EPN2 (epsin 2)

Gene

• Entrez ID: 22905
• Gene name: Epsin 2
• Gene symbol: EPN2
• Synonyms (NCBI Gene): EHB21
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018537	hsa-miR-335-5p	Reporter assay;Western blot	21618216
MIRT040434	hsa-miR-615-3p	CLASH	23622248
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT727759	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727758	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT967063	hsa-miR-1233	CLIP-seq
MIRT967064	hsa-miR-1321	CLIP-seq
MIRT967065	hsa-miR-148a	CLIP-seq
MIRT967066	hsa-miR-148b	CLIP-seq
MIRT967067	hsa-miR-152	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT967069	hsa-miR-3692	CLIP-seq
MIRT967070	hsa-miR-3922-5p	CLIP-seq
MIRT967071	hsa-miR-4257	CLIP-seq
MIRT967072	hsa-miR-4293	CLIP-seq
MIRT967073	hsa-miR-4419a	CLIP-seq
MIRT967074	hsa-miR-4443	CLIP-seq
MIRT967075	hsa-miR-4473	CLIP-seq
MIRT967076	hsa-miR-4510	CLIP-seq
MIRT967077	hsa-miR-4659a-3p	CLIP-seq
MIRT967078	hsa-miR-4659b-3p	CLIP-seq
MIRT967079	hsa-miR-4662a-5p	CLIP-seq
MIRT967080	hsa-miR-4671-3p	CLIP-seq
MIRT967081	hsa-miR-4705	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT967083	hsa-miR-4739	CLIP-seq
MIRT967084	hsa-miR-4756-5p	CLIP-seq
MIRT967085	hsa-miR-4766-5p	CLIP-seq
MIRT967086	hsa-miR-4769-3p	CLIP-seq
MIRT967087	hsa-miR-520f	CLIP-seq
MIRT967088	hsa-miR-596	CLIP-seq
MIRT967089	hsa-miR-7	CLIP-seq
MIRT967090	hsa-miR-765	CLIP-seq
MIRT967091	hsa-miR-1224-5p	CLIP-seq
MIRT967092	hsa-miR-1262	CLIP-seq
MIRT967093	hsa-miR-1290	CLIP-seq
MIRT967094	hsa-miR-1294	CLIP-seq
MIRT967095	hsa-miR-132	CLIP-seq
MIRT967064	hsa-miR-1321	CLIP-seq
MIRT967096	hsa-miR-155	CLIP-seq
MIRT967097	hsa-miR-186	CLIP-seq
MIRT967098	hsa-miR-197	CLIP-seq
MIRT967099	hsa-miR-200b	CLIP-seq
MIRT967100	hsa-miR-200c	CLIP-seq
MIRT967101	hsa-miR-212	CLIP-seq
MIRT967102	hsa-miR-28-5p	CLIP-seq
MIRT967103	hsa-miR-3133	CLIP-seq
MIRT967104	hsa-miR-3139	CLIP-seq
MIRT967105	hsa-miR-3159	CLIP-seq
MIRT967106	hsa-miR-3612	CLIP-seq
MIRT967107	hsa-miR-3975	CLIP-seq
MIRT967108	hsa-miR-421	CLIP-seq
MIRT967109	hsa-miR-429	CLIP-seq
MIRT967073	hsa-miR-4419a	CLIP-seq
MIRT967074	hsa-miR-4443	CLIP-seq
MIRT967076	hsa-miR-4510	CLIP-seq
MIRT967110	hsa-miR-4633-3p	CLIP-seq
MIRT967111	hsa-miR-4701-3p	CLIP-seq
MIRT967112	hsa-miR-4709-5p	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT967083	hsa-miR-4739	CLIP-seq
MIRT967114	hsa-miR-4744	CLIP-seq
MIRT967115	hsa-miR-4751	CLIP-seq
MIRT967084	hsa-miR-4756-5p	CLIP-seq
MIRT967116	hsa-miR-4760-3p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT967118	hsa-miR-505	CLIP-seq
MIRT967119	hsa-miR-541	CLIP-seq
MIRT967120	hsa-miR-548an	CLIP-seq
MIRT967121	hsa-miR-582-5p	CLIP-seq
MIRT967122	hsa-miR-610	CLIP-seq
MIRT967123	hsa-miR-650	CLIP-seq
MIRT967124	hsa-miR-654-5p	CLIP-seq
MIRT967089	hsa-miR-7	CLIP-seq
MIRT967125	hsa-miR-708	CLIP-seq
MIRT1986461	hsa-miR-1207-3p	CLIP-seq
MIRT1986462	hsa-miR-1293	CLIP-seq
MIRT967095	hsa-miR-132	CLIP-seq
MIRT1986463	hsa-miR-1323	CLIP-seq
MIRT1986464	hsa-miR-1343	CLIP-seq
MIRT1986465	hsa-miR-1915	CLIP-seq
MIRT967101	hsa-miR-212	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT1986466	hsa-miR-3192	CLIP-seq
MIRT1986467	hsa-miR-3194-3p	CLIP-seq
MIRT1986468	hsa-miR-3199	CLIP-seq
MIRT1986469	hsa-miR-326	CLIP-seq
MIRT1986470	hsa-miR-330-5p	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT1986472	hsa-miR-3907	CLIP-seq
MIRT967108	hsa-miR-421	CLIP-seq
MIRT1986473	hsa-miR-4251	CLIP-seq
MIRT1986474	hsa-miR-4305	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT1986476	hsa-miR-433	CLIP-seq
MIRT1986477	hsa-miR-4462	CLIP-seq
MIRT1986478	hsa-miR-4483	CLIP-seq
MIRT1986479	hsa-miR-4646-5p	CLIP-seq
MIRT1986480	hsa-miR-4680-5p	CLIP-seq
MIRT1986481	hsa-miR-4691-3p	CLIP-seq
MIRT967112	hsa-miR-4709-5p	CLIP-seq
MIRT1986482	hsa-miR-4726-3p	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT1986483	hsa-miR-4740-5p	CLIP-seq
MIRT1986484	hsa-miR-4757-5p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT967118	hsa-miR-505	CLIP-seq
MIRT1986485	hsa-miR-539	CLIP-seq
MIRT1986486	hsa-miR-548aa	CLIP-seq
MIRT1986487	hsa-miR-548o	CLIP-seq
MIRT1986488	hsa-miR-548u	CLIP-seq
MIRT1986489	hsa-miR-618	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT1986491	hsa-miR-764	CLIP-seq
MIRT1986492	hsa-miR-873	CLIP-seq
MIRT1986463	hsa-miR-1323	CLIP-seq
MIRT2220986	hsa-miR-3184	CLIP-seq
MIRT1986468	hsa-miR-3199	CLIP-seq
MIRT2220987	hsa-miR-423-5p	CLIP-seq
MIRT1986474	hsa-miR-4305	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT1986487	hsa-miR-548o	CLIP-seq
MIRT2220988	hsa-miR-1254	CLIP-seq
MIRT2220989	hsa-miR-1288	CLIP-seq
MIRT2220990	hsa-miR-187	CLIP-seq
MIRT2220991	hsa-miR-3116	CLIP-seq
MIRT2220992	hsa-miR-3158-3p	CLIP-seq
MIRT2220993	hsa-miR-3169	CLIP-seq
MIRT2220994	hsa-miR-342-5p	CLIP-seq
MIRT2220995	hsa-miR-3657	CLIP-seq
MIRT2220996	hsa-miR-3944-3p	CLIP-seq
MIRT2220997	hsa-miR-4278	CLIP-seq
MIRT2220998	hsa-miR-4446-3p	CLIP-seq
MIRT2220999	hsa-miR-4492	CLIP-seq
MIRT2221000	hsa-miR-4498	CLIP-seq
MIRT2221001	hsa-miR-4505	CLIP-seq
MIRT2221002	hsa-miR-4651	CLIP-seq
MIRT2221003	hsa-miR-4656	CLIP-seq
MIRT2221004	hsa-miR-4664-5p	CLIP-seq
MIRT2221005	hsa-miR-4688	CLIP-seq
MIRT2221006	hsa-miR-4731-5p	CLIP-seq
MIRT2221007	hsa-miR-608	CLIP-seq
MIRT2221008	hsa-miR-637	CLIP-seq
MIRT2221009	hsa-miR-661	CLIP-seq
MIRT2221010	hsa-miR-762	CLIP-seq
MIRT2524740	hsa-miR-1252	CLIP-seq
MIRT2524741	hsa-miR-1285	CLIP-seq
MIRT2524742	hsa-miR-1291	CLIP-seq
MIRT2524743	hsa-miR-224	CLIP-seq
MIRT2524744	hsa-miR-25	CLIP-seq
MIRT2524745	hsa-miR-3130-3p	CLIP-seq
MIRT2524746	hsa-miR-3136-3p	CLIP-seq
MIRT2524747	hsa-miR-3147	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT2524748	hsa-miR-3187-5p	CLIP-seq
MIRT2524749	hsa-miR-32	CLIP-seq
MIRT2524750	hsa-miR-363	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT2524751	hsa-miR-367	CLIP-seq
MIRT2524752	hsa-miR-3679-3p	CLIP-seq
MIRT2524753	hsa-miR-378g	CLIP-seq
MIRT2524754	hsa-miR-3973	CLIP-seq
MIRT2524755	hsa-miR-4260	CLIP-seq
MIRT2524756	hsa-miR-4286	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT2524757	hsa-miR-4425	CLIP-seq
MIRT2524758	hsa-miR-4486	CLIP-seq
MIRT2524759	hsa-miR-4707-5p	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT2524760	hsa-miR-4781-3p	CLIP-seq
MIRT2524761	hsa-miR-4786-5p	CLIP-seq
MIRT2524762	hsa-miR-4793-5p	CLIP-seq
MIRT2524763	hsa-miR-520g	CLIP-seq
MIRT2524764	hsa-miR-520h	CLIP-seq
MIRT2524765	hsa-miR-554	CLIP-seq
MIRT2524766	hsa-miR-612	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT2524767	hsa-miR-92a	CLIP-seq
MIRT2524768	hsa-miR-92b	CLIP-seq
MIRT2524769	hsa-miR-934	CLIP-seq
MIRT2524740	hsa-miR-1252	CLIP-seq
MIRT2524741	hsa-miR-1285	CLIP-seq
MIRT2524742	hsa-miR-1291	CLIP-seq
MIRT2524744	hsa-miR-25	CLIP-seq
MIRT2524745	hsa-miR-3130-3p	CLIP-seq
MIRT2524746	hsa-miR-3136-3p	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT2524748	hsa-miR-3187-5p	CLIP-seq
MIRT2524749	hsa-miR-32	CLIP-seq
MIRT2524750	hsa-miR-363	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT2524751	hsa-miR-367	CLIP-seq
MIRT2524753	hsa-miR-378g	CLIP-seq
MIRT2524756	hsa-miR-4286	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT2524758	hsa-miR-4486	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT2524762	hsa-miR-4793-5p	CLIP-seq
MIRT2524765	hsa-miR-554	CLIP-seq
MIRT2524766	hsa-miR-612	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT2524767	hsa-miR-92a	CLIP-seq
MIRT2524768	hsa-miR-92b	CLIP-seq
MIRT2524769	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18199683, 32296183, 37207277
GO:0005543	Function	Phospholipid binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030276	Function	Clathrin binding	IBA
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP	28717225
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045747	Process	Positive regulation of Notch signaling pathway	IMP	28717225
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IMP	28717225

Other IDs

• MIM: 607263
• HGNC: 18639
• e!Ensembl: ENSG00000072134

Protein

• UniProt ID: O95208
• Protein name: Epsin-2 (EPS-15-interacting protein 2)
• Protein function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01417	ENTH	17 → 140	ENTH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression is found in brain. Detected at lower levels in lung and liver. {ECO:0000269|PubMed:10567358}.
• Sequence:

  MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMV
  WKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQG
  INVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTS
  HSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPN
  GDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRG
  DDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSAST
  NQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASS
  AGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQ
  NNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFL
  APGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQP
  ALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL

• Sequence length: 641

Pathways

KEGG:

Endocytosis

Reactome:

Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cholangiocarcinoma	Uncertain significance	rs2152239388	RCV005937467

Associations from Text Mining
Disease Name	Relationship Type	References
Dementia Vascular	Associate	39909351