Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23037
Gene name Gene Name - the full gene name approved by the HGNC.	PDZ domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDZD2
Synonyms (NCBI Gene) Gene synonyms aliases	AIPC, PAPIN, PDZK3, PIN1
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018629	hsa-miR-335-5p	Microarray	18185580
MIRT540798	hsa-miR-8485	HITS-CLIP	23313552
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT626902	hsa-miR-3919	HITS-CLIP	23824327
MIRT626901	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	24906430
MIRT540797	hsa-miR-574-3p	HITS-CLIP	24906430
MIRT607141	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT540798	hsa-miR-8485	HITS-CLIP	24906430
MIRT540797	hsa-miR-574-3p	HITS-CLIP	24906430
MIRT607141	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT540798	hsa-miR-8485	HITS-CLIP	23313552
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT626902	hsa-miR-3919	HITS-CLIP	23824327
MIRT626901	hsa-miR-4756-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT607141	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT621256	hsa-miR-4448	HITS-CLIP	23824327
MIRT621255	hsa-miR-8081	HITS-CLIP	23824327
MIRT621254	hsa-miR-8055	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	HITS-CLIP	23824327
MIRT540797	hsa-miR-574-3p	HITS-CLIP	23824327
MIRT540796	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT540798	hsa-miR-8485	PAR-CLIP	21572407
MIRT540797	hsa-miR-574-3p	PAR-CLIP	21572407
MIRT540796	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT1224026	hsa-miR-1185	CLIP-seq
MIRT1224027	hsa-miR-124	CLIP-seq
MIRT1224028	hsa-miR-1271	CLIP-seq
MIRT1224029	hsa-miR-182	CLIP-seq
MIRT1224030	hsa-miR-31	CLIP-seq
MIRT1224031	hsa-miR-3127-5p	CLIP-seq
MIRT1224032	hsa-miR-3128	CLIP-seq
MIRT1224033	hsa-miR-3145-5p	CLIP-seq
MIRT1224034	hsa-miR-3147	CLIP-seq
MIRT1224035	hsa-miR-3159	CLIP-seq
MIRT1224036	hsa-miR-3605-5p	CLIP-seq
MIRT1224037	hsa-miR-3646	CLIP-seq
MIRT1224038	hsa-miR-3670	CLIP-seq
MIRT1224039	hsa-miR-3679-5p	CLIP-seq
MIRT1224040	hsa-miR-3688-3p	CLIP-seq
MIRT1224041	hsa-miR-3689a-3p	CLIP-seq
MIRT1224042	hsa-miR-3689c	CLIP-seq
MIRT1224043	hsa-miR-3714	CLIP-seq
MIRT1224044	hsa-miR-3910	CLIP-seq
MIRT1224045	hsa-miR-3918	CLIP-seq
MIRT1224046	hsa-miR-4423-3p	CLIP-seq
MIRT1224047	hsa-miR-4425	CLIP-seq
MIRT1224048	hsa-miR-4426	CLIP-seq
MIRT1224049	hsa-miR-4437	CLIP-seq
MIRT1224050	hsa-miR-4470	CLIP-seq
MIRT1224051	hsa-miR-4487	CLIP-seq
MIRT1224052	hsa-miR-4496	CLIP-seq
MIRT1224053	hsa-miR-4647	CLIP-seq
MIRT1224054	hsa-miR-4662b	CLIP-seq
MIRT1224055	hsa-miR-4705	CLIP-seq
MIRT1224056	hsa-miR-4747-5p	CLIP-seq
MIRT1224057	hsa-miR-4781-3p	CLIP-seq
MIRT1224058	hsa-miR-506	CLIP-seq
MIRT1224059	hsa-miR-508-5p	CLIP-seq
MIRT1224060	hsa-miR-567	CLIP-seq
MIRT1224061	hsa-miR-570	CLIP-seq
MIRT1224062	hsa-miR-95	CLIP-seq
MIRT1224063	hsa-miR-96	CLIP-seq
MIRT1224028	hsa-miR-1271	CLIP-seq
MIRT1224029	hsa-miR-182	CLIP-seq
MIRT1224050	hsa-miR-4470	CLIP-seq
MIRT1224052	hsa-miR-4496	CLIP-seq
MIRT1224061	hsa-miR-570	CLIP-seq
MIRT1552210	hsa-miR-944	CLIP-seq
MIRT1224063	hsa-miR-96	CLIP-seq
MIRT2065295	hsa-miR-1225-5p	CLIP-seq
MIRT1224028	hsa-miR-1271	CLIP-seq
MIRT1224029	hsa-miR-182	CLIP-seq
MIRT2065296	hsa-miR-3173-3p	CLIP-seq
MIRT1224050	hsa-miR-4470	CLIP-seq
MIRT1224052	hsa-miR-4496	CLIP-seq
MIRT2065297	hsa-miR-4699-3p	CLIP-seq
MIRT2065298	hsa-miR-548ae	CLIP-seq
MIRT2065299	hsa-miR-548aj	CLIP-seq
MIRT2065300	hsa-miR-548am	CLIP-seq
MIRT2065301	hsa-miR-548x	CLIP-seq
MIRT1224061	hsa-miR-570	CLIP-seq
MIRT1224063	hsa-miR-96	CLIP-seq
MIRT2293100	hsa-miR-105	CLIP-seq
MIRT2293101	hsa-miR-1197	CLIP-seq
MIRT2293102	hsa-miR-1234	CLIP-seq
MIRT2293103	hsa-miR-1252	CLIP-seq
MIRT2293104	hsa-miR-1262	CLIP-seq
MIRT2293105	hsa-miR-154	CLIP-seq
MIRT2293106	hsa-miR-183	CLIP-seq
MIRT2293107	hsa-miR-186	CLIP-seq
MIRT2293108	hsa-miR-187	CLIP-seq
MIRT2293109	hsa-miR-199a-5p	CLIP-seq
MIRT2293110	hsa-miR-199b-5p	CLIP-seq
MIRT2293111	hsa-miR-224	CLIP-seq
MIRT2293112	hsa-miR-23a	CLIP-seq
MIRT2293113	hsa-miR-23b	CLIP-seq
MIRT2293114	hsa-miR-23c	CLIP-seq
MIRT2293115	hsa-miR-299-5p	CLIP-seq
MIRT2293116	hsa-miR-3120-5p	CLIP-seq
MIRT2293117	hsa-miR-3133	CLIP-seq
MIRT2293118	hsa-miR-3158-3p	CLIP-seq
MIRT2293119	hsa-miR-3171	CLIP-seq
MIRT2293120	hsa-miR-3187-3p	CLIP-seq
MIRT2293121	hsa-miR-320a	CLIP-seq
MIRT2293122	hsa-miR-320b	CLIP-seq
MIRT2293123	hsa-miR-320c	CLIP-seq
MIRT2293124	hsa-miR-320d	CLIP-seq
MIRT2293125	hsa-miR-3591-5p	CLIP-seq
MIRT2293126	hsa-miR-3682-3p	CLIP-seq
MIRT2293127	hsa-miR-3914	CLIP-seq
MIRT2293128	hsa-miR-4255	CLIP-seq
MIRT2293129	hsa-miR-4418	CLIP-seq
MIRT2293130	hsa-miR-4421	CLIP-seq
MIRT2293131	hsa-miR-4429	CLIP-seq
MIRT2293132	hsa-miR-4435	CLIP-seq
MIRT2293133	hsa-miR-4446-3p	CLIP-seq
MIRT1224050	hsa-miR-4470	CLIP-seq
MIRT2293134	hsa-miR-4528	CLIP-seq
MIRT2293135	hsa-miR-4639-3p	CLIP-seq
MIRT2293136	hsa-miR-4648	CLIP-seq
MIRT2293137	hsa-miR-4654	CLIP-seq
MIRT2065297	hsa-miR-4699-3p	CLIP-seq
MIRT2293138	hsa-miR-4701-3p	CLIP-seq
MIRT2293139	hsa-miR-4701-5p	CLIP-seq
MIRT2293140	hsa-miR-4769-5p	CLIP-seq
MIRT2293141	hsa-miR-4789-3p	CLIP-seq
MIRT2293142	hsa-miR-508-3p	CLIP-seq
MIRT2293143	hsa-miR-509-3-5p	CLIP-seq
MIRT2293144	hsa-miR-509-5p	CLIP-seq
MIRT2293145	hsa-miR-520d-5p	CLIP-seq
MIRT2293146	hsa-miR-524-5p	CLIP-seq
MIRT2293147	hsa-miR-548s	CLIP-seq
MIRT2293148	hsa-miR-588	CLIP-seq
MIRT2293149	hsa-miR-595	CLIP-seq
MIRT2293150	hsa-miR-616	CLIP-seq
MIRT2293151	hsa-miR-661	CLIP-seq
MIRT2293152	hsa-miR-891b	CLIP-seq
MIRT1552210	hsa-miR-944	CLIP-seq
MIRT2456199	hsa-miR-1273f	CLIP-seq
MIRT2456200	hsa-miR-143	CLIP-seq
MIRT2456201	hsa-miR-147	CLIP-seq
MIRT1224040	hsa-miR-3688-3p	CLIP-seq
MIRT2456202	hsa-miR-3911	CLIP-seq
MIRT1224048	hsa-miR-4426	CLIP-seq
MIRT1224053	hsa-miR-4647	CLIP-seq
MIRT2293136	hsa-miR-4648	CLIP-seq
MIRT2293137	hsa-miR-4654	CLIP-seq
MIRT1224054	hsa-miR-4662b	CLIP-seq
MIRT2456203	hsa-miR-4708-5p	CLIP-seq
MIRT1224056	hsa-miR-4747-5p	CLIP-seq
MIRT2293140	hsa-miR-4769-5p	CLIP-seq
MIRT2456204	hsa-miR-4770	CLIP-seq
MIRT2456205	hsa-miR-576-3p	CLIP-seq
MIRT2456206	hsa-miR-644	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	ISS	12671685
GO:0005634	Component	Nucleus	ISS	12671685
GO:0005737	Component	Cytoplasm	IDA	11289102
GO:0005783	Component	Endoplasmic reticulum	ISS	12671685
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005911	Component	Cell-cell junction	ISS	12671685
GO:0007155	Process	Cell adhesion	IEA
GO:0034451	Component	Centriolar satellite	IDA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA

MIM	HGNC	e!Ensembl
610697	18486	ENSG00000133401

Protein

UniProt ID

O15018

Protein name

PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2]

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	334 → 416	PDZ domain	Domain
PF00595	PDZ	587 → 671	PDZ domain	Domain
PF00595	PDZ	728 → 811	PDZ domain	Domain
PF00595	PDZ	2623 → 2697	PDZ domain	Domain
PF00595	PDZ	2751 → 2833	PDZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 2 is expressed (at protein level) in prostate and many prostate tumors. {ECO:0000269|PubMed:11289102}.

Sequence

MPITQDNAVLHLPLLYQWLQNSLQEGGDGPEQRLCQAAIQKLQEYIQLNFAVDESTVPPD
HSPPEMEICTVYLTKELGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIW
VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK
HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC
EVSSDPSTELENGPDPELGNGHVFQLENGPDSLKEVAGPHLERSEVDRGTEHRIPKTDAP
LTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHA
IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN
SAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVC
GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGR
KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS
IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI
RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG
PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE
VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANS
SPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEE
GSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQR
KVGCYDANDASDEEEFDREGDCISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEER
PRKTLVSKAISAPLLGSSVDLEESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSG
SSSAPKLEYTVRTDTQSPTNTGSPSSPQQKSEGLGSRHRPVARVSPHCKRSEAEAKPSGS
QTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGGAVEKESLGKLTTGDACVSTSCELAS
ALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVS
RPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDYSKTRSASETSTPHNTRRV
AALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLLE
GADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAAR
SPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWASQ
PSVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSS
DPESLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQ
AAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHA
DISTSQNHRPSCAEETTEVTSASSAMENSPLSKVARHFHSPPIILSSPNMVNGLEHDLLD
DETLNQYETSINAAASLSSFSVDVPKNGESVLENLHISESQDLDDLLQKPKMIARRPIMA
WFKEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLEN
KDLSKKSPAEMLLTNGQKAKCGPKLKRLSLKGKAKVNSEAPAANAVKAGGTDHRKPLISP
QTSHKTLSKAVSQRLHVADHEDPDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSDTSIR
TFVSPLTSPKPVPEQGMWSRFHMAVLSEPDRGCPTTPKSPKCRAEGRAPRADSGPVSPAA
SRNGMSVAGNRQSEPRLASHVAADTAQPRPTGEKGGNIMASDRLERTNQLKIVEISAEAV
SETVCGNKPAESDRRGGCLAQGNCQEKSEIRLYRQVAESSTSHPSSLPSHASQAEQEMSR
SFSMAKLASSSSSLQTAIRKAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPAT
RTYSMPAQFSSHFGREGHPPHSLGRSRDSQVPVTSSVVPEAKASRGGLPSLANGQGIYSV
KPLLDTSRNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIK
SFENLANADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGDAAARLLRRSLSSC
SENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLAS
PVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRR
SPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVNLDQL
LVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAGG
TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDA
LVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGL
GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIM
KSVPEGPVQLLIRKHRNSS

Sequence length

2839

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Renal carcinoma	Renal Cell Carcinoma	rs121913668, rs121913670, rs121913243, rs786202724	23184150

Show/Hide Unknown Diseases (13)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Childhood asthma, Asthma		30373671	ClinVar, GWAS
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		29394082	ClinVar
Mental depression	Major Depressive Disorder		24528284	ClinVar
Myocardial infarction	Myocardial Infarction		26708285	ClinVar
Myocardial Infarction	Myocardial Infarction			GWAS
Renal Carcinoma	Renal Carcinoma			GWAS
Intracranial Aneurysm	Intracranial Aneurysm			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Dental caries	Dental caries			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Glaucoma	Glaucoma			GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	32535612
Carcinoma Renal Cell	Associate	26918600, 27229762, 35718636
Neoplasm Metastasis	Associate	34511489
Nephrotic Syndrome	Associate	27932480
Peritonitis	Associate	31570735
Polypoidal Choroidal Vasculopathy	Inhibit	24827138
Pregnancy Complications	Associate	24827138
Prostatic Neoplasms	Associate	16873542
Prostatitis	Associate	16873542
Pulmonary Disease Chronic Obstructive	Associate	29394082
Sacral defect and anterior sacral meningocele	Associate	28007035, 35274497
Stomach Neoplasms	Associate	26330360, 31570735

PDZD2 (PDZ domain containing 2)