Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	22871
Gene name	Neuroligin 1
Gene symbol	NLGN1
Synonyms (NCBI Gene)	NL1NLG1
Chromosome	3
Chromosome location	3q26.31
Summary	This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided b

Show/Hide all (69)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720878	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT720877	hsa-miR-4446-3p	HITS-CLIP	19536157
MIRT720876	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT708819	hsa-miR-4705	HITS-CLIP	19536157
MIRT708818	hsa-miR-31-3p	HITS-CLIP	19536157
MIRT708817	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT708816	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT708815	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT708819	hsa-miR-4705	HITS-CLIP	19536157
MIRT708818	hsa-miR-31-3p	HITS-CLIP	19536157
MIRT708817	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT708816	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT708815	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT736302	hsa-miR-128-3p	Western blottingqRT-PCR	32058631
MIRT720878	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT720877	hsa-miR-4446-3p	HITS-CLIP	19536157
MIRT720876	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT708819	hsa-miR-4705	HITS-CLIP	19536157
MIRT708818	hsa-miR-31-3p	HITS-CLIP	19536157
MIRT708817	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT708816	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT708815	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT708819	hsa-miR-4705	HITS-CLIP	19536157
MIRT708818	hsa-miR-31-3p	HITS-CLIP	19536157
MIRT708817	hsa-miR-1251-3p	HITS-CLIP	19536157
MIRT708816	hsa-miR-670-3p	HITS-CLIP	19536157
MIRT708815	hsa-miR-1238-3p	HITS-CLIP	19536157
MIRT1186650	hsa-miR-129-5p	CLIP-seq
MIRT1186651	hsa-miR-145	CLIP-seq
MIRT1186652	hsa-miR-197	CLIP-seq
MIRT1186653	hsa-miR-300	CLIP-seq
MIRT1186654	hsa-miR-3144-3p	CLIP-seq
MIRT1186655	hsa-miR-3149	CLIP-seq
MIRT1186656	hsa-miR-3671	CLIP-seq
MIRT1186657	hsa-miR-369-3p	CLIP-seq
MIRT1186658	hsa-miR-374a	CLIP-seq
MIRT1186659	hsa-miR-374b	CLIP-seq
MIRT1186660	hsa-miR-381	CLIP-seq
MIRT1186661	hsa-miR-4286	CLIP-seq
MIRT1186662	hsa-miR-4659a-3p	CLIP-seq
MIRT1186663	hsa-miR-4659b-3p	CLIP-seq
MIRT1186664	hsa-miR-4666-3p	CLIP-seq
MIRT1186665	hsa-miR-4778-3p	CLIP-seq
MIRT1186666	hsa-miR-496	CLIP-seq
MIRT1186667	hsa-miR-568	CLIP-seq
MIRT1186668	hsa-miR-607	CLIP-seq
MIRT1186669	hsa-miR-875-5p	CLIP-seq
MIRT2054100	hsa-miR-526b	CLIP-seq
MIRT2581563	hsa-miR-33a	CLIP-seq
MIRT2581564	hsa-miR-33b	CLIP-seq
MIRT2581565	hsa-miR-340	CLIP-seq
MIRT2686386	hsa-miR-193a-3p	CLIP-seq
MIRT2686387	hsa-miR-193b	CLIP-seq
MIRT2686388	hsa-miR-2277-3p	CLIP-seq
MIRT2686389	hsa-miR-3128	CLIP-seq
MIRT2581563	hsa-miR-33a	CLIP-seq
MIRT2581564	hsa-miR-33b	CLIP-seq
MIRT2581565	hsa-miR-340	CLIP-seq
MIRT2686390	hsa-miR-3689a-5p	CLIP-seq
MIRT2686391	hsa-miR-3689b	CLIP-seq
MIRT2686392	hsa-miR-3689e	CLIP-seq
MIRT2686393	hsa-miR-3689f	CLIP-seq
MIRT2686394	hsa-miR-4291	CLIP-seq
MIRT2686395	hsa-miR-4310	CLIP-seq
MIRT2686396	hsa-miR-4470	CLIP-seq
MIRT2686397	hsa-miR-4501	CLIP-seq
MIRT2686398	hsa-miR-4722-3p	CLIP-seq
MIRT2686399	hsa-miR-513a-3p	CLIP-seq
MIRT2686400	hsa-miR-892b	CLIP-seq

Show/Hide all (99)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	NAS	21838267
GO:0005576	Component	Extracellular region	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	28841651
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	NAS	14522992
GO:0005886	Component	Plasma membrane	TAS
GO:0006605	Process	Protein targeting	ISS
GO:0007155	Process	Cell adhesion	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
GO:0007158	Process	Neuron cell-cell adhesion	ISS
GO:0007158	Process	Neuron cell-cell adhesion	NAS	16242404, 25428619
GO:0007158	Process	Neuron cell-cell adhesion	TAS	15797875
GO:0007399	Process	Nervous system development	IMP	28841651
GO:0007399	Process	Nervous system development	ISS
GO:0007416	Process	Synapse assembly	ISS
GO:0009986	Component	Cell surface	ISS	26440732
GO:0010841	Process	Positive regulation of circadian sleep/wake cycle, wakefulness	ISS
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	TAS	15797875
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	21838267
GO:0016080	Process	Synaptic vesicle targeting	ISS
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS	18084303
GO:0023041	Process	Neuronal signal transduction	TAS	15797875
GO:0030165	Function	PDZ domain binding	IDA	17474715
GO:0030425	Component	Dendrite	ISS
GO:0031175	Process	Neuron projection development	IDA	22750515
GO:0031175	Process	Neuron projection development	ISS
GO:0031594	Component	Neuromuscular junction	NAS	28194405
GO:0032230	Process	Positive regulation of synaptic transmission, GABAergic	ISS
GO:0032230	Process	Positive regulation of synaptic transmission, GABAergic	NAS	16846852
GO:0032433	Component	Filopodium tip	ISS
GO:0035418	Process	Protein localization to synapse	ISS
GO:0038023	Function	Signaling receptor activity	ISS
GO:0042043	Function	Neurexin family protein binding	IEA
GO:0042043	Function	Neurexin family protein binding	ISS
GO:0042043	Function	Neurexin family protein binding	NAS	14522992
GO:0042802	Function	Identical protein binding	ISS
GO:0043083	Component	Synaptic cleft	IEA
GO:0043197	Component	Dendritic spine	ISS
GO:0043235	Component	Receptor complex	ISS
GO:0045184	Process	Establishment of protein localization	ISS
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0045211	Component	Postsynaptic membrane	TAS	15797875
GO:0045664	Process	Regulation of neuron differentiation	ISS
GO:0048511	Process	Rhythmic process	IEA
GO:0048789	Process	Cytoskeletal matrix organization at active zone	ISS
GO:0048812	Process	Neuron projection morphogenesis	NAS	29504935
GO:0050804	Process	Modulation of chemical synaptic transmission	ISS
GO:0050839	Function	Cell adhesion molecule binding	ISS
GO:0051491	Process	Positive regulation of filopodium assembly	ISS
GO:0051965	Process	Positive regulation of synapse assembly	IDA	24613359
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	ISS
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	NAS	16846852
GO:0060076	Component	Excitatory synapse	NAS	25428619
GO:0060999	Process	Positive regulation of dendritic spine development	IGI	23143522
GO:0060999	Process	Positive regulation of dendritic spine development	ISS
GO:0061002	Process	Negative regulation of dendritic spine morphogenesis	IGI	23143522
GO:0071277	Process	Cellular response to calcium ion	ISS
GO:0072553	Process	Terminal button organization	ISS
GO:0097060	Component	Synaptic membrane	IEA
GO:0097091	Process	Synaptic vesicle clustering	ISS
GO:0097104	Process	Postsynaptic membrane assembly	ISS
GO:0097105	Process	Presynaptic membrane assembly	ISS
GO:0097110	Function	Scaffold protein binding	IDA	17474715
GO:0097113	Process	AMPA glutamate receptor clustering	ISS
GO:0097114	Process	NMDA glutamate receptor clustering	IGI	23143522
GO:0097114	Process	NMDA glutamate receptor clustering	ISS
GO:0097115	Process	Neurexin clustering involved in presynaptic membrane assembly	ISS
GO:0097119	Process	Postsynaptic density protein 95 clustering	ISS
GO:0097120	Process	Receptor localization to synapse	ISS
GO:0098635	Component	Protein complex involved in cell-cell adhesion	ISO
GO:0098635	Component	Protein complex involved in cell-cell adhesion	NAS	18084303
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	NAS	14522992
GO:0098978	Component	Glutamatergic synapse	NAS	16846852
GO:0098982	Component	GABA-ergic synapse	NAS	16846852
GO:0098984	Component	Neuron to neuron synapse	IEA
GO:0098985	Component	Asymmetric, glutamatergic, excitatory synapse	TAS	21838267
GO:0098989	Process	NMDA selective glutamate receptor signaling pathway	ISS
GO:0098990	Process	AMPA selective glutamate receptor signaling pathway	ISS
GO:0099054	Process	Presynapse assembly	IEA
GO:0099054	Process	Presynapse assembly	TAS	21838267
GO:0099634	Component	Postsynaptic specialization membrane	IBA
GO:0099634	Component	Postsynaptic specialization membrane	ISS
GO:0140058	Process	Neuron projection arborization	ISS
GO:1900029	Process	Positive regulation of ruffle assembly	ISS
GO:1900075	Process	Positive regulation of neuromuscular synaptic transmission	NAS	28194405
GO:1900244	Process	Positive regulation of synaptic vesicle endocytosis	ISS
GO:1902533	Process	Positive regulation of intracellular signal transduction	ISS
GO:1904861	Process	Excitatory synapse assembly	ISS	26440732
GO:2000302	Process	Positive regulation of synaptic vesicle exocytosis	ISS
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	IGI	23143522
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	ISS

MIM	HGNC	e!Ensembl
600568	14291	ENSG00000169760

Q8N2Q7

Protein name

Neuroligin-1

Protein function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other sy

PDB

5OJ6 , 5OJK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00135	COesterase	51 → 646	Carboxylesterase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the blood vessel walls (at protein level). Highly expressed in brain through prenatal stages, and at lower levels in pancreas islet beta cells. {ECO:0000269|PubMed:18755801, ECO:0000269|PubMed:19926856, ECO:0000269|PubMed:

Sequence

MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFG
KIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQN
IIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECARKPGKKI
CRKGGPLTKKQTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASY
GNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS
GAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKV
GCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLN
YDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMY
TDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAW
ADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDT
KFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHNLNDIS
QYTSTTTKVPSTDITFRPTRKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVTI
AVGASLLFLNILAFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHAQEEEIMSLQMKHTDL
DHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPLHTFNTF
TGGQNNTLPHPHPHPHSHSTTRV

Sequence length

863

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		Neurexins and neuroligins

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autism, susceptibility to, 20	Conflicting classifications of pathogenicity; Uncertain significance; risk factor	rs749776633, rs752889815, rs1751123722, rs1750373491, rs1751075634, rs568763160	RCV005399157 RCV003991078 RCV001093627 RCV001093628 RCV001093629 RCV004799426
NLGN1-related disorder	Benign; Uncertain significance; Likely benign	rs7646919, rs147487792, rs2548804496, rs2548762559, rs749502013, rs1025774287, rs776117436, rs150137049, rs981103140, rs16858840, rs2548794862, rs750281465, rs77343837, rs2473592833, rs115286304	RCV003975875 RCV003410146 RCV003400207 RCV003410501 RCV003897065 RCV003964506 RCV003964523 RCV003974258 RCV003964573 RCV003973912 RCV003899583 RCV003933970 RCV003907290 RCV003932101 RCV003910544
See cases	Uncertain significance	rs140900040, rs2546615886	RCV002252601 RCV003128477

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Inhibit	33522967
Autism Spectrum Disorder	Associate	21915259, 22952857, 32127416
Autistic Disorder	Associate	18084303, 19404257, 27219346
Cognition Disorders	Associate	33522967
Colorectal Neoplasms	Associate	34340665
Corticobasal Degeneration	Associate	33522967
Hirschsprung Disease	Associate	26109803
Hypertension	Associate	33792450
Neurodegenerative Diseases	Associate	33522967
Pick Disease of the Brain	Associate	33522967
Prostatic Neoplasms	Associate	34911933
Schizophrenia	Associate	22952857
Stiff Person Syndrome	Associate	27219346
Stress Disorders Post Traumatic	Associate	27219346
Supranuclear Palsy Progressive	Associate	33522967
Tauopathies	Associate	32661233
Tauopathies	Inhibit	33522967
Thrombophilia due to Activated Protein C Resistance	Associate	32661233

NLGN1 (neuroligin 1)