Gene Gene information from NCBI Gene database.
Entrez ID 23011
Gene name RAB21, member RAS oncogene family
Gene symbol RAB21
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q21.1
Summary This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequ
miRNA miRNA information provided by mirtarbase database.
875
miRTarBase ID miRNA Experiments Reference
MIRT000812 hsa-miR-15a-5p qRT-PCR 18362358
MIRT000811 hsa-miR-16-5p qRT-PCR 18362358
MIRT022089 hsa-miR-128-3p Sequencing 20371350
MIRT028612 hsa-miR-30a-5p Proteomics 18668040
MIRT050640 hsa-miR-19b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IDA 16034420
GO:0003924 Function GTPase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612398 18263 ENSG00000080371
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UL25
Protein name Ras-related protein Rab-21 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 1YZT , 1YZU , 1Z08 , 1Z0I , 2OT3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 21 182 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina prop
Sequence
Sequence length 225
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs