Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23107
Gene name Gene Name - the full gene name approved by the HGNC.
Mitochondrial ribosomal protein S27
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MRPS27
Synonyms (NCBI Gene) Gene synonyms aliases
MRP-S27, S27mt, mS27
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001060 hsa-miR-218-5p qRT-PCR, Western blot 17998940
MIRT020718 hsa-miR-155-5p Proteomics 18668040
MIRT020718 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT649783 hsa-miR-6793-3p HITS-CLIP 19536157
MIRT649782 hsa-miR-1470 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000049 Function TRNA binding IDA 22841715
GO:0005515 Function Protein binding IPI 19103604, 22003127, 28514442
GO:0005730 Component Nucleolus IDA
GO:0005737 Component Cytoplasm IDA 28714366
GO:0005739 Component Mitochondrion IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611989 14512 ENSG00000113048
Protein
UniProt ID Q92552
Protein name Small ribosomal subunit protein mS27 (28S ribosomal protein S27, mitochondrial) (MRP-S27) (S27mt) (Mitochondrial ribosomal protein S27)
Protein function RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis (PubMed:22841715). Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron tra
PDB 3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10037 MRP-S27 1 412 Mitochondrial 28S ribosomal protein S27 Family
Tissue specificity TISSUE SPECIFICITY: Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues (at protein level) (PubMed:28714366). Ubiquitous (PubMed:22841715). {ECO:0000269|PubMed:22841715, ECO:0000269|PubMed:28714366}.
Sequence
Sequence length 414
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Mitochondrial translation elongation
Mitochondrial translation termination
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Cerebral Infarction Associate 37603533
Hepatomegaly Associate 37603533
Kidney Diseases Associate 37603533
Liver Failure Associate 37603533
Necrosis Associate 37603533
Neoplasms Associate 37603533