SCAP (SREBF chaperone)

Gene

• Entrez ID: 22937
• Gene name: SREBF chaperone
• Gene symbol: SCAP
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p21.31
• Summary: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBP

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047561	hsa-miR-10a-5p	CLASH	23622248
MIRT047270	hsa-miR-181b-5p	CLASH	23622248
MIRT041708	hsa-miR-484	CLASH	23622248
MIRT038810	hsa-miR-93-3p	CLASH	23622248
MIRT2321741	hsa-miR-148a	CLIP-seq
MIRT2321742	hsa-miR-148b	CLIP-seq
MIRT2321743	hsa-miR-152	CLIP-seq
MIRT2321744	hsa-miR-1827	CLIP-seq
MIRT2321745	hsa-miR-328	CLIP-seq
MIRT2321746	hsa-miR-33a	CLIP-seq
MIRT2321747	hsa-miR-33b	CLIP-seq
MIRT2321748	hsa-miR-3612	CLIP-seq
MIRT2321749	hsa-miR-3652	CLIP-seq
MIRT2321750	hsa-miR-4276	CLIP-seq
MIRT2321751	hsa-miR-4430	CLIP-seq
MIRT2321752	hsa-miR-4433	CLIP-seq
MIRT2321753	hsa-miR-4459	CLIP-seq
MIRT2321754	hsa-miR-4695-5p	CLIP-seq
MIRT2321755	hsa-miR-4768-3p	CLIP-seq
MIRT2321756	hsa-miR-4795-3p	CLIP-seq
MIRT2321757	hsa-miR-556-3p	CLIP-seq
MIRT2321758	hsa-miR-582-5p	CLIP-seq
MIRT2321759	hsa-miR-650	CLIP-seq
MIRT2321760	hsa-miR-656	CLIP-seq
MIRT2321761	hsa-miR-7	CLIP-seq
MIRT2321762	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	32111832
GO:0000139	Component	Golgi membrane	TAS
GO:0001666	Process	Response to hypoxia	IEA
GO:0005515	Function	Protein binding	IPI	17428920, 19706601, 32111832
GO:0005783	Component	Endoplasmic reticulum	NAS	11726962
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	32111832
GO:0005794	Component	Golgi apparatus	NAS	11726962
GO:0006955	Process	Immune response	IEA
GO:0007568	Process	Aging	IEA
GO:0008203	Process	Cholesterol metabolic process	ISS
GO:0012507	Component	ER to Golgi transport vesicle membrane	IEA
GO:0016021	Component	Integral component of membrane	NAS	11726962
GO:0032868	Process	Response to insulin	IEA
GO:0032933	Process	SREBP signaling pathway	IDA	32322062
GO:0032933	Process	SREBP signaling pathway	IMP	11726962
GO:0032934	Function	Sterol binding	ISS
GO:0032991	Component	Protein-containing complex	IEA
GO:0042304	Process	Regulation of fatty acid biosynthetic process	IEA
GO:0044255	Process	Cellular lipid metabolic process	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045541	Process	Negative regulation of cholesterol biosynthetic process	NAS
GO:0045542	Process	Positive regulation of cholesterol biosynthetic process	IDA	32322062
GO:0051082	Function	Unfolded protein binding	NAS	11726962
GO:0090110	Process	COPII-coated vesicle cargo loading	ISS

Other IDs

• MIM: 601510
• HGNC: 30634
• e!Ensembl: ENSG00000114650

Protein

• UniProt ID: Q12770
• Protein name: Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)
• Protein function: Escort protein required for cholesterol as well as lipid homeostasis (By similarity). Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regula
• PDB: 6M49, 7ETW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12349	Sterol-sensing	308 → 457	Sterol-sensing domain of SREBP cleavage-activation	Family
  PF00400	WD40	1109 → 1146	WD domain, G-beta repeat	Repeat

• Sequence:

  MTLTERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTP
  VKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLAVDVFRSPLS
  RAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN
  DWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRMVSYTITLVF
  QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIY
  FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN
  VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLF
  AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPSAKPVGQPTRYERQLAV
  RPSTPHTITLQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR
  NYLAAQVTEQSPLGEGALAPMPVPSGMLPPSHPDPAFSIFPPDAPKLPENQTSPGESPER
  GGPAEVVHDSPVPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYISLLPVIPVTLR
  LNPREALEGRHPQDGRSAWPPPGPIPAGHWEAGPKGPGGVQAHGDVTLYKVAALGLATGI
  VLVLLLLCLYRVLCPRNYGQLGGGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE
  CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPRPGRQRRDSGVGSGLEAQESWERLSDG
  GKAGPEEPGDSPPLRHRPRGPPPPSLFGDQPDLTCLIDTNFSAQPRSSQPTQPEPRHRAV
  CGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSL
  AWAPSAEGSIWSLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRI
  VAARLNGSLDFFSLETHTALSPLQFRGTPGRGSSPASPVYSSSDTVACHLTHTVPCAHQK
  PITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDG
  AICLWDVLTGSRVSHVFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKFYSIQQDL
  GCGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVC
  NFGSELSLVYVPSVLEKLD

• Sequence length: 1279

Pathways

Reactome:

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Atherosclerosis	Associate	12436350
Carcinoma Non Small Cell Lung	Associate	35806291
Diabetes Mellitus	Associate	30907055
Dyslipidemias	Associate	24191141
Hepatitis B	Associate	37437369
HIV Infections	Associate	24191141
Hyperlipoproteinemia Type II	Associate	32811528
Hyperlysinemias	Stimulate	21511699
Hypertension	Associate	28542467
Inflammation	Stimulate	23115640
Mesangial sclerosis diffuse	Associate	21511699
Neoplasms	Associate	31360104, 35534729
Neoplasms	Inhibit	35806291
Obesity	Associate	25028659, 28542467
Overweight	Associate	28542467
Precancerous Conditions	Stimulate	31360104
Thymoma	Associate	33704915
Urinary Bladder Neoplasms	Associate	31360104