Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22998
Gene name Gene Name - the full gene name approved by the HGNC.
LIM and calponin homology domains 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LIMCH1
Synonyms (NCBI Gene) Gene synonyms aliases
LIMCH1A, LMO7B
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p13
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005201 hsa-miR-30a-5p pSILAC 18668040
MIRT004891 hsa-miR-124-3p Microarray 15685193
MIRT004891 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT026786 hsa-miR-192-5p Microarray 19074876
MIRT005201 hsa-miR-30a-5p Proteomics;Other 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IBA 21873635
GO:0001725 Component Stress fiber IDA 28228547
GO:0001934 Process Positive regulation of protein phosphorylation IMP 28228547
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 30429017
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617750 29191 ENSG00000064042
Protein
UniProt ID Q9UPQ0
Protein name LIM and calponin homology domains-containing protein 1
Protein function Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, posit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00307 CH 23 127 Calponin homology (CH) domain Domain
PF15949 DUF4757 250 418 Domain of unknown function (DUF4757) Family
PF00412 LIM 1013 1075 LIM domain Domain
Sequence
MACPALGLEALQPLQPEPPPEPAFSEAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNA
IKPGLVKKINRLPTPIAGLDNIILFLRGCKELGLKESQLFDPSDLQDTSNRVTVKSLDYS
RKLKNVL
VTIYWLGKAANSCTSYSGTTLNLKEFEGLLAQMRKDTDDIESPKRSIRDSGYI
DCWDSERSDSLSPPRHGRDDSFDSLDSFGSRSRQTPSPDVVLRGSSDGRGSDSESDLPHR
KLPDVKKDDMSARRTSHGEPKSAVPFNQYLPNKSNQTAYVPAPLRKKKAEREEYRKSWST
ATSPLGGERPFRYGPRTPVSDDAESTSMFDMRCEEEAAVQPHSRARQEQLQLINNQLREE
DDKWQDDLARWKSRRRSVSQDLIKKEEERKKMEKLLAGEDGTSERRKSIKTYREIVQE
KE
RRERELHEAYKNARSQEEAEGILQQYIERFTISEAVLERLEMPKILERSHSTEPNLSSFL
NDPNPMKYLRQQSLPPPKFTATVETTIARASVLDTSMSAGSGSPSKTVTPKAVPMLTPKP
YSQPKNSQDVLKTFKVDGKVSVNGETVHREEEKERECPTVAPAHSLTKSQMFEGVARVHG
SPLELKQDNGSIEINIKKPNSVPQELAATTEKTEPNSQEDKNDGGKSRKGNIELASSEPQ
HFTTTVTRCSPTVAFVEFPSSPQLKNDVSEEKDQKKPENEMSGKVELVLSQKVVKPKSPE
PEATLTFPFLDKMPEANQLHLPNLNSQVDSPSSEKSPVMTPQFKFWAWDPEEERRRQEKW
QQEQERLLQERYQKEQDKLKEEWEKAQKEVEEEERRYYEEERKIIEDTVVPFTVSSSSAD
QLSTSSSMTEGSGTMNKIDLGNCQDEKQDRRWKKSFQGDDSDLLLKTRESDRLEEKGSLT
EGALAHSGNPVSKGVHEDHQLDTEAGAPHCGTNPQLAQDPSQNQQTSNPTHSSEDVKPKT
LPLDKSINHQIESPSERRKKSPREHFQAGPFSPCSPTPPGQSPNRSISGKKLCSSCGLPL
GKGAAMIIETLNLYFHIQCFRCGICKGQLGDAVSGTDVRIRNGLLNCNDCYMRSR
SAGQP
TTL
Sequence length 1083
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Migraine with Aura Migraine with Aura GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 36444609
Carcinoma Non Small Cell Lung Associate 38057344
Carcinoma Renal Cell Associate 24479813, 38268058
Cleft Palate Associate 34242216
Lung Neoplasms Associate 36444609
Lymphatic Metastasis Stimulate 36444609
Neoplasm Metastasis Stimulate 36444609
Neoplasm Metastasis Associate 38057344
Neoplasms Associate 31959624
Peripheral Nervous System Diseases Associate 36474270