Gene Gene information from NCBI Gene database.
Entrez ID 22808
Gene name Muscle RAS oncogene homolog
Gene symbol MRAS
Synonyms (NCBI Gene)
M-RAsNS11R-RAS3RRAS3
Chromosome 3
Chromosome location 3q22.3
Summary This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with m
SNPs SNP information provided by dbSNP.
4
SNP ID Visualize variation Clinical significance Consequence
rs1560171992 G>C Likely-pathogenic Missense variant, intron variant, coding sequence variant
rs1576359216 G>T Pathogenic Intron variant, missense variant, coding sequence variant
rs1576387876 C>T Pathogenic, likely-pathogenic 5 prime UTR variant, coding sequence variant, missense variant
rs1576387885 A>G Pathogenic 5 prime UTR variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
296
miRTarBase ID miRNA Experiments Reference
MIRT039529 hsa-miR-652-3p CLASH 23622248
MIRT473045 hsa-miR-2392 PAR-CLIP 23592263
MIRT473044 hsa-miR-3605-5p PAR-CLIP 23592263
MIRT473043 hsa-miR-185-5p PAR-CLIP 23592263
MIRT473042 hsa-miR-4306 PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23
GO ID Ontology Definition Evidence Reference
GO:0000164 Component Protein phosphatase type 1 complex IDA 35768504, 35830882, 35831509, 36175670
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity IMP 28289718
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608435 7227 ENSG00000158186
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14807
Protein name Ras-related protein M-Ras (EC 3.6.5.2) (Ras-related protein R-Ras3)
Protein function Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:16630891, PubMed:28289718, PubMed:35768504, PubMed:35830882, PubMed:35831509, PubMed:36175670). Core component of the SHOC2-MRAS-PP1c (SMP
PDB 7SD0 , 7TVF , 7TXH , 7UPI , 9B4R , 9B4T , 9C1A , 9C1B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 15 177 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expression highly restricted to the brain and heart.
Sequence
Sequence length 208
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
C-type lectin receptor signaling pathway
Regulation of actin cytoskeleton
Proteoglycans in cancer
 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Male infertility with azoospermia or oligozoospermia due to single gene mutation Likely pathogenic rs2055287972 RCV003991598
Noonan syndrome 11 Likely pathogenic rs1576359216, rs1576387876, rs1576387885 RCV000787303
RCV000787304
RCV000787305
RASopathy Likely pathogenic rs1560171992, rs1576359216, rs1576387876, rs1576387885 RCV000678907
RCV003155311
RCV004732489
RCV005252058
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
MRAS-related disorder Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity rs368097379, rs372879145, rs151130678, rs373753637, rs16848033, rs149904534, rs541655371, rs752298978 RCV003956221
RCV003893050
RCV003913745
RCV003943399
RCV003980070
RCV003935586
RCV003915685
RCV003945906
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abidi X linked mental retardation syndrome Associate 28737528
Atherosclerosis Associate 32495899
Breast Neoplasms Associate 22121046
Burkitt Lymphoma Associate 26325594
Carcinogenesis Associate 22121046, 27891760
Carcinoma Non Small Cell Lung Associate 33106373
Cardiomegaly Associate 28289718, 31638832
Cardiomyopathy Hypertrophic Associate 36734411, 37141804
Cardiovascular Diseases Associate 23738802, 31770223
Central Nervous System Diseases Associate 24148564