Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2237
Gene name	Flap structure-specific endonuclease 1
Gene symbol	FEN1
Synonyms (NCBI Gene)	FEN-1MF1RAD2
Chromosome	11
Chromosome location	11q12.2
Summary	The protein encoded by this gene removes 5` overhanging flaps in DNA repair and processes the 5` ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excis

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miRTarBase ID	miRNA	Experiments	Reference
MIRT000116	hsa-miR-24-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	19748357
MIRT000116	hsa-miR-24-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	19748357
MIRT016610	hsa-miR-193b-3p	Proteomics	21512034
MIRT016610	hsa-miR-193b-3p	Microarray	20304954
MIRT024421	hsa-miR-215-5p	Microarray	19074876
MIRT025481	hsa-miR-34a-5p	Proteomics	21566225
MIRT025481	hsa-miR-34a-5p	Proteomics	21566225
MIRT026838	hsa-miR-192-5p	Microarray	19074876
MIRT000116	hsa-miR-24-3p	Reporter assay;Western blot;qRT-PCR;Microarray;Other	19748357
MIRT052079	hsa-let-7b-5p	CLASH	23622248
MIRT047080	hsa-miR-183-5p	CLASH	23622248
MIRT042974	hsa-miR-324-3p	CLASH	23622248
MIRT036309	hsa-miR-1229-3p	CLASH	23622248
MIRT267491	hsa-miR-140-5p	PAR-CLIP	20371350
MIRT333719	hsa-miR-548n	PAR-CLIP	20371350
MIRT333726	hsa-miR-548av-3p	PAR-CLIP	20371350
MIRT567567	hsa-miR-548g-3p	PAR-CLIP	20371350
MIRT567566	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT567565	hsa-miR-548k	PAR-CLIP	20371350
MIRT567564	hsa-miR-8054	PAR-CLIP	20371350
MIRT333717	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT567563	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT267494	hsa-miR-4293	PAR-CLIP	20371350
MIRT567562	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT267495	hsa-miR-4324	PAR-CLIP	20371350
MIRT567561	hsa-miR-544b	PAR-CLIP	20371350
MIRT267504	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT267496	hsa-miR-4251	PAR-CLIP	20371350
MIRT267500	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT267492	hsa-miR-1253	PAR-CLIP	20371350
MIRT267506	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT567560	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT567559	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT333716	hsa-miR-610	PAR-CLIP	20371350
MIRT333728	hsa-miR-6124	PAR-CLIP	20371350
MIRT567558	hsa-miR-5087	PAR-CLIP	20371350
MIRT567557	hsa-miR-378a-5p	PAR-CLIP	20371350
MIRT333718	hsa-miR-1200	PAR-CLIP	20371350
MIRT267507	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT567556	hsa-miR-3074-5p	PAR-CLIP	20371350
MIRT567555	hsa-miR-7152-5p	PAR-CLIP	20371350
MIRT267508	hsa-miR-8055	PAR-CLIP	20371350
MIRT567554	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT267491	hsa-miR-140-5p	PAR-CLIP	20371350
MIRT333719	hsa-miR-548n	PAR-CLIP	20371350
MIRT333726	hsa-miR-548av-3p	PAR-CLIP	20371350
MIRT567567	hsa-miR-548g-3p	PAR-CLIP	20371350
MIRT567566	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT567565	hsa-miR-548k	PAR-CLIP	20371350
MIRT567564	hsa-miR-8054	PAR-CLIP	20371350
MIRT333717	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT567563	hsa-miR-6800-3p	PAR-CLIP	20371350
MIRT267494	hsa-miR-4293	PAR-CLIP	20371350
MIRT567562	hsa-miR-885-5p	PAR-CLIP	20371350
MIRT267495	hsa-miR-4324	PAR-CLIP	20371350
MIRT567561	hsa-miR-544b	PAR-CLIP	20371350
MIRT267504	hsa-miR-6719-3p	PAR-CLIP	20371350
MIRT267496	hsa-miR-4251	PAR-CLIP	20371350
MIRT267500	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT267492	hsa-miR-1253	PAR-CLIP	20371350
MIRT267506	hsa-miR-6770-5p	PAR-CLIP	20371350
MIRT567560	hsa-miR-2114-3p	PAR-CLIP	20371350
MIRT567559	hsa-miR-6823-3p	PAR-CLIP	20371350
MIRT333716	hsa-miR-610	PAR-CLIP	20371350
MIRT333728	hsa-miR-6124	PAR-CLIP	20371350
MIRT567558	hsa-miR-5087	PAR-CLIP	20371350
MIRT567557	hsa-miR-378a-5p	PAR-CLIP	20371350
MIRT333718	hsa-miR-1200	PAR-CLIP	20371350
MIRT267507	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT567556	hsa-miR-3074-5p	PAR-CLIP	20371350
MIRT567555	hsa-miR-7152-5p	PAR-CLIP	20371350
MIRT267508	hsa-miR-8055	PAR-CLIP	20371350
MIRT567554	hsa-miR-628-5p	PAR-CLIP	20371350
MIRT994697	hsa-miR-199a-5p	CLIP-seq
MIRT994698	hsa-miR-199b-5p	CLIP-seq
MIRT994699	hsa-miR-4659a-3p	CLIP-seq
MIRT994700	hsa-miR-4659b-3p	CLIP-seq
MIRT994701	hsa-miR-4711-3p	CLIP-seq
MIRT994702	hsa-miR-548aa	CLIP-seq
MIRT994703	hsa-miR-570	CLIP-seq
MIRT1994991	hsa-miR-1202	CLIP-seq
MIRT1994992	hsa-miR-1207-3p	CLIP-seq
MIRT1994993	hsa-miR-1248	CLIP-seq
MIRT1994994	hsa-miR-125a-3p	CLIP-seq
MIRT1994995	hsa-miR-3183	CLIP-seq
MIRT1994996	hsa-miR-3187-3p	CLIP-seq
MIRT1994997	hsa-miR-3194-5p	CLIP-seq
MIRT1994998	hsa-miR-3591-5p	CLIP-seq
MIRT1994999	hsa-miR-3686	CLIP-seq
MIRT1995000	hsa-miR-3922-5p	CLIP-seq
MIRT1995001	hsa-miR-3972	CLIP-seq
MIRT1995002	hsa-miR-4435	CLIP-seq
MIRT1995003	hsa-miR-4652-3p	CLIP-seq
MIRT1995004	hsa-miR-4659a-5p	CLIP-seq
MIRT1995005	hsa-miR-4659b-5p	CLIP-seq
MIRT1995006	hsa-miR-4701-5p	CLIP-seq
MIRT1995007	hsa-miR-4715-5p	CLIP-seq
MIRT1995008	hsa-miR-4723-3p	CLIP-seq
MIRT1995009	hsa-miR-4724-5p	CLIP-seq
MIRT1995010	hsa-miR-4755-3p	CLIP-seq
MIRT1995011	hsa-miR-4776-3p	CLIP-seq
MIRT1995012	hsa-miR-499-3p	CLIP-seq
MIRT1995013	hsa-miR-499a-3p	CLIP-seq
MIRT1995014	hsa-miR-512-5p	CLIP-seq
MIRT1995015	hsa-miR-548s	CLIP-seq
MIRT1995016	hsa-miR-588	CLIP-seq
MIRT1995017	hsa-miR-663b	CLIP-seq
MIRT1994991	hsa-miR-1202	CLIP-seq
MIRT1994992	hsa-miR-1207-3p	CLIP-seq
MIRT2229059	hsa-miR-1251	CLIP-seq
MIRT2229060	hsa-miR-1252	CLIP-seq
MIRT2229061	hsa-miR-1343	CLIP-seq
MIRT2229062	hsa-miR-202	CLIP-seq
MIRT2229063	hsa-miR-3137	CLIP-seq
MIRT2229064	hsa-miR-3173-3p	CLIP-seq
MIRT1994996	hsa-miR-3187-3p	CLIP-seq
MIRT1994997	hsa-miR-3194-5p	CLIP-seq
MIRT2229065	hsa-miR-342-5p	CLIP-seq
MIRT1994998	hsa-miR-3591-5p	CLIP-seq
MIRT2229066	hsa-miR-3667-3p	CLIP-seq
MIRT1994999	hsa-miR-3686	CLIP-seq
MIRT1995001	hsa-miR-3972	CLIP-seq
MIRT2229067	hsa-miR-4297	CLIP-seq
MIRT2229068	hsa-miR-4314	CLIP-seq
MIRT2229069	hsa-miR-4426	CLIP-seq
MIRT1995002	hsa-miR-4435	CLIP-seq
MIRT2229070	hsa-miR-4456	CLIP-seq
MIRT2229071	hsa-miR-4647	CLIP-seq
MIRT2229072	hsa-miR-4651	CLIP-seq
MIRT1995003	hsa-miR-4652-3p	CLIP-seq
MIRT2229073	hsa-miR-4662b	CLIP-seq
MIRT2229074	hsa-miR-4664-5p	CLIP-seq
MIRT2229075	hsa-miR-4667-5p	CLIP-seq
MIRT2229076	hsa-miR-4700-5p	CLIP-seq
MIRT1995006	hsa-miR-4701-5p	CLIP-seq
MIRT1995007	hsa-miR-4715-5p	CLIP-seq
MIRT1995009	hsa-miR-4724-5p	CLIP-seq
MIRT2229077	hsa-miR-4768-5p	CLIP-seq
MIRT2229078	hsa-miR-4778-5p	CLIP-seq
MIRT2229079	hsa-miR-4787-3p	CLIP-seq
MIRT1995014	hsa-miR-512-5p	CLIP-seq
MIRT2229080	hsa-miR-548al	CLIP-seq
MIRT1995015	hsa-miR-548s	CLIP-seq
MIRT1995016	hsa-miR-588	CLIP-seq
MIRT2229081	hsa-miR-608	CLIP-seq
MIRT2229082	hsa-miR-637	CLIP-seq
MIRT2229083	hsa-miR-760	CLIP-seq
MIRT2229077	hsa-miR-4768-5p	CLIP-seq
MIRT2229059	hsa-miR-1251	CLIP-seq
MIRT2229060	hsa-miR-1252	CLIP-seq
MIRT2229061	hsa-miR-1343	CLIP-seq
MIRT2532711	hsa-miR-1913	CLIP-seq
MIRT2532712	hsa-miR-193a-3p	CLIP-seq
MIRT2532713	hsa-miR-193b	CLIP-seq
MIRT2229062	hsa-miR-202	CLIP-seq
MIRT2532714	hsa-miR-214	CLIP-seq
MIRT2229063	hsa-miR-3137	CLIP-seq
MIRT2532715	hsa-miR-3156-3p	CLIP-seq
MIRT2532716	hsa-miR-3160-5p	CLIP-seq
MIRT2229064	hsa-miR-3173-3p	CLIP-seq
MIRT1994995	hsa-miR-3183	CLIP-seq
MIRT2229065	hsa-miR-342-5p	CLIP-seq
MIRT2532717	hsa-miR-3619-5p	CLIP-seq
MIRT2229066	hsa-miR-3667-3p	CLIP-seq
MIRT1995000	hsa-miR-3922-5p	CLIP-seq
MIRT2532718	hsa-miR-3929	CLIP-seq
MIRT2532719	hsa-miR-4267	CLIP-seq
MIRT2532720	hsa-miR-4283	CLIP-seq
MIRT2532721	hsa-miR-4291	CLIP-seq
MIRT2229067	hsa-miR-4297	CLIP-seq
MIRT2532722	hsa-miR-4301	CLIP-seq
MIRT2229068	hsa-miR-4314	CLIP-seq
MIRT2532723	hsa-miR-4326	CLIP-seq
MIRT2532724	hsa-miR-4419b	CLIP-seq
MIRT2229069	hsa-miR-4426	CLIP-seq
MIRT2229070	hsa-miR-4456	CLIP-seq
MIRT2532725	hsa-miR-4478	CLIP-seq
MIRT2532726	hsa-miR-4639-5p	CLIP-seq
MIRT2532727	hsa-miR-4641	CLIP-seq
MIRT2229071	hsa-miR-4647	CLIP-seq
MIRT2229072	hsa-miR-4651	CLIP-seq
MIRT2229073	hsa-miR-4662b	CLIP-seq
MIRT2229074	hsa-miR-4664-5p	CLIP-seq
MIRT2229075	hsa-miR-4667-5p	CLIP-seq
MIRT2532728	hsa-miR-4684-5p	CLIP-seq
MIRT2532729	hsa-miR-4685-5p	CLIP-seq
MIRT2532730	hsa-miR-4686	CLIP-seq
MIRT2532731	hsa-miR-4691-5p	CLIP-seq
MIRT2229076	hsa-miR-4700-5p	CLIP-seq
MIRT1995006	hsa-miR-4701-5p	CLIP-seq
MIRT1995008	hsa-miR-4723-3p	CLIP-seq
MIRT1995009	hsa-miR-4724-5p	CLIP-seq
MIRT2532732	hsa-miR-4727-5p	CLIP-seq
MIRT2532733	hsa-miR-4761-5p	CLIP-seq
MIRT2229077	hsa-miR-4768-5p	CLIP-seq
MIRT2229078	hsa-miR-4778-5p	CLIP-seq
MIRT2229079	hsa-miR-4787-3p	CLIP-seq
MIRT2532734	hsa-miR-493	CLIP-seq
MIRT2532735	hsa-miR-508-5p	CLIP-seq
MIRT2532736	hsa-miR-513c	CLIP-seq
MIRT2532737	hsa-miR-514b-5p	CLIP-seq
MIRT2532738	hsa-miR-532-3p	CLIP-seq
MIRT2532739	hsa-miR-544	CLIP-seq
MIRT2229080	hsa-miR-548al	CLIP-seq
MIRT1995016	hsa-miR-588	CLIP-seq
MIRT2229081	hsa-miR-608	CLIP-seq
MIRT2229082	hsa-miR-637	CLIP-seq
MIRT1995017	hsa-miR-663b	CLIP-seq
MIRT2229083	hsa-miR-760	CLIP-seq
MIRT2532740	hsa-miR-761	CLIP-seq
MIRT2532741	hsa-miR-766	CLIP-seq
MIRT2532742	hsa-miR-922	CLIP-seq
MIRT2532743	hsa-miR-942	CLIP-seq
MIRT2229059	hsa-miR-1251	CLIP-seq
MIRT2229061	hsa-miR-1343	CLIP-seq
MIRT2532711	hsa-miR-1913	CLIP-seq
MIRT2532714	hsa-miR-214	CLIP-seq
MIRT2229063	hsa-miR-3137	CLIP-seq
MIRT2532716	hsa-miR-3160-5p	CLIP-seq
MIRT1994995	hsa-miR-3183	CLIP-seq
MIRT2532717	hsa-miR-3619-5p	CLIP-seq
MIRT2229066	hsa-miR-3667-3p	CLIP-seq
MIRT1995000	hsa-miR-3922-5p	CLIP-seq
MIRT2532718	hsa-miR-3929	CLIP-seq
MIRT2532719	hsa-miR-4267	CLIP-seq
MIRT2532720	hsa-miR-4283	CLIP-seq
MIRT2532721	hsa-miR-4291	CLIP-seq
MIRT2229067	hsa-miR-4297	CLIP-seq
MIRT2229068	hsa-miR-4314	CLIP-seq
MIRT2532723	hsa-miR-4326	CLIP-seq
MIRT2532724	hsa-miR-4419b	CLIP-seq
MIRT2229069	hsa-miR-4426	CLIP-seq
MIRT2229070	hsa-miR-4456	CLIP-seq
MIRT2532725	hsa-miR-4478	CLIP-seq
MIRT2532726	hsa-miR-4639-5p	CLIP-seq
MIRT2532727	hsa-miR-4641	CLIP-seq
MIRT2229071	hsa-miR-4647	CLIP-seq
MIRT2229073	hsa-miR-4662b	CLIP-seq
MIRT2229075	hsa-miR-4667-5p	CLIP-seq
MIRT2532728	hsa-miR-4684-5p	CLIP-seq
MIRT2532729	hsa-miR-4685-5p	CLIP-seq
MIRT2532730	hsa-miR-4686	CLIP-seq
MIRT2532731	hsa-miR-4691-5p	CLIP-seq
MIRT2229076	hsa-miR-4700-5p	CLIP-seq
MIRT1995008	hsa-miR-4723-3p	CLIP-seq
MIRT1995009	hsa-miR-4724-5p	CLIP-seq
MIRT2532732	hsa-miR-4727-5p	CLIP-seq
MIRT2532733	hsa-miR-4761-5p	CLIP-seq
MIRT2229077	hsa-miR-4768-5p	CLIP-seq
MIRT2229078	hsa-miR-4778-5p	CLIP-seq
MIRT2229079	hsa-miR-4787-3p	CLIP-seq
MIRT2532734	hsa-miR-493	CLIP-seq
MIRT2532735	hsa-miR-508-5p	CLIP-seq
MIRT2532736	hsa-miR-513c	CLIP-seq
MIRT2532737	hsa-miR-514b-5p	CLIP-seq
MIRT2532739	hsa-miR-544	CLIP-seq
MIRT2229080	hsa-miR-548al	CLIP-seq
MIRT2229082	hsa-miR-637	CLIP-seq
MIRT2229083	hsa-miR-760	CLIP-seq
MIRT2532740	hsa-miR-761	CLIP-seq
MIRT2532741	hsa-miR-766	CLIP-seq
MIRT2532742	hsa-miR-922	CLIP-seq
MIRT2532743	hsa-miR-942	CLIP-seq

Show/Hide all (60)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IBA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	TAS
GO:0000781	Component	Chromosome, telomeric region	HDA	19135898
GO:0000781	Component	Chromosome, telomeric region	IDA	24270157
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	IMP	11986308
GO:0003684	Function	Damaged DNA binding	TAS	8007985
GO:0003690	Function	Double-stranded DNA binding	TAS	8131753
GO:0003824	Function	Catalytic activity	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IEA
GO:0004519	Function	Endonuclease activity	TAS	8131753
GO:0004520	Function	DNA endonuclease activity	IEA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IBA
GO:0004523	Function	RNA-DNA hybrid ribonuclease activity	IDA	7961795
GO:0004527	Function	Exonuclease activity	IEA
GO:0004527	Function	Exonuclease activity	TAS	9778254
GO:0005515	Function	Protein binding	IPI	9305916, 11430825, 11598021, 14657243, 14688284, 15576034, 18499658, 18692475, 22551069, 26030842, 26496610, 26751069, 26760506, 28514442, 29997244, 31467278, 31515488, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	7961795, 12427278, 18995831
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005739	Component	Mitochondrion	IDA	18995831
GO:0005739	Component	Mitochondrion	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006260	Process	DNA replication	TAS	9778254
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	TAS	8007985
GO:0006284	Process	Base-excision repair	IEA
GO:0006287	Process	Base-excision repair, gap-filling	TAS
GO:0006302	Process	Double-strand break repair	TAS	8131753
GO:0006310	Process	DNA recombination	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007613	Process	Memory	IEA
GO:0008309	Function	Double-stranded DNA exodeoxyribonuclease activity	TAS	8131753
GO:0008409	Function	5'-3' exonuclease activity	IBA
GO:0008409	Function	5'-3' exonuclease activity	IDA	7961795
GO:0008409	Function	5'-3' exonuclease activity	IEA
GO:0009650	Process	UV protection	TAS	8007985
GO:0016020	Component	Membrane	HDA	19946888
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0017108	Function	5'-flap endonuclease activity	IBA
GO:0017108	Function	5'-flap endonuclease activity	IDA	18995831
GO:0017108	Function	5'-flap endonuclease activity	IEA
GO:0017108	Function	5'-flap endonuclease activity	IMP	8621570, 11986308
GO:0017108	Function	5'-flap endonuclease activity	TAS
GO:0030145	Function	Manganese ion binding	IBA
GO:0032201	Process	Telomere maintenance via semi-conservative replication	TAS
GO:0032991	Component	Protein-containing complex	IDA	25378300
GO:0043137	Process	DNA replication, removal of RNA primer	IDA	18995831
GO:0043137	Process	DNA replication, removal of RNA primer	IEA
GO:0045876	Process	Positive regulation of sister chromatid cohesion	IMP	18499658
GO:0046872	Function	Metal ion binding	IEA
GO:0048256	Function	Flap endonuclease activity	IDA	18499658

MIM	HGNC	e!Ensembl
600393	3650	ENSG00000168496

P39748

Protein name

Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)

Protein function

Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA

PDB

1U7B , 1UL1 , 3Q8K , 3Q8L , 3Q8M , 3UVU , 5E0V , 5FV7 , 5K97 , 5KSE , 5UM9 , 5ZOD , 5ZOE , 5ZOF , 5ZOG , 6TNZ , 7QO1 , 8YJH , 8YJL , 8YJQ , 8YJR , 8YJS , 8YJU , 8YJV , 8YJW , 8YJZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00752	XPG_N	1 → 107	XPG N-terminal domain	Family
PF00867	XPG_I	146 → 233	XPG I-region	Family

Sequence

MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK

Sequence length

380

Interactions

View interactions

	KEGG		Reactome
	DNA replication Base excision repair Non-homologous end-joining		POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hereditary breast ovarian cancer syndrome	Uncertain significance	rs750703675	RCV001374574
Non-immune hydrops fetalis	Uncertain significance	rs764549465	RCV001844346

Show/Hide Text Mining Associations (70)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	26431531, 27655641, 33508502, 39267056
Adenoma	Associate	23951112
Adenomatous Polyposis Coli	Associate	22787431, 24259968
Astrocytoma	Associate	19596913
Autoimmune Diseases	Associate	19010819
Bloom Syndrome	Associate	16326861
Brain Neoplasms	Associate	19596913
Breast Neoplasms	Associate	19010819, 22787431, 24880630, 25111287, 25885449, 27801669, 31998443, 34117958
Carcinogenesis	Associate	39766782
Carcinoma Ductal Breast	Associate	34117958
Carcinoma Hepatocellular	Associate	32399086, 33750838, 37978846
Carcinoma Intraductal Noninfiltrating	Associate	34117958
Carcinoma Non Small Cell Lung	Stimulate	19596913
Carcinoma Non Small Cell Lung	Associate	29037854
Carcinoma Squamous Cell	Associate	32340320
Cardiovascular Abnormalities	Associate	23592911
Colorectal Neoplasms	Associate	19218431, 23382697, 28628639
Coronary Artery Disease	Associate	20802161
Crohn Disease	Stimulate	40527798
Diabetes Gestational	Inhibit	27019630
Diabetes Mellitus	Stimulate	27019630
DNA Virus Infections	Associate	24911150
Drug Related Side Effects and Adverse Reactions	Inhibit	28628639
Drug Related Side Effects and Adverse Reactions	Associate	30316293
Endometriosis	Associate	29109095
Esophageal Neoplasms	Associate	28319330
Esophageal Squamous Cell Carcinoma	Associate	23504502, 24022861, 28319330
Fanconi Anemia	Associate	28628639
Friedreich Ataxia	Associate	24691413
Gallbladder Neoplasms	Associate	26668074
Gallstones	Associate	26668074
Glioblastoma	Associate	19596913
Glioma	Associate	29109095, 35414100
Hereditary Breast and Ovarian Cancer Syndrome	Associate	24880630
Inflammation	Associate	19010819
Inflammatory Bowel Diseases	Stimulate	40527798
Lens Subluxation	Associate	23592911
Leukemia	Associate	29109095
Lung Neoplasms	Stimulate	19596913
Lung Neoplasms	Associate	30260965
Lupus Nephritis	Associate	29239254
Lymphatic Metastasis	Associate	27801669
Malformations of Cortical Development Group I	Associate	29239254
Mammary Neoplasms Animal	Associate	22787431
Marfan Syndrome	Associate	23592911
Microsatellite Instability	Associate	35414100
Myotonic Dystrophy	Inhibit	27019630
Necrosis	Associate	34117958
Neoplasm Invasiveness	Stimulate	34117958
Neoplasms	Inhibit	15131255
Neoplasms	Associate	19010819, 24880630, 27655641, 27801669, 28628639, 29109095, 32586310, 33446690, 34117958, 35246224, 35414100, 37326412, 37501391, 8007985
Neoplasms	Stimulate	29037854, 32399086
Neoplasms Squamous Cell	Associate	24114512
Neuroblastoma	Associate	35217496
Ovarian Neoplasms	Associate	27391345, 33169800, 35246224
Personality Disorders	Stimulate	34117958
Prostatic Neoplasms	Associate	37326412
Recombinant chromosome 8 syndrome	Associate	30686591
Seminoma	Stimulate	19596913
Squamous Cell Carcinoma of Head and Neck	Associate	36738487, 37185662, 37993428
Stomach Diseases	Associate	28628639
Stomach Neoplasms	Associate	22894650, 23504502, 29109095, 32586310, 37100457
Tachycardia Atrioventricular Nodal Reentry	Stimulate	26431531
Tertiary Lymphoid Structures	Stimulate	22894650
Testicular Neoplasms	Stimulate	19596913
Triple Negative Breast Neoplasms	Associate	24880630, 26267318
Uveal melanoma	Associate	30107825
Vitelliform Macular Dystrophy	Associate	9445487
Werner Syndrome	Associate	11598021, 15592449, 27849570
Wilms Tumor	Associate	29937070

FEN1 (flap structure-specific endonuclease 1)