Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23091
Gene name	Zinc finger CCCH-type containing 13
Gene symbol	ZC3H13
Synonyms (NCBI Gene)	KIAA0853Xio
Chromosome	13
Chromosome location	13q14.13

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638003	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT439252	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439252	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638003	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT1505654	hsa-miR-128	CLIP-seq
MIRT1505655	hsa-miR-129-5p	CLIP-seq
MIRT1505656	hsa-miR-198	CLIP-seq
MIRT1505657	hsa-miR-2117	CLIP-seq
MIRT1505658	hsa-miR-302a	CLIP-seq
MIRT1505659	hsa-miR-302b	CLIP-seq
MIRT1505660	hsa-miR-302c	CLIP-seq
MIRT1505661	hsa-miR-302d	CLIP-seq
MIRT1505662	hsa-miR-302e	CLIP-seq
MIRT1505663	hsa-miR-3672	CLIP-seq
MIRT1505664	hsa-miR-369-3p	CLIP-seq
MIRT1505665	hsa-miR-372	CLIP-seq
MIRT1505666	hsa-miR-373	CLIP-seq
MIRT1505667	hsa-miR-374c	CLIP-seq
MIRT1505668	hsa-miR-382	CLIP-seq
MIRT1505669	hsa-miR-3974	CLIP-seq
MIRT1505670	hsa-miR-4277	CLIP-seq
MIRT1505671	hsa-miR-4433	CLIP-seq
MIRT1505672	hsa-miR-4648	CLIP-seq
MIRT1505673	hsa-miR-4652-3p	CLIP-seq
MIRT1505674	hsa-miR-4653-3p	CLIP-seq
MIRT1505675	hsa-miR-4654	CLIP-seq
MIRT1505676	hsa-miR-4672	CLIP-seq
MIRT1505677	hsa-miR-4684-3p	CLIP-seq
MIRT1505678	hsa-miR-4684-5p	CLIP-seq
MIRT1505679	hsa-miR-4685-5p	CLIP-seq
MIRT1505680	hsa-miR-4720-3p	CLIP-seq
MIRT1505681	hsa-miR-4757-3p	CLIP-seq
MIRT1505682	hsa-miR-4769-5p	CLIP-seq
MIRT1505683	hsa-miR-4775	CLIP-seq
MIRT1505684	hsa-miR-4778-3p	CLIP-seq
MIRT1505685	hsa-miR-4804-3p	CLIP-seq
MIRT1505686	hsa-miR-499-3p	CLIP-seq
MIRT1505687	hsa-miR-499a-3p	CLIP-seq
MIRT1505688	hsa-miR-518a-5p	CLIP-seq
MIRT1505689	hsa-miR-519a	CLIP-seq
MIRT1505690	hsa-miR-519b-3p	CLIP-seq
MIRT1505691	hsa-miR-519c-3p	CLIP-seq
MIRT1505692	hsa-miR-520a-3p	CLIP-seq
MIRT1505693	hsa-miR-520b	CLIP-seq
MIRT1505694	hsa-miR-520c-3p	CLIP-seq
MIRT1505695	hsa-miR-520d-3p	CLIP-seq
MIRT1505696	hsa-miR-520e	CLIP-seq
MIRT1505697	hsa-miR-527	CLIP-seq
MIRT1505698	hsa-miR-548l	CLIP-seq
MIRT1505699	hsa-miR-618	CLIP-seq
MIRT1505700	hsa-miR-655	CLIP-seq
MIRT2152245	hsa-miR-1182	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT1505655	hsa-miR-129-5p	CLIP-seq
MIRT2152247	hsa-miR-193a-5p	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152250	hsa-miR-3145-3p	CLIP-seq
MIRT2152251	hsa-miR-3194-3p	CLIP-seq
MIRT1505663	hsa-miR-3672	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152253	hsa-miR-431	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2152258	hsa-miR-591	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2372671	hsa-miR-1343	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2372672	hsa-miR-3074-5p	CLIP-seq
MIRT2372673	hsa-miR-338-3p	CLIP-seq
MIRT2372674	hsa-miR-378g	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2372675	hsa-miR-4326	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2372676	hsa-miR-4437	CLIP-seq
MIRT2372677	hsa-miR-4530	CLIP-seq
MIRT2372678	hsa-miR-4674	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2372679	hsa-miR-4777-3p	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2372680	hsa-miR-5096	CLIP-seq
MIRT2372681	hsa-miR-574-5p	CLIP-seq
MIRT2372682	hsa-miR-766	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2397261	hsa-miR-122	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2372681	hsa-miR-574-5p	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	20195357
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	29507755
GO:0005654	Component	Nucleoplasm	IDA	24100041
GO:0005654	Component	Nucleoplasm	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	IMP	29507755
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA	24100041
GO:0016607	Component	Nuclear speck	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IDA	29507755
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IPI	29507755
GO:0046872	Function	Metal ion binding	IEA
GO:2000036	Process	Regulation of stem cell population maintenance	ISS

MIM	HGNC	e!Ensembl
616453	20368	ENSG00000123200

Q5T200

Protein name

Zinc finger CCCH domain-containing protein 13

Protein function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m

PDB

7VF2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	39 → 63	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

Sequence

MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV
HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR
HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL
EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV
SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR
GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ
RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT
RGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSR
EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR
TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS
SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR
EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE
KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER
DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR
RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKE
SSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKA
KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE
AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE
AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS
ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS
HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS
RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ
REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE
SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE
GDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVDW
SGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKDAD
NLFEHELGALNMAALLRKEERASLLSNLGPCCKALCFRRDSAIRKQLVKNEKGTIKQAYT
SAPMVDNELLRLSLRLFKRKTTCHAPGHEKTEDNKLSQSSIQQELCVS

Sequence length

1668

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	36133437	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	32631107, 34312475, 35833147, 36222159, 37301543, 37469973	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Stimulate	32733931	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Inhibit	35278064, 35582419	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	38164857	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Associate	31823961	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	37194014	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Associate	34230220, 34347888	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Associate	35174637	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Breast Neoplasms	Associate	31532791	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	32631107	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35278064, 36091006	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	35582419	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Associate	37217897	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	33225598, 36545327	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Associate	36133437	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	36567510	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	34531875, 36133437	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thalassemia	Associate	34650160	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Inhibit	36058934	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	36091006	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZC3H13 (zinc finger CCCH-type containing 13)