Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	22828
Gene name	SR-related CTD associated factor 8
Gene symbol	SCAF8
Synonyms (NCBI Gene)	RBM16
Chromosome	6
Chromosome location	6q25.2

Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052039	hsa-let-7b-5p	CLASH	23622248
MIRT049583	hsa-miR-92a-3p	CLASH	23622248
MIRT048359	hsa-miR-29b-3p	CLASH	23622248
MIRT037053	hsa-miR-877-3p	CLASH	23622248
MIRT1327762	hsa-miR-103a	CLIP-seq
MIRT1327763	hsa-miR-107	CLIP-seq
MIRT1327764	hsa-miR-1184	CLIP-seq
MIRT1327765	hsa-miR-1205	CLIP-seq
MIRT1327766	hsa-miR-1284	CLIP-seq
MIRT1327767	hsa-miR-223	CLIP-seq
MIRT1327768	hsa-miR-300	CLIP-seq
MIRT1327769	hsa-miR-3158-5p	CLIP-seq
MIRT1327770	hsa-miR-3613-5p	CLIP-seq
MIRT1327771	hsa-miR-3660	CLIP-seq
MIRT1327772	hsa-miR-381	CLIP-seq
MIRT1327773	hsa-miR-3921	CLIP-seq
MIRT1327774	hsa-miR-4282	CLIP-seq
MIRT1327775	hsa-miR-4476	CLIP-seq
MIRT1327776	hsa-miR-4526	CLIP-seq
MIRT1327777	hsa-miR-4653-5p	CLIP-seq
MIRT1327778	hsa-miR-4666-3p	CLIP-seq
MIRT1327779	hsa-miR-4744	CLIP-seq
MIRT1327780	hsa-miR-4796-5p	CLIP-seq
MIRT1327781	hsa-miR-544	CLIP-seq
MIRT1327782	hsa-miR-593	CLIP-seq
MIRT1327783	hsa-miR-944	CLIP-seq
MIRT1327771	hsa-miR-3660	CLIP-seq
MIRT1327773	hsa-miR-3921	CLIP-seq
MIRT1327776	hsa-miR-4526	CLIP-seq
MIRT1327777	hsa-miR-4653-5p	CLIP-seq
MIRT2097293	hsa-miR-520d-5p	CLIP-seq
MIRT2097294	hsa-miR-524-5p	CLIP-seq
MIRT2097295	hsa-miR-548m	CLIP-seq
MIRT1327782	hsa-miR-593	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT1327767	hsa-miR-223	CLIP-seq
MIRT1327768	hsa-miR-300	CLIP-seq
MIRT1327770	hsa-miR-3613-5p	CLIP-seq
MIRT2321632	hsa-miR-3658	CLIP-seq
MIRT1327772	hsa-miR-381	CLIP-seq
MIRT2321633	hsa-miR-3915	CLIP-seq
MIRT2321634	hsa-miR-3928	CLIP-seq
MIRT1327778	hsa-miR-4666-3p	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT1327783	hsa-miR-944	CLIP-seq
MIRT2617975	hsa-miR-186	CLIP-seq
MIRT2617976	hsa-miR-3149	CLIP-seq
MIRT2617977	hsa-miR-361-5p	CLIP-seq
MIRT2617978	hsa-miR-4667-5p	CLIP-seq
MIRT2617979	hsa-miR-4700-5p	CLIP-seq
MIRT2617980	hsa-miR-4781-3p	CLIP-seq
MIRT2617981	hsa-miR-502-5p	CLIP-seq
MIRT2617982	hsa-miR-578	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2617983	hsa-miR-637	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq
MIRT2617984	hsa-miR-889	CLIP-seq
MIRT2617975	hsa-miR-186	CLIP-seq
MIRT2617978	hsa-miR-4667-5p	CLIP-seq
MIRT2617979	hsa-miR-4700-5p	CLIP-seq
MIRT2617981	hsa-miR-502-5p	CLIP-seq
MIRT2321635	hsa-miR-579	CLIP-seq
MIRT2617983	hsa-miR-637	CLIP-seq
MIRT2097296	hsa-miR-664	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000993	Function	RNA polymerase II complex binding	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IDA	31104839
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	31104839
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005849	Component	MRNA cleavage factor complex	IBA
GO:0006369	Process	Termination of RNA polymerase II transcription	IBA
GO:0016363	Component	Nuclear matrix	IEA
GO:0016363	Component	Nuclear matrix	ISS
GO:0032786	Process	Positive regulation of DNA-templated transcription, elongation	IDA	31104839
GO:0043175	Function	RNA polymerase core enzyme binding	IPI	18550522
GO:1990269	Function	RNA polymerase II C-terminal domain phosphoserine binding	IDA	31104839
GO:1990269	Function	RNA polymerase II C-terminal domain phosphoserine binding	IEA
GO:2000805	Process	Negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IDA	31104839
GO:2000805	Process	Negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled	IEA

MIM	HGNC	e!Ensembl
616024	20959	ENSG00000213079

Q9UPN6

Protein name

SR-related and CTD-associated factor 8 (CDC5L complex-associated protein 7) (RNA-binding motif protein 16)

Protein function

Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functiona

PDB

2DIW , 3D9I , 3D9J , 3D9K , 3D9L , 3D9M , 3D9N , 3D9O , 3D9P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04818	CID	5 → 131	CID domain	Domain
PF00076	RRM_1	479 → 545	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKV
PGLYVIDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKN
NVFKSEIIQPLLDMAAGIPPPVVTPVLASTTTAMSNTPGTPVTPVTPANVVQGLPDPWVS
QITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQL
TAAAAAANTLTPLEQGVSFNKKLMDRFDFGEDSEHSEEPKKEIPASQLSHVSESVNNSIF
HQIAEQLQQQNLEHLRQQLLEQQQPQKATPQDSQEGTFGSEHSASPSQGSSQQHFLEPEV
NLDDSIDIQQQDMDIDEGQDGVEEEVFEQEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRS
GSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPIRSKTLSVCSTTLW
VGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDAFRALQKLSSGSYKIG
SKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLEGFAEGGMIDQETVNTEWE
TVKSSEPVKETVQTTQSPTPVEKETVVTTQAEVFPPPVAMLQIPVAPAVPTVSLVPPAFP
VSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPTIPPVVPTSLVQPSL
SMTPETVKDVGFGSLVIPGGSVASNLATSALPAGNVFNAPTKQAEPEEKVPHLIDHQISS
GENTRSVIPNDISSNAAILGGQPPNVTSNSGILGVQRPNVSSNSEILGVRPSNVSSSSGI
IAAQPPNILNNSGILGIQPPSVSNSSGLLGVLPPNIPNNSGLVGVQPPNVPNTPGLLGTQ
PPAGPQNLPPLSIPNQRMPTMPMLDIRPGLIPQAPGPRFPLIQPGIPPQRGIPPPSVLDS
ALHPPPRGPFPPGDIFSQPERPFLAPGRQSVDNVTNPEKRIPLGNDNIQQEGDRDYRFPP
IETRESISRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDIRENLVRPGIDHLG
RRDHFGFNPEKPWGHRGDFDEREHRVLPVYGGPKGLHEERGRFRSGNYRFDPRSGPWNRG
FGQEVHRDFDDRRRPWERQRDRDDRDFDFCREMNGNRLGRDRIQNTWVPPPHARVFDYFE
GATSQRKGDNVPQVNGENTERHAQPPPIPVQNDPELYEKLTSSNEINKEKSDTVADIESE
PVVESTETEGT

Sequence length

1271

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autism spectrum disorder	Likely benign	rs2483503148	RCV003127243

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Diabetic Nephropathies	Associate	28401168
Diabetic Retinopathy	Associate	28401168
DNA Virus Infections	Associate	27184836
Duane Retraction Syndrome	Associate	28401168
Lymphoma	Associate	33883344
Lymphoma B Cell	Associate	33883344

SCAF8 (SR-related CTD associated factor 8)