KIF21B (kinesin family member 21B)

Gene

• Entrez ID: 23046
• Gene name: Kinesin family member 21B
• Gene symbol: KIF21B
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029731	hsa-miR-26b-5p	Microarray	19088304
MIRT489195	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT489194	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT489193	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT489192	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT489191	hsa-miR-6814-5p	PAR-CLIP	23592263
MIRT489190	hsa-miR-4264	PAR-CLIP	23592263
MIRT489189	hsa-miR-3670	PAR-CLIP	23592263
MIRT489187	hsa-miR-4633-3p	PAR-CLIP	23592263
MIRT489188	hsa-miR-6500-5p	PAR-CLIP	23592263
MIRT489186	hsa-miR-6874-5p	PAR-CLIP	23592263
MIRT489185	hsa-miR-484	PAR-CLIP	23592263
MIRT440370	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440370	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT489195	hsa-miR-6854-5p	PAR-CLIP	23592263
MIRT489194	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT489193	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT489192	hsa-miR-1910-5p	PAR-CLIP	23592263
MIRT489191	hsa-miR-6814-5p	PAR-CLIP	23592263
MIRT489190	hsa-miR-4264	PAR-CLIP	23592263
MIRT489189	hsa-miR-3670	PAR-CLIP	23592263
MIRT489187	hsa-miR-4633-3p	PAR-CLIP	23592263
MIRT489188	hsa-miR-6500-5p	PAR-CLIP	23592263
MIRT489186	hsa-miR-6874-5p	PAR-CLIP	23592263
MIRT489185	hsa-miR-484	PAR-CLIP	23592263
MIRT1094119	hsa-miR-1205	CLIP-seq
MIRT1094120	hsa-miR-1224-5p	CLIP-seq
MIRT1094121	hsa-miR-1251	CLIP-seq
MIRT1094122	hsa-miR-1272	CLIP-seq
MIRT1094123	hsa-miR-1275	CLIP-seq
MIRT1094124	hsa-miR-1285	CLIP-seq
MIRT1094125	hsa-miR-1286	CLIP-seq
MIRT1094126	hsa-miR-1291	CLIP-seq
MIRT1094127	hsa-miR-129-5p	CLIP-seq
MIRT1094128	hsa-miR-1470	CLIP-seq
MIRT1094129	hsa-miR-15a	CLIP-seq
MIRT1094130	hsa-miR-15b	CLIP-seq
MIRT1094131	hsa-miR-16	CLIP-seq
MIRT1094132	hsa-miR-185	CLIP-seq
MIRT1094133	hsa-miR-186	CLIP-seq
MIRT1094134	hsa-miR-1908	CLIP-seq
MIRT1094135	hsa-miR-1909	CLIP-seq
MIRT1094136	hsa-miR-1913	CLIP-seq
MIRT1094137	hsa-miR-1914	CLIP-seq
MIRT1094138	hsa-miR-195	CLIP-seq
MIRT1094139	hsa-miR-1976	CLIP-seq
MIRT1094140	hsa-miR-214	CLIP-seq
MIRT1094141	hsa-miR-2278	CLIP-seq
MIRT1094142	hsa-miR-24	CLIP-seq
MIRT1094143	hsa-miR-2861	CLIP-seq
MIRT1094144	hsa-miR-3147	CLIP-seq
MIRT1094145	hsa-miR-3151	CLIP-seq
MIRT1094146	hsa-miR-3155	CLIP-seq
MIRT1094147	hsa-miR-3155b	CLIP-seq
MIRT1094148	hsa-miR-3174	CLIP-seq
MIRT1094149	hsa-miR-3175	CLIP-seq
MIRT1094150	hsa-miR-3180	CLIP-seq
MIRT1094151	hsa-miR-3180-3p	CLIP-seq
MIRT1094152	hsa-miR-3187-5p	CLIP-seq
MIRT1094153	hsa-miR-3194-3p	CLIP-seq
MIRT1094154	hsa-miR-3196	CLIP-seq
MIRT1094155	hsa-miR-3202	CLIP-seq
MIRT1094156	hsa-miR-324-3p	CLIP-seq
MIRT1094157	hsa-miR-3619-5p	CLIP-seq
MIRT1094158	hsa-miR-365	CLIP-seq
MIRT1094159	hsa-miR-3663-3p	CLIP-seq
MIRT1094160	hsa-miR-3682-3p	CLIP-seq
MIRT1094161	hsa-miR-3689a-5p	CLIP-seq
MIRT1094162	hsa-miR-3689b	CLIP-seq
MIRT1094163	hsa-miR-3689e	CLIP-seq
MIRT1094164	hsa-miR-3689f	CLIP-seq
MIRT1094165	hsa-miR-3918	CLIP-seq
MIRT1094166	hsa-miR-3925-3p	CLIP-seq
MIRT1094167	hsa-miR-3945	CLIP-seq
MIRT1094168	hsa-miR-424	CLIP-seq
MIRT1094169	hsa-miR-4253	CLIP-seq
MIRT1094170	hsa-miR-4256	CLIP-seq
MIRT1094171	hsa-miR-4259	CLIP-seq
MIRT1094172	hsa-miR-4260	CLIP-seq
MIRT1094173	hsa-miR-4268	CLIP-seq
MIRT1094174	hsa-miR-4269	CLIP-seq
MIRT1094175	hsa-miR-4271	CLIP-seq
MIRT1094176	hsa-miR-4283	CLIP-seq
MIRT1094177	hsa-miR-4287	CLIP-seq
MIRT1094178	hsa-miR-4291	CLIP-seq
MIRT1094179	hsa-miR-4306	CLIP-seq
MIRT1094180	hsa-miR-4313	CLIP-seq
MIRT1094181	hsa-miR-4425	CLIP-seq
MIRT1094182	hsa-miR-4428	CLIP-seq
MIRT1094183	hsa-miR-4436a	CLIP-seq
MIRT1094184	hsa-miR-4436b-3p	CLIP-seq
MIRT1094185	hsa-miR-4448	CLIP-seq
MIRT1094186	hsa-miR-4469	CLIP-seq
MIRT1094187	hsa-miR-4471	CLIP-seq
MIRT1094188	hsa-miR-4474-3p	CLIP-seq
MIRT1094189	hsa-miR-4476	CLIP-seq
MIRT1094190	hsa-miR-4481	CLIP-seq
MIRT1094191	hsa-miR-4487	CLIP-seq
MIRT1094192	hsa-miR-4488	CLIP-seq
MIRT1094193	hsa-miR-4489	CLIP-seq
MIRT1094194	hsa-miR-4514	CLIP-seq
MIRT1094195	hsa-miR-4532	CLIP-seq
MIRT1094196	hsa-miR-4534	CLIP-seq
MIRT1094197	hsa-miR-4640-5p	CLIP-seq
MIRT1094198	hsa-miR-4644	CLIP-seq
MIRT1094199	hsa-miR-4645-5p	CLIP-seq
MIRT1094200	hsa-miR-4651	CLIP-seq
MIRT1094201	hsa-miR-4665-5p	CLIP-seq
MIRT1094202	hsa-miR-4667-3p	CLIP-seq
MIRT1094203	hsa-miR-4673	CLIP-seq
MIRT1094204	hsa-miR-4685-3p	CLIP-seq
MIRT1094205	hsa-miR-4688	CLIP-seq
MIRT1094206	hsa-miR-4692	CLIP-seq
MIRT1094207	hsa-miR-4697-5p	CLIP-seq
MIRT1094208	hsa-miR-4700-3p	CLIP-seq
MIRT1094209	hsa-miR-4706	CLIP-seq
MIRT1094210	hsa-miR-4714-5p	CLIP-seq
MIRT1094211	hsa-miR-4717-5p	CLIP-seq
MIRT1094212	hsa-miR-4722-5p	CLIP-seq
MIRT1094213	hsa-miR-4723-5p	CLIP-seq
MIRT1094214	hsa-miR-4725-3p	CLIP-seq
MIRT1094215	hsa-miR-4726-5p	CLIP-seq
MIRT1094216	hsa-miR-4728-3p	CLIP-seq
MIRT1094217	hsa-miR-4730	CLIP-seq
MIRT1094218	hsa-miR-4731-5p	CLIP-seq
MIRT1094219	hsa-miR-4742-5p	CLIP-seq
MIRT1094220	hsa-miR-4745-5p	CLIP-seq
MIRT1094221	hsa-miR-4747-5p	CLIP-seq
MIRT1094222	hsa-miR-4749-5p	CLIP-seq
MIRT1094223	hsa-miR-4751	CLIP-seq
MIRT1094224	hsa-miR-4759	CLIP-seq
MIRT1094225	hsa-miR-4763-5p	CLIP-seq
MIRT1094226	hsa-miR-4768-3p	CLIP-seq
MIRT1094227	hsa-miR-497	CLIP-seq
MIRT1094228	hsa-miR-574-5p	CLIP-seq
MIRT1094229	hsa-miR-608	CLIP-seq
MIRT1094230	hsa-miR-609	CLIP-seq
MIRT1094231	hsa-miR-612	CLIP-seq
MIRT1094232	hsa-miR-637	CLIP-seq
MIRT1094233	hsa-miR-645	CLIP-seq
MIRT1094234	hsa-miR-663	CLIP-seq
MIRT1094235	hsa-miR-671-3p	CLIP-seq
MIRT1094236	hsa-miR-760	CLIP-seq
MIRT1094237	hsa-miR-761	CLIP-seq
MIRT1094238	hsa-miR-765	CLIP-seq
MIRT1094239	hsa-miR-921	CLIP-seq
MIRT1094240	hsa-miR-922	CLIP-seq
MIRT1094241	hsa-miR-938	CLIP-seq
MIRT1094242	hsa-miR-940	CLIP-seq
MIRT1550576	hsa-miR-342-5p	CLIP-seq
MIRT1094200	hsa-miR-4651	CLIP-seq
MIRT1550577	hsa-miR-4664-5p	CLIP-seq
MIRT1094229	hsa-miR-608	CLIP-seq
MIRT1094238	hsa-miR-765	CLIP-seq
MIRT2025227	hsa-miR-1202	CLIP-seq
MIRT1094119	hsa-miR-1205	CLIP-seq
MIRT2025228	hsa-miR-1321	CLIP-seq
MIRT2025229	hsa-miR-151-5p	CLIP-seq
MIRT2025230	hsa-miR-151b	CLIP-seq
MIRT1094135	hsa-miR-1909	CLIP-seq
MIRT1094136	hsa-miR-1913	CLIP-seq
MIRT1094139	hsa-miR-1976	CLIP-seq
MIRT2025231	hsa-miR-2355-5p	CLIP-seq
MIRT1094142	hsa-miR-24	CLIP-seq
MIRT2025232	hsa-miR-3117-5p	CLIP-seq
MIRT1094146	hsa-miR-3155	CLIP-seq
MIRT1094147	hsa-miR-3155b	CLIP-seq
MIRT1094148	hsa-miR-3174	CLIP-seq
MIRT2025233	hsa-miR-3189-5p	CLIP-seq
MIRT1094153	hsa-miR-3194-3p	CLIP-seq
MIRT1094156	hsa-miR-324-3p	CLIP-seq
MIRT2025234	hsa-miR-3616-3p	CLIP-seq
MIRT2025235	hsa-miR-3660	CLIP-seq
MIRT2025236	hsa-miR-370	CLIP-seq
MIRT2025237	hsa-miR-384	CLIP-seq
MIRT2025238	hsa-miR-3944-5p	CLIP-seq
MIRT2025239	hsa-miR-3972	CLIP-seq
MIRT1094173	hsa-miR-4268	CLIP-seq
MIRT1094184	hsa-miR-4436b-3p	CLIP-seq
MIRT2025240	hsa-miR-4447	CLIP-seq
MIRT1094185	hsa-miR-4448	CLIP-seq
MIRT2025241	hsa-miR-4472	CLIP-seq
MIRT1094190	hsa-miR-4481	CLIP-seq
MIRT2025242	hsa-miR-4492	CLIP-seq
MIRT2025243	hsa-miR-4494	CLIP-seq
MIRT2025244	hsa-miR-4498	CLIP-seq
MIRT2025245	hsa-miR-4526	CLIP-seq
MIRT1094195	hsa-miR-4532	CLIP-seq
MIRT1094197	hsa-miR-4640-5p	CLIP-seq
MIRT1094199	hsa-miR-4645-5p	CLIP-seq
MIRT1094200	hsa-miR-4651	CLIP-seq
MIRT2025246	hsa-miR-4660	CLIP-seq
MIRT1094203	hsa-miR-4673	CLIP-seq
MIRT2025247	hsa-miR-4709-3p	CLIP-seq
MIRT1094215	hsa-miR-4726-5p	CLIP-seq
MIRT1094218	hsa-miR-4731-5p	CLIP-seq
MIRT2025248	hsa-miR-4739	CLIP-seq
MIRT1094220	hsa-miR-4745-5p	CLIP-seq
MIRT1094221	hsa-miR-4747-5p	CLIP-seq
MIRT2025249	hsa-miR-4756-5p	CLIP-seq
MIRT2025250	hsa-miR-4758-5p	CLIP-seq
MIRT1094225	hsa-miR-4763-5p	CLIP-seq
MIRT2025251	hsa-miR-564	CLIP-seq
MIRT1094229	hsa-miR-608	CLIP-seq
MIRT2025252	hsa-miR-628-5p	CLIP-seq
MIRT2025253	hsa-miR-636	CLIP-seq
MIRT1094236	hsa-miR-760	CLIP-seq
MIRT2025254	hsa-miR-762	CLIP-seq
MIRT1094240	hsa-miR-922	CLIP-seq
MIRT2256499	hsa-miR-1207-3p	CLIP-seq
MIRT2256500	hsa-miR-1207-5p	CLIP-seq
MIRT2256501	hsa-miR-1252	CLIP-seq
MIRT2256502	hsa-miR-1262	CLIP-seq
MIRT2256503	hsa-miR-1266	CLIP-seq
MIRT2256504	hsa-miR-1297	CLIP-seq
MIRT2256505	hsa-miR-140-3p	CLIP-seq
MIRT1094134	hsa-miR-1908	CLIP-seq
MIRT1094136	hsa-miR-1913	CLIP-seq
MIRT2256506	hsa-miR-193a-5p	CLIP-seq
MIRT1094140	hsa-miR-214	CLIP-seq
MIRT2256507	hsa-miR-218	CLIP-seq
MIRT1094141	hsa-miR-2278	CLIP-seq
MIRT2025231	hsa-miR-2355-5p	CLIP-seq
MIRT2256508	hsa-miR-26a	CLIP-seq
MIRT2256509	hsa-miR-26b	CLIP-seq
MIRT2256510	hsa-miR-27a	CLIP-seq
MIRT2256511	hsa-miR-27b	CLIP-seq
MIRT1094143	hsa-miR-2861	CLIP-seq
MIRT2256512	hsa-miR-3140-5p	CLIP-seq
MIRT1094145	hsa-miR-3151	CLIP-seq
MIRT1094146	hsa-miR-3155	CLIP-seq
MIRT1094147	hsa-miR-3155b	CLIP-seq
MIRT1094150	hsa-miR-3180	CLIP-seq
MIRT1094151	hsa-miR-3180-3p	CLIP-seq
MIRT2025233	hsa-miR-3189-5p	CLIP-seq
MIRT1094154	hsa-miR-3196	CLIP-seq
MIRT1094155	hsa-miR-3202	CLIP-seq
MIRT1094156	hsa-miR-324-3p	CLIP-seq
MIRT2025234	hsa-miR-3616-3p	CLIP-seq
MIRT1094157	hsa-miR-3619-5p	CLIP-seq
MIRT1094158	hsa-miR-365	CLIP-seq
MIRT2256513	hsa-miR-3652	CLIP-seq
MIRT2256514	hsa-miR-3664-3p	CLIP-seq
MIRT2256515	hsa-miR-3921	CLIP-seq
MIRT2256516	hsa-miR-425	CLIP-seq
MIRT1094174	hsa-miR-4269	CLIP-seq
MIRT1094175	hsa-miR-4271	CLIP-seq
MIRT2256517	hsa-miR-4430	CLIP-seq
MIRT1094184	hsa-miR-4436b-3p	CLIP-seq
MIRT2256518	hsa-miR-4446-3p	CLIP-seq
MIRT2025240	hsa-miR-4447	CLIP-seq
MIRT2256519	hsa-miR-4465	CLIP-seq
MIRT2025241	hsa-miR-4472	CLIP-seq
MIRT2256520	hsa-miR-4475	CLIP-seq
MIRT2025242	hsa-miR-4492	CLIP-seq
MIRT2025243	hsa-miR-4494	CLIP-seq
MIRT2025244	hsa-miR-4498	CLIP-seq
MIRT2256521	hsa-miR-4505	CLIP-seq
MIRT2256522	hsa-miR-4518	CLIP-seq
MIRT2256523	hsa-miR-4530	CLIP-seq
MIRT1094195	hsa-miR-4532	CLIP-seq
MIRT1094200	hsa-miR-4651	CLIP-seq
MIRT2256524	hsa-miR-4653-5p	CLIP-seq
MIRT2256525	hsa-miR-4701-3p	CLIP-seq
MIRT2256526	hsa-miR-4707-5p	CLIP-seq
MIRT1094214	hsa-miR-4725-3p	CLIP-seq
MIRT1094218	hsa-miR-4731-5p	CLIP-seq
MIRT1094221	hsa-miR-4747-5p	CLIP-seq
MIRT2256527	hsa-miR-4763-3p	CLIP-seq
MIRT2256528	hsa-miR-4773	CLIP-seq
MIRT2256529	hsa-miR-486-3p	CLIP-seq
MIRT2256530	hsa-miR-491-5p	CLIP-seq
MIRT2256531	hsa-miR-502-5p	CLIP-seq
MIRT2256532	hsa-miR-513a-5p	CLIP-seq
MIRT2256533	hsa-miR-541	CLIP-seq
MIRT2256534	hsa-miR-549	CLIP-seq
MIRT2025251	hsa-miR-564	CLIP-seq
MIRT1094229	hsa-miR-608	CLIP-seq
MIRT2256535	hsa-miR-654-5p	CLIP-seq
MIRT1094234	hsa-miR-663	CLIP-seq
MIRT1094236	hsa-miR-760	CLIP-seq
MIRT1094237	hsa-miR-761	CLIP-seq
MIRT2025254	hsa-miR-762	CLIP-seq
MIRT2256536	hsa-miR-942	CLIP-seq
MIRT1094124	hsa-miR-1285	CLIP-seq
MIRT1094134	hsa-miR-1908	CLIP-seq
MIRT2389867	hsa-miR-198	CLIP-seq
MIRT1094150	hsa-miR-3180	CLIP-seq
MIRT1094151	hsa-miR-3180-3p	CLIP-seq
MIRT1094152	hsa-miR-3187-5p	CLIP-seq
MIRT1094154	hsa-miR-3196	CLIP-seq
MIRT1094199	hsa-miR-4645-5p	CLIP-seq
MIRT1094200	hsa-miR-4651	CLIP-seq
MIRT1094203	hsa-miR-4673	CLIP-seq
MIRT1094213	hsa-miR-4723-5p	CLIP-seq
MIRT1094218	hsa-miR-4731-5p	CLIP-seq
MIRT1094229	hsa-miR-608	CLIP-seq
MIRT1094231	hsa-miR-612	CLIP-seq
MIRT2389868	hsa-miR-615-5p	CLIP-seq
MIRT1094234	hsa-miR-663	CLIP-seq
MIRT2452593	hsa-miR-3136-3p	CLIP-seq
MIRT1094184	hsa-miR-4436b-3p	CLIP-seq
MIRT2025247	hsa-miR-4709-3p	CLIP-seq
MIRT1094216	hsa-miR-4728-3p	CLIP-seq
MIRT2557972	hsa-miR-1273g	CLIP-seq
MIRT2025231	hsa-miR-2355-5p	CLIP-seq
MIRT2557972	hsa-miR-1273g	CLIP-seq
MIRT1094123	hsa-miR-1275	CLIP-seq
MIRT2683444	hsa-miR-2355-3p	CLIP-seq
MIRT2025231	hsa-miR-2355-5p	CLIP-seq
MIRT1094172	hsa-miR-4260	CLIP-seq
MIRT2683445	hsa-miR-4646-3p	CLIP-seq
MIRT1094201	hsa-miR-4665-5p	CLIP-seq
MIRT1094230	hsa-miR-609	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IBA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042995	Component	Cell projection	IEA

Other IDs

• MIM: 608322
• HGNC: 29442
• e!Ensembl: ENSG00000116852

Protein

• UniProt ID: O75037
• Protein name: Kinesin-like protein KIF21B
• Protein function: Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	14 → 370	Kinesin motor domain	Domain
  PF00400	WD40	1298 → 1334	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1443 → 1484	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1535 → 1573	WD domain, G-beta repeat	Repeat
  PF00400	WD40	1577 → 1613	WD domain, G-beta repeat	Repeat

• Sequence:

  MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQ
  EQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHL
  FGGIAERKRRAQEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIHEDA
  NGGIYTTGVTSRLIHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCT
  QPDLVNEAVTGLPDGTPPSSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGL
  LALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNT
  LKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDL
  FRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQN
  YIREIEELRTKLLESEAMNESLRRSLSRASARSPYSLGASPAAPAFGGSPASSMEDASEV
  IRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCE
  EEEGREDEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRL
  QTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRD
  LQKLQAAQKEHARLLKNQSRYERELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKR
  NREIAQLKKEQRRQEFQIRALESQKRQQEMVLRRKTQEVSALRRLAKPMSERVAGRAGLK
  PPMLDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPAPTVNGTRPARKKFQ
  KKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRK
  RERLQAESPEEEKGLQELAEEIEVLAANIDYINDGITDCQATIVQLEETKEELDSTDTSV
  VISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMAGSSQNHLLLDAL
  REKAEAHPELQALIYNVQQENGYASTDEEISEFSEGSFSQSFTMKGSTSHDDFKFKSEPK
  LSAQMKAVSAECLGPPLDISTKNITKSLASLVEIKEDGVGFSVRDPYYRDRVSRTVSLPT
  RGSTFPRQSRATETSPLTRRKSYDRGQPIRSTDVGFTPPSSPPTRPRNDRNVFSRLTSNQ
  SQGSALDKSDDSDSSLSEVLRGIISPVGGAKGARTAPLQCVSMAEGHTKPILCLDATDEL
  LFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSTSYIKVWDIRDSA
  KCIRTLTSSGQVISGDACAATSTRAITSAQGEHQINQIALSPSGTMLYAASGNAVRIWEL
  SRFQPVGKLTGHIGPVMCLTVTQTASQHDLVVTGSKDHYVKMFELGECVTGTIGPTHNFE
  PPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFIPGRPML
  LSACRAGVIKVWNVDNFTPIGEIKGHDSPINAICTNAKHIFTASSDCRVKLWNYVPGLTP
  CLPRRVLAIKGRATTLP

• Sequence length: 1637

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs74138804	RCV005902522
Cerebral ischemia	Uncertain significance	rs368704611	RCV001842268
Clear cell carcinoma of kidney	Benign	rs74138804	RCV005902523
Hypotonia	Uncertain significance	rs368704611	RCV001842268
KIF21B-related disorder	Uncertain significance; Likely benign; Benign	rs996349208, rs755110188, rs912118630, rs74962326, rs141871941, rs7556510	RCV003148081 RCV004550760 RCV004554150 RCV004550885 RCV004551040 RCV004554489
KIF21B-related Neurodevelopmental disorder	Uncertain significance	rs759837389, rs1345199231	RCV001839247 RCV002227716
Long QT syndrome	Uncertain significance	rs796052152, rs750865418	RCV000190139 RCV000190240
Lung cancer	Benign	rs74138804	RCV005902524
Macrogyria	Uncertain significance	rs368704611	RCV001842268
Moderate global developmental delay	Uncertain significance	rs368704611	RCV001842268
Neurodevelopmental disorder	Uncertain significance; Conflicting classifications of pathogenicity	rs1459259252, rs893498810, rs2465222033, rs2465113887	RCV002272945 RCV002273201 RCV003983787 RCV004594730
See cases	Uncertain significance	rs750865418	RCV001836749

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Stimulate	25274010
Alzheimer Disease	Associate	33794991
Autoimmune Diseases	Associate	33346730
Carcinoma Hepatocellular	Associate	35341446
Carcinoma Non Small Cell Lung	Associate	35341446
Celiac Disease	Associate	27650971
Demyelinating Diseases	Associate	25274010
Diffuse Neurofibrillary Tangles with Calcification	Associate	25274010
Medulloblastoma	Associate	36273157
Multiple Sclerosis	Associate	20007504, 25274010
Neoplasms	Associate	36273157
Neurodegenerative Diseases	Associate	25274010
Parkinson Disease	Associate	34148545
Prostatic Neoplasms	Associate	30444038
Stomach Neoplasms	Associate	35341446
Uveitis Anterior	Associate	25200001