Gene Gene information from NCBI Gene database.
Entrez ID 22823
Gene name Metal response element binding transcription factor 2
Gene symbol MTF2
Synonyms (NCBI Gene)
M96PCL2TDRD19AdJ976O13.2
Chromosome 1
Chromosome location 1p22.1
miRNA miRNA information provided by mirtarbase database.
597
miRTarBase ID miRNA Experiments Reference
MIRT027495 hsa-miR-98-5p Microarray 19088304
MIRT030417 hsa-miR-24-3p Microarray 19748357
MIRT050645 hsa-miR-19a-3p CLASH 23622248
MIRT047578 hsa-miR-10a-5p CLASH 23622248
MIRT047578 hsa-miR-10a-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
NANOG Activation 22378194
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
GO:0001222 Function Transcription corepressor binding IPI 29628311
GO:0003677 Function DNA binding IBA
GO:0003677 Function DNA binding IEA
GO:0003682 Function Chromatin binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609882 29535 ENSG00000143033
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y483
Protein name Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)
Protein function Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates
PDB 5XFR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18104 Tudor_2 49 84 Jumonji domain-containing protein 2A Tudor domain Domain
PF00628 PHD 104 157 PHD-finger Domain
PF14061 Mtf2_C 544 591 Polycomb-like MTF2 factor 2 Domain
Sequence
MRDSTGAGNSLVHKRSPLRRNQKTPTSLTKLSLQDGHKAKKPACKFEEGQDVLARWSDGL
FYLGTIKKINILKQSCFIIFEDSS
KSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMV
ICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFA
TTTKRGGALKKGPNAKALQVMKQ
TLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLF
GDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENW
DRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFK
AEKEPEGTSHEFKIKGRKASKPISDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAEP
LLDKESISENPTLDLPCSIGRTEGTAHSSNTSDVDFTGASSAKETTSSSISRHYGLSDSR
KRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNNLAD
QELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
Sequence length 593
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Polycomb repressive complex   PRC2 methylates histones and DNA
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adrenocortical Carcinoma Stimulate 37027952
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 37027952
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 37027952
★☆☆☆☆
Found in Text Mining only
Coronary Artery Disease Associate 35151267
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 37027952
★☆☆☆☆
Found in Text Mining only
Glioma Associate 32436117, 37027952
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Associate 30385522
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 32436117, 37027952
★☆☆☆☆
Found in Text Mining only