Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23076
Gene name Gene Name - the full gene name approved by the HGNC.
Ribosomal RNA processing 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RRP1B
Synonyms (NCBI Gene) Gene synonyms aliases
KIAA0179, NNP1L, Nnp1, PPP1R136, RRP1
Chromosome Chromosome number
21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
21q22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005231 hsa-let-7b-5p pSILAC 18668040
MIRT025330 hsa-miR-34a-5p Proteomics 21566225
MIRT027588 hsa-miR-98-5p Microarray 19088304
MIRT005231 hsa-let-7b-5p Proteomics 18668040
MIRT047655 hsa-miR-10a-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
E2F1 Unknown 20040599
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001652 Component Granular component IDA 20926688
GO:0003713 Function Transcription coactivator activity IMP 20040599
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 19389623, 19710015, 20040599, 20926688, 23604122, 24366813, 26311876, 27173435, 28330616, 29568061
GO:0005634 Component Nucleus HDA 16780588
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610654 23818 ENSG00000160208
Protein
UniProt ID Q14684
Protein name Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)
Protein function Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/t
PDB 7T0Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05997 Nop52 10 218 Nucleolar protein,Nop52 Family
Sequence
MAPAMQPAEIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFY
CMWVQDEPLLQEELANTIAQLVHAVNNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYML
IRLVLRQSFEVLKRNGWEESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVG
GKELLADQNLKFIDPFCKIAAKTKDHTLVQTIARGVFE
AIVDQSPFVPEETMEEQKTKVG
DGDLSAEEIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDY
KAVADRLLEMTSRKNTPHFNRKRLSKLIKKFQDLSEGSSISQLSFAEDISADEDDQILSQ
GKHKKKGNKLLEKTNLEKEKGSRVFCVEEEDSESSLQKRRRKKKKKHHLQPENPGPGGAA
PSLEQNRGREPEASGLKALKARVAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSP
RAHREMLESAVLPPEDMSQSGPSGSHPQGPRGSPTGGAQLLKRKRKLGVVPVNGSGLSTP
AWPPLQQEGPPTGPAEGANSHTTLPQRRRLQKKKAGPGSLELCGLPSQKTASLKKRKKMR
VMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQKLRAESDFVKFDTPFLPKPLFFRRAK
SSTATHPPGPAVQLNKTPSSSKKVTFGLNRNMTAEFKKTDKSILVSPTGPSRVAFDPEQK
PLHGVLKTPTSSPASSPLVAKKPLTTTPRRRPRAMDFF
Sequence length 758
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 19825179, 25277657
Calcinosis Cutis Associate 19825179
Neoplasm Metastasis Associate 19825179, 25277657
Neoplasms Inhibit 25277657
Neoplasms Associate 25277657
Obesity Associate 25277657