COPG1 (coat protein complex I subunit gamma 1)

Gene

• Entrez ID: 22820
• Gene name: Coat protein complex I subunit gamma 1
• Gene symbol: COPG1
• Synonyms (NCBI Gene): COPG, IMD128
• Chromosome: 3
• Chromosome location: 3q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017439	hsa-miR-335-5p	Microarray	18185580
MIRT023687	hsa-miR-1-3p	Proteomics	18668040
MIRT023687	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT032263	hsa-let-7b-5p	Proteomics	18668040
MIRT051586	hsa-let-7e-5p	CLASH	23622248
MIRT049305	hsa-miR-92a-3p	CLASH	23622248
MIRT036123	hsa-miR-1296-5p	CLASH	23622248
MIRT440911	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT389726	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440911	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT389726	hsa-miR-142-3p	HITS-CLIP	22473208

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	ISS
GO:0000139	Component	Golgi membrane	TAS
GO:0005198	Function	Structural molecule activity	IEA
GO:0005515	Function	Protein binding	IPI	14527956, 25036637, 26618866, 29924966, 31324722, 33961781, 35156780, 35271311, 36012204
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IBA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
GO:0006891	Process	Intra-Golgi vesicle-mediated transport	IBA
GO:0009306	Process	Protein secretion	IBA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030117	Component	Membrane coat	IEA
GO:0030126	Component	COPI vesicle coat	IBA
GO:0030126	Component	COPI vesicle coat	IEA
GO:0030126	Component	COPI vesicle coat	ISS
GO:0030133	Component	Transport vesicle	IEA
GO:0030133	Component	Transport vesicle	TAS
GO:0030663	Component	COPI-coated vesicle membrane	IEA
GO:0031090	Component	Organelle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0051683	Process	Establishment of Golgi localization	IEA
GO:0051683	Process	Establishment of Golgi localization	ISS
GO:0072384	Process	Organelle transport along microtubule	IBA
GO:0072384	Process	Organelle transport along microtubule	IEA
GO:0072384	Process	Organelle transport along microtubule	ISS

Other IDs

• MIM: 615525
• HGNC: 2236
• e!Ensembl: ENSG00000181789

Protein

• UniProt ID: Q9Y678
• Protein name: Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)
• Protein function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi ne
• PDB: 1R4X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01602	Adaptin_N	23 → 539	Adaptin N terminal region	Family
  PF08752	COP-gamma_platf	611 → 759	Coatomer gamma subunit appendage platform subdomain	Domain
  PF16381	Coatomer_g_Cpla	761 → 873	Coatomer subunit gamma-1 C-terminal appendage platform	Domain

• Sequence:

  MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEH
  LGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNY
  RGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNE
  AQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQL
  EEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPK
  AALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRL
  MKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDC
  IISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTTNPSKYIRFIYNRV
  VLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQK
  ALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLATAPMAEQRTESTPITAVK
  QPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMV
  FQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAV
  ACTFSCMMKFTVKDCDPTTGETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVG
  DEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDI
  LVRSRLLLLDTVTMQVTARSLEELPVDIILASVG

• Sequence length: 874

Pathways

Reactome:

COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Adrenocortical carcinoma, hereditary	Benign	rs62266876	RCV005927800
Cholangiocarcinoma	Benign	rs4927953, rs6802965, rs62266876	RCV005927792 RCV005927798 RCV005927804
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign	rs4927953	RCV005927793
Colorectal cancer	Benign	rs62266876	RCV005927803
Familial pancreatic carcinoma	Benign	rs4927953	RCV005927789
Hepatocellular carcinoma	Benign	rs4927953, rs6802965	RCV005927785 RCV005927794
Lymphoma	Benign	rs4927953	RCV005927790
Malignant lymphoma, large B-cell, diffuse	Benign	rs6802965, rs62266876	RCV005927796 RCV005927802
Nonpapillary renal cell carcinoma	Benign	rs4927953	RCV005927786
Ovarian cancer	Benign	rs4927953	RCV005927787
Uterine carcinosarcoma	Benign	rs4927953, rs6802965	RCV005927791 RCV005927797
Uveal melanoma	Benign	rs4927953, rs6802965, rs62266876	RCV005927788 RCV005927795 RCV005927801

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Renal Cell	Associate	33850477