Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23054
Gene name	Nuclear receptor coactivator 6
Gene symbol	NCOA6
Synonyms (NCBI Gene)	AIB3ASC2NRCPRIPRAP250TRBP
Chromosome	20
Chromosome location	20q11.22
Summary	The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of se

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003235	hsa-miR-224-5p	Luciferase reporter assay	20065103
MIRT023418	hsa-miR-30b-5p	Sequencing	20371350
MIRT028192	hsa-miR-33a-5p	Sequencing	20371350
MIRT031325	hsa-miR-18a-5p	Sequencing	20371350
MIRT044079	hsa-miR-361-5p	CLASH	23622248
MIRT036743	hsa-miR-760	CLASH	23622248
MIRT440129	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439122	hsa-miR-10b-5p	3'LIFE	25074381
MIRT440129	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439122	hsa-miR-10b-5p	3'LIFE	25074381
MIRT1177332	hsa-miR-10a	CLIP-seq
MIRT1177333	hsa-miR-10b	CLIP-seq
MIRT1177334	hsa-miR-1178	CLIP-seq
MIRT1177335	hsa-miR-224	CLIP-seq
MIRT1177336	hsa-miR-302f	CLIP-seq
MIRT1177337	hsa-miR-3620	CLIP-seq
MIRT1177338	hsa-miR-371b-5p	CLIP-seq
MIRT1177339	hsa-miR-3929	CLIP-seq
MIRT1177340	hsa-miR-4266	CLIP-seq
MIRT1177341	hsa-miR-4282	CLIP-seq
MIRT1177342	hsa-miR-4419b	CLIP-seq
MIRT1177343	hsa-miR-4477a	CLIP-seq
MIRT1177344	hsa-miR-4478	CLIP-seq
MIRT1177345	hsa-miR-4637	CLIP-seq
MIRT1177346	hsa-miR-4683	CLIP-seq
MIRT1177347	hsa-miR-4698	CLIP-seq
MIRT1177348	hsa-miR-4803	CLIP-seq
MIRT1177349	hsa-miR-486-5p	CLIP-seq
MIRT1177350	hsa-miR-499-3p	CLIP-seq
MIRT1177351	hsa-miR-499a-3p	CLIP-seq
MIRT1177352	hsa-miR-548c-3p	CLIP-seq
MIRT1177353	hsa-miR-645	CLIP-seq
MIRT2051325	hsa-miR-1283	CLIP-seq
MIRT2051326	hsa-miR-3065-5p	CLIP-seq
MIRT2051327	hsa-miR-374a	CLIP-seq
MIRT2051328	hsa-miR-374b	CLIP-seq
MIRT2051329	hsa-miR-377	CLIP-seq
MIRT2051330	hsa-miR-4496	CLIP-seq
MIRT2280417	hsa-miR-101	CLIP-seq
MIRT1177332	hsa-miR-10a	CLIP-seq
MIRT1177333	hsa-miR-10b	CLIP-seq
MIRT1177334	hsa-miR-1178	CLIP-seq
MIRT2280418	hsa-miR-1253	CLIP-seq
MIRT2051325	hsa-miR-1283	CLIP-seq
MIRT2280419	hsa-miR-132	CLIP-seq
MIRT2280420	hsa-miR-1909	CLIP-seq
MIRT2280421	hsa-miR-1910	CLIP-seq
MIRT2280422	hsa-miR-212	CLIP-seq
MIRT1177335	hsa-miR-224	CLIP-seq
MIRT2280423	hsa-miR-2355-5p	CLIP-seq
MIRT2280424	hsa-miR-23a	CLIP-seq
MIRT2280425	hsa-miR-23b	CLIP-seq
MIRT2280426	hsa-miR-23c	CLIP-seq
MIRT2280427	hsa-miR-25	CLIP-seq
MIRT1177336	hsa-miR-302f	CLIP-seq
MIRT2051326	hsa-miR-3065-5p	CLIP-seq
MIRT2280428	hsa-miR-3140-3p	CLIP-seq
MIRT2280429	hsa-miR-3160-5p	CLIP-seq
MIRT2280430	hsa-miR-3163	CLIP-seq
MIRT2280431	hsa-miR-32	CLIP-seq
MIRT2280432	hsa-miR-3591-3p	CLIP-seq
MIRT1177337	hsa-miR-3620	CLIP-seq
MIRT2280433	hsa-miR-363	CLIP-seq
MIRT2280434	hsa-miR-367	CLIP-seq
MIRT2280435	hsa-miR-3679-3p	CLIP-seq
MIRT2280436	hsa-miR-3691-3p	CLIP-seq
MIRT2280437	hsa-miR-369-3p	CLIP-seq
MIRT2280438	hsa-miR-370	CLIP-seq
MIRT1177338	hsa-miR-371b-5p	CLIP-seq
MIRT2051327	hsa-miR-374a	CLIP-seq
MIRT2051328	hsa-miR-374b	CLIP-seq
MIRT2051329	hsa-miR-377	CLIP-seq
MIRT2280439	hsa-miR-410	CLIP-seq
MIRT2280440	hsa-miR-421	CLIP-seq
MIRT1177340	hsa-miR-4266	CLIP-seq
MIRT1177341	hsa-miR-4282	CLIP-seq
MIRT2280441	hsa-miR-4286	CLIP-seq
MIRT2280442	hsa-miR-4301	CLIP-seq
MIRT2280443	hsa-miR-4313	CLIP-seq
MIRT2280444	hsa-miR-4325	CLIP-seq
MIRT2280445	hsa-miR-4420	CLIP-seq
MIRT2280446	hsa-miR-4437	CLIP-seq
MIRT1177343	hsa-miR-4477a	CLIP-seq
MIRT2051330	hsa-miR-4496	CLIP-seq
MIRT1177345	hsa-miR-4637	CLIP-seq
MIRT1177346	hsa-miR-4683	CLIP-seq
MIRT1177347	hsa-miR-4698	CLIP-seq
MIRT2280447	hsa-miR-4699-3p	CLIP-seq
MIRT2280448	hsa-miR-4699-5p	CLIP-seq
MIRT2280449	hsa-miR-4709-5p	CLIP-seq
MIRT2280450	hsa-miR-4753-3p	CLIP-seq
MIRT2280451	hsa-miR-4760-5p	CLIP-seq
MIRT1177349	hsa-miR-486-5p	CLIP-seq
MIRT2280452	hsa-miR-494	CLIP-seq
MIRT1177350	hsa-miR-499-3p	CLIP-seq
MIRT1177351	hsa-miR-499a-3p	CLIP-seq
MIRT2280453	hsa-miR-500a	CLIP-seq
MIRT1177352	hsa-miR-548c-3p	CLIP-seq
MIRT2280454	hsa-miR-548n	CLIP-seq
MIRT2280455	hsa-miR-548t	CLIP-seq
MIRT2280456	hsa-miR-92a	CLIP-seq
MIRT2280457	hsa-miR-92b	CLIP-seq
MIRT2280458	hsa-miR-944	CLIP-seq
MIRT1177350	hsa-miR-499-3p	CLIP-seq
MIRT1177351	hsa-miR-499a-3p	CLIP-seq
MIRT2280453	hsa-miR-500a	CLIP-seq
MIRT1177332	hsa-miR-10a	CLIP-seq
MIRT1177333	hsa-miR-10b	CLIP-seq
MIRT1177334	hsa-miR-1178	CLIP-seq
MIRT2578885	hsa-miR-1256	CLIP-seq
MIRT2280420	hsa-miR-1909	CLIP-seq
MIRT2578886	hsa-miR-3143	CLIP-seq
MIRT1177337	hsa-miR-3620	CLIP-seq
MIRT2051327	hsa-miR-374a	CLIP-seq
MIRT2051328	hsa-miR-374b	CLIP-seq
MIRT2578887	hsa-miR-3923	CLIP-seq
MIRT1177339	hsa-miR-3929	CLIP-seq
MIRT1177340	hsa-miR-4266	CLIP-seq
MIRT1177341	hsa-miR-4282	CLIP-seq
MIRT1177342	hsa-miR-4419b	CLIP-seq
MIRT2578888	hsa-miR-4448	CLIP-seq
MIRT1177343	hsa-miR-4477a	CLIP-seq
MIRT1177344	hsa-miR-4478	CLIP-seq
MIRT2051330	hsa-miR-4496	CLIP-seq
MIRT1177346	hsa-miR-4683	CLIP-seq
MIRT2578889	hsa-miR-4729	CLIP-seq
MIRT1177349	hsa-miR-486-5p	CLIP-seq
MIRT2280452	hsa-miR-494	CLIP-seq
MIRT1177350	hsa-miR-499-3p	CLIP-seq
MIRT1177351	hsa-miR-499a-3p	CLIP-seq
MIRT2578890	hsa-miR-543	CLIP-seq
MIRT1177352	hsa-miR-548c-3p	CLIP-seq
MIRT2578891	hsa-miR-570	CLIP-seq
MIRT2578892	hsa-miR-628-3p	CLIP-seq
MIRT1177353	hsa-miR-645	CLIP-seq
MIRT2578893	hsa-miR-802	CLIP-seq
MIRT1177332	hsa-miR-10a	CLIP-seq
MIRT1177333	hsa-miR-10b	CLIP-seq
MIRT1177334	hsa-miR-1178	CLIP-seq
MIRT2578885	hsa-miR-1256	CLIP-seq
MIRT2280420	hsa-miR-1909	CLIP-seq
MIRT2578886	hsa-miR-3143	CLIP-seq
MIRT1177337	hsa-miR-3620	CLIP-seq
MIRT2051327	hsa-miR-374a	CLIP-seq
MIRT2051328	hsa-miR-374b	CLIP-seq
MIRT2578887	hsa-miR-3923	CLIP-seq
MIRT1177339	hsa-miR-3929	CLIP-seq
MIRT1177340	hsa-miR-4266	CLIP-seq
MIRT1177342	hsa-miR-4419b	CLIP-seq
MIRT2578888	hsa-miR-4448	CLIP-seq
MIRT1177344	hsa-miR-4478	CLIP-seq
MIRT2051330	hsa-miR-4496	CLIP-seq
MIRT1177346	hsa-miR-4683	CLIP-seq
MIRT2578889	hsa-miR-4729	CLIP-seq
MIRT1177349	hsa-miR-486-5p	CLIP-seq
MIRT2280452	hsa-miR-494	CLIP-seq
MIRT1177350	hsa-miR-499-3p	CLIP-seq
MIRT1177351	hsa-miR-499a-3p	CLIP-seq
MIRT2578890	hsa-miR-543	CLIP-seq
MIRT1177352	hsa-miR-548c-3p	CLIP-seq
MIRT2578891	hsa-miR-570	CLIP-seq
MIRT2578892	hsa-miR-628-3p	CLIP-seq
MIRT1177353	hsa-miR-645	CLIP-seq
MIRT2578893	hsa-miR-802	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	ISS
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	10567404, 11443112
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IPI	11443112
GO:0005515	Function	Protein binding	IPI	10866662, 11443112, 12482968, 14645241, 17021013, 17178841, 17500065, 17925232, 19047629, 19433796, 23870121, 24981860, 27705803, 28514442, 33640491, 33961781
GO:0005634	Component	Nucleus	IDA	11443112, 17500065
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	10567404
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005667	Component	Transcription regulator complex	TAS	11443112
GO:0005829	Component	Cytosol	IDA
GO:0006352	Process	DNA-templated transcription initiation	IDA	10567404
GO:0006974	Process	DNA damage response	IDA	17500065
GO:0007420	Process	Brain development	ISS
GO:0007507	Process	Heart development	ISS
GO:0009725	Process	Response to hormone	TAS	11443112
GO:0019899	Function	Enzyme binding	IPI	12039952
GO:0030099	Process	Myeloid cell differentiation	IDA	11302752
GO:0030331	Function	Nuclear estrogen receptor binding	TAS	11443112
GO:0035097	Component	Histone methyltransferase complex	IBA
GO:0035097	Component	Histone methyltransferase complex	IDA	17500065
GO:0044666	Component	MLL3/4 complex	IPI	23508102
GO:0045893	Process	Positive regulation of DNA-templated transcription	TAS	12519782
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	11443112
GO:0046965	Function	Nuclear retinoid X receptor binding	TAS	11443112
GO:0046966	Function	Nuclear thyroid hormone receptor binding	IDA	11443112

MIM	HGNC	e!Ensembl
605299	15936	ENSG00000198646

Q14686

Protein name

Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein,

Protein function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of diff

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13820	Nucleic_acid_bd	47 → 190	Putative nucleic acid-binding region	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

Sequence

MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKD
FKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLR
DLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPA
TVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPH
HPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQ
GIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQAR
PSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQ
PHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMV
QQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATT
PGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSG
VPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQ
MMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQ
MQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQV
MGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNS
ASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHF
GVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSG
PKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQ
PQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMV
SLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEA
PSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNV
AAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPL
PPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGA
TKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTP
LANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIE
LKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGA
PNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLV
HPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHL
QSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPA
APLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATP
VQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNS
PGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTT
APGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTT
LVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTAL
QASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSR
PASASSSTKDITSAVQSKRRKSK

Sequence length

2063

Interactions

View interactions

	Reactome
			RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Benign	rs146290271	RCV005907150

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	36086920
Cataract	Associate	33339270
Diabetes Mellitus	Associate	35477946
Growth Disorders	Associate	32790097
Melanoma	Associate	24642353, 25837821
Neoplasms	Associate	36086920
Pancreatic Neoplasms	Associate	24642353
Rectal Neoplasms	Associate	26934318
Severe Acute Respiratory Syndrome	Associate	32790097
Skin Diseases	Associate	35477946
Thyroid Cancer Papillary	Associate	36722273

NCOA6 (nuclear receptor coactivator 6)