Gene Gene information from NCBI Gene database.
Entrez ID 23112
Gene name Trinucleotide repeat containing adaptor 6B
Gene symbol TNRC6B
Synonyms (NCBI Gene)
GDSBA
Chromosome 22
Chromosome location 22q13.1
miRNA miRNA information provided by mirtarbase database.
2678
miRTarBase ID miRNA Experiments Reference
MIRT025025 hsa-miR-183-5p Sequencing 20371350
MIRT025876 hsa-miR-7-5p Sequencing 20371350
MIRT027125 hsa-miR-103a-3p Sequencing 20371350
MIRT028348 hsa-miR-32-5p Sequencing 20371350
MIRT030934 hsa-miR-21-5p Microarray 18591254
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0000932 Component P-body IBA
GO:0000932 Component P-body IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610740 29190 ENSG00000100354
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UPQ9
Protein name Trinucleotide repeat-containing gene 6B protein
Protein function Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:16289642, PubMed:19167051, PubMed:19304925, PubMed:32354837). Required for miRNA-dependent translational repression and siRNA-dep
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10427 Ago_hook 912 1068 Argonaute hook Family
PF16608 TNRC6-PABC_bdg 1360 1646 TNRC6-PABC binding domain Disordered
Sequence
MREKEQEREEQLMEDKKRKKEDKKKKEATQKVTEQKTKVPEVTKPSLSQPTAASPIGSSP
SPPVNGGNNAKRVAVPNGQPPSAARYMPREVPPRFRCQQDHKVLLKRGQPPPPSCMLLGG
GAGPPPCTAPGANPNNAQVTGALLQSESGTAPDSTLGGAAASNYANSTWGSGASSNNGTS
PNPIHIWDKVIVDGSDMEEWPCIASKDTESSSENTTDNNSASNPGSEKSTLPGSTTSNKG
KGSQCQSASSGNECNLGVWKSDPKAKSVQSSNSTTENNNGLGNWRNVSGQDRIGPGSGFS
NFNPNSNPSAWPALVQEGTSRKGALETDNSNSSAQVSTVGQTSREQQSKMENAGVNFVVS
GREQAQIHNTDGPKNGNTNSLNLSSPNPMENKGMPFGMGLGNTSRSTDAPSQSTGDRKTG
SVGSWGAARGPSGTDTVSGQSNSGNNGNNGKEREDSWKGASVQKSTGSKNDSWDNNNRST
GGSWNFGPQDSNDNKWGEGNKMTSGVSQGEWKQPTGSDELKIGEWSGPNQPNSSTGAWDN
QKGHPLPENQGNAQAPCWGRSSSSTGSEVGGQSTGSNHKAGSSDSHNSGRRSYRPTHPDC
QAVLQTLLSRTDLDPRVLSNTGWGQTQIKQDTVWDIEEVPRPEGKSDKGTEGWESAATQT
KNSGGWGDAPSQSNQMKSGWGELSASTEWKDPKNTGGWNDYKNNNSSNWGGGRPDEKTPS
SWNENPSKDQGWGGGRQPNQGWSSGKNGWGEEVDQTKNSNWESSASKPVSGWGEGGQNEI
GTWGNGGNASLASKGGWEDCKRSPAWNETGRQPNSWNKQHQQQQPPQQPPPPQPEASGSW
GGPPPPPPGNVRPSNSSWSSGPQPATPKDEEPSGWEEPSPQSISRKMDIDDGTSAWGDPN
SYNYKNVNLWDKNSQGGPAPREPNLPTPMTSKSASVWSKSTPPAPDNGTSAWGEPNESSP
GWGEMDDTGASTTGWGNTPANAPNAMKPNSKSMQDGWGESDGPVTGARHPSWEEEEDGGV
WNTTGSQGSASSHNSASWGQGGKKQMKCSLKGGNNDSWMNPLAKQFSN
MGLLSQTEDNPS
SKMDLSVGSLSDKKFDVDKRAMNLGDFNDIMRKDRSGFRPPNSKDMGTTDSGPYFEKLTL
PFSNQDGCLGDEAPCSPFSPSPSYKLSPSGSTLPNVSLGAIGTGLNPQNFAARQGGSHGL
FGNSTAQSRGLHTPVQPLNSSPSLRAQVPPQFISPQVSASMLKQFPNSGLSPGLFNVGPQ
LSPQQIAMLSQLPQIPQFQLACQLLLQQQQQQQLLQNQRKISQAVRQQQEQQLARMVSAL
QQQQQQQQRQPGMKHSPSHPVGPKPHLDNMVPNALNVGLPDLQTKGPIPGYGSGFSSGGM
DYGMVGGKEAGTESRFKQWTSMMEGLPSVATQEANMHKNGAIVAPGKTRGGSPYNQFDII
PGDTLGGHTGPAGDSWLPAKSPPTNKIGSKSSNASWPPEFQPGVPWKGIQNIDPESDPYV
TPGSVLGGTATSPIVDTDHQLLRDNTTGSNSSLNTSLPSPGAWPYSASDNSFTNVHSTSA
KFPDYKSTWSPDPIGHNPTHLSNKMWKNHISSRNTTPLPRPPPGLTNPKPSSPWSSTAPR
SVRGWGTQDSRLASASTWSDGGSVRP
SYWLVLHNLTPQIDGSTLRTICMQHGPLLTFHLN
LTQGTALIRYSTKQEAAKAQTALHMCVLGNTTILAEFATDDEVSRFLAQAQPPTPAATPS
APAAGWQSLETGQNQSDPVGPALNLFGGSTGLGQWSSSAGGSSGADLAGASLWGPPNYSS
SLWGVPTVEDPHRMGSPAPLLPGDLLGGGSDSI
Sequence length 1833
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ca2+ pathway
Post-transcriptional silencing by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Transcriptional Regulation by VENTX
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
137
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Autism spectrum disorder Pathogenic rs2517988934 RCV003128048
Global developmental delay with speech and behavioral abnormalities Pathogenic; Likely pathogenic rs758228613, rs2146500403, rs2146569465, rs2146548512, rs2146518792, rs774374347, rs2146565741, rs750268759, rs2146471012, rs2518004353, rs2517986894, rs2518047038, rs2518046138, rs2517986860, rs2517985090
View all (7 more)
RCV001353086
RCV001353087
RCV001353088
RCV001353089
RCV001353090
RCV001353091
RCV005867183
RCV001785339
RCV002086742
RCV002291157
RCV002463391
RCV003123259
RCV003149135
RCV003230252
RCV003320348
RCV005429106
RCV003448924
RCV003458995
RCV003482901
RCV004577288
RCV004595264
RCV005232226
Neurodevelopmental delay Likely pathogenic; Pathogenic rs2146500943, rs200598254 RCV002274382
RCV002274383
Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies Pathogenic rs2517986894 RCV002463391
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Atypical behavior Uncertain significance rs1601471441, rs1601505061 RCV000993769
RCV000993770
Autistic behavior Uncertain significance rs1601471441, rs1601505061 RCV000993769
RCV000993770
Developmental disorder Uncertain significance rs2070472785 RCV003764454
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs1774786898 RCV004558019
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Apraxias Associate 29463886
Carcinogenesis Associate 29475968
Carcinoma Hepatocellular Associate 23496901, 24676133, 29556353
Esophageal Squamous Cell Carcinoma Inhibit 37014625
Fibrosis Associate 35474605
Ileal Diseases Associate 35922826
Leiomyoma Associate 23604678, 23892540, 29743541
Leukemia Lymphocytic Chronic B Cell Associate 25793711
Neoplasms Associate 29475968, 29556353
Neoplasms Inhibit 35922826