Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23063
Gene name Gene Name - the full gene name approved by the HGNC.	WAPL cohesin release factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	WAPL
Synonyms (NCBI Gene) Gene synonyms aliases	FOE, KIAA0261, WAPAL
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q23.2

Show/Hide all(14)

miRTarBase ID	miRNA	Experiments	Reference
MIRT533217	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT533216	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT533215	hsa-miR-8485	PAR-CLIP	22012620
MIRT533214	hsa-miR-603	PAR-CLIP	22012620
MIRT533213	hsa-miR-323b-3p	PAR-CLIP	22012620
MIRT533212	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT533211	hsa-miR-3941	PAR-CLIP	22012620
MIRT533210	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT533209	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT533208	hsa-miR-4446-5p	PAR-CLIP	22012620
MIRT533207	hsa-miR-3675-3p	PAR-CLIP	22012620
MIRT533206	hsa-miR-8063	PAR-CLIP	22012620
MIRT533205	hsa-miR-1306-5p	PAR-CLIP	22012620
MIRT533204	hsa-miR-20a-3p	PAR-CLIP	22012620

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0000775	Component	Chromosome, centromeric region	TAS
GO:0000785	Component	Chromatin	IDA	17113138, 19696148
GO:0000795	Component	Synaptonemal complex	IEA
GO:0005515	Function	Protein binding	IPI	17112726, 17113138, 19696148, 19907496, 20360068, 21111234, 25173175, 26496610, 29867216
GO:0005634	Component	Nucleus	IDA	17113138, 19696148
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	TAS
GO:0005737	Component	Cytoplasm	IDA	17113138, 19696148
GO:0005794	Component	Golgi apparatus	IDA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0008156	Process	Negative regulation of DNA replication	IMP	19907496
GO:0009636	Process	Response to toxic substance	IEA
GO:0016032	Process	Viral process	IEA
GO:0035562	Process	Negative regulation of chromatin binding	IMP	17113138, 19696148
GO:0045171	Component	Intercellular bridge	IDA
GO:0045875	Process	Negative regulation of sister chromatid cohesion	IMP	17113138, 19696148, 21111234
GO:0048146	Process	Positive regulation of fibroblast proliferation	IEA
GO:0051301	Process	Cell division	IEA
GO:0051983	Process	Regulation of chromosome segregation	IEA
GO:0060623	Process	Regulation of chromosome condensation	IBA	21873635
GO:0071168	Process	Protein localization to chromatin	IMP	21111234
GO:0071922	Process	Regulation of cohesin loading	IBA	21873635
GO:0071922	Process	Regulation of cohesin loading	IMP	17113138
GO:0072686	Component	Mitotic spindle	IDA

MIM	HGNC	e!Ensembl
610754	23293	ENSG00000062650

Protein

UniProt ID

Q7Z5K2

Protein name

Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor)

Protein function

Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin (PubMed:26299517). Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages o

PDB

4K6J , 5HDT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07814	WAPL	638 → 998	Wings apart-like protein regulation of heterochromatin	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:15383329}.

Sequence

MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPK
KPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSEAAQLEEVTSVLEANSKIS
HVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSCNKLITSDKVENFHEEHEKNS
HHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWD
NDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCRAN
KTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTV
LHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKS
KKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKKRT
KTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTR
KIFSGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPA
PPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEY
LLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCT
AALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVH
NKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDED
EEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNR
AEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGT
ALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEG
DDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQ
WVSTEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINV
TTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC

Sequence length

1190

Interactions

View interactions

	KEGG		Reactome
	Cell cycle		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Migraine	Migraine Disorders	rs794727411	23793025

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Neurodevelopmental Disorders	complex neurodevelopmental disorder	GenCC
Hypertension	Hypertension	GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Burkitt Lymphoma	Associate	39241017
Uterine Cervical Neoplasms	Associate	26722608

WAPL (WAPL cohesin release factor)