Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	22876
Gene name	Inositol polyphosphate-5-phosphatase F
Gene symbol	INPP5F
Synonyms (NCBI Gene)	MSTP007MSTPO47SAC2hSAC2
Chromosome	10
Chromosome location	10q26.11
Summary	The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternati

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002802	hsa-miR-1-3p	Microarray	15685193
MIRT018546	hsa-miR-335-5p	Microarray	18185580
MIRT020983	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT002802	hsa-miR-1-3p	Microarray	18668037
MIRT002802	hsa-miR-1-3p	Microarray	15685193
MIRT024458	hsa-miR-215-5p	Microarray	19074876
MIRT026776	hsa-miR-192-5p	Microarray	19074876
MIRT048003	hsa-miR-30c-5p	CLASH	23622248
MIRT045274	hsa-miR-186-5p	CLASH	23622248
MIRT440453	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440452	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440451	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440453	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440452	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT727444	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727443	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727442	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727441	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT440451	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1067405	hsa-miR-101	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067407	hsa-miR-1200	CLIP-seq
MIRT1067408	hsa-miR-1324	CLIP-seq
MIRT1067409	hsa-miR-135a	CLIP-seq
MIRT1067410	hsa-miR-135b	CLIP-seq
MIRT740121	hsa-miR-145	CLIP-seq
MIRT1067411	hsa-miR-1468	CLIP-seq
MIRT1067412	hsa-miR-181a	CLIP-seq
MIRT1067413	hsa-miR-181b	CLIP-seq
MIRT1067414	hsa-miR-181c	CLIP-seq
MIRT1067415	hsa-miR-181d	CLIP-seq
MIRT1067416	hsa-miR-2116	CLIP-seq
MIRT1067417	hsa-miR-3115	CLIP-seq
MIRT1067418	hsa-miR-3120-3p	CLIP-seq
MIRT1067419	hsa-miR-3136-5p	CLIP-seq
MIRT1067420	hsa-miR-3140-5p	CLIP-seq
MIRT740122	hsa-miR-3180-5p	CLIP-seq
MIRT1067421	hsa-miR-320a	CLIP-seq
MIRT1067422	hsa-miR-320b	CLIP-seq
MIRT1067423	hsa-miR-320c	CLIP-seq
MIRT1067424	hsa-miR-320d	CLIP-seq
MIRT1067425	hsa-miR-421	CLIP-seq
MIRT1067426	hsa-miR-4262	CLIP-seq
MIRT1067427	hsa-miR-4292	CLIP-seq
MIRT1067428	hsa-miR-4308	CLIP-seq
MIRT1067429	hsa-miR-4320	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT1067431	hsa-miR-4429	CLIP-seq
MIRT1067432	hsa-miR-4439	CLIP-seq
MIRT1067433	hsa-miR-4455	CLIP-seq
MIRT1067434	hsa-miR-4509	CLIP-seq
MIRT1067435	hsa-miR-4513	CLIP-seq
MIRT1067436	hsa-miR-4533	CLIP-seq
MIRT1067437	hsa-miR-4645-3p	CLIP-seq
MIRT740118	hsa-miR-4662a-5p	CLIP-seq
MIRT1067438	hsa-miR-4677-5p	CLIP-seq
MIRT1067439	hsa-miR-4704-3p	CLIP-seq
MIRT1067440	hsa-miR-4709-5p	CLIP-seq
MIRT740119	hsa-miR-4712-5p	CLIP-seq
MIRT1067441	hsa-miR-4744	CLIP-seq
MIRT740126	hsa-miR-4777-5p	CLIP-seq
MIRT1067442	hsa-miR-4797-5p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT740124	hsa-miR-518d-5p	CLIP-seq
MIRT740125	hsa-miR-519b-5p	CLIP-seq
MIRT740127	hsa-miR-519c-5p	CLIP-seq
MIRT740123	hsa-miR-520c-5p	CLIP-seq
MIRT740128	hsa-miR-526a	CLIP-seq
MIRT1067445	hsa-miR-545	CLIP-seq
MIRT1067446	hsa-miR-548aa	CLIP-seq
MIRT1067447	hsa-miR-548p	CLIP-seq
MIRT1067448	hsa-miR-548u	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067450	hsa-miR-570	CLIP-seq
MIRT1067451	hsa-miR-580	CLIP-seq
MIRT1067452	hsa-miR-600	CLIP-seq
MIRT1067453	hsa-miR-609	CLIP-seq
MIRT740129	hsa-miR-617	CLIP-seq
MIRT1067454	hsa-miR-758	CLIP-seq
MIRT740120	hsa-miR-770-5p	CLIP-seq
MIRT2016327	hsa-miR-106a	CLIP-seq
MIRT2016328	hsa-miR-106b	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067408	hsa-miR-1324	CLIP-seq
MIRT2016329	hsa-miR-147	CLIP-seq
MIRT2016330	hsa-miR-17	CLIP-seq
MIRT2016331	hsa-miR-20a	CLIP-seq
MIRT2016332	hsa-miR-20b	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT2016334	hsa-miR-302a	CLIP-seq
MIRT2016335	hsa-miR-302b	CLIP-seq
MIRT2016336	hsa-miR-302c	CLIP-seq
MIRT2016337	hsa-miR-302d	CLIP-seq
MIRT2016338	hsa-miR-302e	CLIP-seq
MIRT2016339	hsa-miR-3065-3p	CLIP-seq
MIRT2016340	hsa-miR-3151	CLIP-seq
MIRT2016341	hsa-miR-3689d	CLIP-seq
MIRT2016342	hsa-miR-372	CLIP-seq
MIRT2016343	hsa-miR-373	CLIP-seq
MIRT2016344	hsa-miR-3911	CLIP-seq
MIRT2016345	hsa-miR-4280	CLIP-seq
MIRT2016346	hsa-miR-4291	CLIP-seq
MIRT2016347	hsa-miR-4318	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT2016349	hsa-miR-4447	CLIP-seq
MIRT2016350	hsa-miR-4450	CLIP-seq
MIRT2016351	hsa-miR-4472	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT2016353	hsa-miR-4688	CLIP-seq
MIRT2016354	hsa-miR-4693-5p	CLIP-seq
MIRT2016355	hsa-miR-4697-3p	CLIP-seq
MIRT2016356	hsa-miR-486-3p	CLIP-seq
MIRT2016357	hsa-miR-491-5p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT2016358	hsa-miR-5095	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT2016359	hsa-miR-519d	CLIP-seq
MIRT2016360	hsa-miR-520a-3p	CLIP-seq
MIRT2016361	hsa-miR-520b	CLIP-seq
MIRT2016362	hsa-miR-520c-3p	CLIP-seq
MIRT2016363	hsa-miR-520d-3p	CLIP-seq
MIRT2016364	hsa-miR-520e	CLIP-seq
MIRT2016365	hsa-miR-520g	CLIP-seq
MIRT2016366	hsa-miR-520h	CLIP-seq
MIRT2016367	hsa-miR-550b	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT2016368	hsa-miR-568	CLIP-seq
MIRT2016369	hsa-miR-644	CLIP-seq
MIRT2016370	hsa-miR-759	CLIP-seq
MIRT2016371	hsa-miR-892a	CLIP-seq
MIRT2016372	hsa-miR-93	CLIP-seq
MIRT2016355	hsa-miR-4697-3p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT1067407	hsa-miR-1200	CLIP-seq
MIRT2552145	hsa-miR-129-5p	CLIP-seq
MIRT740121	hsa-miR-145	CLIP-seq
MIRT2552146	hsa-miR-1539	CLIP-seq
MIRT1067412	hsa-miR-181a	CLIP-seq
MIRT1067413	hsa-miR-181b	CLIP-seq
MIRT1067414	hsa-miR-181c	CLIP-seq
MIRT1067415	hsa-miR-181d	CLIP-seq
MIRT2552147	hsa-miR-1976	CLIP-seq
MIRT1067416	hsa-miR-2116	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT1067417	hsa-miR-3115	CLIP-seq
MIRT1067418	hsa-miR-3120-3p	CLIP-seq
MIRT1067420	hsa-miR-3140-5p	CLIP-seq
MIRT2552148	hsa-miR-3149	CLIP-seq
MIRT740122	hsa-miR-3180-5p	CLIP-seq
MIRT2552149	hsa-miR-3193	CLIP-seq
MIRT2552150	hsa-miR-3646	CLIP-seq
MIRT2552151	hsa-miR-3662	CLIP-seq
MIRT2552152	hsa-miR-3674	CLIP-seq
MIRT1067426	hsa-miR-4262	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT1067433	hsa-miR-4455	CLIP-seq
MIRT740118	hsa-miR-4662a-5p	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT1067438	hsa-miR-4677-5p	CLIP-seq
MIRT2552153	hsa-miR-4698	CLIP-seq
MIRT740119	hsa-miR-4712-5p	CLIP-seq
MIRT2552154	hsa-miR-4735-5p	CLIP-seq
MIRT2552155	hsa-miR-4775	CLIP-seq
MIRT740126	hsa-miR-4777-5p	CLIP-seq
MIRT2552156	hsa-miR-501-3p	CLIP-seq
MIRT2552157	hsa-miR-502-3p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT740124	hsa-miR-518d-5p	CLIP-seq
MIRT740125	hsa-miR-519b-5p	CLIP-seq
MIRT740127	hsa-miR-519c-5p	CLIP-seq
MIRT740123	hsa-miR-520c-5p	CLIP-seq
MIRT740128	hsa-miR-526a	CLIP-seq
MIRT1067445	hsa-miR-545	CLIP-seq
MIRT1067447	hsa-miR-548p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT1067450	hsa-miR-570	CLIP-seq
MIRT2552158	hsa-miR-590-3p	CLIP-seq
MIRT1067452	hsa-miR-600	CLIP-seq
MIRT1067453	hsa-miR-609	CLIP-seq
MIRT740129	hsa-miR-617	CLIP-seq
MIRT2552159	hsa-miR-767-5p	CLIP-seq
MIRT740120	hsa-miR-770-5p	CLIP-seq
MIRT1067406	hsa-miR-1184	CLIP-seq
MIRT2552145	hsa-miR-129-5p	CLIP-seq
MIRT2552146	hsa-miR-1539	CLIP-seq
MIRT2552147	hsa-miR-1976	CLIP-seq
MIRT2016333	hsa-miR-216a	CLIP-seq
MIRT2552148	hsa-miR-3149	CLIP-seq
MIRT2552149	hsa-miR-3193	CLIP-seq
MIRT1067430	hsa-miR-4418	CLIP-seq
MIRT2016348	hsa-miR-4437	CLIP-seq
MIRT2016352	hsa-miR-4674	CLIP-seq
MIRT2552154	hsa-miR-4735-5p	CLIP-seq
MIRT2552155	hsa-miR-4775	CLIP-seq
MIRT2552156	hsa-miR-501-3p	CLIP-seq
MIRT2552157	hsa-miR-502-3p	CLIP-seq
MIRT1067443	hsa-miR-509-3-5p	CLIP-seq
MIRT1067444	hsa-miR-509-5p	CLIP-seq
MIRT1067449	hsa-miR-564	CLIP-seq
MIRT2552158	hsa-miR-590-3p	CLIP-seq
MIRT2552159	hsa-miR-767-5p	CLIP-seq

Show/Hide all (52)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001921	Process	Positive regulation of receptor recycling	IDA	25869669
GO:0001921	Process	Positive regulation of receptor recycling	IEA
GO:0005515	Function	Protein binding	IPI	25476455
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	25869669
GO:0005769	Component	Early endosome	IEA
GO:0005905	Component	Clathrin-coated pit	IDA	25869669
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0014898	Process	Cardiac muscle hypertrophy in response to stress	IEA
GO:0014898	Process	Cardiac muscle hypertrophy in response to stress	ISS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031161	Process	Phosphatidylinositol catabolic process	IEA
GO:0031161	Process	Phosphatidylinositol catabolic process	ISS
GO:0031901	Component	Early endosome membrane	TAS
GO:0034595	Function	Phosphatidylinositol phosphate 5-phosphatase activity	IDA	25869669
GO:0034595	Function	Phosphatidylinositol phosphate 5-phosphatase activity	IDA	11274189
GO:0034596	Function	Phosphatidylinositol phosphate 4-phosphatase activity	IDA	25869669
GO:0034596	Function	Phosphatidylinositol phosphate 4-phosphatase activity	IEA
GO:0034596	Function	Phosphatidylinositol phosphate 4-phosphatase activity	TAS
GO:0042803	Function	Protein homodimerization activity	IDA	25869669
GO:0043025	Component	Neuronal cell body	IEA
GO:0043491	Process	Phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0043812	Function	Phosphatidylinositol-4-phosphate phosphatase activity	IBA
GO:0045334	Component	Clathrin-coated endocytic vesicle	IBA
GO:0045334	Component	Clathrin-coated endocytic vesicle	IDA	25869669
GO:0045334	Component	Clathrin-coated endocytic vesicle	IEA
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IBA
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	11274189, 25869669
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	ISS
GO:0048681	Process	Negative regulation of axon regeneration	IEA
GO:0048681	Process	Negative regulation of axon regeneration	ISS
GO:0052833	Function	Inositol monophosphate 4-phosphatase activity	IEA
GO:0052834	Function	Inositol monophosphate phosphatase activity	IEA
GO:0055037	Component	Recycling endosome	IDA	25869669
GO:0055037	Component	Recycling endosome	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	ISS
GO:2000145	Process	Regulation of cell motility	IEA
GO:2000145	Process	Regulation of cell motility	IMP	25869669
GO:2001135	Process	Regulation of endocytic recycling	IBA
GO:2001135	Process	Regulation of endocytic recycling	IEA
GO:2001135	Process	Regulation of endocytic recycling	IMP	25869669

MIM	HGNC	e!Ensembl
609389	17054	ENSG00000198825

Q9Y2H2

Protein name

Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)

Protein function

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylino

PDB

4XUU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02383	Syja_N	49 → 415	SacI homology domain	Family
PF12456	hSac2	590 → 698	Inositol phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). {ECO:0000269|PubMed:11274189, ECO:0000269|PubMed:26203138}.

Sequence

MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSD
LPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKI
IPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSL
TYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQ
IEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDK
NGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCA
HFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFE
NVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQ
LKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKD
GVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELIS
QLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDK
VNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGK
DTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSK
FSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVM
DKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPR
LGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYC
HRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSA
TGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQ
VASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI

Sequence length

1132

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system		Synthesis of PIPs at the early endosome membrane

INPP5F (inositol polyphosphate-5-phosphatase F)