Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
22849
Gene name Gene Name - the full gene name approved by the HGNC.
Cytoplasmic polyadenylation element binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CPEB3
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q23.32
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005588 hsa-miR-26a-5p Luciferase reporter assay, Northern blot, qRT-PCR 20660482
MIRT005588 hsa-miR-26a-5p Luciferase reporter assay, Northern blot, qRT-PCR 20660482
MIRT005591 hsa-miR-29a-3p Luciferase reporter assay, Northern blot, qRT-PCR 20660482
MIRT005591 hsa-miR-29a-3p Luciferase reporter assay, Northern blot, qRT-PCR 20660482
MIRT023472 hsa-miR-23b-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 20639532
GO:0000900 Function Translation repressor activity, mRNA regulatory element binding IBA 21873635
GO:0000900 Function Translation repressor activity, mRNA regulatory element binding ISS
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IDA 22730302
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610606 21746 ENSG00000107864
Protein
UniProt ID Q8NE35
Protein name Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3)
Protein function Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cyto
PDB 2DNL , 2RUG , 7N2E , 7N2F , 7N2G , 8SPA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16367 RRM_7 440 529 RNA recognition motif Domain
PF16366 CEBP_ZZ 622 685 Cytoplasmic polyadenylation element-binding protein ZZ domain Domain
Sequence
MQDDLLMDKSKTQPQPQQQQRQQQQPQPESSVSEAPSTPLSSETPKPEENSAVPALSPAA
APPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGASLSPSFGSTWSTGTTNAVE
DSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPAPQPAQPAQ
PPQAQPPQQRRSPASPSQAPYAQRSAAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASS
SWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNV
IAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTD
HEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNNAFLDDSHGDQAL
SSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSY
FPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRP
WNLSDSDFVMD
GSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSN
QQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQ
YYCEYCWASIHSRAGREFHKPLVKE
GGDRPRHVPFRWS
Sequence length 698
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Oocyte meiosis
Progesterone-mediated oocyte maturation
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23945395
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33159015
Carcinoma Hepatocellular Associate 29850575, 31321712, 31335995, 32968053, 33812045, 34738854, 35805200, 36458010
Glioma Associate 27256982
Melanoma Inhibit 33506034
Neoplasm Metastasis Associate 32968053
Neoplasms Associate 27256982, 29850575, 32968053, 35805200
Neoplasms Inhibit 33506034
Neuroblastoma Associate 34879089
Stomach Neoplasms Associate 33099959