Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2295
Gene name Gene Name - the full gene name approved by the HGNC.	Forkhead box F2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FOXF2
Synonyms (NCBI Gene) Gene synonyms aliases	FKHL6, FREAC-2, FREAC2
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p25.3
Summary Summary of gene provided in NCBI Entrez Gene.	FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by R

Show/Hide all(228)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007330	hsa-miR-182-5p	Luciferase reporter assay	23383207
MIRT022115	hsa-miR-124-3p	Microarray	18668037
MIRT028797	hsa-miR-26b-5p	Microarray	19088304
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT623911	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT623914	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT623913	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT623912	hsa-miR-3920	HITS-CLIP	23824327
MIRT623911	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT623910	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623909	hsa-miR-5096	HITS-CLIP	23824327
MIRT623908	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT098706	hsa-miR-519a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693396
MIRT098706	hsa-miR-519a-3p	Luciferase reporter assay, qRT-PCR, Western blot	26693396
MIRT737446	hsa-miR-182-3p	Western blotting, qRT-PCR	31933939
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT623911	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT623914	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT623913	hsa-miR-3620-3p	HITS-CLIP	23824327
MIRT623912	hsa-miR-3920	HITS-CLIP	23824327
MIRT623911	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT623910	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623909	hsa-miR-5096	HITS-CLIP	23824327
MIRT623908	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT612027	hsa-miR-8485	HITS-CLIP	23824327
MIRT612026	hsa-miR-346	HITS-CLIP	23824327
MIRT612025	hsa-miR-4288	HITS-CLIP	23824327
MIRT612024	hsa-miR-632	HITS-CLIP	23824327
MIRT612023	hsa-miR-1231	HITS-CLIP	23824327
MIRT1548884	hsa-miR-185	CLIP-seq
MIRT1548885	hsa-miR-3150b-3p	CLIP-seq
MIRT1548886	hsa-miR-3175	CLIP-seq
MIRT1548887	hsa-miR-4306	CLIP-seq
MIRT1548888	hsa-miR-4529-5p	CLIP-seq
MIRT1548889	hsa-miR-4644	CLIP-seq
MIRT1548890	hsa-miR-4779	CLIP-seq
MIRT1548891	hsa-miR-4784	CLIP-seq
MIRT1548884	hsa-miR-185	CLIP-seq
MIRT1548885	hsa-miR-3150b-3p	CLIP-seq
MIRT1548886	hsa-miR-3175	CLIP-seq
MIRT1548887	hsa-miR-4306	CLIP-seq
MIRT1548888	hsa-miR-4529-5p	CLIP-seq
MIRT1548889	hsa-miR-4644	CLIP-seq
MIRT1548890	hsa-miR-4779	CLIP-seq
MIRT1548891	hsa-miR-4784	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	8626802
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	8626802
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	8626802
GO:0001837	Process	Epithelial to mesenchymal transition	NAS	19220249
GO:0003677	Function	DNA binding	IDA	7957066
GO:0003700	Function	DNA-binding transcription factor activity	IDA	9722567
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IC	8626802
GO:0005634	Component	Nucleus	IDA	9722567, 9799607, 29374064
GO:0005667	Component	Transcription regulator complex	IDA	9722567
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0008134	Function	Transcription factor binding	IPI	9722567
GO:0009887	Process	Animal organ morphogenesis	IBA	21873635
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0032434	Process	Regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	29374064
GO:0042249	Process	Establishment of planar polarity of embryonic epithelium	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	7957066, 8626802
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	8626802
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	8626802
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	8626802
GO:0048566	Process	Embryonic digestive tract development	IEA
GO:0048596	Process	Embryonic camera-type eye morphogenesis	IEA
GO:0048806	Process	Genitalia development	IMP	19276632
GO:0060021	Process	Roof of mouth development	IMP	19276632
GO:1902914	Process	Regulation of protein polyubiquitination	IDA	29374064

MIM	HGNC	e!Ensembl
603250	3810	ENSG00000137273

Protein

UniProt ID

Q12947

Protein name

Forkhead box protein F2 (Forkhead-related activator 2) (FREAC-2) (Forkhead-related protein FKHL6) (Forkhead-related transcription factor 2)

Protein function

Probable transcription activator for a number of lung-specific genes (PubMed:8626802). Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (PubMed:29374064). {ECO:0000269|PubMed:29374064, ECO:00002

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00250	Forkhead	99 → 185	Forkhead domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Lung and placenta (PubMed:8626802). Predominantly expressed in gastrointestinal tract including stomach (PubMed:29374064). {ECO:0000269|PubMed:29374064, ECO:0000269|PubMed:8626802}.

Sequence

MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPETTSSSSSSSSASCASSS
SSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYIALIVMAIQSSPSKR
LTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPAS
EFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGASLLPQGFDFQAPPSAPLGCHSQ
GGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAA
GGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYTSPAAHWSSPGASPYLKQPPALTPSSN
PAASAGLHSSMSSYSLEQSYLHQNAREDLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFH
PSASGSYYHHHHQSVCQDIKPCVM

Sequence length

444

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Erectile Dysfunction	Erectile Dysfunction	GWAS
Astrocytoma	Astrocytoma	GWAS

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining
Agranulocytosis	Associate	27157822
Ascending aortic aneurysm hypertelorism bifid uvula cleft palate and arterial tortuosity	Associate	30917284
Breast Neoplasms	Associate	23620774, 26070560, 28829888, 35660418
Breast Neoplasms	Inhibit	26210254
Bronchopulmonary Dysplasia	Associate	30459472
Carcinoma Non Small Cell Lung	Associate	27487137
Carcinoma Non Small Cell Lung	Stimulate	31858547
Cleft Palate	Associate	19276632, 30917284
Colorectal Neoplasms	Associate	28849155, 30987631, 32103872
Developmental Disabilities	Associate	19276632
Disorders of Sex Development	Associate	19276632
Endometrial Neoplasms	Associate	36373483
Esophageal Squamous Cell Carcinoma	Associate	28222662
Lung Neoplasms	Associate	28829888
Lymphatic Metastasis	Associate	28222662, 32103872
Microcephaly seizures genital hypoplasia	Associate	19276632
Neoplasm Metastasis	Associate	23620774, 28121627, 35660418
Neoplasm Metastasis	Inhibit	28829888
Neoplasms	Associate	23620774, 28222662, 35660418
Pediatric Obesity	Associate	30459472
Prostatic Hyperplasia	Associate	37705744
Reflex Abnormal	Associate	30917284
Squamous Cell Carcinoma of Head and Neck	Associate	32014885
Triple Negative Breast Neoplasms	Associate	23620774, 26210254

FOXF2 (forkhead box F2)