Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	22797
Gene name Gene Name - the full gene name approved by the HGNC.	Transcription factor EC
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TFEC
Synonyms (NCBI Gene) Gene synonyms aliases	TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q31.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodime

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miRTarBase ID	miRNA	Experiments	Reference
MIRT531710	hsa-miR-506-5p	PAR-CLIP	22012620
MIRT531709	hsa-miR-873-5p	PAR-CLIP	22012620
MIRT531708	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT531706	hsa-miR-5096	PAR-CLIP	22012620
MIRT531707	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT439472	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439471	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT439472	ebv-miR-BART7-3p	HITS-CLIP	22473208
MIRT439471	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT531710	hsa-miR-506-5p	PAR-CLIP	22012620
MIRT531709	hsa-miR-873-5p	PAR-CLIP	22012620
MIRT531708	hsa-miR-769-5p	PAR-CLIP	22012620
MIRT531706	hsa-miR-5096	PAR-CLIP	22012620
MIRT531707	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT1420494	hsa-miR-1197	CLIP-seq
MIRT1420495	hsa-miR-130a	CLIP-seq
MIRT1420496	hsa-miR-130b	CLIP-seq
MIRT1420497	hsa-miR-148a	CLIP-seq
MIRT1420498	hsa-miR-148b	CLIP-seq
MIRT1420499	hsa-miR-152	CLIP-seq
MIRT1420500	hsa-miR-155	CLIP-seq
MIRT1420501	hsa-miR-216b	CLIP-seq
MIRT1420502	hsa-miR-301a	CLIP-seq
MIRT1420503	hsa-miR-301b	CLIP-seq
MIRT1420504	hsa-miR-3123	CLIP-seq
MIRT1420505	hsa-miR-3148	CLIP-seq
MIRT1420506	hsa-miR-3606	CLIP-seq
MIRT1420507	hsa-miR-3616-5p	CLIP-seq
MIRT1420508	hsa-miR-3617	CLIP-seq
MIRT1420509	hsa-miR-3646	CLIP-seq
MIRT1420510	hsa-miR-3647-5p	CLIP-seq
MIRT1420511	hsa-miR-365	CLIP-seq
MIRT1420512	hsa-miR-3666	CLIP-seq
MIRT1420513	hsa-miR-3688-3p	CLIP-seq
MIRT1420514	hsa-miR-380	CLIP-seq
MIRT1420515	hsa-miR-3919	CLIP-seq
MIRT1420516	hsa-miR-3924	CLIP-seq
MIRT1420517	hsa-miR-4295	CLIP-seq
MIRT1420518	hsa-miR-4311	CLIP-seq
MIRT1420519	hsa-miR-4436b-3p	CLIP-seq
MIRT1420520	hsa-miR-454	CLIP-seq
MIRT1420521	hsa-miR-4738-3p	CLIP-seq
MIRT1420522	hsa-miR-4742-3p	CLIP-seq
MIRT1420523	hsa-miR-4761-3p	CLIP-seq
MIRT1420524	hsa-miR-4795-5p	CLIP-seq
MIRT1420525	hsa-miR-4797-5p	CLIP-seq
MIRT1420526	hsa-miR-532-5p	CLIP-seq
MIRT1420527	hsa-miR-573	CLIP-seq
MIRT1420528	hsa-miR-607	CLIP-seq
MIRT1420529	hsa-miR-641	CLIP-seq
MIRT1420530	hsa-miR-944	CLIP-seq
MIRT1420531	hsa-miR-188-5p	CLIP-seq
MIRT1420532	hsa-miR-204	CLIP-seq
MIRT1420533	hsa-miR-211	CLIP-seq
MIRT1420534	hsa-miR-4668-3p	CLIP-seq
MIRT1420535	hsa-miR-548c-3p	CLIP-seq
MIRT1420536	hsa-miR-605	CLIP-seq
MIRT1420505	hsa-miR-3148	CLIP-seq
MIRT2126305	hsa-miR-3153	CLIP-seq
MIRT2126306	hsa-miR-3163	CLIP-seq
MIRT2126307	hsa-miR-3662	CLIP-seq
MIRT2126308	hsa-miR-4328	CLIP-seq
MIRT2126309	hsa-miR-433	CLIP-seq
MIRT2126310	hsa-miR-4668-5p	CLIP-seq
MIRT2348290	hsa-miR-1267	CLIP-seq
MIRT2348291	hsa-miR-1539	CLIP-seq
MIRT2348292	hsa-miR-3074-5p	CLIP-seq
MIRT1420505	hsa-miR-3148	CLIP-seq
MIRT2126305	hsa-miR-3153	CLIP-seq
MIRT2348293	hsa-miR-3182	CLIP-seq
MIRT2348294	hsa-miR-3193	CLIP-seq
MIRT2126307	hsa-miR-3662	CLIP-seq
MIRT1420514	hsa-miR-380	CLIP-seq
MIRT1420516	hsa-miR-3924	CLIP-seq
MIRT2348295	hsa-miR-4282	CLIP-seq
MIRT2348296	hsa-miR-4495	CLIP-seq
MIRT2348297	hsa-miR-4652-3p	CLIP-seq
MIRT2348298	hsa-miR-4659a-3p	CLIP-seq
MIRT2348299	hsa-miR-4659b-3p	CLIP-seq
MIRT2126310	hsa-miR-4668-5p	CLIP-seq
MIRT2348300	hsa-miR-4698	CLIP-seq
MIRT2348301	hsa-miR-501-5p	CLIP-seq
MIRT1420528	hsa-miR-607	CLIP-seq
MIRT2461375	hsa-miR-1276	CLIP-seq
MIRT1420518	hsa-miR-4311	CLIP-seq
MIRT2461376	hsa-miR-583	CLIP-seq
MIRT2640939	hsa-miR-3614-5p	CLIP-seq
MIRT2640940	hsa-miR-450b-3p	CLIP-seq
MIRT2640941	hsa-miR-4713-3p	CLIP-seq
MIRT2640942	hsa-miR-543	CLIP-seq
MIRT2640943	hsa-miR-570	CLIP-seq
MIRT2640944	hsa-miR-638	CLIP-seq
MIRT2640945	hsa-miR-769-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	9256061
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	9256061
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	TAS	9256061
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0034605	Process	Cellular response to heat	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9256061
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
604732	11754	ENSG00000105967

Protein

UniProt ID

O14948

Protein name

Transcription factor EC (TFE-C) (Class E basic helix-loop-helix protein 34) (bHLHe34) (Transcription factor EC-like) (hTFEC-L)

Protein function

Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	140 → 193	Helix-loop-helix DNA-binding domain	Domain
PF11851	DUF3371	225 → 344	Domain of unknown function (DUF3371)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed moderately in spleen, kidney, bone marrow, small intestine and leukocytes. Expressed weakly in testis, trachea and colon. {ECO:0000269|PubMed:11467950, ECO:0000269|PubMed:15118077}.

Sequence

MTLDHQIINPTLKWSQPAVPSGGPLVQHAHTTLDSDAGLTENPLTKLLAIGKEDDNAQWH
MEDVIEDIIGMESSFKEEGADSPLLMQRTLSGSILDVYSGEQGISPINMGLTSASCPSSL
PMKREITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDPDMRWNKGT
ILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGT
VDLGAHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKE
EQRLDGMLLDDTISPFGTDPLLSATSPAVSKESSRRSSFSSDDGDEL

Sequence length

347

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Glaucoma	Glaucoma	N/A	N/A	GWAS

TFEC (transcription factor EC)