PXT1 (peroxisomal testis enriched protein 1)

Gene

• Entrez ID: 222659
• Gene name: Peroxisomal testis enriched protein 1
• Gene symbol: PXT1
• Synonyms (NCBI Gene): STEPP
• Chromosome: 6
• Chromosome location: 6p21.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1279246	hsa-let-7a	CLIP-seq
MIRT1279247	hsa-let-7b	CLIP-seq
MIRT1279248	hsa-let-7c	CLIP-seq
MIRT1279249	hsa-let-7d	CLIP-seq
MIRT1279250	hsa-let-7e	CLIP-seq
MIRT1279251	hsa-let-7f	CLIP-seq
MIRT1279252	hsa-let-7g	CLIP-seq
MIRT1279253	hsa-let-7i	CLIP-seq
MIRT1279254	hsa-miR-1207-5p	CLIP-seq
MIRT1279255	hsa-miR-1252	CLIP-seq
MIRT1279256	hsa-miR-1298	CLIP-seq
MIRT1279257	hsa-miR-1321	CLIP-seq
MIRT1279258	hsa-miR-1343	CLIP-seq
MIRT1279259	hsa-miR-185	CLIP-seq
MIRT1279260	hsa-miR-202	CLIP-seq
MIRT1279261	hsa-miR-2117	CLIP-seq
MIRT1279262	hsa-miR-3126-5p	CLIP-seq
MIRT1279263	hsa-miR-3175	CLIP-seq
MIRT1279264	hsa-miR-3202	CLIP-seq
MIRT1279265	hsa-miR-3529	CLIP-seq
MIRT1279266	hsa-miR-3689d	CLIP-seq
MIRT1279267	hsa-miR-3690	CLIP-seq
MIRT1279268	hsa-miR-379	CLIP-seq
MIRT1279269	hsa-miR-3927	CLIP-seq
MIRT1279270	hsa-miR-4254	CLIP-seq
MIRT1279271	hsa-miR-4260	CLIP-seq
MIRT1279272	hsa-miR-4270	CLIP-seq
MIRT1279273	hsa-miR-4306	CLIP-seq
MIRT1279274	hsa-miR-4441	CLIP-seq
MIRT1279275	hsa-miR-4458	CLIP-seq
MIRT1279276	hsa-miR-4500	CLIP-seq
MIRT1279277	hsa-miR-4533	CLIP-seq
MIRT1279278	hsa-miR-4644	CLIP-seq
MIRT1279279	hsa-miR-4739	CLIP-seq
MIRT1279280	hsa-miR-4753-3p	CLIP-seq
MIRT1279281	hsa-miR-4756-5p	CLIP-seq
MIRT1279282	hsa-miR-4763-3p	CLIP-seq
MIRT1279283	hsa-miR-486-3p	CLIP-seq
MIRT1279284	hsa-miR-98	CLIP-seq
MIRT2307885	hsa-miR-122	CLIP-seq
MIRT2307886	hsa-miR-1285	CLIP-seq
MIRT2307887	hsa-miR-141	CLIP-seq
MIRT2307888	hsa-miR-200a	CLIP-seq
MIRT2307889	hsa-miR-3153	CLIP-seq
MIRT2307890	hsa-miR-3187-5p	CLIP-seq
MIRT2307891	hsa-miR-378g	CLIP-seq
MIRT2307892	hsa-miR-4314	CLIP-seq
MIRT2307893	hsa-miR-4486	CLIP-seq
MIRT2307894	hsa-miR-4668-5p	CLIP-seq
MIRT2307895	hsa-miR-4708-3p	CLIP-seq
MIRT2307896	hsa-miR-570	CLIP-seq
MIRT2307897	hsa-miR-612	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005777	Component	Peroxisome	IEA
GO:0005777	Component	Peroxisome	ISS	18160785

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8NFP0
• Protein name: Peroxisomal testis-specific protein 1 (Small testis-specific peroxisomal protein)
• PDB: 7WJH, 8GSV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15214	PXT1	84 → 134	Peroxisomal testis-specific protein 1	Family

• Sequence:

  MKKKHDGIVYETKEVLNPSPKVTHCCKSLWLKYSFQKAYMTQLVSSQPVPAMSRNPDHNL
  LSQPKEHSIVQKHHQEEIIHKLAMQLRHIGDNIDHRMVREDLQQDGRDALDHFVFFFFRR
  VQVLLHFFWNNHLL

• Sequence length: 134

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations