TRAPPC8 (trafficking protein particle complex subunit 8)

Gene

• Entrez ID: 22878
• Gene name: Trafficking protein particle complex subunit 8
• Gene symbol: TRAPPC8
• Synonyms (NCBI Gene): GSG1, HsT2706, KIAA1012, TRS85
• Chromosome: 18
• Chromosome location: 18q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT652225	hsa-miR-1323	HITS-CLIP	23824327
MIRT652224	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT652223	hsa-miR-3148	HITS-CLIP	23824327
MIRT652222	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT652221	hsa-miR-607	HITS-CLIP	23824327
MIRT652225	hsa-miR-1323	HITS-CLIP	23824327
MIRT652224	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT652223	hsa-miR-3148	HITS-CLIP	23824327
MIRT652222	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT652221	hsa-miR-607	HITS-CLIP	23824327
MIRT652225	hsa-miR-1323	HITS-CLIP	23824327
MIRT652224	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT652223	hsa-miR-3148	HITS-CLIP	23824327
MIRT652222	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT652221	hsa-miR-607	HITS-CLIP	23824327
MIRT652225	hsa-miR-1323	HITS-CLIP	23824327
MIRT652224	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT652223	hsa-miR-3148	HITS-CLIP	23824327
MIRT652222	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT652221	hsa-miR-607	HITS-CLIP	23824327
MIRT1452203	hsa-miR-105	CLIP-seq
MIRT1452204	hsa-miR-1245b-5p	CLIP-seq
MIRT1452205	hsa-miR-1278	CLIP-seq
MIRT1452206	hsa-miR-128	CLIP-seq
MIRT1452207	hsa-miR-1290	CLIP-seq
MIRT1452208	hsa-miR-1303	CLIP-seq
MIRT1452209	hsa-miR-135a	CLIP-seq
MIRT1452210	hsa-miR-135b	CLIP-seq
MIRT1452211	hsa-miR-141	CLIP-seq
MIRT1452212	hsa-miR-151-3p	CLIP-seq
MIRT1452213	hsa-miR-15a	CLIP-seq
MIRT1452214	hsa-miR-15b	CLIP-seq
MIRT1452215	hsa-miR-16	CLIP-seq
MIRT1452216	hsa-miR-194	CLIP-seq
MIRT1452217	hsa-miR-195	CLIP-seq
MIRT1452218	hsa-miR-200a	CLIP-seq
MIRT1452219	hsa-miR-27a	CLIP-seq
MIRT1452220	hsa-miR-27b	CLIP-seq
MIRT1452221	hsa-miR-3124-3p	CLIP-seq
MIRT1452222	hsa-miR-3142	CLIP-seq
MIRT1452223	hsa-miR-3167	CLIP-seq
MIRT1452224	hsa-miR-320a	CLIP-seq
MIRT1452225	hsa-miR-320b	CLIP-seq
MIRT1452226	hsa-miR-320c	CLIP-seq
MIRT1452227	hsa-miR-320d	CLIP-seq
MIRT1452228	hsa-miR-320e	CLIP-seq
MIRT1452229	hsa-miR-365	CLIP-seq
MIRT1452230	hsa-miR-3691-5p	CLIP-seq
MIRT1452231	hsa-miR-382	CLIP-seq
MIRT1452232	hsa-miR-3920	CLIP-seq
MIRT1452233	hsa-miR-3921	CLIP-seq
MIRT1452234	hsa-miR-3922-5p	CLIP-seq
MIRT1452235	hsa-miR-424	CLIP-seq
MIRT1452236	hsa-miR-4330	CLIP-seq
MIRT1452237	hsa-miR-4429	CLIP-seq
MIRT1452238	hsa-miR-4433	CLIP-seq
MIRT1452239	hsa-miR-4641	CLIP-seq
MIRT1452240	hsa-miR-4653-5p	CLIP-seq
MIRT1452241	hsa-miR-4752	CLIP-seq
MIRT1452242	hsa-miR-4771	CLIP-seq
MIRT1452243	hsa-miR-4775	CLIP-seq
MIRT1452244	hsa-miR-4804-3p	CLIP-seq
MIRT1452245	hsa-miR-497	CLIP-seq
MIRT1452246	hsa-miR-499a-5p	CLIP-seq
MIRT1452247	hsa-miR-513a-5p	CLIP-seq
MIRT1452248	hsa-miR-548c-3p	CLIP-seq
MIRT1452249	hsa-miR-590-3p	CLIP-seq
MIRT1452250	hsa-miR-876-5p	CLIP-seq
MIRT1452251	hsa-miR-922	CLIP-seq
MIRT2135392	hsa-miR-3611	CLIP-seq
MIRT2135393	hsa-miR-4477b	CLIP-seq
MIRT2135394	hsa-miR-451b	CLIP-seq
MIRT2135395	hsa-miR-4696	CLIP-seq
MIRT2135396	hsa-miR-548o	CLIP-seq
MIRT2135397	hsa-miR-892a	CLIP-seq
MIRT1452205	hsa-miR-1278	CLIP-seq
MIRT1452206	hsa-miR-128	CLIP-seq
MIRT1452208	hsa-miR-1303	CLIP-seq
MIRT1452209	hsa-miR-135a	CLIP-seq
MIRT1452210	hsa-miR-135b	CLIP-seq
MIRT2356506	hsa-miR-144	CLIP-seq
MIRT2356507	hsa-miR-200b	CLIP-seq
MIRT2356508	hsa-miR-200c	CLIP-seq
MIRT2356509	hsa-miR-224	CLIP-seq
MIRT1452219	hsa-miR-27a	CLIP-seq
MIRT1452220	hsa-miR-27b	CLIP-seq
MIRT2356510	hsa-miR-3074-3p	CLIP-seq
MIRT1452224	hsa-miR-320a	CLIP-seq
MIRT1452225	hsa-miR-320b	CLIP-seq
MIRT1452226	hsa-miR-320c	CLIP-seq
MIRT1452227	hsa-miR-320d	CLIP-seq
MIRT1452228	hsa-miR-320e	CLIP-seq
MIRT2356511	hsa-miR-331-5p	CLIP-seq
MIRT2356512	hsa-miR-3607-3p	CLIP-seq
MIRT2135392	hsa-miR-3611	CLIP-seq
MIRT2356513	hsa-miR-3671	CLIP-seq
MIRT2356514	hsa-miR-369-3p	CLIP-seq
MIRT2356515	hsa-miR-374a	CLIP-seq
MIRT2356516	hsa-miR-374b	CLIP-seq
MIRT2356517	hsa-miR-3924	CLIP-seq
MIRT2356518	hsa-miR-429	CLIP-seq
MIRT1452237	hsa-miR-4429	CLIP-seq
MIRT1452238	hsa-miR-4433	CLIP-seq
MIRT2356519	hsa-miR-4678	CLIP-seq
MIRT2356520	hsa-miR-4705	CLIP-seq
MIRT2356521	hsa-miR-4714-3p	CLIP-seq
MIRT2356522	hsa-miR-4718	CLIP-seq
MIRT1452244	hsa-miR-4804-3p	CLIP-seq
MIRT1452247	hsa-miR-513a-5p	CLIP-seq
MIRT2356523	hsa-miR-548aa	CLIP-seq
MIRT2356524	hsa-miR-568	CLIP-seq
MIRT2650074	hsa-miR-1266	CLIP-seq
MIRT2650075	hsa-miR-1273f	CLIP-seq
MIRT1452205	hsa-miR-1278	CLIP-seq
MIRT2650076	hsa-miR-143	CLIP-seq
MIRT1452212	hsa-miR-151-3p	CLIP-seq
MIRT2650077	hsa-miR-186	CLIP-seq
MIRT2650078	hsa-miR-18a	CLIP-seq
MIRT2650079	hsa-miR-18b	CLIP-seq
MIRT2650080	hsa-miR-3133	CLIP-seq
MIRT2650081	hsa-miR-3184	CLIP-seq
MIRT2650082	hsa-miR-330-3p	CLIP-seq
MIRT2650083	hsa-miR-3664-3p	CLIP-seq
MIRT2650084	hsa-miR-3675-5p	CLIP-seq
MIRT2650085	hsa-miR-423-5p	CLIP-seq
MIRT2650086	hsa-miR-4272	CLIP-seq
MIRT2650087	hsa-miR-4282	CLIP-seq
MIRT2650088	hsa-miR-4283	CLIP-seq
MIRT2650089	hsa-miR-4422	CLIP-seq
MIRT2650090	hsa-miR-4426	CLIP-seq
MIRT1452238	hsa-miR-4433	CLIP-seq
MIRT2650091	hsa-miR-4489	CLIP-seq
MIRT2650092	hsa-miR-4495	CLIP-seq
MIRT2650093	hsa-miR-4518	CLIP-seq
MIRT2650094	hsa-miR-4647	CLIP-seq
MIRT2650095	hsa-miR-4662b	CLIP-seq
MIRT2650096	hsa-miR-4708-5p	CLIP-seq
MIRT2650097	hsa-miR-4711-5p	CLIP-seq
MIRT2650098	hsa-miR-4719	CLIP-seq
MIRT2650099	hsa-miR-4728-3p	CLIP-seq
MIRT2650100	hsa-miR-4735-3p	CLIP-seq
MIRT2650101	hsa-miR-4742-3p	CLIP-seq
MIRT2650102	hsa-miR-4770	CLIP-seq
MIRT1452244	hsa-miR-4804-3p	CLIP-seq
MIRT2650103	hsa-miR-486-5p	CLIP-seq
MIRT2135396	hsa-miR-548o	CLIP-seq
MIRT2650104	hsa-miR-556-5p	CLIP-seq
MIRT2650105	hsa-miR-599	CLIP-seq
MIRT2650106	hsa-miR-629	CLIP-seq
MIRT2650107	hsa-miR-944	CLIP-seq
MIRT2650074	hsa-miR-1266	CLIP-seq
MIRT1452205	hsa-miR-1278	CLIP-seq
MIRT1452212	hsa-miR-151-3p	CLIP-seq
MIRT2650077	hsa-miR-186	CLIP-seq
MIRT2650078	hsa-miR-18a	CLIP-seq
MIRT2650079	hsa-miR-18b	CLIP-seq
MIRT2650080	hsa-miR-3133	CLIP-seq
MIRT2650083	hsa-miR-3664-3p	CLIP-seq
MIRT2650084	hsa-miR-3675-5p	CLIP-seq
MIRT2650088	hsa-miR-4283	CLIP-seq
MIRT2650090	hsa-miR-4426	CLIP-seq
MIRT1452238	hsa-miR-4433	CLIP-seq
MIRT2650091	hsa-miR-4489	CLIP-seq
MIRT2650092	hsa-miR-4495	CLIP-seq
MIRT2650093	hsa-miR-4518	CLIP-seq
MIRT2650094	hsa-miR-4647	CLIP-seq
MIRT2650095	hsa-miR-4662b	CLIP-seq
MIRT2650098	hsa-miR-4719	CLIP-seq
MIRT2650099	hsa-miR-4728-3p	CLIP-seq
MIRT2650100	hsa-miR-4735-3p	CLIP-seq
MIRT2650101	hsa-miR-4742-3p	CLIP-seq
MIRT1452244	hsa-miR-4804-3p	CLIP-seq
MIRT2650103	hsa-miR-486-5p	CLIP-seq
MIRT2135396	hsa-miR-548o	CLIP-seq
MIRT2650104	hsa-miR-556-5p	CLIP-seq
MIRT2650105	hsa-miR-599	CLIP-seq
MIRT2650106	hsa-miR-629	CLIP-seq
MIRT2650107	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21453443, 21525244, 33961781
GO:0005737	Component	Cytoplasm	NAS	27066478
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	NAS	27066478
GO:0007030	Process	Golgi organization	IMP	21525244
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030008	Component	TRAPP complex	IDA	21525244
GO:0032964	Process	Collagen biosynthetic process	IMP	32095531
GO:0048208	Process	COPII vesicle coating	NAS	27066478
GO:0099022	Process	Vesicle tethering	NAS	27066478
GO:1990072	Component	TRAPPIII protein complex	IBA
GO:1990072	Component	TRAPPIII protein complex	NAS	27066478

Other IDs

• MIM: 614136
• HGNC: 29169
• e!Ensembl: ENSG00000153339

Protein

• UniProt ID: Q9Y2L5
• Protein name: Trafficking protein particle complex subunit 8 (Protein TRS85 homolog)
• Protein function: Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy (PubMed:26711178). Involved in collagen s
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12739	TRAPPC-Trs85	157 → 604	ER-Golgi trafficking TRAPP I complex 85 kDa subunit	Family

• Sequence:

  MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNN
  QLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATT
  PWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYS
  YPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQ
  IPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPL
  QLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGL
  LPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPE
  LQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPY
  PAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSAL
  LLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAE
  DHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDG
  PLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSV
  VNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKF
  HPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVV
  YNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPD
  RRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTF
  GGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLP
  DTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLN
  VRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNL
  SENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFY
  RSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQ
  HHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESF
  NHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQL
  KSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV

• Sequence length: 1435

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Malignant tumor of esophagus	Uncertain significance	rs144259519	RCV005929220