Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2274
Gene name Gene Name - the full gene name approved by the HGNC.
Four and a half LIM domains 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FHL2
Synonyms (NCBI Gene) Gene synonyms aliases
AAG11, DRAL, FHL-2, SLIM-3, SLIM3
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023214 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT643969 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT643970 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT643968 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT643967 hsa-miR-412-3p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
PAX5 Activation 21540083
RUNX1 Unknown 18768464
SKI Activation 14583455
SRF Unknown 22456196
ZBTB14 Activation 21540083
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15692560
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001649 Process Osteoblast differentiation IEA
GO:0003714 Function Transcription corepressor activity IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602633 3703 ENSG00000115641
Protein
UniProt ID Q14192
Protein name Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Protein function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and
PDB 1X4K , 1X4L , 2D8Z , 2MIU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 40 97 LIM domain Domain
PF00412 LIM 101 158 LIM domain Domain
PF00412 LIM 162 217 LIM domain Domain
PF00412 LIM 221 278 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11813260}.
Sequence
Sequence length 279
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Osteoclast differentiation
Cytoskeleton in muscle cells
  PPARA activates gene expression
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy N/A N/A ClinVar
Cardiomyopathy Primary dilated cardiomyopathy, left ventricular noncompaction cardiomyopathy N/A N/A ClinVar
cardiomyopathy Cardiomyopathy N/A N/A ClinVar
Dilated Cardiomyopathy familial isolated dilated cardiomyopathy N/A N/A GenCC
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amenorrhea Associate 25747126
Aortic Valve Stenosis Associate 37175670
Atrial Fibrillation Associate 32682418
Breast Neoplasms Inhibit 14550570
Breast Neoplasms Associate 18853468
Carcinogenesis Associate 18752053, 18853468, 32236623
Carcinoma Hepatocellular Associate 32236623
Carcinoma Ovarian Epithelial Associate 15161045
Cardiomyopathies Associate 32344918
Cardiomyopathy Hypertrophic Associate 32344918