Gene Gene information from NCBI Gene database.
Entrez ID 2274
Gene name Four and a half LIM domains 2
Gene symbol FHL2
Synonyms (NCBI Gene)
AAG11DRALFHL-2SLIM-3SLIM3
Chromosome 2
Chromosome location 2q12.2
Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is th
miRNA miRNA information provided by mirtarbase database.
456
miRTarBase ID miRNA Experiments Reference
MIRT023214 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT643969 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT643970 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT643968 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT643967 hsa-miR-412-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
PAX5 Activation 21540083
RUNX1 Unknown 18768464
SKI Activation 14583455
SRF Unknown 22456196
ZBTB14 Activation 21540083
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15692560
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001649 Process Osteoblast differentiation IEA
GO:0003714 Function Transcription corepressor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602633 3703 ENSG00000115641
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14192
Protein name Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Protein function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and
PDB 1X4K , 1X4L , 2D8Z , 2MIU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 40 97 LIM domain Domain
PF00412 LIM 101 158 LIM domain Domain
PF00412 LIM 162 217 LIM domain Domain
PF00412 LIM 221 278 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11813260}.
Sequence
Sequence length 279
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Osteoclast differentiation
Cytoskeleton in muscle cells
  PPARA activates gene expression
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
242
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Arrhythmogenic right ventricular cardiomyopathy Uncertain significance rs869025433 RCV000208406
Cardiomyopathy Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign rs373259092, rs140148322, rs138189036, rs141208906, rs201189319, rs375234968, rs139644436, rs113188481, rs137869171, rs115841332, rs56284940, rs777846521, rs757222173, rs188279857, rs754744445 RCV000768815
RCV001171209
RCV001171211
RCV000768818
RCV000769833
RCV001171213
RCV000768817
RCV000768816
RCV000768814
RCV000768813
RCV001171212
RCV000769831
RCV000769832
RCV001170738
RCV001171210
Cervical cancer Benign rs11537578, rs115841332 RCV005890266
RCV005890273
Chronic lymphocytic leukemia/small lymphocytic lymphoma Benign rs2244182 RCV005890281
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Amenorrhea Associate 25747126
Aortic Valve Stenosis Associate 37175670
Atrial Fibrillation Associate 32682418
Breast Neoplasms Inhibit 14550570
Breast Neoplasms Associate 18853468
Carcinogenesis Associate 18752053, 18853468, 32236623
Carcinoma Hepatocellular Associate 32236623
Carcinoma Ovarian Epithelial Associate 15161045
Cardiomyopathies Associate 32344918
Cardiomyopathy Hypertrophic Associate 32344918