Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	22859
Gene name	Adhesion G protein-coupled receptor L1
Gene symbol	ADGRL1
Synonyms (NCBI Gene)	CIRL1CL1DEDBANPLEC2LPHN1
Chromosome	19
Chromosome location	19p13.12
Summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cystein

148

Show/Hide all (148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740408	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT740409	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT740410	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT740411	hsa-miR-2276-5p	HITS-CLIP	19536157
MIRT740412	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT740413	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT740414	hsa-miR-4469	HITS-CLIP	19536157
MIRT740415	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT740416	hsa-miR-4287	HITS-CLIP	19536157
MIRT740417	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT740418	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT740419	hsa-miR-1260a	HITS-CLIP	19536157
MIRT740420	hsa-miR-1260b	HITS-CLIP	19536157
MIRT740421	hsa-miR-642a-5p	HITS-CLIP	19536157
MIRT740422	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT740423	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT740424	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT753869	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT753871	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT753873	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT753874	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT753876	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT753877	hsa-miR-548p	PAR-CLIP	20371350
MIRT753878	hsa-miR-646	PAR-CLIP	20371350
MIRT753879	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT753880	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT753882	hsa-miR-1470	PAR-CLIP	20371350
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	20371350
MIRT753884	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	20371350
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT753869	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT753871	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT753873	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT753874	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT753876	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT753877	hsa-miR-548p	PAR-CLIP	20371350
MIRT753878	hsa-miR-646	PAR-CLIP	20371350
MIRT753879	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT753880	hsa-miR-4691-3p	PAR-CLIP	20371350
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT753882	hsa-miR-1470	PAR-CLIP	20371350
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	20371350
MIRT753884	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	20371350
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT753869	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT753871	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT753873	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT753874	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT753876	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT753877	hsa-miR-548p	PAR-CLIP	20371350
MIRT753878	hsa-miR-646	PAR-CLIP	20371350
MIRT753879	hsa-miR-545-3p	PAR-CLIP	20371350
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	20371350
MIRT753882	hsa-miR-1470	PAR-CLIP	20371350
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	20371350
MIRT753884	hsa-miR-766-3p	PAR-CLIP	20371350
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	20371350
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	20371350
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	20371350
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	20371350
MIRT753869	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT753871	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT753873	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT753874	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT753876	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT753877	hsa-miR-548p	PAR-CLIP	21572407
MIRT753878	hsa-miR-646	PAR-CLIP	21572407
MIRT753879	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT753880	hsa-miR-4691-3p	PAR-CLIP	21572407
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT753882	hsa-miR-1470	PAR-CLIP	21572407
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	21572407
MIRT753884	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	21572407
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	21572407
MIRT753869	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT753871	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT753873	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT753874	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT753876	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT753877	hsa-miR-548p	PAR-CLIP	23446348
MIRT753878	hsa-miR-646	PAR-CLIP	23446348
MIRT753879	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT753880	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT753882	hsa-miR-1470	PAR-CLIP	23446348
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	23446348
MIRT753884	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	23446348
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	23446348
MIRT753869	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT753870	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT753871	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT753872	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT753873	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT753874	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT753875	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT753876	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT753877	hsa-miR-548p	PAR-CLIP	23446348
MIRT753878	hsa-miR-646	PAR-CLIP	23446348
MIRT753879	hsa-miR-545-3p	PAR-CLIP	23446348
MIRT753880	hsa-miR-4691-3p	PAR-CLIP	23446348
MIRT753881	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT753882	hsa-miR-1470	PAR-CLIP	23446348
MIRT753883	hsa-miR-4667-3p	PAR-CLIP	23446348
MIRT753884	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT753885	hsa-miR-3160-5p	PAR-CLIP	23446348
MIRT753886	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT753887	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT753888	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT753889	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT753890	hsa-miR-1287-3p	PAR-CLIP	23446348

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005515	Function	Protein binding	IPI	21078624
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	15203201
GO:0016524	Function	Latrotoxin receptor activity	IBA
GO:0016524	Function	Latrotoxin receptor activity	ISS
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030426	Component	Growth cone	IEA
GO:0030426	Component	Growth cone	ISS
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042734	Component	Presynaptic membrane	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043005	Component	Neuron projection	ISS
GO:0045202	Component	Synapse	IEA
GO:0045202	Component	Synapse	ISS
GO:0050839	Function	Cell adhesion molecule binding	ISS

MIM	HGNC	e!Ensembl
616416	20973	ENSG00000072071

O94910

Protein name

Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2)

Protein function

Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405). Receptor for TENM2 that m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02140	Gal_Lectin	48 → 128	Galactose binding lectin domain	Domain
PF02191	OLF	144 → 396	Olfactomedin-like domain	Family
PF02793	HRM	477 → 535	Hormone receptor domain	Family
PF16489	GAIN	549 → 774	GPCR-Autoproteolysis INducing (GAIN) domain	Domain
PF01825	GPS	800 → 844	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	857 → 1093	7 transmembrane receptor (Secretin family)	Family
PF02354	Latrophilin	1113 → 1474	Latrophilin Cytoplasmic C-terminal region	Family

Sequence

MARLAAVLWNLCVTAVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVEN
ANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYK
YLEVQYDCVPYKVEQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWI
PYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRT
RIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTL
RFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSL
TFPNPYQFISSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPT
PLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPVPSTRRPPAPNLHVSPELFC
EPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQV
AQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAG
KNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAF
LLADNVREPARFLAAKENVVLEVTVLNTEGQVQELVFPQEEYPRKNSIQLSAKTIKQNSR
NGVVKVVFILYNNLGLFLSTENATVKLAGEAGPGGPGGASLVVNSQVIAASINKESSRVF
LMDPVIFTVAHLEDKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTN
FAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLC
INLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEY
SRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLV
FLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAY
LFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTR
YYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPY
NTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFP
PGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGSSSAAKGPPPPEPPVPPVPGGGGEE
EAGGPGGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPG
RDSLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGY
YQVRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL

Sequence length

1474

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Attention deficit hyperactivity disorder	Pathogenic; Likely pathogenic	rs2144666888, rs2144755046, rs1971372172, rs2144613361, rs2144699293	RCV002274837 RCV002274841 RCV002274842 RCV002274843 RCV002274844	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Autistic behavior	Pathogenic; Likely pathogenic	rs2144666888, rs2144755046, rs1971372172, rs2144613361, rs2144699293	RCV002274837 RCV002274841 RCV002274842 RCV002274843 RCV002274844	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Developmental delay, behavioral abnormalities, and neuropsychiatric disorders	Pathogenic; Likely pathogenic	rs2144666888, rs2144613733, rs2144755046, rs1971372172, rs2144613361, rs2512766503, rs2513043216, rs2512827446	RCV002287907 RCV002287908 RCV002287909 RCV002287910 RCV002287911 RCV003444144 RCV003458951 RCV003988346	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Global developmental delay	Pathogenic; Likely pathogenic	rs2144666888, rs2144613733, rs2144616263, rs2144755046, rs2144613361, rs2144699293, rs907174700, rs1395589626	RCV002274837 RCV002274838 RCV002274839 RCV002274841 RCV002274843 RCV002274844 RCV002274845 RCV002274846	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intellectual disability	Pathogenic; Likely pathogenic	rs2144666888, rs2144755046, rs907174700, rs1395589626	RCV002274837 RCV002274841 RCV002274845 RCV002274846	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Seizure	Pathogenic	rs2144613361, rs2144699293	RCV002274843 RCV002274844	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Specific learning disability	Pathogenic	rs2144616263, rs907174700	RCV002274839 RCV002274845	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ADGRL1-related condition	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	23951353	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries Traumatic	Associate	36482407	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholera	Associate	26627831	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	37398658	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cutis Laxa Autosomal Dominant	Associate	21309044	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperkinesis	Associate	20648052	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Associate	20648052	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Leukemia Lymphocytic Chronic B Cell	Associate	21911837	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Associate	27322212	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	27258612	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	27322212	★★★★★ ★☆☆☆☆ Found in Text Mining only

ADGRL1 (adhesion G protein-coupled receptor L1)