Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23051
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc fingers and homeoboxes 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZHX3
Synonyms (NCBI Gene) Gene synonyms aliases
TIX1
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleu
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022152 hsa-miR-124-3p Microarray 18668037
MIRT037094 hsa-miR-877-3p CLASH 23622248
MIRT723734 hsa-miR-483-3p HITS-CLIP 19536157
MIRT723735 hsa-miR-425-5p HITS-CLIP 19536157
MIRT723734 hsa-miR-483-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609598 15935 ENSG00000174306
Protein
UniProt ID Q9H4I2
Protein name Zinc fingers and homeoboxes protein 3 (Triple homeobox protein 1) (Zinc finger and homeodomain protein 3)
Protein function Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:
PDB 2DA5 , 2DN0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18387 zf_C2H2_ZHX 105 157 Zinc-fingers and homeoboxes C2H2 finger domain Domain
PF00046 Homeodomain 498 551 Homeodomain Domain
PF00046 Homeodomain 614 668 Homeodomain Domain
PF11569 Homez 846 893 Homeodomain leucine-zipper encoding, Homez Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. High expression in kidney. Expressed during osteogenic differentiation. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}.
Sequence
MASKRKSTTPCMIPVKTVVLQDASMEAQPAETLPEGPQQDLPPEASAASSEAAQNPSSTD
GSTLANGHRSTLDGYLYSCKYCDFRSHDMTQFVGHMNSEHTDFNKDPTFVCSGCSFLAKT
PEGLSLHNATCHSGEASFVWNVAKPDNHVVVEQSIPE
STSTPDLAGEPSAEGADGQAEII
ITKTPIMKIMKGKAEAKKIHTLKENVPSQPVGEALPKLSTGEMEVREGDHSFINGAVPVS
QASASSAKNPHAANGPLIGTVPVLPAGIAQFLSLQQQPPVHAQHHVHQPLPTAKALPKVM
IPLSSIPTYNAAMDSNSFLKNSFHKFPYPTKAELCYLTVVTKYPEEQLKIWFTAQRLKQG
ISWSPEEIEDARKKMFNTVIQSVPQPTITVLNTPLVASAGNVQHLIQAALPGHVVGQPEG
TGGGLLVTQPLMANGLQATSSPLPLTVTSVPKQPGVAPINTVCSNTTSAVKVVNAAQSLL
TACPSITSQAFLDASIYKNKKSHEQLSALKGSFCRNQFPGQSEVEHLTKVTGLSTREVRK
WFSDRRYHCRN
LKGSRAMIPGDHSSIIIDSVPEVSFSPSSKVPEVTCIPTTATLATHPSA
KRQSWHQTPDFTPTKYKERAPEQLRALESSFAQNPLPLDEELDRLRSETKMTRREIDSWF
SERRKKVN
AEETKKAEENASQEEEEAAEDEGGEEDLASELRVSGENGSLEMPSSHILAER
KVSPIKINLKNLRVTEANGRNEIPGLGACDPEDDESNKLAEQLPGKVSCKKTAQQRHLLR
QLFVQTQWPSNQDYDSIMAQTGLPRPEVVRWFGDSRYALKNGQLKWYEDYKRGNFPPGLL
VIAPGNRELLQDYYMTHKMLYEEDLQNLCDKTQMSSQQVKQWFAEKMGEETRAVADTGSE
DQGPGTGELTAVHKGMGDTYSEVSENSESWEPRVPEASSEPFDTSSPQAGRQLETD
Sequence length 956
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
29632382
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 27622933 ClinVar
Multiple Sclerosis Multiple Sclerosis GWAS
Diabetes Diabetes GWAS
Myocardial Infarction Myocardial Infarction GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Inhibit 28152006