Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	22921
Gene name	Methionine sulfoxide reductase B2
Gene symbol	MSRB2
Synonyms (NCBI Gene)	CBS-1CBS1CGI-131MSRBPILB
Chromosome	10
Chromosome location	10p12.2

211

Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT684208	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684207	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684206	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684205	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684204	hsa-miR-302e	HITS-CLIP	23313552
MIRT684203	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684202	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684201	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684200	hsa-miR-520b	HITS-CLIP	23313552
MIRT684199	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684198	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684197	hsa-miR-520e	HITS-CLIP	23313552
MIRT684196	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684195	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT684194	hsa-miR-3665	HITS-CLIP	23313552
MIRT684193	hsa-miR-657	HITS-CLIP	23313552
MIRT684192	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684191	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684190	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT684189	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT684188	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT684187	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT684186	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT662810	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT662809	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662808	hsa-miR-561-5p	HITS-CLIP	23824327
MIRT662807	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662806	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662805	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662804	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662803	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662802	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662801	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662800	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662799	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662798	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662797	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662796	hsa-miR-3122	HITS-CLIP	23824327
MIRT662795	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662794	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662793	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT684208	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT684207	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT684206	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT684205	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT684204	hsa-miR-302e	HITS-CLIP	23313552
MIRT684203	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT684202	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT684201	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT684200	hsa-miR-520b	HITS-CLIP	23313552
MIRT684199	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT684198	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT684197	hsa-miR-520e	HITS-CLIP	23313552
MIRT684196	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT684195	hsa-miR-3934-5p	HITS-CLIP	23313552
MIRT684194	hsa-miR-3665	HITS-CLIP	23313552
MIRT684193	hsa-miR-657	HITS-CLIP	23313552
MIRT684192	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT684191	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT684190	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT684189	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT684188	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT684187	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT684186	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT662810	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT662809	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT662808	hsa-miR-561-5p	HITS-CLIP	23824327
MIRT662807	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT662806	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT662805	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT662804	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT662803	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT662802	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT662801	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT662800	hsa-miR-3689c	HITS-CLIP	23824327
MIRT662799	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT662798	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT662797	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT662796	hsa-miR-3122	HITS-CLIP	23824327
MIRT662795	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT662794	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT662793	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT1161821	hsa-miR-105	CLIP-seq
MIRT1161822	hsa-miR-125a-3p	CLIP-seq
MIRT1161823	hsa-miR-1266	CLIP-seq
MIRT1161824	hsa-miR-127-5p	CLIP-seq
MIRT1161825	hsa-miR-1292	CLIP-seq
MIRT1161826	hsa-miR-1297	CLIP-seq
MIRT1161827	hsa-miR-219-2-3p	CLIP-seq
MIRT1161828	hsa-miR-26a	CLIP-seq
MIRT1161829	hsa-miR-26b	CLIP-seq
MIRT1161830	hsa-miR-2964a-3p	CLIP-seq
MIRT1161831	hsa-miR-31	CLIP-seq
MIRT1161832	hsa-miR-3159	CLIP-seq
MIRT1161833	hsa-miR-3160-5p	CLIP-seq
MIRT1161834	hsa-miR-3179	CLIP-seq
MIRT1161835	hsa-miR-3190	CLIP-seq
MIRT1161836	hsa-miR-3591-5p	CLIP-seq
MIRT1161837	hsa-miR-3606	CLIP-seq
MIRT1161838	hsa-miR-3664-3p	CLIP-seq
MIRT1161839	hsa-miR-3686	CLIP-seq
MIRT1161840	hsa-miR-3688-5p	CLIP-seq
MIRT1161841	hsa-miR-382	CLIP-seq
MIRT1161842	hsa-miR-3934	CLIP-seq
MIRT1161843	hsa-miR-3936	CLIP-seq
MIRT1161844	hsa-miR-4264	CLIP-seq
MIRT1161845	hsa-miR-4275	CLIP-seq
MIRT1161846	hsa-miR-4426	CLIP-seq
MIRT1161847	hsa-miR-4465	CLIP-seq
MIRT1161848	hsa-miR-4518	CLIP-seq
MIRT1161849	hsa-miR-4520a-3p	CLIP-seq
MIRT1161850	hsa-miR-4520b-3p	CLIP-seq
MIRT1161851	hsa-miR-4529-3p	CLIP-seq
MIRT1161852	hsa-miR-4635	CLIP-seq
MIRT1161853	hsa-miR-4647	CLIP-seq
MIRT1161854	hsa-miR-4651	CLIP-seq
MIRT1161855	hsa-miR-4652-3p	CLIP-seq
MIRT1161856	hsa-miR-4662b	CLIP-seq
MIRT1161857	hsa-miR-4677-3p	CLIP-seq
MIRT1161858	hsa-miR-4678	CLIP-seq
MIRT1161859	hsa-miR-4699-5p	CLIP-seq
MIRT1161860	hsa-miR-4709-3p	CLIP-seq
MIRT1161861	hsa-miR-4752	CLIP-seq
MIRT1161862	hsa-miR-510	CLIP-seq
MIRT1161863	hsa-miR-512-5p	CLIP-seq
MIRT1161864	hsa-miR-518a-5p	CLIP-seq
MIRT1161865	hsa-miR-527	CLIP-seq
MIRT1161866	hsa-miR-590-3p	CLIP-seq
MIRT1161867	hsa-miR-608	CLIP-seq
MIRT1161868	hsa-miR-622	CLIP-seq
MIRT1161869	hsa-miR-764	CLIP-seq
MIRT1161870	hsa-miR-767-5p	CLIP-seq
MIRT1161871	hsa-miR-921	CLIP-seq
MIRT1161839	hsa-miR-3686	CLIP-seq
MIRT1161823	hsa-miR-1266	CLIP-seq
MIRT1161824	hsa-miR-127-5p	CLIP-seq
MIRT1161826	hsa-miR-1297	CLIP-seq
MIRT1161827	hsa-miR-219-2-3p	CLIP-seq
MIRT2046412	hsa-miR-25	CLIP-seq
MIRT1161828	hsa-miR-26a	CLIP-seq
MIRT1161829	hsa-miR-26b	CLIP-seq
MIRT1161830	hsa-miR-2964a-3p	CLIP-seq
MIRT1161831	hsa-miR-31	CLIP-seq
MIRT2046413	hsa-miR-3134	CLIP-seq
MIRT1161834	hsa-miR-3179	CLIP-seq
MIRT1161835	hsa-miR-3190	CLIP-seq
MIRT2046414	hsa-miR-32	CLIP-seq
MIRT2046415	hsa-miR-363	CLIP-seq
MIRT1161838	hsa-miR-3664-3p	CLIP-seq
MIRT2046416	hsa-miR-367	CLIP-seq
MIRT2046417	hsa-miR-3674	CLIP-seq
MIRT2046418	hsa-miR-3688-3p	CLIP-seq
MIRT1161840	hsa-miR-3688-5p	CLIP-seq
MIRT2046419	hsa-miR-370	CLIP-seq
MIRT1161843	hsa-miR-3936	CLIP-seq
MIRT1161844	hsa-miR-4264	CLIP-seq
MIRT2046420	hsa-miR-4268	CLIP-seq
MIRT1161845	hsa-miR-4275	CLIP-seq
MIRT1161847	hsa-miR-4465	CLIP-seq
MIRT1161848	hsa-miR-4518	CLIP-seq
MIRT2046421	hsa-miR-4534	CLIP-seq
MIRT1161854	hsa-miR-4651	CLIP-seq
MIRT2046422	hsa-miR-4659a-5p	CLIP-seq
MIRT2046423	hsa-miR-4659b-5p	CLIP-seq
MIRT1161857	hsa-miR-4677-3p	CLIP-seq
MIRT1161858	hsa-miR-4678	CLIP-seq
MIRT1161861	hsa-miR-4752	CLIP-seq
MIRT1161862	hsa-miR-510	CLIP-seq
MIRT1161863	hsa-miR-512-5p	CLIP-seq
MIRT1161864	hsa-miR-518a-5p	CLIP-seq
MIRT1161865	hsa-miR-527	CLIP-seq
MIRT1161867	hsa-miR-608	CLIP-seq
MIRT1161868	hsa-miR-622	CLIP-seq
MIRT2046424	hsa-miR-92a	CLIP-seq
MIRT2046425	hsa-miR-92b	CLIP-seq
MIRT1161824	hsa-miR-127-5p	CLIP-seq
MIRT1161826	hsa-miR-1297	CLIP-seq
MIRT1161827	hsa-miR-219-2-3p	CLIP-seq
MIRT1161828	hsa-miR-26a	CLIP-seq
MIRT1161829	hsa-miR-26b	CLIP-seq
MIRT1161830	hsa-miR-2964a-3p	CLIP-seq
MIRT2046413	hsa-miR-3134	CLIP-seq
MIRT2275503	hsa-miR-3174	CLIP-seq
MIRT1161835	hsa-miR-3190	CLIP-seq
MIRT2046418	hsa-miR-3688-3p	CLIP-seq
MIRT2046419	hsa-miR-370	CLIP-seq
MIRT2046420	hsa-miR-4268	CLIP-seq
MIRT1161845	hsa-miR-4275	CLIP-seq
MIRT1161847	hsa-miR-4465	CLIP-seq
MIRT2046421	hsa-miR-4534	CLIP-seq
MIRT2046422	hsa-miR-4659a-5p	CLIP-seq
MIRT2046423	hsa-miR-4659b-5p	CLIP-seq
MIRT1161857	hsa-miR-4677-3p	CLIP-seq
MIRT1161861	hsa-miR-4752	CLIP-seq
MIRT2275504	hsa-miR-4765	CLIP-seq
MIRT1161824	hsa-miR-127-5p	CLIP-seq
MIRT2046413	hsa-miR-3134	CLIP-seq
MIRT1161835	hsa-miR-3190	CLIP-seq
MIRT2046418	hsa-miR-3688-3p	CLIP-seq
MIRT2046421	hsa-miR-4534	CLIP-seq
MIRT2391124	hsa-miR-561	CLIP-seq
MIRT2685426	hsa-miR-18a	CLIP-seq
MIRT2685427	hsa-miR-18b	CLIP-seq
MIRT2685428	hsa-miR-1909	CLIP-seq
MIRT1161827	hsa-miR-219-2-3p	CLIP-seq
MIRT1161835	hsa-miR-3190	CLIP-seq
MIRT2685429	hsa-miR-3202	CLIP-seq
MIRT2046417	hsa-miR-3674	CLIP-seq
MIRT2685430	hsa-miR-4533	CLIP-seq
MIRT2685431	hsa-miR-4735-3p	CLIP-seq
MIRT2685432	hsa-miR-633	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0005515	Function	Protein binding	IPI	27499296, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	ISS	14699060
GO:0005829	Component	Cytosol	TAS
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	ISS	14699060
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016671	Function	Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEA
GO:0030041	Process	Actin filament polymerization	IEA
GO:0030041	Process	Actin filament polymerization	ISS
GO:0030091	Process	Protein repair	IEA
GO:0030091	Process	Protein repair	IEA
GO:0030091	Process	Protein repair	ISS	14699060
GO:0030091	Process	Protein repair	TAS
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IBA
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IEA
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	ISS	14699060
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	TAS
GO:0033745	Function	L-methionine-(R)-S-oxide reductase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
613782	17061	ENSG00000148450

Q9Y3D2

Protein name

Methionine-R-sulfoxide reductase B2, mitochondrial (MsrB2) (EC 1.8.4.12) (EC 1.8.4.14)

Protein function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-tra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01641	SelR	53 → 179	SelR domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. {ECO:0000269|PubMed:10375640, ECO

Sequence

MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTP
EQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTS
GSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPR
KH

Sequence length

182

Interactions

View interactions

	Reactome
			Protein repair

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Leukemia	Associate	18424444	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	18424444	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitiligo	Inhibit	17943184	★★★★★ ★☆☆☆☆ Found in Text Mining only

MSRB2 (methionine sulfoxide reductase B2)