ERP44 (endoplasmic reticulum protein 44)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23071 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Endoplasmic reticulum protein 44 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ERP44 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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PDIA10, TXNDC4 |
Chromosome
Chromosome number
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9 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q31.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-rete |
miRNA
miRNA information provided by mirtarbase database.
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Transcription factors | ||||||||||
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q9BS26 | |||||||||||||||
Protein name | Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4) | |||||||||||||||
Protein function | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652 | |||||||||||||||
PDB | 2R2J , 5GU6 , 5GU7 , 5HQP , 5XWM | |||||||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 406 | |||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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