Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	230
Gene name	Aldolase, fructose-bisphosphate C
Gene symbol	ALDOC
Synonyms (NCBI Gene)	ALDC
Chromosome	17
Chromosome location	17q11.2
Summary	This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fruc

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016877	hsa-miR-335-5p	Microarray	18185580
MIRT040405	hsa-miR-615-3p	CLASH	23622248
MIRT644456	hsa-miR-6085	HITS-CLIP	23824327
MIRT644455	hsa-miR-6813-5p	HITS-CLIP	23824327
MIRT644454	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT644453	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT644452	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT644451	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT644450	hsa-miR-1914-3p	HITS-CLIP	23824327
MIRT644449	hsa-miR-5194	HITS-CLIP	23824327
MIRT644448	hsa-miR-6738-5p	HITS-CLIP	23824327
MIRT644447	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT644446	hsa-miR-4283	HITS-CLIP	23824327
MIRT644445	hsa-miR-4281	HITS-CLIP	23824327
MIRT644444	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT644443	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT644442	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT644441	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT644440	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT644456	hsa-miR-6085	HITS-CLIP	23824327
MIRT644455	hsa-miR-6813-5p	HITS-CLIP	23824327
MIRT644454	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT644453	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT644452	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT644451	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT644450	hsa-miR-1914-3p	HITS-CLIP	23824327
MIRT644449	hsa-miR-5194	HITS-CLIP	23824327
MIRT644448	hsa-miR-6738-5p	HITS-CLIP	23824327
MIRT644447	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT644446	hsa-miR-4283	HITS-CLIP	23824327
MIRT644445	hsa-miR-4281	HITS-CLIP	23824327
MIRT644444	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT644443	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT644442	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT644441	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT644440	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT777897	hsa-miR-31	CLIP-seq
MIRT777898	hsa-miR-4436b-3p	CLIP-seq
MIRT777899	hsa-miR-4742-5p	CLIP-seq
MIRT777900	hsa-miR-4768-3p	CLIP-seq
MIRT777901	hsa-miR-665	CLIP-seq
MIRT1929631	hsa-miR-3187-3p	CLIP-seq
MIRT1929632	hsa-miR-4529-5p	CLIP-seq
MIRT1929633	hsa-miR-4726-3p	CLIP-seq
MIRT1929634	hsa-miR-4796-3p	CLIP-seq
MIRT1929635	hsa-miR-548p	CLIP-seq
MIRT1929636	hsa-miR-548t	CLIP-seq
MIRT2170471	hsa-miR-3910	CLIP-seq
MIRT2170472	hsa-miR-3922-5p	CLIP-seq
MIRT2170473	hsa-miR-888	CLIP-seq
MIRT2170471	hsa-miR-3910	CLIP-seq
MIRT2170472	hsa-miR-3922-5p	CLIP-seq
MIRT2384081	hsa-miR-4718	CLIP-seq
MIRT2170473	hsa-miR-888	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IBA
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IDA	9244396, 15537755
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IEA
GO:0005515	Function	Protein binding	IPI	11399750, 25416956, 25910212, 26496610, 28514442, 29924966, 31515488, 32296183, 33961781, 35156780, 36012204
GO:0005576	Component	Extracellular region	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IC	9244396
GO:0006000	Process	Fructose metabolic process	TAS	3105602
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0008092	Function	Cytoskeletal protein binding	IDA	9244396
GO:0016829	Function	Lyase activity	IEA
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IBA
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IDA	9244396, 15537755
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0034774	Component	Secretory granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
103870	418	ENSG00000109107

P09972

Protein name

Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase)

PDB

1XFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00274	Glycolytic	15 → 364	Fructose-bisphosphate aldolase class-I	Domain

Sequence

MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYR
QVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTD
GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQ
NGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHAC
PIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTF
SYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIA
NHAY

Sequence length

364

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids HIF-1 signaling pathway		Neutrophil degranulation Glycolysis Gluconeogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	33664453	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	33737938	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Disease	Associate	33904367	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Cardiomyopathies	Associate	30246236	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Associate	38274229	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Associate	32502493	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	33607293	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	30396920	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	30396920	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36945054	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	37062455	★★★★★ ★☆☆☆☆ Found in Text Mining only
Raynaud Disease	Associate	33904367	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Associate	19405953	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	35922788	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	34456184	★★★★★ ★☆☆☆☆ Found in Text Mining only

ALDOC (aldolase, fructose-bisphosphate C)