Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23008
Gene name Gene Name - the full gene name approved by the HGNC.
Kelch domain containing 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLHDC10
Synonyms (NCBI Gene) Gene synonyms aliases
PNAS-138, slim
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q32.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT040901 hsa-miR-18a-3p CLASH 23622248
MIRT723202 hsa-miR-3121-3p HITS-CLIP 19536157
MIRT723201 hsa-miR-5197-3p HITS-CLIP 19536157
MIRT402088 hsa-miR-7705 HITS-CLIP 19536157
MIRT392663 hsa-miR-4696 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20562859, 25036637
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0032874 Process Positive regulation of stress-activated MAPK cascade IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615152 22194 ENSG00000128607
Protein
UniProt ID Q6PID8
Protein name Kelch domain-containing protein 10
Protein function Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their
PDB 9D8P
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13964 Kelch_6 91 153 Repeat
PF13418 Kelch_4 205 253 Repeat
PF01344 Kelch_1 259 306 Kelch motif Repeat
PF01344 Kelch_1 315 360 Kelch motif Repeat
Sequence
MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKI
RWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRE
LASMSLVLHGNNLLVFGGTGIPFGESN
GNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLN
TREWTQLKPNNLS
CDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWE
EIATKP
HEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNL
ANLSRTQLLHLGLTQGLIERLK
Sequence length 442
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
29915430
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29915430
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
29915430
Unknown
Disease term Disease name Evidence References Source
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Colorectal Neoplasms Associate 35247911