Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23013
Gene name Gene Name - the full gene name approved by the HGNC.	Spen family transcriptional repressor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPEN
Synonyms (NCBI Gene) Gene synonyms aliases	HIAA0929, MINT, RATARS, RBM15C, SHARP
Disease Acronyms (UniProt) Disease acronyms from UniProt database	RATARS
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.21-p36.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestrat

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019521	hsa-miR-151a-5p	Sequencing	20371350
MIRT051293	hsa-miR-16-5p	CLASH	23622248
MIRT049048	hsa-miR-92a-3p	CLASH	23622248
MIRT048159	hsa-miR-196a-5p	CLASH	23622248
MIRT046031	hsa-miR-125b-5p	CLASH	23622248
MIRT045089	hsa-miR-186-5p	CLASH	23622248
MIRT044789	hsa-miR-320a	CLASH	23622248
MIRT044364	hsa-miR-106b-5p	CLASH	23622248
MIRT043756	hsa-miR-328-3p	CLASH	23622248
MIRT043465	hsa-miR-331-3p	CLASH	23622248
MIRT043099	hsa-miR-324-5p	CLASH	23622248
MIRT042502	hsa-miR-423-3p	CLASH	23622248
MIRT041415	hsa-miR-193b-3p	CLASH	23622248
MIRT041415	hsa-miR-193b-3p	CLASH	23622248
MIRT039949	hsa-miR-615-3p	CLASH	23622248
MIRT039166	hsa-miR-769-5p	CLASH	23622248
MIRT038656	hsa-miR-23b-5p	CLASH	23622248
MIRT037187	hsa-miR-877-3p	CLASH	23622248
MIRT755932	hsa-miR-6779-5p	Luciferase reporter assay, Western blotting, qRT-PCR, in vitro cullelar assays, Flow cytometry	36087384
MIRT1383699	hsa-miR-1238	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT1383701	hsa-miR-1273f	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383704	hsa-miR-18a	CLIP-seq
MIRT1383705	hsa-miR-18b	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT1383717	hsa-miR-329	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT1383722	hsa-miR-3617	CLIP-seq
MIRT1383723	hsa-miR-3618	CLIP-seq
MIRT1383724	hsa-miR-362-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT1383727	hsa-miR-3941	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT1383732	hsa-miR-4504	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383739	hsa-miR-4766-5p	CLIP-seq
MIRT1383740	hsa-miR-4778-3p	CLIP-seq
MIRT1383741	hsa-miR-4783-3p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT1383744	hsa-miR-520a-5p	CLIP-seq
MIRT1383745	hsa-miR-525-5p	CLIP-seq
MIRT1383746	hsa-miR-542-3p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT1383749	hsa-miR-570	CLIP-seq
MIRT1383750	hsa-miR-603	CLIP-seq
MIRT1383751	hsa-miR-641	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT2114838	hsa-miR-1233	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT2114839	hsa-miR-1285	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2114840	hsa-miR-1323	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT2114841	hsa-miR-217	CLIP-seq
MIRT2114842	hsa-miR-224	CLIP-seq
MIRT2114843	hsa-miR-2355-3p	CLIP-seq
MIRT2114844	hsa-miR-2467-3p	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT2114845	hsa-miR-3121-5p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT2114846	hsa-miR-3158-5p	CLIP-seq
MIRT2114847	hsa-miR-3187-5p	CLIP-seq
MIRT2114848	hsa-miR-323b-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT2114849	hsa-miR-3678-3p	CLIP-seq
MIRT2114850	hsa-miR-3691-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT2114851	hsa-miR-3940-5p	CLIP-seq
MIRT2114852	hsa-miR-412	CLIP-seq
MIRT2114853	hsa-miR-4292	CLIP-seq
MIRT2114854	hsa-miR-4418	CLIP-seq
MIRT2114855	hsa-miR-4420	CLIP-seq
MIRT2114856	hsa-miR-4421	CLIP-seq
MIRT2114857	hsa-miR-4450	CLIP-seq
MIRT2114858	hsa-miR-4507	CLIP-seq
MIRT2114859	hsa-miR-4525	CLIP-seq
MIRT2114860	hsa-miR-4646-5p	CLIP-seq
MIRT2114861	hsa-miR-4699-5p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT2114862	hsa-miR-4735-5p	CLIP-seq
MIRT2114863	hsa-miR-4747-5p	CLIP-seq
MIRT2114864	hsa-miR-4787-5p	CLIP-seq
MIRT2114865	hsa-miR-509-3-5p	CLIP-seq
MIRT2114866	hsa-miR-509-5p	CLIP-seq
MIRT1383744	hsa-miR-520a-5p	CLIP-seq
MIRT1383745	hsa-miR-525-5p	CLIP-seq
MIRT2114867	hsa-miR-548a-3p	CLIP-seq
MIRT2114868	hsa-miR-548e	CLIP-seq
MIRT2114869	hsa-miR-548f	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT2114870	hsa-miR-548o	CLIP-seq
MIRT2114871	hsa-miR-612	CLIP-seq
MIRT2114872	hsa-miR-676	CLIP-seq
MIRT2114873	hsa-miR-759	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT1383700	hsa-miR-1271	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT1383703	hsa-miR-182	CLIP-seq
MIRT1383706	hsa-miR-214	CLIP-seq
MIRT2114842	hsa-miR-224	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383717	hsa-miR-329	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383721	hsa-miR-3607-3p	CLIP-seq
MIRT1383722	hsa-miR-3617	CLIP-seq
MIRT1383723	hsa-miR-3618	CLIP-seq
MIRT1383724	hsa-miR-362-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383727	hsa-miR-3941	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT2114857	hsa-miR-4450	CLIP-seq
MIRT2114859	hsa-miR-4525	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT2337581	hsa-miR-4652-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383739	hsa-miR-4766-5p	CLIP-seq
MIRT1383741	hsa-miR-4783-3p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383748	hsa-miR-548g	CLIP-seq
MIRT1383749	hsa-miR-570	CLIP-seq
MIRT1383750	hsa-miR-603	CLIP-seq
MIRT1383751	hsa-miR-641	CLIP-seq
MIRT2337582	hsa-miR-934	CLIP-seq
MIRT1383752	hsa-miR-96	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383708	hsa-miR-30a	CLIP-seq
MIRT1383709	hsa-miR-30b	CLIP-seq
MIRT1383710	hsa-miR-30c	CLIP-seq
MIRT1383711	hsa-miR-30d	CLIP-seq
MIRT1383712	hsa-miR-30e	CLIP-seq
MIRT2460399	hsa-miR-380	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2460400	hsa-miR-3924	CLIP-seq
MIRT2460401	hsa-miR-4422	CLIP-seq
MIRT2460402	hsa-miR-4495	CLIP-seq
MIRT2460403	hsa-miR-624	CLIP-seq
MIRT1383699	hsa-miR-1238	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2631111	hsa-miR-1289	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383714	hsa-miR-3120-3p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT2631112	hsa-miR-3198	CLIP-seq
MIRT1383718	hsa-miR-337-5p	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT2631113	hsa-miR-3647-3p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2631114	hsa-miR-4294	CLIP-seq
MIRT2631115	hsa-miR-4309	CLIP-seq
MIRT2631116	hsa-miR-4427	CLIP-seq
MIRT1383728	hsa-miR-4436a	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT2631117	hsa-miR-4517	CLIP-seq
MIRT1383733	hsa-miR-4537	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT2631118	hsa-miR-4680-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT2631119	hsa-miR-520d-5p	CLIP-seq
MIRT2631120	hsa-miR-524-5p	CLIP-seq
MIRT1383747	hsa-miR-545	CLIP-seq
MIRT1383702	hsa-miR-1286	CLIP-seq
MIRT2631111	hsa-miR-1289	CLIP-seq
MIRT1383707	hsa-miR-300	CLIP-seq
MIRT1383713	hsa-miR-3117-5p	CLIP-seq
MIRT1383715	hsa-miR-3124-5p	CLIP-seq
MIRT1383716	hsa-miR-3128	CLIP-seq
MIRT2631112	hsa-miR-3198	CLIP-seq
MIRT1383719	hsa-miR-34a	CLIP-seq
MIRT1383720	hsa-miR-34c-5p	CLIP-seq
MIRT1383725	hsa-miR-3692	CLIP-seq
MIRT1383726	hsa-miR-381	CLIP-seq
MIRT2631114	hsa-miR-4294	CLIP-seq
MIRT2631115	hsa-miR-4309	CLIP-seq
MIRT1383729	hsa-miR-4481	CLIP-seq
MIRT1383730	hsa-miR-449a	CLIP-seq
MIRT1383731	hsa-miR-449b	CLIP-seq
MIRT1383734	hsa-miR-4666-3p	CLIP-seq
MIRT1383735	hsa-miR-4718	CLIP-seq
MIRT1383736	hsa-miR-4720-5p	CLIP-seq
MIRT1383737	hsa-miR-4745-5p	CLIP-seq
MIRT1383738	hsa-miR-4758-5p	CLIP-seq
MIRT1383742	hsa-miR-4789-5p	CLIP-seq
MIRT1383743	hsa-miR-4799-3p	CLIP-seq
MIRT2691865	hsa-miR-495	CLIP-seq
MIRT2691866	hsa-miR-548ac	CLIP-seq
MIRT2691867	hsa-miR-548ae	CLIP-seq
MIRT2691868	hsa-miR-548aj	CLIP-seq
MIRT2691869	hsa-miR-548am	CLIP-seq
MIRT2691870	hsa-miR-548d-3p	CLIP-seq
MIRT2691871	hsa-miR-548x	CLIP-seq
MIRT2691872	hsa-miR-548z	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	16287852
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0001085	Function	RNA polymerase II transcription factor binding	IPI	16287852
GO:0003676	Function	Nucleic acid binding	IBA	21873635
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	16287852
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16129689, 16287852, 17474147, 21102556, 24268649, 25609649
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0016032	Process	Viral process	IEA
GO:0017053	Component	Transcription repressor complex	IDA	16287852
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	16129689
GO:0050769	Process	Positive regulation of neurogenesis	IMP	16287852
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
613484	17575	ENSG00000065526

Protein

UniProt ID

Q96T58

Protein name

Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)

Protein function

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive eleme

PDB

1OW1 , 2RT5 , 4P6Q , 7Z1K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	8 → 75	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	337 → 407	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	440 → 507	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	519 → 583	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF07744	SPOC	3499 → 3664	SPOC domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin.

Sequence

MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQ
KAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPP
SLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQH
GLYYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNYQHS
RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSS
SSDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSTDTSLKDGLFHEFK
KFGKVTSVQIHGTSEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWIGPETESEN
EFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAF
LQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRY
GPVVKVVFDRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCME
KSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGREFYSE
WETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRDHERR
PIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKS
RLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQ
ENEREQSPEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLK
AKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKA
RKHLKPEQPADGVSAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQP
DVSSREVILLREGEAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRP
SSDLQARLGELAGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDET
PERKSGQEKSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVD
EYERRSLVHEVGKPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG
SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQM
ADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPS
DSDEDGEHKSHSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTI
TPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKI
RTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRI
YGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTP
ESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVS
EEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGA
SFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPP
ASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG
EAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPV
KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEG
WRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSE
QKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAV
SPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSP
EATQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIG
SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATE
SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR
KRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTS
DLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVT
PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPALPP
DTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK
PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLA
KPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVTTLKSLVSTPAGPVNVLKGPVNVL
TGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVTAASGGVTATTGTV
TMAGAVIAPSTKCKQRASANENSRFHPGSMPVIDDRPADAGSGAGLRVNTSEGVVLLSYS
GQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTASQPPSKGPQAPAGYANV
ATHSTLVLTAQTYNASPVISSVKADRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPP
VLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGSTLTPHHPPALPSKLPTEVNH
VPSGPSIPADRTVSHLAAAKLDAHSPRPSGPGPSSFPRASHPSSTASTALSTNATVMLAA
GIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSP
RAPLQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVM
QSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAK
AAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSG
ELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQST
QPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQ
RAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVPTTSGPSTPPGLVLPHTEFQP
APKQDSSPHLTSQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPL
SEGGPPLRIAQRMRLEATQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFI
TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIV
IASV

Sequence length

3664

Interactions

View interactions

	KEGG
	Notch signaling pathway

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Non-hodgkin lymphoma	Lymphoma, Non-Hodgkin	rs121908689, rs28936699, rs121909775, rs398122800, rs121913357, rs121913355, rs398122820
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Source
Unknown
Neurodevelopmental Disorders	complex neurodevelopmental disorder	GenCC
Psoriasis	Psoriasis	GWAS
Alzheimer disease	Alzheimer disease	GWAS
Atrial Fibrillation	Atrial Fibrillation	GWAS

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	22355143
Attention Deficit Disorder with Hyperactivity	Associate	33596411
Autism Spectrum Disorder	Associate	33596411
Breast Neoplasms	Associate	32641685
Carcinogenesis	Associate	37620924
Carcinoma Adenoid Cystic	Associate	23778135, 23778141
Carcinoma Adenosquamous	Associate	31958074
Carcinoma Hepatocellular	Associate	34288818
Cardiovascular Abnormalities	Associate	24454898
Chromosome 1p36 Deletion Syndrome	Inhibit	33596411
Colorectal Neoplasms	Associate	32641685
Developmental Disabilities	Associate	33004838, 33596411
Epstein Barr Virus Infections	Associate	33297669
Gastro enteropancreatic neuroendocrine tumor	Associate	26684240
Hereditary leiomyomatosis and renal cell cancer	Associate	32191807
Leukemia Lymphocytic Chronic B Cell	Associate	31467127, 35430388
Lymphoma B Cell Marginal Zone	Associate	22891273, 24349473, 29481902, 32173361
Lymphoma Large B Cell Diffuse	Associate	32139889
Lymphoma Mantle Cell	Associate	32173361
Lymphoproliferative Disorders	Associate	37705050
Microsatellite Instability	Associate	37620924
Multiple Myeloma	Associate	25743686
Myotonic Dystrophy	Associate	21637295
Nasopharyngeal Carcinoma	Stimulate	32641685
Neoplasm Metastasis	Associate	32641685
Neoplasms	Associate	23778141, 26684240, 27494029, 29259115, 34001978, 36911742, 37620924, 38049758
Ovarian Neoplasms	Associate	32641685
Plasmablastic Lymphoma	Associate	33297669
Prostatic Neoplasms	Associate	29610475
Rectal Diseases	Associate	37387515
Triple Negative Breast Neoplasms	Associate	38049758

SPEN (spen family transcriptional repressor)