Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	231
Gene name	Aldo-keto reductase family 1 member B
Gene symbol	AKR1B1
Synonyms (NCBI Gene)	ADRALDR1ALR2AR
Chromosome	7
Chromosome location	7q33
Summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025547	hsa-miR-34a-5p	Proteomics	21566225
MIRT038212	hsa-miR-342-5p	CLASH	23622248
MIRT036537	hsa-miR-1226-3p	CLASH	23622248
MIRT776271	hsa-miR-214	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776273	hsa-miR-3154	CLIP-seq
MIRT776274	hsa-miR-330-3p	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472638	hsa-miR-1264	CLIP-seq
MIRT2472639	hsa-miR-1304	CLIP-seq
MIRT2472640	hsa-miR-139-5p	CLIP-seq
MIRT2472641	hsa-miR-140-3p	CLIP-seq
MIRT2472642	hsa-miR-1827	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2472643	hsa-miR-2110	CLIP-seq
MIRT2472644	hsa-miR-31	CLIP-seq
MIRT2472645	hsa-miR-3144-5p	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2472646	hsa-miR-3150a-3p	CLIP-seq
MIRT2472647	hsa-miR-3156-3p	CLIP-seq
MIRT2472648	hsa-miR-3191	CLIP-seq
MIRT2472649	hsa-miR-3614-5p	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT2472650	hsa-miR-4301	CLIP-seq
MIRT2472651	hsa-miR-4305	CLIP-seq
MIRT2472652	hsa-miR-431	CLIP-seq
MIRT2472653	hsa-miR-4311	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT2472654	hsa-miR-4652-5p	CLIP-seq
MIRT2472655	hsa-miR-4663	CLIP-seq
MIRT2472656	hsa-miR-4690-5p	CLIP-seq
MIRT2472657	hsa-miR-4701-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2472658	hsa-miR-4719	CLIP-seq
MIRT2472659	hsa-miR-4742-5p	CLIP-seq
MIRT2472660	hsa-miR-4765	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2472661	hsa-miR-552	CLIP-seq
MIRT2472662	hsa-miR-588	CLIP-seq
MIRT2472663	hsa-miR-626	CLIP-seq
MIRT2472664	hsa-miR-628-5p	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472665	hsa-miR-720	CLIP-seq
MIRT2472638	hsa-miR-1264	CLIP-seq
MIRT2472639	hsa-miR-1304	CLIP-seq
MIRT2674852	hsa-miR-133a	CLIP-seq
MIRT2674853	hsa-miR-133b	CLIP-seq
MIRT2472640	hsa-miR-139-5p	CLIP-seq
MIRT2472641	hsa-miR-140-3p	CLIP-seq
MIRT2674854	hsa-miR-145	CLIP-seq
MIRT2472642	hsa-miR-1827	CLIP-seq
MIRT2674855	hsa-miR-192	CLIP-seq
MIRT2426161	hsa-miR-1972	CLIP-seq
MIRT2472643	hsa-miR-2110	CLIP-seq
MIRT776271	hsa-miR-214	CLIP-seq
MIRT2674856	hsa-miR-215	CLIP-seq
MIRT1929130	hsa-miR-2355-5p	CLIP-seq
MIRT2472644	hsa-miR-31	CLIP-seq
MIRT776272	hsa-miR-3132	CLIP-seq
MIRT2472645	hsa-miR-3144-5p	CLIP-seq
MIRT2426162	hsa-miR-3148	CLIP-seq
MIRT2472646	hsa-miR-3150a-3p	CLIP-seq
MIRT776273	hsa-miR-3154	CLIP-seq
MIRT2472647	hsa-miR-3156-3p	CLIP-seq
MIRT2472648	hsa-miR-3191	CLIP-seq
MIRT776274	hsa-miR-330-3p	CLIP-seq
MIRT2674857	hsa-miR-3529	CLIP-seq
MIRT2674858	hsa-miR-3613-5p	CLIP-seq
MIRT2472649	hsa-miR-3614-5p	CLIP-seq
MIRT776275	hsa-miR-3619-5p	CLIP-seq
MIRT2435292	hsa-miR-3660	CLIP-seq
MIRT2674859	hsa-miR-3661	CLIP-seq
MIRT2426163	hsa-miR-3662	CLIP-seq
MIRT1929131	hsa-miR-3679-3p	CLIP-seq
MIRT2674860	hsa-miR-379	CLIP-seq
MIRT2674861	hsa-miR-3977	CLIP-seq
MIRT2674862	hsa-miR-4274	CLIP-seq
MIRT2472650	hsa-miR-4301	CLIP-seq
MIRT2472651	hsa-miR-4305	CLIP-seq
MIRT2472652	hsa-miR-431	CLIP-seq
MIRT2472653	hsa-miR-4311	CLIP-seq
MIRT2674863	hsa-miR-4451	CLIP-seq
MIRT2426164	hsa-miR-450b-5p	CLIP-seq
MIRT2435293	hsa-miR-4526	CLIP-seq
MIRT776276	hsa-miR-4530	CLIP-seq
MIRT776277	hsa-miR-4650-3p	CLIP-seq
MIRT2472654	hsa-miR-4652-5p	CLIP-seq
MIRT2472655	hsa-miR-4663	CLIP-seq
MIRT2472656	hsa-miR-4690-5p	CLIP-seq
MIRT2472657	hsa-miR-4701-5p	CLIP-seq
MIRT2426165	hsa-miR-4708-3p	CLIP-seq
MIRT2472658	hsa-miR-4719	CLIP-seq
MIRT2472659	hsa-miR-4742-5p	CLIP-seq
MIRT2674864	hsa-miR-4753-3p	CLIP-seq
MIRT2472660	hsa-miR-4765	CLIP-seq
MIRT2674865	hsa-miR-4766-5p	CLIP-seq
MIRT2674866	hsa-miR-488	CLIP-seq
MIRT2435294	hsa-miR-526b	CLIP-seq
MIRT2472661	hsa-miR-552	CLIP-seq
MIRT2472662	hsa-miR-588	CLIP-seq
MIRT2472663	hsa-miR-626	CLIP-seq
MIRT2472664	hsa-miR-628-5p	CLIP-seq
MIRT2674867	hsa-miR-631	CLIP-seq
MIRT2426166	hsa-miR-642b	CLIP-seq
MIRT2472665	hsa-miR-720	CLIP-seq
MIRT776278	hsa-miR-761	CLIP-seq
MIRT2674868	hsa-miR-9	CLIP-seq
MIRT2674869	hsa-miR-942	CLIP-seq

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Transcription factor	Regulation	Reference
EGR1	Unknown	12890669

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	IMP	12732097
GO:0001758	Function	Retinal dehydrogenase (NAD+) activity	IDA	12732097
GO:0002070	Process	Epithelial cell maturation	IEA
GO:0003091	Process	Renal water homeostasis	IEA
GO:0004032	Function	Aldose reductase (NADPH) activity	EXP	1420136, 2112546, 8645003
GO:0004032	Function	Aldose reductase (NADPH) activity	IBA
GO:0004032	Function	Aldose reductase (NADPH) activity	IDA	8435445
GO:0004032	Function	Aldose reductase (NADPH) activity	IEA
GO:0004032	Function	Aldose reductase (NADPH) activity	TAS	2112546
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005615	Component	Extracellular space	TAS	2112546
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	TAS	2112546
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006693	Process	Prostaglandin metabolic process	IEA
GO:0006700	Process	C21-steroid hormone biosynthetic process	TAS
GO:0009055	Function	Electron transfer activity	TAS	2112546
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0035809	Process	Regulation of urine volume	IEA
GO:0036130	Function	Prostaglandin H2 endoperoxidase reductase activity	IEA
GO:0042572	Process	Retinol metabolic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043795	Function	Glyceraldehyde oxidoreductase activity	IDA	20837989
GO:0044597	Process	Daunorubicin metabolic process	IMP	20837989
GO:0044598	Process	Doxorubicin metabolic process	IMP	20837989
GO:0046370	Process	Fructose biosynthetic process	IEA
GO:0046370	Process	Fructose biosynthetic process	TAS
GO:0047655	Function	Allyl-alcohol dehydrogenase activity	IEA
GO:0047939	Function	L-glucuronate reductase activity	IEA
GO:0047956	Function	Glycerol dehydrogenase (NADP+) activity	IEA
GO:0052650	Function	All-trans-retinol dehydrogenase (NADP+) activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0071475	Process	Cellular hyperosmotic salinity response	IDA	8435445
GO:0072205	Process	Metanephric collecting duct development	IEA

MIM	HGNC	e!Ensembl
103880	381	ENSG00000085662

P15121

Protein name

Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR)

Protein function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosachari

PDB

1ABN , 1ADS , 1AZ1 , 1AZ2 , 1EF3 , 1EL3 , 1IEI , 1MAR , 1PWL , 1PWM , 1T40 , 1T41 , 1US0 , 1X96 , 1X97 , 1X98 , 1XGD , 1Z3N , 1Z89 , 1Z8A , 2ACQ , 2ACR , 2ACS , 2ACU , 2AGT , 2DUX , 2DUZ , 2DV0 , 2F2K , 2FZ8 , 2FZ9 , 2FZB , 2FZD , 2HV5 , 2HVN , 2HVO , 2I16 , 2I17 , 2IKG , 2IKH , 2IKI , 2IKJ , 2INE , 2INZ , 2IPW , 2IQ0 , 2IQD , 2IS7 , 2ISF , 2J8T , 2NVC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00248	Aldo_ket_red	15 → 294	Aldo/keto reductase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. {ECO:0000269|PubMed:8435445}.

Sequence

MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF

Sequence length

316

Interactions

View interactions

	KEGG		Reactome
	Pentose and glucuronate interconversions Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Folate biosynthesis Metabolic pathways		Pregnenolone biosynthesis Fructose biosynthesis

AKR1B1 (aldo-keto reductase family 1 member B)