FHIT (fragile histidine triad diadenosine triphosphatase)

Gene

• Entrez ID: 2272
• Gene name: Fragile histidine triad diadenosine triphosphatase
• Gene symbol: FHIT
• Synonyms (NCBI Gene): AP3Aase, FRA3B
• Chromosome: 3
• Chromosome location: 3p14.2
• Summary: The protein encoded by this gene is a P1-P3-bis(5`-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006363	hsa-miR-217	Luciferase reporter assay	21711110
MIRT006364	hsa-miR-331-3p	Luciferase reporter assay	21711110
MIRT006365	hsa-miR-625-5p	Luciferase reporter assay	21711110
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006365	hsa-miR-625-5p	Luciferase reporter assay	21711110
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006362	hsa-miR-143-3p	Luciferase reporter assay	21711110
MIRT006365	hsa-miR-625-5p	Luciferase reporter assay	21711110
MIRT996523	hsa-miR-103a	CLIP-seq
MIRT996524	hsa-miR-107	CLIP-seq
MIRT996525	hsa-miR-1252	CLIP-seq
MIRT996526	hsa-miR-1301	CLIP-seq
MIRT996527	hsa-miR-3919	CLIP-seq
MIRT996528	hsa-miR-5047	CLIP-seq
MIRT996529	hsa-miR-922	CLIP-seq
MIRT996530	hsa-miR-1287	CLIP-seq
MIRT996531	hsa-miR-3135b	CLIP-seq
MIRT996532	hsa-miR-4766-5p	CLIP-seq
MIRT1995487	hsa-miR-1273f	CLIP-seq
MIRT1995488	hsa-miR-143	CLIP-seq
MIRT1995489	hsa-miR-3185	CLIP-seq
MIRT1995490	hsa-miR-4708-5p	CLIP-seq
MIRT1995491	hsa-miR-4710	CLIP-seq
MIRT1995492	hsa-miR-4738-3p	CLIP-seq
MIRT1995493	hsa-miR-4770	CLIP-seq
MIRT1995494	hsa-miR-4792	CLIP-seq
MIRT1995487	hsa-miR-1273f	CLIP-seq
MIRT1995488	hsa-miR-143	CLIP-seq
MIRT1995489	hsa-miR-3185	CLIP-seq
MIRT1995490	hsa-miR-4708-5p	CLIP-seq
MIRT1995491	hsa-miR-4710	CLIP-seq
MIRT1995492	hsa-miR-4738-3p	CLIP-seq
MIRT1995493	hsa-miR-4770	CLIP-seq
MIRT1995494	hsa-miR-4792	CLIP-seq
MIRT1995487	hsa-miR-1273f	CLIP-seq
MIRT1995488	hsa-miR-143	CLIP-seq
MIRT1995489	hsa-miR-3185	CLIP-seq
MIRT1995490	hsa-miR-4708-5p	CLIP-seq
MIRT1995491	hsa-miR-4710	CLIP-seq
MIRT1995492	hsa-miR-4738-3p	CLIP-seq
MIRT1995493	hsa-miR-4770	CLIP-seq
MIRT1995494	hsa-miR-4792	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Repression	15044096

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	18077326, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15007172
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA	15313915
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0006163	Process	Purine nucleotide metabolic process	IBA	21873635
GO:0006163	Process	Purine nucleotide metabolic process	IDA	9323207
GO:0015964	Process	Diadenosine triphosphate catabolic process	IBA	21873635
GO:0015964	Process	Diadenosine triphosphate catabolic process	IDA	8794732
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15313915
GO:0032435	Process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0032435	Process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	15313915
GO:0042802	Function	Identical protein binding	IPI	9261067, 9576908, 16189514, 18077326, 24722188, 25416956, 27107012, 31515488, 32296183
GO:0047710	Function	Bis(5'-adenosyl)-triphosphatase activity	IBA	21873635
GO:0047710	Function	Bis(5'-adenosyl)-triphosphatase activity	IDA	8794732, 9323207
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IBA	21873635
GO:0072332	Process	Intrinsic apoptotic signaling pathway by p53 class mediator	IMP	15313915

Other IDs

• MIM: 601153
• HGNC: 3701
• e!Ensembl: ENSG00000189283

Protein

• UniProt ID: P49789
• Protein name: Bis(5'-adenosyl)-triphosphatase (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Adenosine 5'-monophosphoramidase FHIT) (EC 3.9.1.-) (Adenylylsulfatase) (EC 3.6.2.1) (Adenylylsulfate-ammonia adenylyltransferase) (EC 2.7.7.51) (Diadenosine 5',5'''-P1,P3-triphosph
• Protein function: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9543008, PubMed:9576908). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:125745
• PDB: 1FHI, 1FIT, 2FHI, 2FIT, 3FIT, 4FIT, 5FIT, 6FIT, 7P8P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01230	HIT	9 → 105	HIT domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines.
• Sequence:

  MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
  TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
  DKEDFPASWRSEEEMAAEAAALRVYFQ

• Sequence length: 147

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Small cell lung cancer
Non-small cell lung cancer

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	16061637
Colorectal neoplasms	Secondary malignant neoplasm of colon and/or rectum	rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049, rs63750451, rs121434629, rs63751247, rs63750710, rs63751615, rs63750781, rs63750899, rs63750691, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs63750245, rs193922372, rs63750393, rs63749932, rs193922375, rs193922376, rs193922343, rs397514684, rs397515875, rs267608094, rs587779204, rs267608077, rs587779206, rs63750439, rs63751405, rs63750741, rs63750854, rs63750909, rs587779212, rs587779215, rs587779216, rs587779219, rs63749874, rs267608076, rs587779220, rs267608050, rs63750735, rs63750564, rs71539659, rs267608082, rs63751167, rs267608057, rs587779227, rs267608068, rs63750075, rs587779228, rs63751419, rs587779231, rs587779232, rs267608058, rs63751442, rs63751127, rs63750647, rs63750138, rs587779235, rs267608065, rs63751321, rs587779241, rs587779243, rs63750904, rs63751017, rs587779246, rs267608063, rs63750140, rs63750940, rs63750111, rs587779250, rs63750258, rs63750563, rs267608073, rs63751407, rs267608059, rs63749999, rs267608042, rs63750833, rs587779255, rs587779256, rs63749821, rs63749843, rs63750617, rs267608078, rs587779259, rs267608092, rs587779260, rs267608086, rs1553331676, rs63750356, rs587779263, rs267608098, rs587779264, rs587779267, rs63750194, rs63751327, rs587779269, rs63751328, rs587779274, rs587779279, rs267608111, rs1553332996, rs587779284, rs63749942, rs587779288, rs63751058, rs63750554, rs267608114, rs267608118, rs63750139, rs63751319, rs267608128, rs587779295, rs267608127, rs267608126, rs63750767, rs267608120, rs587779299, rs267608121, rs587779301, rs267608131, rs267608122, rs63749873, rs63751077, rs1800937, rs587779315, rs587779318, rs63750019, rs267608066, rs63749980, rs63750552, rs1553412283, rs146816935, rs587779001, rs63750677, rs63750339, rs63751609, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs587778882, rs587778883, rs63751012, rs63750715, rs63750580, rs587778888, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs587778896, rs63751015, rs267607713, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607837, rs267607836, rs63750028, rs587778930, rs63751277, rs587778933, rs267607843, rs63750192, rs63750300, rs63750193, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs63751608, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750587, rs63749863, rs63749868, rs63750035, rs63750604, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63750152, rs63750850, rs267607867, rs267607869, rs63751632, rs267607871, rs587778956, rs63749792, rs267607875, rs63750610, rs281864938, rs63751465, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs63751662, rs267607884, rs267607883, rs63750639, rs63750206, rs587778967, rs63750663, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs267607717, rs587778973, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs267607888, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63751642, rs63751022, rs587778983, rs587778984, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63749859, rs63750437, rs587778997, rs63749990, rs587778998, rs63750005, rs63750641, rs63751421, rs63750266, rs111052004, rs267607726, rs63750453, rs267607734, rs267607735, rs63751665, rs267607732, rs63749816, rs63750539, rs587779006, rs63751606, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs63750866, rs63750865, rs587779010, rs587779012, rs63750057, rs72481822, rs587779014, rs587779015, rs63751045, rs63749820, rs267607750, rs267607749, rs267607753, rs63750891, rs63749959, rs63749804, rs63750903, rs63750211, rs267607765, rs267607760, rs587779021, rs587779022, rs267607759, rs63750515, rs63750648, rs63751480, rs267607772, rs587779024, rs267607768, rs63751653, rs587779027, rs267607767, rs63750581, rs63750706, rs63750385, rs587779031, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs267607785, rs267607783, rs63750823, rs63750822, rs267607787, rs63750303, rs587779037, rs63750948, rs63749827, rs587779039, rs267607789, rs267607790, rs267607791, rs267607786, rs267607795, rs267607794, rs267607788, rs63750792, rs63749950, rs587779045, rs63750034, rs587779047, rs63750216, rs63750517, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs587779054, rs587779055, rs63751259, rs63749926, rs63750796, rs587779058, rs63751197, rs587779063, rs63750778, rs63751004, rs63751147, rs63751027, rs63750396, rs587779067, rs267607940, rs267607943, rs63751617, rs63750558, rs63750267, rs63749849, rs587779075, rs63750302, rs63750611, rs63750984, rs63750586, rs63751412, rs63751413, rs587779076, rs63751142, rs63750086, rs63750006, rs267607950, rs267607949, rs63751693, rs587779083, rs587779084, rs63750807, rs63749920, rs267607954, rs267607957, rs587779087, rs63750384, rs63750615, rs63750068, rs63749947, rs1114167806, rs63750936, rs267607962, rs587779097, rs63750780, rs63749930, rs63750224, rs63750094, rs63750337, rs63751656, rs267607969, rs267607972, rs63750597, rs267607970, rs267607971, rs587779101, rs587779103, rs63751149, rs63750474, rs587779105, rs63751411, rs587779108, rs267607976, rs63751140, rs587779110, rs267607977, rs63750200, rs63751236, rs267607985, rs63750951, rs587779112, rs63750493, rs267607984, rs63750312, rs63750508, rs63750280, rs63750160, rs63750203, rs63750960, rs63750893, rs63751317, rs587779119, rs267607986, rs267607987, rs587779125, rs267607988, rs267607990, rs63751640, rs63751123, rs587779129, rs587779131, rs267607995, rs63750199, rs587779133, rs63749993, rs63750232, rs63751432, rs267607994, rs63750961, rs63750398, rs587779136, rs267607915, rs267607914, rs267607917, rs587779138, rs63750636, rs63751453, rs587779139, rs63750572, rs267608002, rs267608006, rs267607979, rs267608001, rs63751155, rs63751477, rs63750042, rs63749854, rs587779143, rs63751105, rs63750346, rs63749848, rs63750618, rs63750149, rs63750233, rs63750803, rs63750463, rs63749983, rs63751018, rs63749917, rs267608010, rs267608012, rs63751621, rs63750623, rs63751117, rs63751447, rs587779148, rs63750857, rs587779149, rs63749830, rs63750849, rs63750291, rs63751618, rs267608019, rs267608017, rs63751624, rs267608020, rs587779153, rs63751469, rs267607920, rs63750084, rs63750808, rs63751007, rs63751429, rs63750970, rs63751099, rs63750318, rs587779157, rs63750501, rs63750614, rs587779159, rs63750458, rs267607924, rs267607925, rs63750924, rs63750704, rs63750408, rs63750910, rs63751426, rs63750624, rs63750214, rs63750582, rs587779163, rs63750843, rs63750933, rs63750070, rs587779164, rs63750382, rs63750551, rs63751444, rs63750088, rs587779165, rs63751326, rs63750682, rs63751110, rs63751136, rs587779167, rs63750574, rs63749984, rs63751622, rs63751274, rs267607689, rs587779169, rs267607930, rs267607929, rs63751602, rs587779170, rs63749897, rs63750426, rs281864944, rs63750488, rs63749832, rs63750347, rs267607934, rs587779185, rs63750091, rs63750276, rs63750097, rs587779189, rs587779190, rs587779191, rs63750934, rs63750885, rs63749915, rs63749914, rs63750640, rs587779193, rs587779195, rs12476364, rs587779198, rs63750502, rs63751044, rs63750630, rs63750468, rs63750828, rs267608156, rs587779326, rs587778617, rs587779330, rs267608169, rs63750477, rs63750793, rs63750250, rs63750490, rs63751422, rs201451115, rs587779333, rs267608170, rs267608161, rs267608172, rs63750695, rs587779336, rs267608173, rs267608160, rs1554306445, rs587779338, rs63751029, rs267608148, rs587779343, rs63750261, rs267608147, rs587779344, rs267608149, rs267608151, rs267608154, rs63750246, rs267608153, rs200640585, rs143277125, rs587779347, rs398123231, rs398123232, rs587779778, rs587779254, rs587779914, rs200492211, rs587779936, rs587779941, rs587779950, rs587779964, rs587779979, rs587780059, rs188006077, rs587780062, rs587780064, rs587780538, rs587778618, rs587780683, rs587780724, rs63751427, rs587781317, rs63750119, rs587781339, rs587781372, rs587781395, rs267608064, rs587781462, rs63750737, rs587781544, rs587781554, rs587781626, rs587781691, rs587781716, rs587782074, rs587782111, rs587782277, rs587782326, rs587782336, rs587782561, rs587782593, rs141577476, rs587782659, rs587782704, rs63751604, rs587782710, rs587782712, rs267607712, rs587782787, rs587783056, rs373885654, rs730881775, rs587779166, rs730881774, rs730881816, rs730881825, rs730881827, rs730881829, rs730881830, rs730881734, rs41542214, rs786202037, rs786203424, rs786203604, rs786201066, rs786203036, rs786201590, rs786203704, rs786201042, rs786203597, rs587782281, rs786202848, rs786201049, rs750528093, rs786202363, rs786202108, rs267608083, rs786201050, rs374230313, rs786203924, rs786202842, rs786203331, rs786201084, rs1553333738, rs267607716, rs786202328, rs786203456, rs786201990, rs786201039, rs786201062, rs778531080, rs786203073, rs63751228, rs786201047, rs573125799, rs786203954, rs786202098, rs587779340, rs763308607, rs786204082, rs786204144, rs786204050, rs786204252, rs786204104, rs786204321, rs869320619, rs863224481, rs863224833, rs863224473, rs863224829, rs863224474, rs863224475, rs863224476, rs863224480, rs63750549, rs863224498, rs863224497, rs863224496, rs267608159, rs863224450, rs863224676, rs863225397, rs863225386, rs863225387, rs267607953, rs863225389, rs863225390, rs370970617, rs759263820, rs863225392, rs863225394, rs863225395, rs863225402, rs863225421, rs863225398, rs863225399, rs863225400, rs863225403, rs863225404, rs863225406, rs587782562, rs863225408, rs863225409, rs863225412, rs863225416, rs863225418, rs863225383, rs863225384, rs863225377, rs863225378, rs863225381, rs864622041, rs63750059, rs1553350680, rs864622183, rs63749991, rs864622340, rs63750330, rs864622436, rs864622121, rs864622435, rs864622153, rs864622257, rs864622585, rs864622607, rs786203968, rs267607744, rs267607823, rs267607832, rs864622457, rs864622600, rs3209663, rs869312768, rs869312769, rs869312770, rs869312767, rs759151952, rs876657701, rs876661033, rs876661205, rs876661025, rs876661193, rs63749919, rs876661073, rs876661222, rs876661171, rs876661159, rs63749818, rs876658915, rs876661113, rs876661203, rs766389591, rs760228510, rs763939668, rs876660480, rs876658996, rs876660655, rs876658918, rs876658223, rs876660711, rs876658211, rs876660095, rs876658296, rs876660549, rs876658881, rs876660630, rs876659189, rs876660283, rs876660943, rs866771359, rs876658817, rs876658962, rs876658339, rs876658657, rs876658821, rs876659068, rs63750217, rs876659681, rs876659608, rs876659480, rs876659900, rs876660459, rs876658862, rs587782898, rs876658964, rs876659736, rs878853815, rs878853824, rs878853802, rs878853809, rs267608041, rs878853702, rs878853709, rs878853711, rs878853718, rs878853721, rs878853729, rs878853736, rs878853739, rs878853742, rs878853745, rs878853792, rs878853794, rs878853777, rs878853778, rs878853780, rs878853785, rs878853787, rs878854037, rs878854060, rs878854059, rs763872353, rs879254025, rs879254104, rs879253899, rs879254234, rs1553640314, rs886039424, rs886039646, rs886039615, rs886044911, rs63750058, rs1057517551, rs1057517541, rs756843954, rs1057517764, rs1057517763, rs1057517801, rs769742496, rs1057520605, rs1057520735, rs1057524433, rs786202083, rs1553350787, rs1060502035, rs267607694, rs1060502039, rs1060502014, rs1060502038, rs1060502032, rs1060502001, rs1060502000, rs1060502885, rs1060502941, rs1060502029, rs775464903, rs1064792951, rs1553413673, rs1060502918, rs1060502876, rs1060502888, rs1060502932, rs1060502901, rs1060502891, rs1060502940, rs1060502937, rs1060502926, rs1060502886, rs1060501993, rs1060501989, rs1060502890, rs1060502027, rs1060502023, rs1060501991, rs1060502903, rs1553333432, rs1060502875, rs1060502946, rs1060502882, rs1060502881, rs1060500689, rs764085979, rs1060500707, rs1064792918, rs1060500698, rs1060500699, rs1060500706, rs63750867, rs1060500688, rs1060500703, rs1060500692, rs1060500687, rs1060503142, rs111466480, rs1060503137, rs746766787, rs758304323, rs764342199, rs876659162, rs1554300763, rs730881920, rs1060503148, rs1060503110, rs1060503138, rs1064794155, rs1064794809, rs1553352505, rs267607939, rs876658187, rs1064793561, rs1064795653, rs1064795329, rs267608011, rs1064794075, rs1553411392, rs1023534466, rs1553412609, rs1064794388, rs1064793600, rs1064795256, rs1064795591, rs1064794055, rs1064794164, rs1553414010, rs1064793671, rs1064794943, rs876660853, rs1064793489, rs1064795629, rs1064794384, rs1553333072, rs1553333078, rs1553333127, rs1553333500, rs1064793895, rs760190301, rs1064795341, rs1064793607, rs587778968, rs1064795441, rs1064794612, rs1064795515, rs1064794267, rs1064793823, rs1064794331, rs63750978, rs1064796500, rs1064794566, rs1064793234, rs757324104, rs1064794905, rs1064795447, rs1064796190, rs1064793868, rs1554304940, rs1064794083, rs1064795705, rs1064794173, rs1064794152, rs1085308057, rs1114167435, rs1114167883, rs1114167831, rs1114167877, rs1114167855, rs587782537, rs1114167814, rs1114167848, rs1114167845, rs979212552, rs1114167809, rs1114167858, rs1553356720, rs1114167833, rs1114167852, rs1114167835, rs1114167854, rs1114167815, rs267607982, rs1114167844, rs1114167805, rs730881762, rs1114167857, rs1114167832, rs1114167826, rs1114167841, rs1114167828, rs1114167818, rs1114167719, rs1114167776, rs1114167689, rs1114167728, rs1114167692, rs1114167725, rs1114167704, rs1114167696, rs1114167748, rs1114167763, rs1114167804, rs1114167731, rs1114167801, rs753796271, rs1114167736, rs1114167756, rs267608055, rs1114167746, rs1114167715, rs587782706, rs1114167750, rs1114167702, rs1114167765, rs587780670, rs1114167766, rs777159874, rs587782638, rs1114167747, rs1114167709, rs1114167694, rs786204048, rs1114167771, rs1114167794, rs1114167714, rs765411990, rs587782862, rs1114167773, rs1114167724, rs1114167707, rs1114167782, rs1114167793, rs1114167767, rs766905993, rs1114167723, rs1114167755, rs752404604, rs1114167706, rs1114167717, rs1114167783, rs1114167760, rs1553333599, rs1553333615, rs1553333644, rs1114167790, rs587779297, rs1553351549, rs753075410, rs63751271, rs371776176, rs63750689, rs1553369164, rs202145681, rs1553370310, rs1230083633, rs1553412966, rs1553413710, rs1348956744, rs1553331290, rs1553333421, rs1553333598, rs1416452389, rs1553333707, rs1553641362, rs63751448, rs1553648058, rs587778937, rs1553662753, rs1554292880, rs988423880, rs1553353114, rs63751119, rs1553647995, rs1553663750, rs1458321358, rs730881919, rs1553413178, rs63750443, rs63751596, rs1554309086, rs1553348794, rs1553348882, rs1553348898, rs1553348901, rs1553370371, rs1553365799, rs1553370431, rs1553366510, rs1553408158, rs1553366680, rs1553370404, rs1553411419, rs1553408136, rs1553412397, rs869040863, rs1553348842, rs1553348904, rs1553413599, rs1553413655, rs1553413732, rs1553414022, rs767021188, rs1553350966, rs1553412409, rs796532309, rs587779064, rs1553365711, rs1553333017, rs1553412649, rs1553333175, rs1553333301, rs1553333605, rs1553369100, rs1553369131, rs1553331722, rs1324100572, rs1553332776, rs761037236, rs1553412755, rs1553333438, rs1553333449, rs1553412835, rs1553412735, rs1553413424, rs1553414131, rs1553331337, rs1553332297, rs773262801, rs1553333185, rs1553331454, rs1553332151, rs1553333530, rs1553333633, rs587779285, rs1553333310, rs1553333321, rs1553333497, rs1553646681, rs1553647894, rs1553648195, rs1553653158, rs550890395, rs1064796057, rs1553651130, rs1553662800, rs1553665467, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1553652930, rs1434898623, rs1553665683, rs1554298087, rs1554295967, rs1554297040, rs1554298741, rs1554294393, rs1554297523, rs1554293920, rs1554301486, rs1554304974, rs1553348896, rs1553368675, rs1203462814, rs1553369665, rs1553350721, rs1553369812, rs1553361261, rs1553370443, rs1553408388, rs1553413717, rs63749973, rs1553412064, rs1553408467, rs267608062, rs765873566, rs730881815, rs1553414578, rs1553331665, rs1553331366, rs1553332166, rs1553413663, rs1553332622, rs1553333164, rs63751137, rs1553642777, rs1553648068, rs1553332733, rs1553644123, rs1553648149, rs1302248679, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664702, rs1553647969, rs1437454428, rs1231406078, rs1554293991, rs1554297488, rs1554297534, rs1064794577, rs1554297764, rs1554298082, rs876661256, rs1554298056, rs1554293810, rs939641251, rs1554304979, rs1554297058, rs1554298067, rs1554306288, rs151244108, rs1553412129, rs1054003194, rs1553412824, rs1553413253, rs1553332671, rs1553333168, rs1553333700, rs63751101, rs1553646764, rs1554300689, rs1554297877, rs1437858319, rs1432436629, rs1553648225, rs1553352462, rs1553332772, rs1553648201, rs1553333635, rs1554297125, rs753256070, rs1553414092, rs587779923, rs1554297962, rs1553361162, rs1554294448, rs1553412495, rs1253275403, rs1553350167, rs267607937, rs1553361231, rs730881755, rs1553408306, rs1553365719, rs1553370366, rs1553370397, rs1553412441, rs1553412960, rs1553411391, rs770110491, rs1553350466, rs1553350758, rs1553413116, rs1553413294, rs1553413074, rs1553361289, rs1553413640, rs1553413784, rs1553414488, rs1553331242, rs1553410300, rs1553414498, rs1553332312, rs1553412502, rs1114167705, rs1553331659, rs1553332768, rs1553414102, rs1553414395, rs1553414519, rs1553331228, rs1553333674, rs1553638868, rs1553663981, rs1553644277, rs1553665866, rs1554297082, rs1554297564, rs1394474494, rs1554293959, rs587782175, rs1554297285, rs1554298786, rs1553356605, rs1553356700, rs1553369034, rs1553370435, rs1553413305, rs1553331304, rs1553652883, rs63751435, rs1553653195, rs1553662622, rs1554293975, rs1554297164, rs1554297342, rs1554297636, rs1461669945, rs1553658104, rs1553350250, rs1553410230, rs1554304745, rs1554298756, rs1553648220, rs1559543768, rs745487791, rs1558438591, rs1558508067, rs1558508343, rs1558645195, rs1558658971, rs1558661368, rs1558663954, rs1558390582, rs1558392228, rs1558461615, rs1558466434, rs1558519611, rs1558521949, rs1558644886, rs587782101, rs1558661380, rs1558662873, rs1558392033, rs1558394093, rs1559544064, rs63750584, rs1558459096, rs1060501994, rs63751667, rs878853704, rs1558665297, rs1558387361, rs1558393006, rs1558394104, rs1559524070, rs1559530646, rs1553645226, rs1559551570, rs1559575107, rs1559597322, rs1558451119, rs1558459882, rs1558478567, rs1562605623, rs1562614946, rs781078805, rs1558644683, rs1558658980, rs1558659056, rs1558659699, rs1558667222, rs1558668156, rs1558668258, rs1558393070, rs1558394336, rs1562626204, rs1562629003, rs1562632035, rs587782602, rs1562634737, rs1562635799, rs1562669585, rs1060500702, rs1559539489, rs1559553501, rs1562616355, rs1562644987, rs764171734, rs1562711587, rs1562598658, rs1562604682, rs1562664845, rs1562678257, rs1558666177, rs1562633172, rs1559558071, rs1261282733, rs63750832, rs587778978, rs1064795063, rs1558511051, rs63751097, rs765763906, rs1562626070, rs1562671039, rs1558518588, rs1558461683, rs63751115, rs1558644995, rs1558659265, rs1558660612, rs1559521039, rs1559574795, rs1562626011, rs1562636427, rs1559578422, rs772491283, rs1573424223, rs730881784, rs1573446614, rs1573451108, rs1558464008, rs1573484655, rs1573566217, rs1573566488, rs1573567212, rs63750078, rs1573567340, rs1573567537, rs1573567630, rs1573569948, rs1573570621, rs1573574086, rs1573578423, rs1573578439, rs1573579206, rs1572698011, rs1572708636, rs1473648816, rs1276159036, rs1572716371, rs1572719776, rs1572719974, rs1572720016, rs1572720562, rs1572720704, rs778555956, rs1553412720, rs1572723270, rs1572723640, rs587779221, rs1572725436, rs1572725803, rs1572726309, rs1572726468, rs63750985, rs1572727440, rs1572727797, rs1572729033, rs367758473, rs587779253, rs1572730002, rs1572730065, rs1315445200, rs1572735072, rs1572735943, rs1572738865, rs1572745157, rs754469538, rs1572746365, rs1572747837, rs1575376458, rs1575376830, rs1575395515, rs63750507, rs1575469070, rs1575481212, rs1575537843, rs1575620443, rs1575621386, rs1575621506, rs63750740, rs1386031101, rs1575640892, rs1583285552, rs1583299686, rs1583318494, rs1583320992, rs1243063129, rs757679199, rs1583375182, rs762387250, rs36038802, rs267608035, rs1572716545, rs1572739097, rs1575628928, rs746306598, rs1572747278, rs1572747685, rs1583374709, rs1572708580, rs1572736122, rs1575414321, rs1573437173, rs1573456772, rs1583316404, rs1583363851, rs1572727176, rs1573423412, rs1573440880, rs1573442100, rs369670665, rs1573451078, rs1573547745, rs1573548065, rs1573553636, rs1573567132, rs63750234, rs63751409, rs138465383, rs1573573619, rs1572720192, rs1572720794, rs1572722737, rs1572723723, rs1572725235, rs745483465, rs1572728039, rs1572728112, rs1572728472, rs1572729161, rs1175196087, rs1572736128, rs1572738533, rs1572739043, rs891318615, rs1572741984, rs1572745084, rs1572746382, rs1572746488, rs1060504739, rs1575414904, rs1575448385, rs1575469505, rs1466223609, rs63750198, rs1575639851, rs1575640960, rs1583269216, rs1583285344, rs1583319050, rs1583334346, rs1562651617, rs1583410315, rs767028531, rs1573566175, rs1572739119, rs1572746025, rs1575449402, rs1325835006, rs1672250353, rs1672664863, rs1672951706, rs1673066717, rs1673067879, rs1673070318, rs1666728055, rs1667076589, rs63751433, rs1667245819, rs1667245915, rs1667313093, rs1667395869, rs1667504677, rs1668118988, rs1668692410, rs587779313, rs1669058948, rs1669059418, rs1669245178, rs1669252923, rs1669287624, rs1007311950, rs1669354866, rs1669364351, rs1669365820, rs41295270, rs1669441162, rs1669445829, rs1669451548, rs1669467747, rs1669486855, rs1669487701, rs1669491751, rs1669493890, rs1669760609, rs1669874125, rs1670044220, rs1670120965, rs2080898853, rs2080899985, rs2081922847, rs2083403132, rs2083405700, rs2085310643, rs2085311497, rs2085415927, rs2085469647, rs1782934080, rs1782947222, rs1782958183, rs1782962828, rs1064793426, rs63750456, rs1783004175, rs1783147885, rs1783516106, rs1344095646, rs1784299649, rs1784536095, rs1784802468, rs1784806713, rs1221485925, rs1299958102, rs1669882321, rs2082517369, rs1673083690, rs1667266283, rs1307026290, rs1672953209, rs1667575488	30738427
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	12958204
Intracranial aneurysm	Intracranial Aneurysm	rs1594095223	29531279
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297	27903959
Lip and oral cavity carcinoma	Lip and Oral Cavity Carcinoma	rs121913388, rs121912651, rs11540652, rs28934573, rs28934578, rs28933406, rs104894229, rs104894230, rs121913273, rs104894228, rs587778720, rs55832599, rs121913344, rs587782705, rs104894226, rs730882001, rs876660754, rs876660726, rs121913449, rs121913454, rs121913389, rs1057519927, rs985033810, rs868137297	28580594
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	11788890
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	10959838, 16061637
Mesothelioma	Mesothelioma	rs121907908, rs387906350, rs387906351	14569398, 18038314
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Prostate cancer	Malignant neoplasm of prostate, Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17548701, 31095341
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26198764, 30626913, 30285260, 28540026, 28991256

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary heart disease	Coronary heart disease		28753643	ClinVar
Coronary syndrome	Acute Coronary Syndrome		28753643	ClinVar
Hereditary renal carcinoma	Hereditary clear cell renal cell carcinoma			ClinVar
Mental depression	Unipolar Depression, Major Depressive Disorder		28049566, 30718901, 30626913	ClinVar
Attention Deficit Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder			GWAS
Mental Depression	Mental Depression			GWAS
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia			GWAS
Intracranial Aneurysm	Intracranial Aneurysm			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Neuroblastoma	Neuroblastoma	Loss of SNAI2 function reduces self-renewal, 3D invasion as well as metastatic spread in vivo, while strongly sensitizing neuroblastoma cells to RA-induced growth inhibition.		GWAS, CBGDA
Neuroticism	Neuroticism			GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.		GWAS, CBGDA
Dementia	Dementia			GWAS
Dyslexia	Dyslexia			GWAS
Insomnia	Insomnia			GWAS
Eosinophilia	Eosinophilia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Abnormalities Drug Induced	Associate	18592004
Adenocarcinoma	Associate	11170287, 11461085, 12765416, 15150628, 16237777, 17348444, 18663352, 31001805
Adenocarcinoma	Inhibit	12865924
Adenocarcinoma of Lung	Associate	25401976, 38069335
Adenocarcinoma of Lung	Stimulate	35254116
Adenoma	Associate	12890744, 25091577
Adenoma	Inhibit	14760383
Aneuploidy	Associate	23019410, 30737237
Anophthalmia with pulmonary hypoplasia	Associate	28289900
Anus Neoplasms	Associate	17393360
Anxiety	Associate	22628180, 29249830
Asthma	Associate	37466093
Autistic Disorder	Associate	23375656, 24204716
Barrett Esophagus	Associate	20647332, 31001805
Breast Carcinoma In Situ	Associate	17164758
Breast Diseases	Associate	17164758
Breast Neoplasms	Associate	10666370, 15047740, 15073846, 20417865, 25735361, 30941950
Breast Neoplasms	Inhibit	19130459
Burkitt Lymphoma	Associate	19759907
Carcinogenesis	Associate	10027335, 10411902, 10555761, 10732756, 11746990, 12669232, 12698186, 12800227, 14675322, 15256063, 15627891, 15929169, 16187332, 16237777, 18517280, 18592004, 19414370, 19760177, 20606729, 22393963, 22496620, 25040980, 28289900, 38069335, 8620533, 9261067, 9401074, 9403704
Carcinogenesis	Inhibit	14760383, 16821595
Carcinoma	Associate	18517280
Carcinoma Hepatocellular	Associate	10389981, 15060557, 15633221, 18567082, 19818350, 21679157, 30773529, 9472637
Carcinoma Hepatocellular	Inhibit	12800227
Carcinoma in Situ	Associate	17164758
Carcinoma Intraductal Noninfiltrating	Inhibit	17164758
Carcinoma Large Cell	Associate	17348444
Carcinoma Non Small Cell Lung	Inhibit	10735505, 14976524
Carcinoma Non Small Cell Lung	Associate	12765416, 12865924, 15042681, 15150628, 16533421, 17328863, 20521346, 20736951, 25040980, 8620533
Carcinoma Pancreatic Ductal	Associate	28289900
Carcinoma Renal Cell	Associate	10666370, 18517280, 25230976, 3125959, 8598045
Carcinoma Signet Ring Cell	Inhibit	12218081
Carcinoma Small Cell	Associate	17348444
Carcinoma Squamous Cell	Associate	10027335, 10732756, 15150628, 16821595, 19047905, 19131950
Carcinoma Squamous Cell	Inhibit	12765416, 12865924, 35254116
Carcinoma Transitional Cell	Inhibit	10666370
Carcinoma Transitional Cell	Associate	22393963
Chagas Disease	Associate	19414370
Cholangiocarcinoma	Associate	24757411
Chordoma	Inhibit	23019410
Chromosome Fragility	Associate	12057912
Colitis Ulcerative	Inhibit	17143956
Colonic Neoplasms	Associate	17393360, 8598045
Colorectal Neoplasms	Associate	10555761, 12177781, 17373735, 23573237, 39332629, 9197530
Colorectal Neoplasms	Inhibit	23797051
Crohn Disease	Inhibit	17143956
Digestive System Neoplasms	Associate	8598045
Dyskinesias	Associate	10732756
Dyspepsia	Inhibit	15609389
Dysplastic Nevus Syndrome	Associate	12057912
Encephalitis Herpes Simplex	Associate	10027335
Endometrial Hyperplasia	Associate	15627891
Epstein Barr Virus Infections	Associate	15929169
Esophageal Achalasia	Associate	19414370, 20163722
Esophageal Neoplasms	Inhibit	16821595
Esophageal Neoplasms	Associate	39725880
Esophageal Squamous Cell Carcinoma	Associate	22578181, 26857264
Focal Nodular Hyperplasia	Associate	10389981
Gallbladder Neoplasms	Associate	12057912
Gastrointestinal Neoplasms	Associate	12973852
Genetic Diseases Inborn	Associate	20647332
Glioblastoma	Associate	19760177
Granulosa Cell Tumor	Associate	15574200
Granulosa cell tumor of the ovary	Associate	15574200
Head and Neck Neoplasms	Associate	11683369, 8790406
Helicobacter Infections	Inhibit	15609389
Hereditary Breast and Ovarian Cancer Syndrome	Associate	15073846, 17164758
HIV Infections	Associate	19832807
HTLV I Infections	Associate	34092254
Idiopathic Pulmonary Fibrosis	Associate	12169206
Inflammation	Associate	17143956
Inflammatory Bowel Diseases	Inhibit	17143956
Intracranial Aneurysm	Associate	29531279
Intracranial Hypertension	Associate	29531279
Kidney Neoplasms	Associate	15357873, 27725787
Kidney Neoplasms	Inhibit	9403704
Kininogen Deficiency High Molecular Weight and Low Molecular Weight	Associate	10735505
Krukenberg Tumor	Inhibit	12218081
Leigh syndrome French Canadian type	Associate	29531279
Leukemia Lymphoma Adult T Cell	Associate	34092254
Leukemia Myeloid Acute	Associate	9401074
Leukemia Prolymphocytic T Cell	Associate	34092254
Lung Diseases	Associate	11683369, 19931269
Lung Neoplasms	Associate	10411902, 10735505, 11683369, 12169206, 12765416, 14976524, 15627891, 16513840, 16885564, 17328863, 17348444, 17694439, 17890317, 18319262, 18484646, 19181417, 20814237, 22425911, 23614702, 23709347, 24757411, 25040980, 25340791, 29540221, 30770797, 33437205, 34257703, 35254116, 8620533
Lung Neoplasms	Inhibit	24464917
Lymphatic Metastasis	Associate	17373735, 23573237
Lymphatic Metastasis	Inhibit	20606729, 30941950
Lymphoma Large B Cell Diffuse	Associate	16715073, 19832807, 20230398
Lymphoma Non Hodgkin	Associate	19832807, 20651033
Lymphoma Primary Effusion	Associate	21685375
Lymphoma T Cell Cutaneous	Associate	35787399
Mouth Diseases	Associate	10732756
Mouth Neoplasms	Associate	19138989
Myelodysplastic Syndromes	Associate	21286011
Nasopharyngeal Carcinoma	Associate	11932901, 20473931, 22815911
Nasopharyngeal Carcinoma	Inhibit	23534718
Neoplasm Invasiveness	Associate	10027335, 12057912
Neoplasm Invasiveness	Inhibit	17164758
Neoplasm Metastasis	Inhibit	15633221, 25340791
Neoplasm Metastasis	Associate	23573237, 27245195
Neoplasms	Associate	10377436, 10732756, 10735505, 11170287, 11683369, 11746990, 12574506, 12771912, 12890744, 15042681, 15389252, 15570308, 15574200, 16237777, 16343185, 17142325, 17143956, 17164758, 17552003, 17876837, 18413833, 19130459, 19399343, 19419937, 19434452, 19700237, 19760177, 20647332, 22425911, 22613411, 22675076, 23534718, 23573237, 23947369, 24477574, 24757411, 24782031, 25040980, 26857264, 27725787, 27835588, 28423547, 29752880, 33810183, 35176183, 8620533, 9197530, 9261067, 9405656, 9406824, 9543008, 9569038, 9667647
Neoplasms	Inhibit	10389981, 10411902, 10666370, 11085938, 12057912, 12177781, 12627509, 12657123, 12669232, 12765416, 12800227, 12865924, 14675322, 14760383, 14976524, 15073846, 15150628, 15256063, 15627891, 15633221, 16187332, 16454554, 16885564, 17017123, 17142325, 17328863, 17393360, 17694439, 17890317, 18319262, 18953408, 19448592, 19818350, 20073072, 20671427, 20736951, 21069451, 21679157, 21685375, 21999220, 22085272, 22393963, 23704090, 24252461, 24464917, 25340791, 25401976, 25633809, 25735361, 26188848, 26497576, 28093273, 29282095, 29540221, 30737237, 30770797, 31266828, 33437205, 34092254, 35254116, 35787399, 38069335, 9573184, 9744498
Neoplasms Adipose Tissue	Associate	28767316
Neoplasms Glandular and Epithelial	Associate	12765416
Neuroblastoma	Associate	23991058, 9667647
Neuromuscular Diseases	Associate	29095316
Obesity	Associate	28767316, 33491310
Osteosarcoma	Associate	9818023
Ovarian Diseases	Associate	9569038
Ovarian Neoplasms	Associate	11461085, 9569038
Pancreatic Neoplasms	Associate	17912030
Pancreatic Neoplasms	Inhibit	19434452
Panic Disorder	Associate	29249830
Paraparesis Tropical Spastic	Associate	34092254
Polyposis Syndrome Hereditary Mixed 1	Associate	17373735
Precancerous Conditions	Associate	19700237
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	20435627, 26745060
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	9401074
Prostatic Neoplasms	Associate	18953408, 20053773
Prostatitis	Associate	12627509
Respiratory Insufficiency	Associate	29095316
Retinal Dysplasia	Associate	19931269, 31001805
Sarcoma Ewing	Associate	9818023
Skin Neoplasms	Associate	9406824
Skull Base Neoplasms	Inhibit	23019410
Small Cell Lung Carcinoma	Associate	22085272, 3125959, 8620533
Spastic paraplegia 11 autosomal recessive	Associate	10666370
Squamous Cell Carcinoma of Head and Neck	Associate	10732756, 11683369, 16454554, 19138989, 24278325, 25735654, 8790406, 9797729
Stomach Neoplasms	Inhibit	12218081, 12669232, 15609389
Stomach Neoplasms	Associate	14760383, 15929169, 16237777, 16773697, 17552003, 19419937, 22969225, 23131390, 25875960, 26857264
Tertiary Lymphoid Structures	Associate	15570308
Testicular Germ Cell Tumor	Associate	14670177
Thrombocytopenia	Associate	12771912
Thyroid Neoplasms	Associate	19589279, 20606729, 28703219
Triple Negative Breast Neoplasms	Inhibit	21069451
Tuberculosis Pulmonary	Associate	15627891
Urethral Neoplasms	Associate	22613411
Urinary Bladder Neoplasms	Associate	10666370, 22393963, 22613411, 29752880
Uterine Cervical Dysplasia	Associate	11875703, 14675322, 15570308, 31771040
Uterine Cervical Dysplasia	Inhibit	28414756
Uterine Cervical Neoplasms	Associate	10027335, 12657123, 12698186, 14675322, 15570308, 16004614, 17009983, 19700237, 25422218, 31771040
Uterine Cervical Neoplasms	Inhibit	28414756
Uterine Cervicitis	Associate	28414756
Vulvar Neoplasms	Associate	27835588