FGL1 (fibrinogen like 1)

Gene
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2267
Gene name Gene Name - the full gene name approved by the HGNC.
Fibrinogen like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FGL1
Synonyms (NCBI Gene) Gene synonyms aliases
HFREP1, HP-041, HPS, LFIRE-1, LFIRE1
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p22
Summary Summary of gene provided in NCBI Entrez Gene.
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, thi
Transcription factors
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
STAT3 Unknown 19304666
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all(14)
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 30580966
GO:0005576 Component Extracellular region IDA 30580966
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
605776 3695 ENSG00000104760
Protein
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Q08830
Protein name Fibrinogen-like protein 1 (HP-041) (Hepassocin) (HPS) (Hepatocyte-derived fibrinogen-related protein 1) (HFREP-1) (Liver fibrinogen-related protein 1) (LFIRE-1)
Protein function Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MH
PDB 7TZ2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C 79 → 305 Fibrinogen beta and gamma chains, C-terminal globular domain Domain
Tissue specificity TISSUE SPECIFICITY: Under normal conditions, liver-specific. {ECO:0000269|PubMed:11470158}.
Sequence
Sequence length 312
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma N/A N/A GWAS
Show/Hide Text Mining Associations (15)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36268014
Arthritis Rheumatoid Associate 33123164
Basal Laminar Drusen Associate 27007659
Carcinoma Hepatocellular Associate 16980951, 32762721, 34069373, 35776395
Carcinoma Pancreatic Ductal Associate 33801246
Colorectal Neoplasms Associate 37872170
Crohn Disease Associate 34629811
Inflammation Stimulate 18039467
Liver Failure Associate 29845203
Neoplasm Metastasis Associate 29845203, 35776395