Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22876
Gene name Gene Name - the full gene name approved by the HGNC.	Inositol polyphosphate-5-phosphatase F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	INPP5F
Synonyms (NCBI Gene) Gene synonyms aliases	MSTP007, MSTPO47, SAC2, hSAC2
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q26.11
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternati

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002802	hsa-miR-1-3p	Microarray	15685193
MIRT018546	hsa-miR-335-5p	Microarray	18185580
MIRT020983	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT002802	hsa-miR-1-3p	Microarray	18668037
MIRT002802	hsa-miR-1-3p	Microarray	15685193
MIRT024458	hsa-miR-215-5p	Microarray	19074876
MIRT026776	hsa-miR-192-5p	Microarray	19074876
MIRT048003	hsa-miR-30c-5p	CLASH	23622248
MIRT045274	hsa-miR-186-5p	CLASH	23622248
MIRT440453	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440452	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440451	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440453	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440452	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT727444	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727443	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727442	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727441	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440451	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1067405	hsa-miR-101	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067407	hsa-miR-1200	CLIP-seq
MIRT1067408	hsa-miR-1324	CLIP-seq
MIRT1067409	hsa-miR-135a	CLIP-seq
MIRT1067410	hsa-miR-135b	CLIP-seq
MIRT740121	hsa-miR-145	CLIP-seq
MIRT1067411	hsa-miR-1468	CLIP-seq
MIRT1067412	hsa-miR-181a	CLIP-seq
MIRT1067413	hsa-miR-181b	CLIP-seq
MIRT1067414	hsa-miR-181c	CLIP-seq
MIRT1067415	hsa-miR-181d	CLIP-seq
MIRT1067416	hsa-miR-2116	CLIP-seq
MIRT1067417	hsa-miR-3115	CLIP-seq
MIRT1067418	hsa-miR-3120-3p	CLIP-seq
MIRT1067419	hsa-miR-3136-5p	CLIP-seq
MIRT1067420	hsa-miR-3140-5p	CLIP-seq
MIRT740122	hsa-miR-3180-5p	CLIP-seq
MIRT1067421	hsa-miR-320a	CLIP-seq
MIRT1067422	hsa-miR-320b	CLIP-seq
MIRT1067423	hsa-miR-320c	CLIP-seq
MIRT1067424	hsa-miR-320d	CLIP-seq
MIRT1067425	hsa-miR-421	CLIP-seq
MIRT1067426	hsa-miR-4262	CLIP-seq
MIRT1067427	hsa-miR-4292	CLIP-seq
MIRT1067428	hsa-miR-4308	CLIP-seq
MIRT1067429	hsa-miR-4320	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT1067431	hsa-miR-4429	CLIP-seq
MIRT1067432	hsa-miR-4439	CLIP-seq
MIRT1067433	hsa-miR-4455	CLIP-seq
MIRT1067434	hsa-miR-4509	CLIP-seq
MIRT1067435	hsa-miR-4513	CLIP-seq
MIRT1067436	hsa-miR-4533	CLIP-seq
MIRT1067437	hsa-miR-4645-3p	CLIP-seq
MIRT740118	hsa-miR-4662a-5p	CLIP-seq
MIRT1067438	hsa-miR-4677-5p	CLIP-seq
MIRT1067439	hsa-miR-4704-3p	CLIP-seq
MIRT1067440	hsa-miR-4709-5p	CLIP-seq
MIRT740119	hsa-miR-4712-5p	CLIP-seq
MIRT1067441	hsa-miR-4744	CLIP-seq
MIRT740126	hsa-miR-4777-5p	CLIP-seq
MIRT1067442	hsa-miR-4797-5p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT740124	hsa-miR-518d-5p	CLIP-seq
MIRT740125	hsa-miR-519b-5p	CLIP-seq
MIRT740127	hsa-miR-519c-5p	CLIP-seq
MIRT740123	hsa-miR-520c-5p	CLIP-seq
MIRT740128	hsa-miR-526a	CLIP-seq
MIRT1067445	hsa-miR-545	CLIP-seq
MIRT1067446	hsa-miR-548aa	CLIP-seq
MIRT1067447	hsa-miR-548p	CLIP-seq
MIRT1067448	hsa-miR-548u	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067450	hsa-miR-570	CLIP-seq
MIRT1067451	hsa-miR-580	CLIP-seq
MIRT1067452	hsa-miR-600	CLIP-seq
MIRT1067453	hsa-miR-609	CLIP-seq
MIRT740129	hsa-miR-617	CLIP-seq
MIRT1067454	hsa-miR-758	CLIP-seq
MIRT740120	hsa-miR-770-5p	CLIP-seq
MIRT2016327	hsa-miR-106a	CLIP-seq
MIRT2016328	hsa-miR-106b	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067408	hsa-miR-1324	CLIP-seq
MIRT2016329	hsa-miR-147	CLIP-seq
MIRT2016330	hsa-miR-17	CLIP-seq
MIRT2016331	hsa-miR-20a	CLIP-seq
MIRT2016332	hsa-miR-20b	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT2016334	hsa-miR-302a	CLIP-seq
MIRT2016335	hsa-miR-302b	CLIP-seq
MIRT2016336	hsa-miR-302c	CLIP-seq
MIRT2016337	hsa-miR-302d	CLIP-seq
MIRT2016338	hsa-miR-302e	CLIP-seq
MIRT2016339	hsa-miR-3065-3p	CLIP-seq
MIRT2016340	hsa-miR-3151	CLIP-seq
MIRT2016341	hsa-miR-3689d	CLIP-seq
MIRT2016342	hsa-miR-372	CLIP-seq
MIRT2016343	hsa-miR-373	CLIP-seq
MIRT2016344	hsa-miR-3911	CLIP-seq
MIRT2016345	hsa-miR-4280	CLIP-seq
MIRT2016346	hsa-miR-4291	CLIP-seq
MIRT2016347	hsa-miR-4318	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT2016349	hsa-miR-4447	CLIP-seq
MIRT2016350	hsa-miR-4450	CLIP-seq
MIRT2016351	hsa-miR-4472	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT2016353	hsa-miR-4688	CLIP-seq
MIRT2016354	hsa-miR-4693-5p	CLIP-seq
MIRT2016355	hsa-miR-4697-3p	CLIP-seq
MIRT2016356	hsa-miR-486-3p	CLIP-seq
MIRT2016357	hsa-miR-491-5p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT2016358	hsa-miR-5095	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT2016359	hsa-miR-519d	CLIP-seq
MIRT2016360	hsa-miR-520a-3p	CLIP-seq
MIRT2016361	hsa-miR-520b	CLIP-seq
MIRT2016362	hsa-miR-520c-3p	CLIP-seq
MIRT2016363	hsa-miR-520d-3p	CLIP-seq
MIRT2016364	hsa-miR-520e	CLIP-seq
MIRT2016365	hsa-miR-520g	CLIP-seq
MIRT2016366	hsa-miR-520h	CLIP-seq
MIRT2016367	hsa-miR-550b	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT2016368	hsa-miR-568	CLIP-seq
MIRT2016369	hsa-miR-644	CLIP-seq
MIRT2016370	hsa-miR-759	CLIP-seq
MIRT2016371	hsa-miR-892a	CLIP-seq
MIRT2016372	hsa-miR-93	CLIP-seq
MIRT2016355	hsa-miR-4697-3p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067407	hsa-miR-1200	CLIP-seq
MIRT2552145	hsa-miR-129-5p	CLIP-seq
MIRT740121	hsa-miR-145	CLIP-seq
MIRT2552146	hsa-miR-1539	CLIP-seq
MIRT1067412	hsa-miR-181a	CLIP-seq
MIRT1067413	hsa-miR-181b	CLIP-seq
MIRT1067414	hsa-miR-181c	CLIP-seq
MIRT1067415	hsa-miR-181d	CLIP-seq
MIRT2552147	hsa-miR-1976	CLIP-seq
MIRT1067416	hsa-miR-2116	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT1067417	hsa-miR-3115	CLIP-seq
MIRT1067418	hsa-miR-3120-3p	CLIP-seq
MIRT1067420	hsa-miR-3140-5p	CLIP-seq
MIRT2552148	hsa-miR-3149	CLIP-seq
MIRT740122	hsa-miR-3180-5p	CLIP-seq
MIRT2552149	hsa-miR-3193	CLIP-seq
MIRT2552150	hsa-miR-3646	CLIP-seq
MIRT2552151	hsa-miR-3662	CLIP-seq
MIRT2552152	hsa-miR-3674	CLIP-seq
MIRT1067426	hsa-miR-4262	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT1067433	hsa-miR-4455	CLIP-seq
MIRT740118	hsa-miR-4662a-5p	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT1067438	hsa-miR-4677-5p	CLIP-seq
MIRT2552153	hsa-miR-4698	CLIP-seq
MIRT740119	hsa-miR-4712-5p	CLIP-seq
MIRT2552154	hsa-miR-4735-5p	CLIP-seq
MIRT2552155	hsa-miR-4775	CLIP-seq
MIRT740126	hsa-miR-4777-5p	CLIP-seq
MIRT2552156	hsa-miR-501-3p	CLIP-seq
MIRT2552157	hsa-miR-502-3p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT740124	hsa-miR-518d-5p	CLIP-seq
MIRT740125	hsa-miR-519b-5p	CLIP-seq
MIRT740127	hsa-miR-519c-5p	CLIP-seq
MIRT740123	hsa-miR-520c-5p	CLIP-seq
MIRT740128	hsa-miR-526a	CLIP-seq
MIRT1067445	hsa-miR-545	CLIP-seq
MIRT1067447	hsa-miR-548p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067450	hsa-miR-570	CLIP-seq
MIRT2552158	hsa-miR-590-3p	CLIP-seq
MIRT1067452	hsa-miR-600	CLIP-seq
MIRT1067453	hsa-miR-609	CLIP-seq
MIRT740129	hsa-miR-617	CLIP-seq
MIRT2552159	hsa-miR-767-5p	CLIP-seq
MIRT740120	hsa-miR-770-5p	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT2552145	hsa-miR-129-5p	CLIP-seq
MIRT2552146	hsa-miR-1539	CLIP-seq
MIRT2552147	hsa-miR-1976	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT2552148	hsa-miR-3149	CLIP-seq
MIRT2552149	hsa-miR-3193	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT2552154	hsa-miR-4735-5p	CLIP-seq
MIRT2552155	hsa-miR-4775	CLIP-seq
MIRT2552156	hsa-miR-501-3p	CLIP-seq
MIRT2552157	hsa-miR-502-3p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT2552158	hsa-miR-590-3p	CLIP-seq
MIRT2552159	hsa-miR-767-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001921	Process	Positive regulation of receptor recycling	IDA	25869669
GO:0005515	Function	Protein binding	IPI	25476455
GO:0005769	Component	Early endosome	IBA	21873635
GO:0005769	Component	Early endosome	IDA	25869669
GO:0005905	Component	Clathrin-coated pit	IDA	25869669
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0008934	Function	Inositol monophosphate 1-phosphatase activity	IEA
GO:0014898	Process	Cardiac muscle hypertrophy in response to stress	ISS
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031161	Process	Phosphatidylinositol catabolic process	ISS
GO:0031901	Component	Early endosome membrane	TAS
GO:0033137	Process	Negative regulation of peptidyl-serine phosphorylation	IEA
GO:0034595	Function	Phosphatidylinositol phosphate 5-phosphatase activity	IDA	11274189
GO:0034595	Function	Phosphatidylinositol phosphate 5-phosphatase activity	IDA	25869669
GO:0034596	Function	Phosphatidylinositol phosphate 4-phosphatase activity	IDA	25869669
GO:0034596	Function	Phosphatidylinositol phosphate 4-phosphatase activity	TAS
GO:0042532	Process	Negative regulation of tyrosine phosphorylation of STAT protein	IDA	25476455
GO:0042803	Function	Protein homodimerization activity	IDA	25869669
GO:0043025	Component	Neuronal cell body	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043812	Function	Phosphatidylinositol-4-phosphate phosphatase activity	IBA	21873635
GO:0045334	Component	Clathrin-coated endocytic vesicle	IBA	21873635
GO:0045334	Component	Clathrin-coated endocytic vesicle	IDA	25869669
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IBA	21873635
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	11274189, 25869669
GO:0048015	Process	Phosphatidylinositol-mediated signaling	ISS
GO:0048681	Process	Negative regulation of axon regeneration	ISS
GO:0051896	Process	Regulation of protein kinase B signaling	IEA
GO:0052832	Function	Inositol monophosphate 3-phosphatase activity	IEA
GO:0052833	Function	Inositol monophosphate 4-phosphatase activity	IEA
GO:0055037	Component	Recycling endosome	IDA	25869669
GO:0072583	Process	Clathrin-dependent endocytosis	ISS
GO:2000145	Process	Regulation of cell motility	IMP	25869669
GO:2001135	Process	Regulation of endocytic recycling	IBA	21873635
GO:2001135	Process	Regulation of endocytic recycling	IMP	25869669

MIM	HGNC	e!Ensembl
609389	17054	ENSG00000198825

Protein

UniProt ID

Q9Y2H2

Protein name

Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)

Protein function

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylino

PDB

4XUU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02383	Syja_N	49 → 415	SacI homology domain	Family
PF12456	hSac2	590 → 698	Inositol phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). {ECO:0000269|PubMed:11274189, ECO:0000269|PubMed:26203138}.

Sequence

MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSD
LPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKI
IPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSL
TYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQ
IEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDK
NGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCA
HFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFE
NVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQ
LKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKD
GVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELIS
QLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDK
VNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGK
DTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSK
FSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVM
DKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPR
LGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYC
HRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSA
TGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQ
VASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI

Sequence length

1132

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system		Synthesis of PIPs at the early endosome membrane

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	28892059, 25064009

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Parkinson Disease	Parkinson Disease	GWAS
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Capillary Malformation Arteriovenous Malformation	Associate	32693431
Glioblastoma	Inhibit	25476455
Glioma	Associate	25476455
Heart Defects Congenital	Associate	32693431, 33407475
Leukemia Lymphocytic Chronic B Cell	Associate	26430724, 29367434
Neoplasms	Inhibit	25476455
Neuroblastoma	Associate	39217334
Parkinson Disease	Associate	30957308

INPP5F (inositol polyphosphate-5-phosphatase F)