Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
222894
Gene name Gene Name - the full gene name approved by the HGNC.
Fer3 like bHLH transcription factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FERD3L
Synonyms (NCBI Gene) Gene synonyms aliases
N-TWIST, NATO3, NTWIST, PTFB, bHLHa31
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p21.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT994712 hsa-miR-329 CLIP-seq
MIRT994713 hsa-miR-362-3p CLIP-seq
MIRT994714 hsa-miR-642b CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
617578 16660 ENSG00000146618
Protein
UniProt ID Q96RJ6
Protein name Fer3-like protein (Basic helix-loop-helix protein N-twist) (Class A basic helix-loop-helix protein 31) (bHLHa31) (Nephew of atonal 3) (Neuronal twist)
Protein function Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (By similarity). {ECO:0000
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00010 HLH 102 154 Helix-loop-helix DNA-binding domain Domain
Sequence
MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEG
DPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEA
FDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMT
ELLESCEKKESG
Sequence length 166
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Intracranial Aneurysm Intracranial Aneurysm GWAS
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis GWAS
Borderline personality disorder Borderline personality disorder GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Triple Negative Breast Neoplasms Associate 30786922