit Disorder with Hyperactivity	Associate	33155823, 36251081
Autism Spectrum Disorder	Associate	36251081
Breast Neoplasms	Associate	21841772, 33962648, 37223020
Carcinogenesis	Associate	35254477, 36564369
Carcinoma Hepatocellular	Associate	25049231, 35254477
Carcinoma Merkel Cell	Associate	34399838
Carcinoma Non Small Cell Lung	Associate	26303949, 31210309
Carcinoma Non Small Cell Lung	Inhibit	31155967
Carcinoma Renal Cell	Associate	23057811, 26261509, 28177890
Carcinoma Renal Cell	Inhibit	27983522
Cardiovascular Diseases	Associate	34667186
Cartilage Diseases	Associate	35831280
Chromosome 1q21.1 Deletion Syndrome 1.35 Mb	Associate	23184418
Colitis Ulcerative	Associate	33362389
Colonic Neoplasms	Associate	21890490
Colorectal Neoplasms	Associate	21890490
COVID 19	Associate	37486005
Degloving Injuries	Associate	38013320
Developmental Disabilities	Associate	36251081
Diabetes Mellitus Type 2	Inhibit	32210958
Esophageal Squamous Cell Carcinoma	Associate	33318475
Glioblastoma	Associate	28384648
Glioma	Associate	25652587
Gout	Associate	33155823
Hashimoto Disease	Associate	20714105
Hypertension	Associate	34667186
Hypoxia	Inhibit	25351418
Hypoxia	Stimulate	33318475
Hypoxia	Associate	35930654
Hypoxia Brain	Associate	27529370, 33318475
Hypoxia Brain	Inhibit	34667186
Inflammation	Associate	25652587
Inflammation	Inhibit	32210958
Intracranial Aneurysm	Associate	37286519
Leukemia	Associate	29224413, 29477140
Leukemia Biphenotypic Acute	Associate	36213329
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	39327604
Leukemia Myeloid	Associate	29224413
Lupus Erythematosus Systemic	Associate	28430662, 36213329
Lymphatic Metastasis	Associate	26261509
Lymphatic Metastasis	Inhibit	31155967
Lymphatic Metastasis	Stimulate	31210309
Lymphoma Large B Cell Diffuse	Associate	27742770
Mesothelioma Malignant	Associate	27529370
Monosomy	Inhibit	25593028
Multiple Myeloma	Associate	28487543
Myelodysplastic Syndromes	Associate	23538751
Neoplasm Metastasis	Inhibit	26303949
Neoplasm Metastasis	Stimulate	31210309, 36564369
Neoplasms	Stimulate	23057811, 31210309
Neoplasms	Associate	24046371, 25593028, 25652587, 27800026, 27983522, 28487543, 30696880, 35887001, 36564369, 37658535
Neoplasms	Inhibit	35855897
Nerve Degeneration	Inhibit	35831280
Neuroblastoma	Associate	34893606
Osteoarthritis	Associate	27388528, 35831280
Osteoglophonic dwarfism	Associate	33546766
Ovarian Diseases	Associate	28849826
Ovarian Neoplasms	Associate	26864203, 28849826
Periodontitis	Associate	32210958
Prostatic Neoplasms	Associate	37840069
Retinitis Pigmentosa	Associate	33546766
Squamous Cell Carcinoma of Head and Neck	Associate	25275298, 35855897
Stomach Neoplasms	Associate	30696880
Stomach Neoplasms	Stimulate	36564369
Urethral Neoplasms	Associate	37658535
Urinary Bladder Neoplasms	Stimulate	27983522
Urinary Bladder Neoplasms	Associate	37658535
Uterine Cervical Neoplasms	Associate	21245294
Uterine Cervicitis	Associate	21245294
Uveal melanoma	Associate	25593028
Wounds and Injuries	Inhibit	35831280

KDM6B (lysine demethylase 6B)