Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23034
Gene name Gene Name - the full gene name approved by the HGNC.
Sterile alpha motif domain containing 4A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SAMD4A
Synonyms (NCBI Gene) Gene synonyms aliases
SAMD4, SMAUG, SMAUG1, SMG, SMGA
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q22.2
Summary Summary of gene provided in NCBI Entrez Gene.
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Sma
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019866 hsa-miR-375 Microarray 20215506
MIRT720127 hsa-miR-6895-5p HITS-CLIP 19536157
MIRT720126 hsa-miR-3158-3p HITS-CLIP 19536157
MIRT720125 hsa-miR-3918 HITS-CLIP 19536157
MIRT720124 hsa-miR-4685-5p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
SRF Activation 16814806
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000289 Process Nuclear-transcribed mRNA poly(A) tail shortening IBA
GO:0000932 Component P-body IBA
GO:0001650 Component Fibrillar center IDA
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610747 23023 ENSG00000020577
Protein
UniProt ID Q9UPU9
Protein name Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)
Protein function Acts as a translational repressor of SRE-containing messengers.
PDB 8OIK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00536 SAM_1 321 381 SAM domain (Sterile alpha motif) Domain
Sequence
MMFRDQVGVLAGWFKGWNECEQTVALLSLLKRVSQTQARFLQLCLEHSLADCAELHVLER
EANSPGIINQWQQESKDKVISLLLTHLPLLKPGNLDAKVEYMKLLPKILAHSIEHNQHIE
ESRQLLSYALIHPATSLEDRSALAMWLNHLEDRTSTSFGGQNRGRSDSVDYGQTHYYHQR
QNSDDKLNGWQNSRDSGICINASNWQDKSMGCENGHVPLYSSSSVPTTINTIGTSTSTIL
SGQAHHSPLKRSVSLTPPMNVPNQPLGHGWMSHEDLRARGPQCLPSDHAPLSPQSSVASS
GSGGSEHLEDQTTARNTFQEEGSGMKDVPAWLKSLRLHKYAALFSQMTYEEMMALTECQL
EAQNVTKGARHKIVISIQKLK
ERQNLLKSLERDIIEGGSLRIPLQELHQMILTPIKAYSS
PSTTPEARRREPQAPRQPSLMGPESQSPDCKDGAAATGATATPSAGASGGLQPHQLSSCD
GELAVAPLPEGDLPGQFTRVMGKVCTQLLVSRPDEENISSYLQLIDKCLIHEAFTETQKK
RLLSWKQQVQKLFRSFPRKTLLDISGYRQQRNRGFGQSNSLPTAGSVGGGMGRRNPRQYQ
IPSRNVPSARLGLLGTSGFVSSNQRNTTATPTIMKQGRQNLWFANPGGSNSMPSRTHSSV
QRTRSLPVHTSPQNMLMFQQPEFQLPVTEPDINNRLESLCLSMTEHALGDGVDRTSTI
Sequence length 718
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Lip and Oral Cavity Carcinoma lip and oral cavity carcinoma N/A N/A ClinVar
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colonic Neoplasms Associate 35151825
Diabetes Mellitus Type 2 Associate 27448167
Drug Related Side Effects and Adverse Reactions Associate 23637619
Muscular Atrophy Associate 23637619
Muscular Diseases Inhibit 23637619
Myocardial Infarction Associate 35791879
Myotonic Dystrophy Associate 23637619
Osteoarthritis Associate 34669172
Ovarian Neoplasms Associate 28611294