Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2252
Gene name Gene Name - the full gene name approved by the HGNC.
Fibroblast growth factor 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FGF7
Synonyms (NCBI Gene) Gene synonyms aliases
HBGF-7, KGF
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cel
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19701459
MIRT003482 hsa-miR-155-5p Luciferase reporter assay 19177201
MIRT003482 hsa-miR-155-5p Review 20026422
Transcription factors
Transcription factor Regulation Reference
JUN Unknown 15840658
NFKB1 Unknown 9869450
RELA Unknown 9869450
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001934 Process Positive regulation of protein phosphorylation IBA 21873635
GO:0005104 Function Fibroblast growth factor receptor binding IBA 21873635
GO:0005111 Function Type 2 fibroblast growth factor receptor binding IBA 21873635
GO:0005515 Function Protein binding IPI 1309608
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
148180 3685 ENSG00000140285
Protein
UniProt ID P21781
Protein name Fibroblast growth factor 7 (FGF-7) (Heparin-binding growth factor 7) (HBGF-7) (Keratinocyte growth factor)
Protein function Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00167 FGF 65 189 Fibroblast growth factor Domain
Tissue specificity TISSUE SPECIFICITY: Epithelial cell.
Sequence
Sequence length 194
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
PI3K-Akt signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Chemical carcinogenesis - receptor activation
Melanoma
Breast cancer
Gastric cancer
  PI3K Cascade
PIP3 activates AKT signaling
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
28604730
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)
15677771
Unknown
Disease term Disease name Evidence References Source
Hyperthyroidism Hyperthyroidism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acute Lung Injury Stimulate 18065658
Adenocarcinoma Scirrhous Associate 23545898
Arthritis Rheumatoid Associate 39342401
Ataxia Telangiectasia Associate 26587829
Autoimmune enteropathy Stimulate 11454791
Basal Cell Nevus Syndrome Associate 19287498
Breast Neoplasms Associate 15311216, 15781986, 16827106, 18225535, 18383836, 19035303, 19661335, 27852068, 28869838, 35726195, 9184170
Bronchopulmonary Dysplasia Associate 29722558
Bronchopulmonary Dysplasia Inhibit 30459472
Burns Associate 23896833