Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23026
Gene name	Myosin XVI
Gene symbol	MYO16
Synonyms (NCBI Gene)	MYAP3MYR8Myo16bNYAP3PPP1R107
Chromosome	13
Chromosome location	13q33.3
Summary	This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression.

Show/Hide all (1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs774060871	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant

Show/Hide all (77)

miRTarBase ID	miRNA	Experiments	Reference
MIRT693550	hsa-miR-3133	HITS-CLIP	23313552
MIRT693549	hsa-miR-548b-3p	HITS-CLIP	23313552
MIRT615711	hsa-miR-8485	HITS-CLIP	23313552
MIRT615710	hsa-miR-602	HITS-CLIP	23313552
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	27418678
MIRT615711	hsa-miR-8485	HITS-CLIP	27418678
MIRT615711	hsa-miR-8485	HITS-CLIP	27418678
MIRT615711	hsa-miR-8485	HITS-CLIP	27418678
MIRT693550	hsa-miR-3133	HITS-CLIP	23313552
MIRT693549	hsa-miR-548b-3p	HITS-CLIP	23313552
MIRT615711	hsa-miR-8485	HITS-CLIP	23313552
MIRT615710	hsa-miR-602	HITS-CLIP	23313552
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT615711	hsa-miR-8485	HITS-CLIP	23824327
MIRT615710	hsa-miR-602	HITS-CLIP	23824327
MIRT615709	hsa-miR-4695-3p	HITS-CLIP	23824327
MIRT1169211	hsa-miR-1245b-5p	CLIP-seq
MIRT1169212	hsa-miR-29a	CLIP-seq
MIRT1169213	hsa-miR-29b	CLIP-seq
MIRT1169214	hsa-miR-29c	CLIP-seq
MIRT1169215	hsa-miR-3126-5p	CLIP-seq
MIRT1169216	hsa-miR-3142	CLIP-seq
MIRT1169217	hsa-miR-3185	CLIP-seq
MIRT1169218	hsa-miR-3922-5p	CLIP-seq
MIRT1169219	hsa-miR-4419a	CLIP-seq
MIRT1169220	hsa-miR-4510	CLIP-seq
MIRT1169221	hsa-miR-4709-3p	CLIP-seq
MIRT1169222	hsa-miR-4742-3p	CLIP-seq
MIRT1169223	hsa-miR-4797-5p	CLIP-seq
MIRT2277623	hsa-miR-1271	CLIP-seq
MIRT2277624	hsa-miR-1305	CLIP-seq
MIRT2277625	hsa-miR-4496	CLIP-seq
MIRT2277626	hsa-miR-4773	CLIP-seq
MIRT2277627	hsa-miR-607	CLIP-seq
MIRT2277628	hsa-miR-96	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003774	Function	Cytoskeletal motor activity	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	25902260
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA	17029291
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS	11588169
GO:0005886	Component	Plasma membrane	ISS	11588169, 17029291
GO:0008285	Process	Negative regulation of cell population proliferation	ISS	17029291
GO:0016459	Component	Myosin complex	IBA
GO:0016459	Component	Myosin complex	IEA
GO:0019903	Function	Protein phosphatase binding	IBA
GO:0021549	Process	Cerebellum development	ISS	11588169
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17029291
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	ISS	11588169
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IBA
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	ISS	17029291

MIM	HGNC	e!Ensembl
615479	29822	ENSG00000041515

Q9Y6X6

Protein name

Unconventional myosin-XVI (Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3) (Unconventional myosin-16)

Protein function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	64 → 156	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	200 → 285	Ankyrin repeats (3 copies)	Repeat
PF00063	Myosin_head	403 → 1133	Myosin head (motor domain)	Domain
PF15439	NYAP_N	1221 → 1589	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter	Family

Sequence

MEIDQCLLESLPLGQRQRLVKRMRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNL
TDMLQDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVN
HQDEDFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYL
DENGVDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSL
ILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFI
EEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEK
DIMFKDATKGLCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYE
IQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERA
FHQLFREQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFG
HAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLM
DGLSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVE
NLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFK
GDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIF
GFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDF
FFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGT
AFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAY
PSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRLERGDPVTIASQL
RKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPV
RLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQL
NDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQNTEDMGLKTYDALV
IQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAV
DGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLS
AAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEISGSRPGDARPAGAP
GAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLP
DDGGPGAGSFLLHGASPPLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPV
TCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPASPGLAL
FNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKP
NSAPVAGPCSSFPKIPYSPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFN
SGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSS
AITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQE
LLDWRRKLCEEGQDWQQILHHAEPRVPPPPPCKKPSLLKKPEGASCNRLPSELWDTTI

Sequence length

1858

Interactions

View interactions

	KEGG
	Motor proteins

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
MYO16-associated developmental delay	Likely pathogenic	rs774060871	RCV000767344

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs61745206	RCV005913427
Clear cell carcinoma of kidney	Benign; Likely benign	rs61745206, rs76952704	RCV005913428 RCV005908749
Colon adenocarcinoma	Benign	rs61743216	RCV005935254
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2502328560	RCV004557825
Gastric cancer	Benign	rs61743216	RCV005935256
Lung cancer	Benign; Likely benign	rs61745206, rs76952704	RCV005913432 RCV005908750
Melanoma	Benign	rs61743216	RCV005935258
MYO16-related disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs2502499854, rs201341139, rs200595201, rs28664189, rs157024, rs3825491, rs375111602, rs911973, rs9559428, rs41308564, rs2502112117, rs147534854, rs2303965, rs150813880, rs141423536 View all (40 more)	RCV003412427 RCV003919116 RCV003980884 RCV003917283 RCV003974335 RCV003967375 RCV003979730 RCV003979816 RCV003979878 RCV003984785 RCV003893839 RCV003903957 RCV003914216 RCV003916961 RCV003973818 RCV003977070 RCV003977294 RCV003977369 RCV003959495 RCV003917108 RCV003931701 RCV003951805 RCV003937088 RCV003951402 RCV003921930 RCV003936857 RCV003979120 RCV003982038 RCV003982158 RCV003978912 RCV003966839 RCV003981329 RCV003933275 RCV003970677 RCV003903301 RCV003935814 RCV003935915 RCV003972962 RCV003918534 RCV003906078 RCV003972911 RCV003905925 RCV003940436 RCV003922832 RCV003948334 RCV003920553 RCV003940679 RCV003967973 RCV003922919 RCV003968275 RCV003910827 RCV003922965 RCV003923280 RCV003903300 RCV003972870 RCV003905862
Ovarian serous cystadenocarcinoma	Benign	rs61745206	RCV005913430
Prostate cancer	Uncertain significance	rs193921058	RCV000149225
Sarcoma	Benign	rs61743216, rs61745206	RCV005935255 RCV005913429
Thyroid cancer, nonmedullary, 1	Benign	rs61743216	RCV005935257
Uterine carcinosarcoma	Benign	rs61745206	RCV005913431

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	37333771
Bipolar Disorder	Associate	27450446
Heart Defects Congenital	Associate	34324492
Metabolic Syndrome	Associate	25646961
Multiple Sclerosis	Associate	34889895
Neoplasms	Associate	35655316
Pressure Ulcer	Associate	24473254
Schizophrenia	Associate	24141571
Thymic epithelial tumor	Associate	36916520
Thymoma	Associate	36916520
Urinary Bladder Neoplasms	Associate	30170380

MYO16 (myosin XVI)