Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22904
Gene name Gene Name - the full gene name approved by the HGNC.	Strawberry notch homolog 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SBNO2
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA0963, SNO, STNO
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3

Show/Hide all(49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022166	hsa-miR-124-3p	Microarray	18668037
MIRT028257	hsa-miR-32-5p	Sequencing	20371350
MIRT050357	hsa-miR-25-3p	CLASH	23622248
MIRT1327209	hsa-miR-1275	CLIP-seq
MIRT1327210	hsa-miR-153	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT1327212	hsa-miR-4419a	CLIP-seq
MIRT1327213	hsa-miR-4446-3p	CLIP-seq
MIRT1327214	hsa-miR-448	CLIP-seq
MIRT1327215	hsa-miR-4492	CLIP-seq
MIRT1327216	hsa-miR-4498	CLIP-seq
MIRT1327217	hsa-miR-4505	CLIP-seq
MIRT1327218	hsa-miR-4510	CLIP-seq
MIRT1327219	hsa-miR-4525	CLIP-seq
MIRT1327220	hsa-miR-4665-5p	CLIP-seq
MIRT1327221	hsa-miR-4723-5p	CLIP-seq
MIRT1327222	hsa-miR-4728-5p	CLIP-seq
MIRT1327223	hsa-miR-4731-5p	CLIP-seq
MIRT1327224	hsa-miR-625	CLIP-seq
MIRT1327225	hsa-miR-637	CLIP-seq
MIRT1327226	hsa-miR-762	CLIP-seq
MIRT1327227	hsa-miR-1200	CLIP-seq
MIRT1327228	hsa-miR-125a-5p	CLIP-seq
MIRT1327229	hsa-miR-125b	CLIP-seq
MIRT1327230	hsa-miR-3074-5p	CLIP-seq
MIRT1327231	hsa-miR-3170	CLIP-seq
MIRT1327232	hsa-miR-3663-3p	CLIP-seq
MIRT1327233	hsa-miR-4319	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097173	hsa-miR-1234	CLIP-seq
MIRT2097174	hsa-miR-124	CLIP-seq
MIRT2097175	hsa-miR-2861	CLIP-seq
MIRT1327211	hsa-miR-2964a-3p	CLIP-seq
MIRT2097176	hsa-miR-3192	CLIP-seq
MIRT1327234	hsa-miR-4324	CLIP-seq
MIRT2097177	hsa-miR-4493	CLIP-seq
MIRT2097178	hsa-miR-4750	CLIP-seq
MIRT2097179	hsa-miR-4792	CLIP-seq
MIRT2097180	hsa-miR-506	CLIP-seq
MIRT1327235	hsa-miR-544b	CLIP-seq
MIRT2097181	hsa-miR-661	CLIP-seq
MIRT2321514	hsa-miR-1225-3p	CLIP-seq
MIRT2321515	hsa-miR-499-3p	CLIP-seq
MIRT2321516	hsa-miR-499a-3p	CLIP-seq
MIRT2394064	hsa-miR-1280	CLIP-seq
MIRT2394065	hsa-miR-4286	CLIP-seq
MIRT2442588	hsa-miR-361-3p	CLIP-seq
MIRT2442589	hsa-miR-4707-5p	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0002281	Process	Macrophage activation involved in immune response	IBA
GO:0002281	Process	Macrophage activation involved in immune response	IEA
GO:0002281	Process	Macrophage activation involved in immune response	IMP	18025162
GO:0005634	Component	Nucleus	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030282	Process	Bone mineralization	IEA
GO:0030316	Process	Osteoclast differentiation	IBA
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0031490	Function	Chromatin DNA binding	IBA
GO:0042393	Function	Histone binding	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	18025162
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0050727	Process	Regulation of inflammatory response	IBA
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	IMP	18025162
GO:0061430	Process	Bone trabecula morphogenesis	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0071348	Process	Cellular response to interleukin-11	IEA
GO:0071348	Process	Cellular response to interleukin-11	ISS
GO:0071354	Process	Cellular response to interleukin-6	IBA
GO:0071354	Process	Cellular response to interleukin-6	IDA	25903009
GO:0071354	Process	Cellular response to interleukin-6	IEA
GO:0072674	Process	Multinuclear osteoclast differentiation	IEA
GO:0072675	Process	Osteoclast fusion	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	ISS

MIM	HGNC	e!Ensembl
615729	29158	ENSG00000064932

Protein

UniProt ID

Q9Y2G9

Protein name

Protein strawberry notch homolog 2

Protein function

Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13872	AAA_34	215 → 505	P-loop containing NTP hydrolase pore-1	Domain
PF13871	Helicase_C_4	732 → 1010	C-terminal domain on Strawberry notch homologue	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. {ECO:0000269|PubMed:18025162}.

Sequence

MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMS
SASFLGSQPCPDTSYAPVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDT
PDFLPADSLNQVSTIWDDNPAPSTHDKLFQLSRPFAGFEDFLPSHSTPLLVSYQEQSVQS
QPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETSTLSSVPPPDITYTLAL
PSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGR
KKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQ
AGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYAS
ATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRGVGAMEIVAMDMKVSGMYIARQ
LSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIGLESRKSLWGQFWSAH
QRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAA
EGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESD
PGLDSDFNSSPESLVDDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLD
KVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGTVAFESRAEQGLSIDHV
NLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGR
THRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENK
YGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVE
KDCSITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYE
ESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSC
LLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEPWESGYALSLTHCSHS
AWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKD
RKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLT
YSPPAEAFPPPPHFSFPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDML
RSLHAGPPSEGALGEGAGAGGAAGGGPERQSVIQFSPPFPGAQAPL

Sequence length

1366

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma, Age of onset of childhood onset asthma, Asthma (childhood onset), Asthma onset (childhood vs adult)	N/A	N/A	GWAS
Carcinoma	Basal cell carcinoma	N/A	N/A	GWAS
Colorectal Cancer	Distal/Left-sided colorectal cancer	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease, Inflammatory bowel disease (MTAG)	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Crohn Disease	Associate	20570966
Depressive Disorder Major	Associate	22373040
Inflammatory Bowel Diseases	Associate	34758847
Neoplasms	Associate	25851338
Neoplasms	Stimulate	33282955
Non Muscle Invasive Bladder Neoplasms	Associate	25851338
Obesity	Associate	30397228
Schizophrenia	Associate	22373040
Stomach Neoplasms	Associate	33282955
Uterine Cervical Neoplasms	Associate	20193846

SBNO2 (strawberry notch homolog 2)