Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23011
Gene name Gene Name - the full gene name approved by the HGNC.
RAB21, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB21
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequ
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000812 hsa-miR-15a-5p qRT-PCR 18362358
MIRT000811 hsa-miR-16-5p qRT-PCR 18362358
MIRT022089 hsa-miR-128-3p Sequencing 20371350
MIRT028612 hsa-miR-30a-5p Proteomics 18668040
MIRT050640 hsa-miR-19b-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 16034420
GO:0005515 Function Protein binding IPI 16525121, 17450153, 17581628, 28514442, 31455601
GO:0005525 Function GTP binding IDA 16034420
GO:0005525 Function GTP binding IMP 15561770
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612398 18263 ENSG00000080371
Protein
UniProt ID Q9UL25
Protein name Ras-related protein Rab-21 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1YZT , 1YZU , 1Z08 , 1Z0I , 2OT3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 21 182 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina prop
Sequence
Sequence length 225
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Obesity Obesity rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562
View all (27 more)
29273807
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 24447584
Carcinoma Hepatocellular Associate 35220907
Carcinoma Pancreatic Ductal Associate 32759795
Glioma Associate 29270202
Pyruvate Carboxylase Deficiency Disease Associate 32759795