Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2254
Gene name Gene Name - the full gene name approved by the HGNC.
Fibroblast growth factor 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FGF9
Synonyms (NCBI Gene) Gene synonyms aliases
FGF-9, GAF, HBFG-9, HBGF-9, SYNS3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
SYNS3
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.11
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cel
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs121918322 G>A Pathogenic Missense variant, coding sequence variant
rs1555223925 A>G Pathogenic Genic upstream transcript variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006823 hsa-miR-182-5p Luciferase reporter assay, Western blot 22917588
MIRT006823 hsa-miR-182-5p Luciferase reporter assay, Western blot 22917588
MIRT007378 hsa-miR-140-5p Luciferase reporter assay 23401231
MIRT029384 hsa-miR-26b-5p Microarray 19088304
MIRT053574 hsa-miR-26a-5p Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot 24015269
Transcription factors
Transcription factor Regulation Reference
FUBP3 Unknown 21252297
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001934 Process Positive regulation of protein phosphorylation IBA 21873635
GO:0005104 Function Fibroblast growth factor receptor binding IBA 21873635
GO:0005576 Component Extracellular region TAS
GO:0005604 Component Basement membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600921 3687 ENSG00000102678
Protein
UniProt ID P31371
Protein name Fibroblast growth factor 9 (FGF-9) (Glia-activating factor) (GAF) (Heparin-binding growth factor 9) (HBGF-9)
Protein function Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration
PDB 1G82 , 1IHK , 5W59
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00167 FGF 62 188 Fibroblast growth factor Domain
Tissue specificity TISSUE SPECIFICITY: Glial cells.
Sequence
Sequence length 208
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Chemical carcinogenesis - receptor activation
Melanoma
Breast cancer
Gastric cancer
  PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 point mutants in cancer
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 20464547
Brachydactyly Brachydactyly rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852
View all (22 more)
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 20464547
Hearing loss Conductive hearing loss rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359
View all (184 more)
Unknown
Disease term Disease name Evidence References Source
Multiple Synostoses Syndrome multiple synostoses syndrome GenCC
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
46 XX Testicular Disorders of Sex Development Associate 23380608
Acrospiroma Associate 27166269
Arthritis Rheumatoid Associate 30123050
Bisphosphonate Associated Osteonecrosis of the Jaw Inhibit 26141514
Brain Neoplasms Associate 15691381
Breast Neoplasms Associate 21098263
Carcinogenesis Associate 27166269
Carcinoma Hepatocellular Associate 32161315, 32378800
Carcinoma Non Small Cell Lung Associate 18849352, 26020126, 30999114, 31884893
Carcinoma Pancreatic Ductal Associate 34061869