SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23049 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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SMG1 nonsense mediated mRNA decay associated PI3K related kinase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SMG1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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61E3.4, ATX, LIP |
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Chromosome
Chromosome number
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16 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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16p12.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alte |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||||||||||||
| UniProt ID | Q96Q15 | |||||||||||||||||||||||||
| Protein name | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | |||||||||||||||||||||||||
| Protein function | Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature st | |||||||||||||||||||||||||
| PDB | 6L53 , 6L54 , 6SYT , 6Z3R , 7PW4 , 7PW5 , 7PW6 , 7PW7 , 7PW8 , 7PW9 | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed, with highest level in heart and skeletal muscle. Expressed in placenta, brain, lung and spleen, but not in liver. {ECO:0000269|PubMed:15175154, ECO:0000269|PubMed:8524286}. | |||||||||||||||||||||||||
| Sequence |
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| Sequence length | 3661 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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