Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23094
Gene name	Signal induced proliferation associated 1 like 3
Gene symbol	SIPA1L3
Synonyms (NCBI Gene)	CTRCT45SPAL3SPAR3
Chromosome	19
Chromosome location	19q13.13-q13.2
Summary	This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization

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SNP ID	Visualize variation	Clinical significance	Consequence
rs756898971	C>T	Pathogenic	Stop gained, coding sequence variant, genic downstream transcript variant

306

Show/Hide all (306)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019987	hsa-miR-375	Microarray	20215506
MIRT050905	hsa-miR-17-5p	CLASH	23622248
MIRT048328	hsa-miR-106a-5p	CLASH	23622248
MIRT045593	hsa-miR-149-5p	CLASH	23622248
MIRT039665	hsa-miR-615-3p	CLASH	23622248
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT521121	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521120	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT439629	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT439629	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT521121	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT521120	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT612232	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT612231	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT521122	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT521121	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521120	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1349820	hsa-miR-1200	CLIP-seq
MIRT1349821	hsa-miR-1234	CLIP-seq
MIRT1349822	hsa-miR-143	CLIP-seq
MIRT1349823	hsa-miR-146b-3p	CLIP-seq
MIRT1349824	hsa-miR-147	CLIP-seq
MIRT1349825	hsa-miR-185	CLIP-seq
MIRT1349826	hsa-miR-2117	CLIP-seq
MIRT1349827	hsa-miR-3150b-3p	CLIP-seq
MIRT1349828	hsa-miR-3158-3p	CLIP-seq
MIRT1349829	hsa-miR-3184	CLIP-seq
MIRT1349830	hsa-miR-339-5p	CLIP-seq
MIRT1349831	hsa-miR-3616-3p	CLIP-seq
MIRT1349832	hsa-miR-3662	CLIP-seq
MIRT1349833	hsa-miR-3690	CLIP-seq
MIRT1349834	hsa-miR-370	CLIP-seq
MIRT1349835	hsa-miR-3911	CLIP-seq
MIRT1349836	hsa-miR-423-5p	CLIP-seq
MIRT1349837	hsa-miR-4254	CLIP-seq
MIRT1349838	hsa-miR-4271	CLIP-seq
MIRT1349839	hsa-miR-4273	CLIP-seq
MIRT1349840	hsa-miR-4279	CLIP-seq
MIRT1349841	hsa-miR-4306	CLIP-seq
MIRT1349842	hsa-miR-4324	CLIP-seq
MIRT1349843	hsa-miR-4493	CLIP-seq
MIRT1349844	hsa-miR-4533	CLIP-seq
MIRT1349845	hsa-miR-4644	CLIP-seq
MIRT1349846	hsa-miR-4687-3p	CLIP-seq
MIRT1349847	hsa-miR-4691-5p	CLIP-seq
MIRT1349848	hsa-miR-4698	CLIP-seq
MIRT1349849	hsa-miR-4716-5p	CLIP-seq
MIRT1349850	hsa-miR-4721	CLIP-seq
MIRT1349851	hsa-miR-4725-3p	CLIP-seq
MIRT1349852	hsa-miR-4747-5p	CLIP-seq
MIRT1349853	hsa-miR-4770	CLIP-seq
MIRT1349854	hsa-miR-4784	CLIP-seq
MIRT1349855	hsa-miR-4785	CLIP-seq
MIRT1349856	hsa-miR-544b	CLIP-seq
MIRT1349857	hsa-miR-548aa	CLIP-seq
MIRT1349858	hsa-miR-548ac	CLIP-seq
MIRT1349859	hsa-miR-548d-3p	CLIP-seq
MIRT1349860	hsa-miR-548z	CLIP-seq
MIRT1349861	hsa-miR-644	CLIP-seq
MIRT1349862	hsa-miR-765	CLIP-seq
MIRT1349863	hsa-miR-766	CLIP-seq
MIRT2103689	hsa-miR-1275	CLIP-seq
MIRT2103690	hsa-miR-133a	CLIP-seq
MIRT2103691	hsa-miR-133b	CLIP-seq
MIRT2103692	hsa-miR-3152-5p	CLIP-seq
MIRT2103693	hsa-miR-3160-3p	CLIP-seq
MIRT1349829	hsa-miR-3184	CLIP-seq
MIRT2103694	hsa-miR-3612	CLIP-seq
MIRT2103695	hsa-miR-3614-3p	CLIP-seq
MIRT2103696	hsa-miR-3929	CLIP-seq
MIRT2103697	hsa-miR-3975	CLIP-seq
MIRT1349836	hsa-miR-423-5p	CLIP-seq
MIRT2103698	hsa-miR-4299	CLIP-seq
MIRT2103699	hsa-miR-4419b	CLIP-seq
MIRT2103700	hsa-miR-4443	CLIP-seq
MIRT2103701	hsa-miR-4456	CLIP-seq
MIRT2103702	hsa-miR-4478	CLIP-seq
MIRT2103703	hsa-miR-4532	CLIP-seq
MIRT2103704	hsa-miR-4640-5p	CLIP-seq
MIRT2103705	hsa-miR-4665-5p	CLIP-seq
MIRT2103706	hsa-miR-4707-5p	CLIP-seq
MIRT2103707	hsa-miR-4710	CLIP-seq
MIRT2103708	hsa-miR-4726-5p	CLIP-seq
MIRT2103709	hsa-miR-4792	CLIP-seq
MIRT2103710	hsa-miR-485-5p	CLIP-seq
MIRT2103711	hsa-miR-494	CLIP-seq
MIRT2103712	hsa-miR-513a-5p	CLIP-seq
MIRT2103713	hsa-miR-516b	CLIP-seq
MIRT2103714	hsa-miR-548q	CLIP-seq
MIRT2103715	hsa-miR-650	CLIP-seq
MIRT2103716	hsa-miR-760	CLIP-seq
MIRT2103717	hsa-miR-939	CLIP-seq
MIRT2327783	hsa-miR-1193	CLIP-seq
MIRT2327784	hsa-miR-1207-3p	CLIP-seq
MIRT2327785	hsa-miR-1224-5p	CLIP-seq
MIRT2327786	hsa-miR-1270	CLIP-seq
MIRT2327787	hsa-miR-1273f	CLIP-seq
MIRT2103689	hsa-miR-1275	CLIP-seq
MIRT2327788	hsa-miR-1291	CLIP-seq
MIRT2103690	hsa-miR-133a	CLIP-seq
MIRT2103691	hsa-miR-133b	CLIP-seq
MIRT2327789	hsa-miR-1587	CLIP-seq
MIRT1349825	hsa-miR-185	CLIP-seq
MIRT2327790	hsa-miR-28-5p	CLIP-seq
MIRT2327791	hsa-miR-3121-5p	CLIP-seq
MIRT2327792	hsa-miR-3139	CLIP-seq
MIRT2327793	hsa-miR-3147	CLIP-seq
MIRT2327794	hsa-miR-3148	CLIP-seq
MIRT2327795	hsa-miR-3150a-3p	CLIP-seq
MIRT2103693	hsa-miR-3160-3p	CLIP-seq
MIRT2327796	hsa-miR-3175	CLIP-seq
MIRT2327797	hsa-miR-3192	CLIP-seq
MIRT2327798	hsa-miR-3622b-5p	CLIP-seq
MIRT2327799	hsa-miR-3671	CLIP-seq
MIRT1349833	hsa-miR-3690	CLIP-seq
MIRT2327800	hsa-miR-371-5p	CLIP-seq
MIRT2327801	hsa-miR-371b-5p	CLIP-seq
MIRT1349837	hsa-miR-4254	CLIP-seq
MIRT1349838	hsa-miR-4271	CLIP-seq
MIRT1349841	hsa-miR-4306	CLIP-seq
MIRT2327802	hsa-miR-4308	CLIP-seq
MIRT2327803	hsa-miR-4419a	CLIP-seq
MIRT2327804	hsa-miR-4425	CLIP-seq
MIRT2327805	hsa-miR-4435	CLIP-seq
MIRT2327806	hsa-miR-4446-3p	CLIP-seq
MIRT2327807	hsa-miR-4492	CLIP-seq
MIRT2327808	hsa-miR-4498	CLIP-seq
MIRT2327809	hsa-miR-4505	CLIP-seq
MIRT2327810	hsa-miR-4510	CLIP-seq
MIRT2327811	hsa-miR-4525	CLIP-seq
MIRT2327812	hsa-miR-4632	CLIP-seq
MIRT1349845	hsa-miR-4644	CLIP-seq
MIRT2327813	hsa-miR-4656	CLIP-seq
MIRT2103705	hsa-miR-4665-5p	CLIP-seq
MIRT2327814	hsa-miR-4675	CLIP-seq
MIRT2327815	hsa-miR-4683	CLIP-seq
MIRT2327816	hsa-miR-4685-5p	CLIP-seq
MIRT2327817	hsa-miR-4694-5p	CLIP-seq
MIRT2103707	hsa-miR-4710	CLIP-seq
MIRT1349849	hsa-miR-4716-5p	CLIP-seq
MIRT1349851	hsa-miR-4725-3p	CLIP-seq
MIRT2327818	hsa-miR-4728-5p	CLIP-seq
MIRT2327819	hsa-miR-4730	CLIP-seq
MIRT2327820	hsa-miR-4741	CLIP-seq
MIRT2327821	hsa-miR-4751	CLIP-seq
MIRT2327822	hsa-miR-4768-5p	CLIP-seq
MIRT2103711	hsa-miR-494	CLIP-seq
MIRT2327823	hsa-miR-518a-5p	CLIP-seq
MIRT2327824	hsa-miR-527	CLIP-seq
MIRT2103714	hsa-miR-548q	CLIP-seq
MIRT2327825	hsa-miR-620	CLIP-seq
MIRT2327826	hsa-miR-708	CLIP-seq
MIRT2327827	hsa-miR-762	CLIP-seq
MIRT2103717	hsa-miR-939	CLIP-seq
MIRT2459391	hsa-miR-106a	CLIP-seq
MIRT2459392	hsa-miR-106b	CLIP-seq
MIRT2459393	hsa-miR-17	CLIP-seq
MIRT2459394	hsa-miR-20a	CLIP-seq
MIRT2459395	hsa-miR-20b	CLIP-seq
MIRT2459396	hsa-miR-302a	CLIP-seq
MIRT2459397	hsa-miR-302b	CLIP-seq
MIRT2459398	hsa-miR-302c	CLIP-seq
MIRT2459399	hsa-miR-302d	CLIP-seq
MIRT2459400	hsa-miR-302e	CLIP-seq
MIRT2459401	hsa-miR-3064-5p	CLIP-seq
MIRT2459402	hsa-miR-372	CLIP-seq
MIRT2459403	hsa-miR-373	CLIP-seq
MIRT2459404	hsa-miR-4268	CLIP-seq
MIRT2459405	hsa-miR-4448	CLIP-seq
MIRT2459406	hsa-miR-519d	CLIP-seq
MIRT2459407	hsa-miR-520a-3p	CLIP-seq
MIRT2459408	hsa-miR-520b	CLIP-seq
MIRT2459409	hsa-miR-520c-3p	CLIP-seq
MIRT2459410	hsa-miR-520d-3p	CLIP-seq
MIRT2459411	hsa-miR-520e	CLIP-seq
MIRT2459412	hsa-miR-604	CLIP-seq
MIRT2459413	hsa-miR-618	CLIP-seq
MIRT2459414	hsa-miR-647	CLIP-seq
MIRT2459415	hsa-miR-93	CLIP-seq
MIRT2622851	hsa-miR-1261	CLIP-seq
MIRT1349834	hsa-miR-370	CLIP-seq
MIRT2622852	hsa-miR-4665-3p	CLIP-seq
MIRT2622853	hsa-miR-4714-3p	CLIP-seq
MIRT2622854	hsa-miR-4773	CLIP-seq
MIRT2103711	hsa-miR-494	CLIP-seq
MIRT1349858	hsa-miR-548ac	CLIP-seq
MIRT1349859	hsa-miR-548d-3p	CLIP-seq
MIRT1349860	hsa-miR-548z	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001654	Process	Eye development	IEA
GO:0001654	Process	Eye development	ISS
GO:0001725	Component	Stress fiber	IDA	26231217
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0003382	Process	Epithelial cell morphogenesis	IBA
GO:0003382	Process	Epithelial cell morphogenesis	IDA	26231217
GO:0003382	Process	Epithelial cell morphogenesis	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	15161933, 15778465, 28514442, 33961781, 35271311, 36931259
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0045177	Component	Apical part of cell	IMP	26231217
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0061689	Component	Tricellular tight junction	IDA	26231217
GO:0090162	Process	Establishment of epithelial cell polarity	IBA
GO:0090162	Process	Establishment of epithelial cell polarity	IDA	26231217
GO:0090162	Process	Establishment of epithelial cell polarity	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099091	Component	Postsynaptic specialization, intracellular component	IEA

MIM	HGNC	e!Ensembl
616655	23801	ENSG00000105738

O60292

Protein name

Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)

Protein function

Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens (PubMed:26231217).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02145	Rap_GAP	640 → 822	Rap/ran-GAP	Family
PF11881	SPAR_C	1477 → 1726	C-terminal domain of SPAR protein	Family

Sequence

MTTYRAIPSDGVDLAASCGARVGDVLPGPHTGDYAPLGFWAQNGSMSQPLGESPATATAT
ATATTRPSPTTPAMPKMGVRARVADWPPKREALREHSNPSPSQDTDGTKATKMAHSMRSI
QNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQDGWPRSPGRAFLPLRHRSSSEITLSECD
AEDAGEPRGARHTGALPLFREYGSTSSIDVQGMPEQSFFDILNEFRSEQPDARGCQALTE
LLRADPGPHLMGGGGGAKGDSHNGQPAKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSS
IFRKLRSSKPEGEAGRSPGEADEGRSPPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRV
SVSQRRNTTTGASAASAASAMASLTASRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNS
NDLLLSCPHFRNEIGGECERNVSFSRASVGSPSSGEGHLAEPALSAYRTNASISVLEVPK
EQQRTQSRPRQYSIEHVDLGARYYQDYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKE
HGPQYQYRIIFRTRELITLRGSILEDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRL
ALNTPKVTEQLLKLDEQGLCRKHKVGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEK
VCLKGFTKYAAQLDVKTDSTGTHSLYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGN
DIVTIIFQEPGALPFTPKNIRSHFQHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPI
PSGTTFRKSDVFRDFLLAKVINAENAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDS
TGKFNLISLTSKKKEKTKARAGAEQHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLL
DLRTKEVVFNCYCGDVIGWTPDSSTLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTS
GWETVDMTLRRNGLGQLGFHVKYDGTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTH
DQMIDLLRTSVTVKVVIIPPFEDGTPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNA
PWQWSGPASHNSLPASKWATPTTPGHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFPETP
YTVSPAGADRVPPYRQPSGSFSTPGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSS
GDSSSGGLTSQESTMERQKPEPLWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSK
GEPQYSSHSSSNTLSSNASSSHSDDRWFDPLDPLEPEQDPLSKGGSSDSGIDTTLYTSSP
SCMSLAKAPRPAKPHKPPGSMGLCGGGREAAGRSHHADRRREVSPAPAVAGQSKGYRPKL
YSSGSSTPTGLAGGSRDPPRQPSDMGSRVGYPAQVYKTASAETPRPSQLAQPSPFQLSAS
VPKSFFSKQPVRNKHPTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLR
SPRKNYKSTIEDDLKKLIIMDNLGPEQERDTGQSPQKGLQRTLSDESLCSGRREPSFASP
AGLEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTISASE
LSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYEVQRAVSLFSLNDPALSPDI
PPAHSPVHSHLSLERGPPTPRTTPTMSEEPPLDLTGKVYQLEVMLKQLHTDLQKEKQDKV
VLQSEVASLRQNNQRLQEESQAASEQLRKFAEIFCREKKEL

Sequence length

1781

Interactions

View interactions

	KEGG
	Rap1 signaling pathway

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cataract 45	Pathogenic	rs1568573490, rs756898971	RCV002251032 RCV000208874

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs3760882	RCV005918563
Cervical cancer	Benign; Likely benign	rs141958728	RCV005905757
Colon adenocarcinoma	Uncertain significance; Benign; Likely benign	rs748028255, rs141958728	RCV005926970 RCV005905755
Hepatocellular carcinoma	Benign; Likely benign	rs141958728	RCV005905756
Lung cancer	Benign; Likely benign	rs3760882, rs141958728	RCV005918567 RCV005905760
Malignant tumor of esophagus	Benign	rs3760882	RCV005918564
Malignant tumor of urinary bladder	Uncertain significance	rs61729138	RCV005926402
Melanoma	Benign; Likely benign	rs141958728	RCV005905759
Ovarian serous cystadenocarcinoma	Benign	rs3760882	RCV005918566
Sarcoma	Benign; Likely benign	rs3760882, rs141958728	RCV005918565 RCV005905758
SIPA1L3-related disorder	Benign; Likely benign; Uncertain significance	rs143617253, rs141373470, rs150886878, rs368914529, rs182152072, rs200615573, rs776331340, rs184751502, rs528673872, rs748915011, rs758200193, rs754538272, rs142598144, rs145667425, rs202019209 View all (11 more)	RCV003931329 RCV004758217 RCV003923475 RCV003961060 RCV003906277 RCV003936502 RCV003908978 RCV003929270 RCV003929317 RCV004758288 RCV003949376 RCV003949555 RCV003936829 RCV003942305 RCV003946823 RCV003954369 RCV003971497 RCV003908136 RCV003928312 RCV003915835 RCV003960710 RCV003957941 RCV003910785 RCV003902852 RCV003960391 RCV003950786

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	30924596
Angiomyolipoma	Associate	31077186
Cataract	Associate	25804400
Colorectal Neoplasms	Associate	31554631
Papillomavirus Infections	Associate	32164487
Renal Insufficiency Chronic	Associate	40770708

SIPA1L3 (signal induced proliferation associated 1 like 3)