SETD1B (SET domain containing 1B, histone lysine methyltransferase)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
23067 |
Gene name
Gene Name - the full gene name approved by the HGNC.
|
SET domain containing 1B, histone lysine methyltransferase |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
SETD1B |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
IDDSELD, KMT2G, Set1B |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
|
IDDSELD |
Chromosome
Chromosome number
|
12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
12q24.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008] |
SNPs
SNP information provided by dbSNP.
|
|||||||||||||
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
Protein | |||||||||||||||||||||
UniProt ID | Q9UPS6 | ||||||||||||||||||||
Protein name | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | ||||||||||||||||||||
Protein function | Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:17355966, PubMed:25561738). Part of chromatin remodelin | ||||||||||||||||||||
PDB | 3UVO , 4ES0 , 8ILZ , 8WXV | ||||||||||||||||||||
Family and domains |
Pfam
|
||||||||||||||||||||
Sequence |
|
||||||||||||||||||||
Sequence length | 1966 | ||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||||||
|
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|