SETD1B (SET domain containing 1B, histone lysine methyltransferase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23067 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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SET domain containing 1B, histone lysine methyltransferase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SETD1B |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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IDDSELD, KMT2G, Set1B |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q24.31 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008] |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q9UPS6 | ||||||||||||||||||||
| Protein name | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | ||||||||||||||||||||
| Protein function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodelin | ||||||||||||||||||||
| PDB | 3UVO , 4ES0 , 8ILZ , 8WXV | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 1966 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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