PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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22843 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein phosphatase, Mg2+/Mn2+ dependent 1E |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PPM1E |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CAMKPN, CaMKP-N, POPX1, PP2CH, caMKN |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q22 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5`-AMP-activat |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q8WY54 | ||||||||||
| Protein name | Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) | ||||||||||
| Protein function | Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 755 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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