RAP1GAP2 (RAP1 GTPase activating protein 2)

Gene

• Entrez ID: 23108
• Gene name: RAP1 GTPase activating protein 2
• Gene symbol: RAP1GAP2
• Synonyms (NCBI Gene): GARNL4, RAP1GA3
• Chromosome: 17
• Chromosome location: 17p13.3
• Summary: This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at site

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047265	hsa-miR-181b-5p	CLASH	23622248
MIRT046810	hsa-miR-222-3p	CLASH	23622248
MIRT045523	hsa-miR-149-5p	CLASH	23622248
MIRT039493	hsa-miR-652-3p	CLASH	23622248
MIRT570205	hsa-miR-637	PAR-CLIP	20371350
MIRT570204	hsa-miR-4537	PAR-CLIP	20371350
MIRT570203	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT570202	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT570201	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT570200	hsa-miR-5194	PAR-CLIP	20371350
MIRT570198	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT570199	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT570197	hsa-miR-765	PAR-CLIP	20371350
MIRT570196	hsa-miR-4505	PAR-CLIP	20371350
MIRT570195	hsa-miR-5787	PAR-CLIP	20371350
MIRT570194	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT570193	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT570192	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT570191	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT570190	hsa-miR-5698	PAR-CLIP	20371350
MIRT570189	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT570188	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT570187	hsa-miR-4525	PAR-CLIP	20371350
MIRT570185	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT570186	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT570184	hsa-miR-1275	PAR-CLIP	20371350
MIRT570183	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT570182	hsa-miR-6085	PAR-CLIP	20371350
MIRT570205	hsa-miR-637	PAR-CLIP	20371350
MIRT570204	hsa-miR-4537	PAR-CLIP	20371350
MIRT570203	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT570202	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT570201	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT570200	hsa-miR-5194	PAR-CLIP	20371350
MIRT570198	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT570199	hsa-miR-4731-5p	PAR-CLIP	20371350
MIRT570197	hsa-miR-765	PAR-CLIP	20371350
MIRT570196	hsa-miR-4505	PAR-CLIP	20371350
MIRT570195	hsa-miR-5787	PAR-CLIP	20371350
MIRT570194	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT570193	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT570192	hsa-miR-625-5p	PAR-CLIP	20371350
MIRT570191	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT570190	hsa-miR-5698	PAR-CLIP	20371350
MIRT570189	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT570188	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT570187	hsa-miR-4525	PAR-CLIP	20371350
MIRT570185	hsa-miR-5010-5p	PAR-CLIP	20371350
MIRT570186	hsa-miR-615-5p	PAR-CLIP	20371350
MIRT570184	hsa-miR-1275	PAR-CLIP	20371350
MIRT570183	hsa-miR-4665-5p	PAR-CLIP	20371350
MIRT570182	hsa-miR-6085	PAR-CLIP	20371350
MIRT1290014	hsa-miR-1271	CLIP-seq
MIRT1290015	hsa-miR-1276	CLIP-seq
MIRT1290016	hsa-miR-1278	CLIP-seq
MIRT1290017	hsa-miR-142-3p	CLIP-seq
MIRT1290018	hsa-miR-181a	CLIP-seq
MIRT1290019	hsa-miR-181b	CLIP-seq
MIRT1290020	hsa-miR-181c	CLIP-seq
MIRT1290021	hsa-miR-181d	CLIP-seq
MIRT1290022	hsa-miR-193a-3p	CLIP-seq
MIRT1290023	hsa-miR-193b	CLIP-seq
MIRT1290024	hsa-miR-196a	CLIP-seq
MIRT1290025	hsa-miR-196b	CLIP-seq
MIRT1290026	hsa-miR-2116	CLIP-seq
MIRT1290027	hsa-miR-214	CLIP-seq
MIRT1290028	hsa-miR-219-1-3p	CLIP-seq
MIRT1290029	hsa-miR-28-3p	CLIP-seq
MIRT1290030	hsa-miR-298	CLIP-seq
MIRT1290031	hsa-miR-3127-3p	CLIP-seq
MIRT1290032	hsa-miR-3130-3p	CLIP-seq
MIRT1290033	hsa-miR-3176	CLIP-seq
MIRT1290034	hsa-miR-3619-5p	CLIP-seq
MIRT1290035	hsa-miR-3678-3p	CLIP-seq
MIRT1290036	hsa-miR-3922-3p	CLIP-seq
MIRT1290037	hsa-miR-3923	CLIP-seq
MIRT1290038	hsa-miR-4255	CLIP-seq
MIRT1290039	hsa-miR-4262	CLIP-seq
MIRT1290040	hsa-miR-4277	CLIP-seq
MIRT1290041	hsa-miR-4470	CLIP-seq
MIRT1290042	hsa-miR-4508	CLIP-seq
MIRT1290043	hsa-miR-4530	CLIP-seq
MIRT1290044	hsa-miR-4690-5p	CLIP-seq
MIRT1290045	hsa-miR-4715-5p	CLIP-seq
MIRT1290046	hsa-miR-4757-5p	CLIP-seq
MIRT1290047	hsa-miR-4781-5p	CLIP-seq
MIRT1290048	hsa-miR-4793-3p	CLIP-seq
MIRT1290049	hsa-miR-513a-3p	CLIP-seq
MIRT1290050	hsa-miR-539	CLIP-seq
MIRT1290051	hsa-miR-548m	CLIP-seq
MIRT1290052	hsa-miR-571	CLIP-seq
MIRT1290053	hsa-miR-581	CLIP-seq
MIRT1290054	hsa-miR-590-3p	CLIP-seq
MIRT1290055	hsa-miR-761	CLIP-seq
MIRT1290056	hsa-miR-892b	CLIP-seq
MIRT1290057	hsa-miR-96	CLIP-seq
MIRT1290058	hsa-miR-1178	CLIP-seq
MIRT1290059	hsa-miR-1299	CLIP-seq
MIRT1290060	hsa-miR-1587	CLIP-seq
MIRT1290061	hsa-miR-1827	CLIP-seq
MIRT1290022	hsa-miR-193a-3p	CLIP-seq
MIRT1290023	hsa-miR-193b	CLIP-seq
MIRT1290027	hsa-miR-214	CLIP-seq
MIRT1290062	hsa-miR-2276	CLIP-seq
MIRT1290063	hsa-miR-2277-3p	CLIP-seq
MIRT1290064	hsa-miR-3120-5p	CLIP-seq
MIRT1290031	hsa-miR-3127-3p	CLIP-seq
MIRT1290065	hsa-miR-3136-5p	CLIP-seq
MIRT1290066	hsa-miR-3152-5p	CLIP-seq
MIRT1290033	hsa-miR-3176	CLIP-seq
MIRT1290067	hsa-miR-3180-5p	CLIP-seq
MIRT1290068	hsa-miR-3199	CLIP-seq
MIRT1290069	hsa-miR-3619-3p	CLIP-seq
MIRT1290034	hsa-miR-3619-5p	CLIP-seq
MIRT1290070	hsa-miR-362-5p	CLIP-seq
MIRT1290071	hsa-miR-3652	CLIP-seq
MIRT1290072	hsa-miR-3664-5p	CLIP-seq
MIRT1290073	hsa-miR-3690	CLIP-seq
MIRT1290074	hsa-miR-3921	CLIP-seq
MIRT1290036	hsa-miR-3922-3p	CLIP-seq
MIRT1290075	hsa-miR-4261	CLIP-seq
MIRT1290076	hsa-miR-4417	CLIP-seq
MIRT1290077	hsa-miR-4430	CLIP-seq
MIRT1290078	hsa-miR-4436a	CLIP-seq
MIRT1290079	hsa-miR-4439	CLIP-seq
MIRT1290080	hsa-miR-4446-3p	CLIP-seq
MIRT1290081	hsa-miR-4447	CLIP-seq
MIRT1290082	hsa-miR-4472	CLIP-seq
MIRT1290083	hsa-miR-4492	CLIP-seq
MIRT1290084	hsa-miR-4498	CLIP-seq
MIRT1290042	hsa-miR-4508	CLIP-seq
MIRT1290085	hsa-miR-4649-3p	CLIP-seq
MIRT1290086	hsa-miR-4653-5p	CLIP-seq
MIRT1290087	hsa-miR-4656	CLIP-seq
MIRT1290088	hsa-miR-4675	CLIP-seq
MIRT1290089	hsa-miR-4700-3p	CLIP-seq
MIRT1290090	hsa-miR-4714-5p	CLIP-seq
MIRT1290091	hsa-miR-4741	CLIP-seq
MIRT1290046	hsa-miR-4757-5p	CLIP-seq
MIRT1290092	hsa-miR-4772-3p	CLIP-seq
MIRT1290093	hsa-miR-4776-5p	CLIP-seq
MIRT1290094	hsa-miR-4786-3p	CLIP-seq
MIRT1290095	hsa-miR-486-3p	CLIP-seq
MIRT1290096	hsa-miR-500b	CLIP-seq
MIRT1290097	hsa-miR-518a-5p	CLIP-seq
MIRT1290098	hsa-miR-519a	CLIP-seq
MIRT1290099	hsa-miR-519b-3p	CLIP-seq
MIRT1290100	hsa-miR-519c-3p	CLIP-seq
MIRT1290101	hsa-miR-527	CLIP-seq
MIRT1290102	hsa-miR-541	CLIP-seq
MIRT1290103	hsa-miR-544	CLIP-seq
MIRT1290104	hsa-miR-593	CLIP-seq
MIRT1290105	hsa-miR-619	CLIP-seq
MIRT1290106	hsa-miR-625	CLIP-seq
MIRT1290107	hsa-miR-654-5p	CLIP-seq
MIRT1290108	hsa-miR-665	CLIP-seq
MIRT1290109	hsa-miR-671-5p	CLIP-seq
MIRT1290055	hsa-miR-761	CLIP-seq
MIRT1290110	hsa-miR-762	CLIP-seq
MIRT1290111	hsa-miR-767-3p	CLIP-seq
MIRT1290112	hsa-miR-875-3p	CLIP-seq
MIRT1290056	hsa-miR-892b	CLIP-seq
MIRT1290113	hsa-miR-943	CLIP-seq
MIRT2086149	hsa-miR-105	CLIP-seq
MIRT2086150	hsa-miR-1207-5p	CLIP-seq
MIRT2086151	hsa-miR-1238	CLIP-seq
MIRT2086152	hsa-miR-1262	CLIP-seq
MIRT2086153	hsa-miR-1265	CLIP-seq
MIRT2086154	hsa-miR-1266	CLIP-seq
MIRT2086155	hsa-miR-1321	CLIP-seq
MIRT2086156	hsa-miR-145	CLIP-seq
MIRT2086157	hsa-miR-150	CLIP-seq
MIRT1290061	hsa-miR-1827	CLIP-seq
MIRT2086158	hsa-miR-184	CLIP-seq
MIRT2086159	hsa-miR-185	CLIP-seq
MIRT2086160	hsa-miR-1913	CLIP-seq
MIRT2086161	hsa-miR-2052	CLIP-seq
MIRT2086162	hsa-miR-208a	CLIP-seq
MIRT2086163	hsa-miR-208b	CLIP-seq
MIRT2086164	hsa-miR-218	CLIP-seq
MIRT2086165	hsa-miR-2278	CLIP-seq
MIRT2086166	hsa-miR-2355-5p	CLIP-seq
MIRT2086167	hsa-miR-2392	CLIP-seq
MIRT2086168	hsa-miR-2682	CLIP-seq
MIRT2086169	hsa-miR-2964a-5p	CLIP-seq
MIRT2086170	hsa-miR-29a	CLIP-seq
MIRT2086171	hsa-miR-29b	CLIP-seq
MIRT2086172	hsa-miR-29c	CLIP-seq
MIRT2086173	hsa-miR-3064-5p	CLIP-seq
MIRT2086174	hsa-miR-3115	CLIP-seq
MIRT1290064	hsa-miR-3120-5p	CLIP-seq
MIRT2086175	hsa-miR-3125	CLIP-seq
MIRT1290032	hsa-miR-3130-3p	CLIP-seq
MIRT2086176	hsa-miR-3135b	CLIP-seq
MIRT2086177	hsa-miR-3158-5p	CLIP-seq
MIRT2086178	hsa-miR-3160-3p	CLIP-seq
MIRT1290033	hsa-miR-3176	CLIP-seq
MIRT1290067	hsa-miR-3180-5p	CLIP-seq
MIRT2086179	hsa-miR-3183	CLIP-seq
MIRT2086180	hsa-miR-3184	CLIP-seq
MIRT2086181	hsa-miR-3189-3p	CLIP-seq
MIRT2086182	hsa-miR-3192	CLIP-seq
MIRT1290068	hsa-miR-3199	CLIP-seq
MIRT2086183	hsa-miR-323-3p	CLIP-seq
MIRT2086184	hsa-miR-324-3p	CLIP-seq
MIRT2086185	hsa-miR-3612	CLIP-seq
MIRT2086186	hsa-miR-3616-3p	CLIP-seq
MIRT2086187	hsa-miR-3617	CLIP-seq
MIRT2086188	hsa-miR-3663-3p	CLIP-seq
MIRT2086189	hsa-miR-3664-3p	CLIP-seq
MIRT2086190	hsa-miR-3667-5p	CLIP-seq
MIRT2086191	hsa-miR-3682-3p	CLIP-seq
MIRT2086192	hsa-miR-3687	CLIP-seq
MIRT2086193	hsa-miR-3689a-3p	CLIP-seq
MIRT2086194	hsa-miR-3689c	CLIP-seq
MIRT2086195	hsa-miR-3689d	CLIP-seq
MIRT2086196	hsa-miR-383	CLIP-seq
MIRT2086197	hsa-miR-3908	CLIP-seq
MIRT2086198	hsa-miR-3916	CLIP-seq
MIRT1290036	hsa-miR-3922-3p	CLIP-seq
MIRT2086199	hsa-miR-3925-3p	CLIP-seq
MIRT2086200	hsa-miR-3942-5p	CLIP-seq
MIRT2086201	hsa-miR-423-5p	CLIP-seq
MIRT2086202	hsa-miR-4253	CLIP-seq
MIRT2086203	hsa-miR-4270	CLIP-seq
MIRT2086204	hsa-miR-4292	CLIP-seq
MIRT2086205	hsa-miR-4306	CLIP-seq
MIRT2086206	hsa-miR-4313	CLIP-seq
MIRT2086207	hsa-miR-432	CLIP-seq
MIRT2086208	hsa-miR-4433	CLIP-seq
MIRT1290078	hsa-miR-4436a	CLIP-seq
MIRT2086209	hsa-miR-4440	CLIP-seq
MIRT2086210	hsa-miR-4441	CLIP-seq
MIRT2086211	hsa-miR-4442	CLIP-seq
MIRT2086212	hsa-miR-4443	CLIP-seq
MIRT1290081	hsa-miR-4447	CLIP-seq
MIRT2086213	hsa-miR-4459	CLIP-seq
MIRT2086214	hsa-miR-4468	CLIP-seq
MIRT1290082	hsa-miR-4472	CLIP-seq
MIRT2086215	hsa-miR-4487	CLIP-seq
MIRT2086216	hsa-miR-4488	CLIP-seq
MIRT1290083	hsa-miR-4492	CLIP-seq
MIRT1290084	hsa-miR-4498	CLIP-seq
MIRT2086217	hsa-miR-449c	CLIP-seq
MIRT2086218	hsa-miR-4503	CLIP-seq
MIRT2086219	hsa-miR-4514	CLIP-seq
MIRT2086220	hsa-miR-4518	CLIP-seq
MIRT2086221	hsa-miR-4639-3p	CLIP-seq
MIRT2086222	hsa-miR-4644	CLIP-seq
MIRT2086223	hsa-miR-4666-3p	CLIP-seq
MIRT2086224	hsa-miR-4687-3p	CLIP-seq
MIRT2086225	hsa-miR-4692	CLIP-seq
MIRT2086226	hsa-miR-4697-5p	CLIP-seq
MIRT1290089	hsa-miR-4700-3p	CLIP-seq
MIRT2086227	hsa-miR-4701-3p	CLIP-seq
MIRT2086228	hsa-miR-4703-5p	CLIP-seq
MIRT2086229	hsa-miR-4714-3p	CLIP-seq
MIRT2086230	hsa-miR-4722-3p	CLIP-seq
MIRT2086231	hsa-miR-4723-3p	CLIP-seq
MIRT2086232	hsa-miR-4725-5p	CLIP-seq
MIRT2086233	hsa-miR-4728-5p	CLIP-seq
MIRT2086234	hsa-miR-4736	CLIP-seq
MIRT2086235	hsa-miR-4739	CLIP-seq
MIRT2086236	hsa-miR-4756-5p	CLIP-seq
MIRT1290046	hsa-miR-4757-5p	CLIP-seq
MIRT2086237	hsa-miR-4760-5p	CLIP-seq
MIRT2086238	hsa-miR-4761-3p	CLIP-seq
MIRT2086239	hsa-miR-4763-3p	CLIP-seq
MIRT2086240	hsa-miR-4766-3p	CLIP-seq
MIRT2086241	hsa-miR-4768-3p	CLIP-seq
MIRT2086242	hsa-miR-4777-5p	CLIP-seq
MIRT2086243	hsa-miR-4792	CLIP-seq
MIRT1290048	hsa-miR-4793-3p	CLIP-seq
MIRT2086244	hsa-miR-4804-5p	CLIP-seq
MIRT2086245	hsa-miR-499-5p	CLIP-seq
MIRT2086246	hsa-miR-504	CLIP-seq
MIRT2086247	hsa-miR-505	CLIP-seq
MIRT2086248	hsa-miR-513a-5p	CLIP-seq
MIRT1290103	hsa-miR-544	CLIP-seq
MIRT2086249	hsa-miR-558	CLIP-seq
MIRT2086250	hsa-miR-576-5p	CLIP-seq
MIRT1290104	hsa-miR-593	CLIP-seq
MIRT2086251	hsa-miR-636	CLIP-seq
MIRT2086252	hsa-miR-641	CLIP-seq
MIRT2086253	hsa-miR-650	CLIP-seq
MIRT1290108	hsa-miR-665	CLIP-seq
MIRT1290110	hsa-miR-762	CLIP-seq
MIRT2086254	hsa-miR-766	CLIP-seq
MIRT2086255	hsa-miR-767-5p	CLIP-seq
MIRT2086256	hsa-miR-885-5p	CLIP-seq
MIRT2086257	hsa-miR-940	CLIP-seq
MIRT2311384	hsa-miR-103a	CLIP-seq
MIRT2311385	hsa-miR-107	CLIP-seq
MIRT1290083	hsa-miR-4492	CLIP-seq
MIRT1290084	hsa-miR-4498	CLIP-seq
MIRT1290110	hsa-miR-762	CLIP-seq
MIRT2311386	hsa-miR-124	CLIP-seq
MIRT2311387	hsa-miR-1825	CLIP-seq
MIRT2086162	hsa-miR-208a	CLIP-seq
MIRT2086163	hsa-miR-208b	CLIP-seq
MIRT1290032	hsa-miR-3130-3p	CLIP-seq
MIRT2086176	hsa-miR-3135b	CLIP-seq
MIRT2086185	hsa-miR-3612	CLIP-seq
MIRT2086190	hsa-miR-3667-5p	CLIP-seq
MIRT2311388	hsa-miR-3714	CLIP-seq
MIRT2311389	hsa-miR-3910	CLIP-seq
MIRT1290078	hsa-miR-4436a	CLIP-seq
MIRT2086212	hsa-miR-4443	CLIP-seq
MIRT2086215	hsa-miR-4487	CLIP-seq
MIRT2311390	hsa-miR-4490	CLIP-seq
MIRT1290083	hsa-miR-4492	CLIP-seq
MIRT1290084	hsa-miR-4498	CLIP-seq
MIRT2086218	hsa-miR-4503	CLIP-seq
MIRT2086221	hsa-miR-4639-3p	CLIP-seq
MIRT1290089	hsa-miR-4700-3p	CLIP-seq
MIRT1290048	hsa-miR-4793-3p	CLIP-seq
MIRT2086245	hsa-miR-499-5p	CLIP-seq
MIRT2311391	hsa-miR-506	CLIP-seq
MIRT1290103	hsa-miR-544	CLIP-seq
MIRT2086253	hsa-miR-650	CLIP-seq
MIRT1290110	hsa-miR-762	CLIP-seq
MIRT2393470	hsa-miR-1207-3p	CLIP-seq
MIRT2086150	hsa-miR-1207-5p	CLIP-seq
MIRT2086157	hsa-miR-150	CLIP-seq
MIRT1290060	hsa-miR-1587	CLIP-seq
MIRT1290061	hsa-miR-1827	CLIP-seq
MIRT1290071	hsa-miR-3652	CLIP-seq
MIRT1290076	hsa-miR-4417	CLIP-seq
MIRT1290077	hsa-miR-4430	CLIP-seq
MIRT1290083	hsa-miR-4492	CLIP-seq
MIRT1290084	hsa-miR-4498	CLIP-seq
MIRT1290087	hsa-miR-4656	CLIP-seq
MIRT1290088	hsa-miR-4675	CLIP-seq
MIRT1290091	hsa-miR-4741	CLIP-seq
MIRT2086239	hsa-miR-4763-3p	CLIP-seq
MIRT1290098	hsa-miR-519a	CLIP-seq
MIRT1290099	hsa-miR-519b-3p	CLIP-seq
MIRT1290100	hsa-miR-519c-3p	CLIP-seq
MIRT1290102	hsa-miR-541	CLIP-seq
MIRT1290107	hsa-miR-654-5p	CLIP-seq
MIRT1290110	hsa-miR-762	CLIP-seq
MIRT2086257	hsa-miR-940	CLIP-seq
MIRT2607717	hsa-miR-1205	CLIP-seq
MIRT2607718	hsa-miR-122	CLIP-seq
MIRT2607719	hsa-miR-1286	CLIP-seq
MIRT2607720	hsa-miR-182	CLIP-seq
MIRT2086176	hsa-miR-3135b	CLIP-seq
MIRT2607721	hsa-miR-3155	CLIP-seq
MIRT2607722	hsa-miR-3155b	CLIP-seq
MIRT2086215	hsa-miR-4487	CLIP-seq
MIRT2607723	hsa-miR-4722-5p	CLIP-seq
MIRT2607724	hsa-miR-4772-5p	CLIP-seq
MIRT2607725	hsa-miR-484	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002250	Process	Adaptive immune response	TAS
GO:0005096	Function	GTPase activator activity	EXP	16076873
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	24284068, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IGI	24284068
GO:0008361	Process	Regulation of cell size	IGI	24284068
GO:0008361	Process	Regulation of cell size	IMP	24284068
GO:0031965	Component	Nuclear membrane	IDA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA

Other IDs

• MIM: 618714
• HGNC: 29176
• e!Ensembl: ENSG00000132359

Protein

• UniProt ID: Q684P5
• Protein name: Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)
• Protein function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02145	Rap_GAP	277 → 458	Rap/ran-GAP	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in platelets with isoform 2 being the predominant form. Expressed in lymphocytes, heart, testis and pancreas. {ECO:0000269|PubMed:15632203}.
• Sequence:

  MFGRKRSVSFGGFGWIDKTMLASLKVKKQELANSSDATLPDRPLSPPLTAPPTMKSSEFF
  EMLEKMQGIKLEEQKPGPQKNKDDYIPYPSIDEVVEKGGPYPQVILPQFGGYWIEDPENV
  GTPTSLGSSICEEEEEDNLSPNTFGYKLECKGEARAYRRHFLGKDHLNFYCTGSSLGNLI
  LSVKCEEAEGIEYLRVILRSKLKTVHERIPLAGLSKLPSVPQIAKAFCDDAVGLRFNPVL
  YPKASQMIVSYDEHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITL
  QDFKGFRGGLDVTHGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIV
  AIIFQEENTPFVPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPP
  VFQKGPEFREFLLTKLTNAENACCKSDKFAKLEDRTRAALLDNLHDELHAHTQAMLGLGP
  EEDKFENGGHGGFLESFKRAIRVRSHSMETMVGGQKKSHSGGIPGSLSGGISHNSMEVTK
  TTFSPPVVAATVKNQSRSPIKRRSGLFPRLHTGSEGQGDSRARCDSTSSTPKTPDGGHSS
  QEIKSETSSNPSSPEICPNKEKPFMKLKENGRAISRSSSSTSSVSSTAGEGEAMEEGDSG
  GSQPSTTSPFKQEVFVYSPSPSSESPSLGAAATPIIMSRSPTDAKSRNSPRSNLKFRFDK
  LSHASSGAGH

• Sequence length: 730

Pathways

Reactome:

Rap1 signalling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY SKIN DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTERSTITIAL LUNG DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE ACUTE RESPIRATORY SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Neoplasms Adipose Tissue	Associate	32901515	★☆☆☆☆ Found in Text Mining only
Paranoid Disorders	Associate	22832427	★☆☆☆☆ Found in Text Mining only