Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22904
Gene name Gene Name - the full gene name approved by the HGNC.	Strawberry notch homolog 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SBNO2
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA0963, SNO, STNO
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3

Show/Hide all(49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022166	hsa-miR-124-3p	Microarray	18668037
MIRT028257	hsa-miR-32-5p	Sequencing	20371350
MIRT050357	hsa-miR-25-3p	CLASH	23622248
MIRT1327209	hsa-miR-1275	CLIP-seq
MIRT1327210	hsa-miR-153	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT1327212	hsa-miR-4419a	CLIP-seq
MIRT1327213	hsa-miR-4446-3p	CLIP-seq
MIRT1327214	hsa-miR-448	CLIP-seq
MIRT1327215	hsa-miR-4492	CLIP-seq
MIRT1327216	hsa-miR-4498	CLIP-seq
MIRT1327217	hsa-miR-4505	CLIP-seq
MIRT1327218	hsa-miR-4510	CLIP-seq
MIRT1327219	hsa-miR-4525	CLIP-seq
MIRT1327220	hsa-miR-4665-5p	CLIP-seq
MIRT1327221	hsa-miR-4723-5p	CLIP-seq
MIRT1327222	hsa-miR-4728-5p	CLIP-seq
MIRT1327223	hsa-miR-4731-5p	CLIP-seq
MIRT1327224	hsa-miR-625	CLIP-seq
MIRT1327225	hsa-miR-637	CLIP-seq
MIRT1327226	hsa-miR-762	CLIP-seq
MIRT1327227	hsa-miR-1200	CLIP-seq
MIRT1327228	hsa-miR-125a-5p	CLIP-seq
MIRT1327229	hsa-miR-125b	CLIP-seq
MIRT1327230	hsa-miR-3074-5p	CLIP-seq
MIRT1327231	hsa-miR-3170	CLIP-seq
MIRT1327232	hsa-miR-3663-3p	CLIP-seq
MIRT1327233	hsa-miR-4319	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097173	hsa-miR-1234	CLIP-seq
MIRT2097174	hsa-miR-124	CLIP-seq
MIRT2097175	hsa-miR-2861	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT2097176	hsa-miR-3192	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT2097177	hsa-miR-4493	CLIP-seq
MIRT2097178	hsa-miR-4750	CLIP-seq
MIRT2097179	hsa-miR-4792	CLIP-seq
MIRT2097180	hsa-miR-506	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097181	hsa-miR-661	CLIP-seq
MIRT2321514	hsa-miR-1225-3p	CLIP-seq
MIRT2321515	hsa-miR-499-3p	CLIP-seq
MIRT2321516	hsa-miR-499a-3p	CLIP-seq
MIRT2394064	hsa-miR-1280	CLIP-seq
MIRT2394065	hsa-miR-4286	CLIP-seq
MIRT2442588	hsa-miR-361-3p	CLIP-seq
MIRT2442589	hsa-miR-4707-5p	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002281	Process	Macrophage activation involved in immune response	IBA	21873635
GO:0002281	Process	Macrophage activation involved in immune response	IMP	18025162
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0030282	Process	Bone mineralization	IEA
GO:0030316	Process	Osteoclast differentiation	IBA	21873635
GO:0031490	Function	Chromatin DNA binding	IBA	21873635
GO:0042393	Function	Histone binding	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IBA	21873635
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	18025162
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0050727	Process	Regulation of inflammatory response	IBA	21873635
GO:0050727	Process	Regulation of inflammatory response	IMP	18025162
GO:0061430	Process	Bone trabecula morphogenesis	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071348	Process	Cellular response to interleukin-11	ISS
GO:0071354	Process	Cellular response to interleukin-6	IBA	21873635
GO:0071354	Process	Cellular response to interleukin-6	IDA	25903009
GO:0072675	Process	Osteoclast fusion	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	ISS

MIM	HGNC	e!Ensembl
615729	29158	ENSG00000064932

Protein

UniProt ID

Q9Y2G9

Protein name

Protein strawberry notch homolog 2

Protein function

Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13872	AAA_34	215 → 505	P-loop containing NTP hydrolase pore-1	Domain
PF13871	Helicase_C_4	732 → 1010	C-terminal domain on Strawberry notch homologue	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. {ECO:0000269|PubMed:18025162}.

Sequence

MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMS
SASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDT
PDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQS
QPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLAL
PSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGR
KKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQ
AGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYAS
ATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQ
LSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAH
QRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAA
EGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESD
PGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLD
KVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHV
NLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGR
THRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENK
YGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVE
KDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYE
ESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSC
LLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHS
AWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKD
RKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLT
YSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDML
RSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL

Sequence length

1366

Interactions

View interactions

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908, 26192919
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	22190364
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	22373040

Show/Hide Unknown Diseases (9)

Disease term	Disease name	Evidence	References	Source
Unknown
Asthma	Asthma, Childhood asthma		30929738, 31036433	ClinVar, GWAS
Crohn disease	Crohn Disease		21102463, 23128233, 18587394, 28067908, 26192919, 26974007	ClinVar
Crohn Disease	Crohn Disease			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Carcinoma	Carcinoma			GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Diabetes	Diabetes			GWAS
Ulcerative colitis	Ulcerative colitis			GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining
Crohn Disease	Associate	20570966
Depressive Disorder Major	Associate	22373040
Inflammatory Bowel Diseases	Associate	34758847
Neoplasms	Associate	25851338
Neoplasms	Stimulate	33282955
Non Muscle Invasive Bladder Neoplasms	Associate	25851338
Obesity	Associate	30397228
Schizophrenia	Associate	22373040
Stomach Neoplasms	Associate	33282955
Uterine Cervical Neoplasms	Associate	20193846

SBNO2 (strawberry notch homolog 2)